Title: Intravitreal Bevacizumab for Treatment of Diabetic Macular Oedema
Abstract: Diabetic macular oedema (DMO) is a leading cause of vision loss in the working-age population worldwide. Numerous early studies suggest an important role for intravitreal anti-VEGF agents such as bevacizumab in the management of DMO. We reviewed manuscripts that had investigated pharmacokinetic, efficacy, safety, dose and frequency of intravitreal bevacizumab (IVB) injections as well as effect of macular ischaemia, initial macular thickness and optical coherence tomography (OCT) patterns of DMO on the final results of treatment with IVB. In summery literature searches disclosed that almost all studies published up to now provided evidence supporting use of IVB for treatment of either naïve or persistent DMO in short and long term up to 2 years.