Get quick answers to your questions about the article from our AI researcher chatbot
{'id': 'https://openalex.org/W2505453924', 'doi': 'https://doi.org/10.1139/cjas-2016-0021', 'title': 'Apical Na+-dependent neutral amino acid exchanger ASCT2 (ATB0) and mTOR-signaling components are expressed along the entire jejunal crypt-villus axis in young pigs fed a liquid milk replacer', 'display_name': 'Apical Na+-dependent neutral amino acid exchanger ASCT2 (ATB0) and mTOR-signaling components are expressed along the entire jejunal crypt-villus axis in young pigs fed a liquid milk replacer', 'publication_year': 2016, 'publication_date': '2016-08-04', 'ids': {'openalex': 'https://openalex.org/W2505453924', 'doi': 'https://doi.org/10.1139/cjas-2016-0021', 'mag': '2505453924'}, 'language': 'en', 'primary_location': {'is_oa': True, 'landing_page_url': 'https://doi.org/10.1139/cjas-2016-0021', 'pdf_url': 'https://www.nrcresearchpress.com/doi/pdf/10.1139/cjas-2016-0021', 'source': {'id': 'https://openalex.org/S54036783', 'display_name': 'Canadian Journal of Animal Science', 'issn_l': '0008-3984', 'issn': ['0008-3984', '1918-1825'], 'is_oa': False, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310312929', 'host_organization_name': 'Canadian Science Publishing', 'host_organization_lineage': ['https://openalex.org/P4310312929'], 'host_organization_lineage_names': ['Canadian Science Publishing'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, 'type': 'article', 'type_crossref': 'journal-article', 'indexed_in': ['crossref'], 'open_access': {'is_oa': True, 'oa_status': 'bronze', 'oa_url': 'https://www.nrcresearchpress.com/doi/pdf/10.1139/cjas-2016-0021', 'any_repository_has_fulltext': True}, 'authorships': [{'author_position': 'first', 'author': {'id': 'https://openalex.org/A5008471593', 'display_name': 'Chengbo Yang', 'orcid': 'https://orcid.org/0000-0003-4449-5132'}, 'institutions': [{'id': 'https://openalex.org/I46247651', 'display_name': 'University of Manitoba', 'ror': 'https://ror.org/02gfys938', 'country_code': 'CA', 'type': 'education', 'lineage': ['https://openalex.org/I46247651']}, {'id': 'https://openalex.org/I79817857', 'display_name': 'University of Guelph', 'ror': 'https://ror.org/01r7awg59', 'country_code': 'CA', 'type': 'education', 'lineage': ['https://openalex.org/I79817857']}], 'countries': ['CA'], 'is_corresponding': False, 'raw_author_name': 'Chengbo Yang', 'raw_affiliation_strings': ['Department of Animal Biosciences, University of Guelph, Guelph, ON N1G 2W1, Canada.', 'Department of Animal Science, Faculty of Agricultural and Food Sciences, University of Manitoba, Winnipeg, MB R3T 2N2, Canada.'], 'affiliations': [{'raw_affiliation_string': 'Department of Animal Science, Faculty of Agricultural and Food Sciences, University of Manitoba, Winnipeg, MB R3T 2N2, Canada.', 'institution_ids': ['https://openalex.org/I46247651']}, {'raw_affiliation_string': 'Department of Animal Biosciences, University of Guelph, Guelph, ON N1G 2W1, Canada.', 'institution_ids': ['https://openalex.org/I79817857']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5101484752', 'display_name': 'Xiaojian Yang', 'orcid': 'https://orcid.org/0000-0002-7838-0109'}, 'institutions': [{'id': 'https://openalex.org/I2799834026', 'display_name': 'University of Minnesota, Waseca', 'ror': 'https://ror.org/0241gfe92', 'country_code': 'US', 'type': 'education', 'lineage': ['https://openalex.org/I2799834026']}, {'id': 'https://openalex.org/I79817857', 'display_name': 'University of Guelph', 'ror': 'https://ror.org/01r7awg59', 'country_code': 'CA', 'type': 'education', 'lineage': ['https://openalex.org/I79817857']}], 'countries': ['CA', 'US'], 'is_corresponding': False, 'raw_author_name': 'Xiaojian Yang', 'raw_affiliation_strings': ['Department of Animal Biosciences, University of Guelph, Guelph, ON N1G 2W1, Canada.', 'Southern Research and Outreach Center, University of Minnesota, Waseca, MN 56093, USA.'], 'affiliations': [{'raw_affiliation_string': 'Southern Research and Outreach Center, University of Minnesota, Waseca, MN 56093, USA.', 'institution_ids': ['https://openalex.org/I2799834026']}, {'raw_affiliation_string': 'Department of Animal Biosciences, University of Guelph, Guelph, ON N1G 2W1, Canada.', 'institution_ids': ['https://openalex.org/I79817857']}]}, {'author_position': 'last', 'author': {'id': 'https://openalex.org/A5109522609', 'display_name': 'Ming Fan', 'orcid': 'https://orcid.org/0009-0007-5315-2007'}, 'institutions': [{'id': 'https://openalex.org/I79817857', 'display_name': 'University of Guelph', 'ror': 'https://ror.org/01r7awg59', 'country_code': 'CA', 'type': 'education', 'lineage': ['https://openalex.org/I79817857']}], 'countries': ['CA'], 'is_corresponding': False, 'raw_author_name': 'Ming Z. Fan', 'raw_affiliation_strings': ['Department of Animal Biosciences, University of Guelph, Guelph, ON N1G 2W1, Canada.'], 'affiliations': [{'raw_affiliation_string': 'Department of Animal Biosciences, University of Guelph, Guelph, ON N1G 2W1, Canada.', 'institution_ids': ['https://openalex.org/I79817857']}]}], 'institution_assertions': [], 'countries_distinct_count': 2, 'institutions_distinct_count': 3, 'corresponding_author_ids': [], 'corresponding_institution_ids': [], 'apc_list': None, 'apc_paid': None, 'fwci': 0.324, 'has_fulltext': True, 'fulltext_origin': 'ngrams', 'cited_by_count': 3, 'citation_normalized_percentile': {'value': 0.554181, 'is_in_top_1_percent': False, 'is_in_top_10_percent': False}, 'cited_by_percentile_year': {'min': 77, 'max': 79}, 'biblio': {'volume': None, 'issue': None, 'first_page': None, 'last_page': None}, 'is_retracted': False, 'is_paratext': False, 'primary_topic': {'id': 'https://openalex.org/T12770', 'display_name': 'Amino Acid Enzymes and Metabolism', 'score': 0.9998, 'subfield': {'id': 'https://openalex.org/subfields/1303', 'display_name': 'Biochemistry'}, 'field': {'id': 'https://openalex.org/fields/13', 'display_name': 'Biochemistry, Genetics and Molecular Biology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}, 'topics': [{'id': 'https://openalex.org/T12770', 'display_name': 'Amino Acid Enzymes and Metabolism', 'score': 0.9998, 'subfield': {'id': 'https://openalex.org/subfields/1303', 'display_name': 'Biochemistry'}, 'field': {'id': 'https://openalex.org/fields/13', 'display_name': 'Biochemistry, Genetics and Molecular Biology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}, {'id': 'https://openalex.org/T10839', 'display_name': 'Pancreatic function and diabetes', 'score': 0.9995, 'subfield': {'id': 'https://openalex.org/subfields/2746', 'display_name': 'Surgery'}, 'field': {'id': 'https://openalex.org/fields/27', 'display_name': 'Medicine'}, 'domain': {'id': 'https://openalex.org/domains/4', 'display_name': 'Health Sciences'}}, {'id': 'https://openalex.org/T10724', 'display_name': 'Ion Transport and Channel Regulation', 'score': 0.996, 'subfield': {'id': 'https://openalex.org/subfields/1312', 'display_name': 'Molecular Biology'}, 'field': {'id': 'https://openalex.org/fields/13', 'display_name': 'Biochemistry, Genetics and Molecular Biology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}], 'keywords': [{'id': 'https://openalex.org/keywords/intestinal-villus', 'display_name': 'Intestinal villus', 'score': 0.46586585}], 'concepts': [{'id': 'https://openalex.org/C66090201', 'wikidata': 'https://www.wikidata.org/wiki/Q15995009', 'display_name': 'Crypt', 'level': 2, 'score': 0.8333514}, {'id': 'https://openalex.org/C86554907', 'wikidata': 'https://www.wikidata.org/wiki/Q285613', 'display_name': 'PI3K/AKT/mTOR pathway', 'level': 3, 'score': 0.6914296}, {'id': 'https://openalex.org/C2779349466', 'wikidata': 'https://www.wikidata.org/wiki/Q181619', 'display_name': 'Glutamine', 'level': 3, 'score': 0.6573668}, {'id': 'https://openalex.org/C104202773', 'wikidata': 'https://www.wikidata.org/wiki/Q18031289', 'display_name': 'P70-S6 Kinase 1', 'level': 4, 'score': 0.63415796}, {'id': 'https://openalex.org/C2781456731', 'wikidata': 'https://www.wikidata.org/wiki/Q868506', 'display_name': 'Intestinal villus', 'level': 3, 'score': 0.46586585}, {'id': 'https://openalex.org/C185592680', 'wikidata': 'https://www.wikidata.org/wiki/Q2329', 'display_name': 'Chemistry', 'level': 0, 'score': 0.45970306}, {'id': 'https://openalex.org/C86803240', 'wikidata': 'https://www.wikidata.org/wiki/Q420', 'display_name': 'Biology', 'level': 0, 'score': 0.39716092}, {'id': 'https://openalex.org/C95444343', 'wikidata': 'https://www.wikidata.org/wiki/Q7141', 'display_name': 'Cell biology', 'level': 1, 'score': 0.3731528}, {'id': 'https://openalex.org/C515207424', 'wikidata': 'https://www.wikidata.org/wiki/Q8066', 'display_name': 'Amino acid', 'level': 2, 'score': 0.3460195}, {'id': 'https://openalex.org/C16685009', 'wikidata': 'https://www.wikidata.org/wiki/Q335057', 'display_name': 'Andrology', 'level': 1, 'score': 0.3300991}, {'id': 'https://openalex.org/C62478195', 'wikidata': 'https://www.wikidata.org/wiki/Q828130', 'display_name': 'Signal transduction', 'level': 2, 'score': 0.2893666}, {'id': 'https://openalex.org/C134018914', 'wikidata': 'https://www.wikidata.org/wiki/Q162606', 'display_name': 'Endocrinology', 'level': 1, 'score': 0.23547971}, {'id': 'https://openalex.org/C55493867', 'wikidata': 'https://www.wikidata.org/wiki/Q7094', 'display_name': 'Biochemistry', 'level': 1, 'score': 0.22105744}, {'id': 'https://openalex.org/C71924100', 'wikidata': 'https://www.wikidata.org/wiki/Q11190', 'display_name': 'Medicine', 'level': 0, 'score': 0.07585877}], 'mesh': [], 'locations_count': 2, 'locations': [{'is_oa': True, 'landing_page_url': 'https://doi.org/10.1139/cjas-2016-0021', 'pdf_url': 'https://www.nrcresearchpress.com/doi/pdf/10.1139/cjas-2016-0021', 'source': {'id': 'https://openalex.org/S54036783', 'display_name': 'Canadian Journal of Animal Science', 'issn_l': '0008-3984', 'issn': ['0008-3984', '1918-1825'], 'is_oa': False, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310312929', 'host_organization_name': 'Canadian Science Publishing', 'host_organization_lineage': ['https://openalex.org/P4310312929'], 'host_organization_lineage_names': ['Canadian Science Publishing'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, {'is_oa': True, 'landing_page_url': 'http://hdl.handle.net/1807/75395', 'pdf_url': 'https://tspace.library.utoronto.ca/bitstream/1807/75395/1/cjas-2016-0021.pdf', 'source': {'id': 'https://openalex.org/S4306400261', 'display_name': 'TSpace (University of Toronto)', 'issn_l': None, 'issn': None, 'is_oa': True, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I185261750', 'host_organization_name': 'University of Toronto', 'host_organization_lineage': ['https://openalex.org/I185261750'], 'host_organization_lineage_names': ['University of Toronto'], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': 'acceptedVersion', 'is_accepted': True, 'is_published': False}], 'best_oa_location': {'is_oa': True, 'landing_page_url': 'https://doi.org/10.1139/cjas-2016-0021', 'pdf_url': 'https://www.nrcresearchpress.com/doi/pdf/10.1139/cjas-2016-0021', 'source': {'id': 'https://openalex.org/S54036783', 'display_name': 'Canadian Journal of Animal Science', 'issn_l': '0008-3984', 'issn': ['0008-3984', '1918-1825'], 'is_oa': False, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310312929', 'host_organization_name': 'Canadian Science Publishing', 'host_organization_lineage': ['https://openalex.org/P4310312929'], 'host_organization_lineage_names': ['Canadian Science Publishing'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, 'sustainable_development_goals': [], 'grants': [], 'datasets': [], 'versions': [], 'referenced_works_count': 38, 'referenced_works': ['https://openalex.org/W109523419', 'https://openalex.org/W115815853', 'https://openalex.org/W14733619', 'https://openalex.org/W1899439971', 'https://openalex.org/W1905499293', 'https://openalex.org/W1976433941', 'https://openalex.org/W1977550714', 'https://openalex.org/W1979631068', 'https://openalex.org/W1979927918', 'https://openalex.org/W1982557947', 'https://openalex.org/W1996831070', 'https://openalex.org/W1998475753', 'https://openalex.org/W2004975140', 'https://openalex.org/W2026288278', 'https://openalex.org/W2047379418', 'https://openalex.org/W2049857974', 'https://openalex.org/W2062898391', 'https://openalex.org/W2079978538', 'https://openalex.org/W2080391155', 'https://openalex.org/W2081970367', 'https://openalex.org/W2092574194', 'https://openalex.org/W2094391131', 'https://openalex.org/W2104213367', 'https://openalex.org/W2106600448', 'https://openalex.org/W2107277218', 'https://openalex.org/W2114711522', 'https://openalex.org/W2116387597', 'https://openalex.org/W2116997602', 'https://openalex.org/W2121354127', 'https://openalex.org/W2125459722', 'https://openalex.org/W2128600167', 'https://openalex.org/W2128931982', 'https://openalex.org/W2137635725', 'https://openalex.org/W2140932205', 'https://openalex.org/W2150178760', 'https://openalex.org/W2169903226', 'https://openalex.org/W2266317072', 'https://openalex.org/W2296959914'], 'related_works': ['https://openalex.org/W4309779541', 'https://openalex.org/W4254042120', 'https://openalex.org/W4248518057', 'https://openalex.org/W4235939794', 'https://openalex.org/W4212829917', 'https://openalex.org/W2265863784', 'https://openalex.org/W2144059623', 'https://openalex.org/W2138871725', 'https://openalex.org/W2116838883', 'https://openalex.org/W2006559495'], 'abstract_inverted_index': {'The': [0, 36], 'Na+-dependent': [1], 'neutral': [2, 19], 'amino': [3], 'acid': [4], '(AA)': [5], 'exchanger': [6], 'ASCT2': [7], '(ATB0)': [8], 'plays': [9], 'an': [10], 'important': [11], 'role': [12], 'in': [13, 61, 68, 96, 100, 116, 121, 152, 157, 174, 178, 202, 211], 'the': [14, 46, 51, 64, 85, 97, 101, 105, 117, 122, 125, 129, 133, 153, 158, 175, 179, 184, 193, 203, 206, 212], 'apical': [15, 130], 'exchange': [16], 'of': [17, 38, 45, 56, 142], 'large': [18], 'AAs': [20], 'such': [21], 'as': [22], 'glutamine': [23], '(Gln)': [24], 'and': [25, 28, 50, 104, 128, 138, 189, 192, 198], 'leucine': [26], '(Leu)': [27], 'is': [29], 'essential': [30], 'to': [31, 42], 'maintaining': [32], 'gut': [33], 'mucosal': [34], 'growth.': [35], 'objectives': [37], 'this': [39], 'study': [40], 'were': [41, 110, 200], 'investigate': [43], 'expression': [44], 'ASCT2/ATB0': [47, 86, 118, 185], '(SLC1A5)': [48, 87, 186], 'gene': [49, 88, 187], 'key': [52, 194], 'mechanistic': [53], '(mammalian)': [54], 'target': [55], 'rapamycin': [57], '(mTOR)': [58], 'signaling': [59], 'components': [60], 'epithelia': [62, 204], 'along': [63, 205], 'jejunal': [65, 208], 'crypt–villus': [66, 209], 'axis': [67, 210], 'young': [69, 213], 'pigs': [70, 214], 'fed': [71, 215], 'a': [72, 216], 'liquid': [73, 217], 'milk': [74, 218], 'replacer.': [75, 219], 'Reverse': [76], 'transcription': [77], 'polymerase': [78], 'chain': [79], 'reaction': [80], '(RT-PCR)': [81], 'analyses': [82], 'showed': [83], 'that': [84], 'mRNA': [89, 188], 'abundance': [90, 168], 'was': [91, 147, 169], 'higher': [92, 148, 170], '(P': [93, 113, 149, 171], '<': [94, 150, 172], '0.05)': [95, 115, 151, 173], 'crypt': [98, 139, 176], 'than': [99, 156, 177], 'upper': [102, 134, 159, 180], 'villus': [103, 107, 155, 160, 181], 'middle': [106, 136, 154], 'cells.': [108, 140, 161, 182], 'There': [109], 'no': [111], 'differences': [112], '>': [114], 'protein': [119, 146, 166, 190], 'abundances': [120], 'cell': [123], 'homogenate,': [124], 'intracellular': [126], 'fraction,': [127], 'membrane': [131], 'among': [132], 'villus,': [135, 137], 'Abundance': [141], 'phosphorylated': [143], 'mTOR': [144], '(p-mTOR)': [145], 'Phosphorylated': [162], 'p70': [163], 'S6': [164], 'kinase': [165], '(p-S6K1)': [167], 'Thus,': [183], 'ATB0': [191], 'mTOR-signaling': [195], 'components,': [196], 'p-mTOR': [197], 'p-S6K1,': [199], 'expressed': [201], 'entire': [207]}, 'cited_by_api_url': 'https://api.openalex.org/works?filter=cites:W2505453924', 'counts_by_year': [{'year': 2021, 'cited_by_count': 1}, {'year': 2019, 'cited_by_count': 1}, {'year': 2018, 'cited_by_count': 1}], 'updated_date': '2024-12-14T11:41:45.929642', 'created_date': '2016-08-23'}