Get quick answers to your questions about the article from our AI researcher chatbot
{'id': 'https://openalex.org/W2504543139', 'doi': 'https://doi.org/10.1186/s12885-016-2542-4', 'title': 'Prognostic significance of FOXM1 expression and antitumor effect of FOXM1 inhibition in synovial sarcomas', 'display_name': 'Prognostic significance of FOXM1 expression and antitumor effect of FOXM1 inhibition in synovial sarcomas', 'publication_year': 2016, 'publication_date': '2016-07-20', 'ids': {'openalex': 'https://openalex.org/W2504543139', 'doi': 'https://doi.org/10.1186/s12885-016-2542-4', 'mag': '2504543139', 'pmid': 'https://pubmed.ncbi.nlm.nih.gov/27439614', 'pmcid': 'https://www.ncbi.nlm.nih.gov/pmc/articles/4955131'}, 'language': 'en', 'primary_location': {'is_oa': True, 'landing_page_url': 'https://doi.org/10.1186/s12885-016-2542-4', 'pdf_url': 'https://bmccancer.biomedcentral.com/track/pdf/10.1186/s12885-016-2542-4', 'source': {'id': 'https://openalex.org/S192926780', 'display_name': 'BMC Cancer', 'issn_l': '1471-2407', 'issn': ['1471-2407'], 'is_oa': True, 'is_in_doaj': True, 'is_core': True, 'host_organization': 'https://openalex.org/P4310320256', 'host_organization_name': 'BioMed Central', 'host_organization_lineage': ['https://openalex.org/P4310319965', 'https://openalex.org/P4310320256'], 'host_organization_lineage_names': ['Springer Nature', 'BioMed Central'], 'type': 'journal'}, 'license': 'cc-by', 'license_id': 'https://openalex.org/licenses/cc-by', 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, 'type': 'article', 'type_crossref': 'journal-article', 'indexed_in': ['crossref', 'pubmed'], 'open_access': {'is_oa': True, 'oa_status': 'gold', 'oa_url': 'https://bmccancer.biomedcentral.com/track/pdf/10.1186/s12885-016-2542-4', 'any_repository_has_fulltext': True}, 'authorships': [{'author_position': 'first', 'author': {'id': 'https://openalex.org/A5070821567', 'display_name': 'Akira Maekawa', 'orcid': 'https://orcid.org/0000-0002-0775-816X'}, 'institutions': [{'id': 'https://openalex.org/I135598925', 'display_name': 'Kyushu University', 'ror': 'https://ror.org/00p4k0j84', 'country_code': 'JP', 'type': 'education', 'lineage': ['https://openalex.org/I135598925']}], 'countries': ['JP'], 'is_corresponding': False, 'raw_author_name': 'Akira Maekawa', 'raw_affiliation_strings': ['Department of Anatomic Pathology, Graduate School of Medical Sciences, Kyushu University, 3-1-1 Maidashi, Higashi-ku, Fukuoka, 812-8582, Japan'], 'affiliations': [{'raw_affiliation_string': 'Department of Anatomic Pathology, Graduate School of Medical Sciences, Kyushu University, 3-1-1 Maidashi, Higashi-ku, Fukuoka, 812-8582, Japan', 'institution_ids': ['https://openalex.org/I135598925']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5012193751', 'display_name': 'Kenichi Kohashi', 'orcid': 'https://orcid.org/0000-0002-2358-7452'}, 'institutions': [{'id': 'https://openalex.org/I135598925', 'display_name': 'Kyushu University', 'ror': 'https://ror.org/00p4k0j84', 'country_code': 'JP', 'type': 'education', 'lineage': ['https://openalex.org/I135598925']}], 'countries': ['JP'], 'is_corresponding': False, 'raw_author_name': 'Kenichi Kohashi', 'raw_affiliation_strings': ['Department of Anatomic Pathology, Graduate School of Medical Sciences, Kyushu University, 3-1-1 Maidashi, Higashi-ku, Fukuoka, 812-8582, Japan'], 'affiliations': [{'raw_affiliation_string': 'Department of Anatomic Pathology, Graduate School of Medical Sciences, Kyushu University, 3-1-1 Maidashi, Higashi-ku, Fukuoka, 812-8582, Japan', 'institution_ids': ['https://openalex.org/I135598925']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5034675576', 'display_name': 'Masaaki Kuda', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I135598925', 'display_name': 'Kyushu University', 'ror': 'https://ror.org/00p4k0j84', 'country_code': 'JP', 'type': 'education', 'lineage': ['https://openalex.org/I135598925']}], 'countries': ['JP'], 'is_corresponding': False, 'raw_author_name': 'Masaaki Kuda', 'raw_affiliation_strings': ['Department of Anatomic Pathology, Graduate School of Medical Sciences, Kyushu University, 3-1-1 Maidashi, Higashi-ku, Fukuoka, 812-8582, Japan'], 'affiliations': [{'raw_affiliation_string': 'Department of Anatomic Pathology, Graduate School of Medical Sciences, Kyushu University, 3-1-1 Maidashi, Higashi-ku, Fukuoka, 812-8582, Japan', 'institution_ids': ['https://openalex.org/I135598925']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5003131051', 'display_name': 'Kunio Iura', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I135598925', 'display_name': 'Kyushu University', 'ror': 'https://ror.org/00p4k0j84', 'country_code': 'JP', 'type': 'education', 'lineage': ['https://openalex.org/I135598925']}], 'countries': ['JP'], 'is_corresponding': False, 'raw_author_name': 'Kunio Iura', 'raw_affiliation_strings': ['Department of Anatomic Pathology, Graduate School of Medical Sciences, Kyushu University, 3-1-1 Maidashi, Higashi-ku, Fukuoka, 812-8582, Japan'], 'affiliations': [{'raw_affiliation_string': 'Department of Anatomic Pathology, Graduate School of Medical Sciences, Kyushu University, 3-1-1 Maidashi, Higashi-ku, Fukuoka, 812-8582, Japan', 'institution_ids': ['https://openalex.org/I135598925']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5044407567', 'display_name': 'Takeaki Ishii', 'orcid': 'https://orcid.org/0000-0003-0131-205X'}, 'institutions': [{'id': 'https://openalex.org/I135598925', 'display_name': 'Kyushu University', 'ror': 'https://ror.org/00p4k0j84', 'country_code': 'JP', 'type': 'education', 'lineage': ['https://openalex.org/I135598925']}], 'countries': ['JP'], 'is_corresponding': False, 'raw_author_name': 'Takeaki Ishii', 'raw_affiliation_strings': ['Department of Anatomic Pathology, Graduate School of Medical Sciences, Kyushu University, 3-1-1 Maidashi, Higashi-ku, Fukuoka, 812-8582, Japan'], 'affiliations': [{'raw_affiliation_string': 'Department of Anatomic Pathology, Graduate School of Medical Sciences, Kyushu University, 3-1-1 Maidashi, Higashi-ku, Fukuoka, 812-8582, Japan', 'institution_ids': ['https://openalex.org/I135598925']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5048210816', 'display_name': 'Makoto Endo', 'orcid': 'https://orcid.org/0000-0002-7956-2190'}, 'institutions': [{'id': 'https://openalex.org/I135598925', 'display_name': 'Kyushu University', 'ror': 'https://ror.org/00p4k0j84', 'country_code': 'JP', 'type': 'education', 'lineage': ['https://openalex.org/I135598925']}], 'countries': ['JP'], 'is_corresponding': False, 'raw_author_name': 'Makoto Endo', 'raw_affiliation_strings': ['Departments of Orthopedic Surgery, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan'], 'affiliations': [{'raw_affiliation_string': 'Departments of Orthopedic Surgery, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan', 'institution_ids': ['https://openalex.org/I135598925']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5067576408', 'display_name': 'Tetsuya Nakatsura', 'orcid': 'https://orcid.org/0000-0003-3918-2385'}, 'institutions': [{'id': 'https://openalex.org/I4210145079', 'display_name': 'National Cancer Center Hospital East', 'ror': 'https://ror.org/03rm3gk43', 'country_code': 'JP', 'type': 'healthcare', 'lineage': ['https://openalex.org/I4210145079']}], 'countries': ['JP'], 'is_corresponding': False, 'raw_author_name': 'Tetsuya Nakatsura', 'raw_affiliation_strings': ['Division of Cancer Immunotherapy, National Cancer Center Hospital East, Kashiwa, Japan'], 'affiliations': [{'raw_affiliation_string': 'Division of Cancer Immunotherapy, National Cancer Center Hospital East, Kashiwa, Japan', 'institution_ids': ['https://openalex.org/I4210145079']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5011966088', 'display_name': 'Yukihide Iwamoto', 'orcid': 'https://orcid.org/0000-0003-0453-1733'}, 'institutions': [{'id': 'https://openalex.org/I135598925', 'display_name': 'Kyushu University', 'ror': 'https://ror.org/00p4k0j84', 'country_code': 'JP', 'type': 'education', 'lineage': ['https://openalex.org/I135598925']}], 'countries': ['JP'], 'is_corresponding': False, 'raw_author_name': 'Yukihide Iwamoto', 'raw_affiliation_strings': ['Departments of Orthopedic Surgery, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan'], 'affiliations': [{'raw_affiliation_string': 'Departments of Orthopedic Surgery, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan', 'institution_ids': ['https://openalex.org/I135598925']}]}, {'author_position': 'last', 'author': {'id': 'https://openalex.org/A5049884976', 'display_name': 'Yoshinao Oda', 'orcid': 'https://orcid.org/0000-0001-9636-1182'}, 'institutions': [{'id': 'https://openalex.org/I135598925', 'display_name': 'Kyushu University', 'ror': 'https://ror.org/00p4k0j84', 'country_code': 'JP', 'type': 'education', 'lineage': ['https://openalex.org/I135598925']}], 'countries': ['JP'], 'is_corresponding': False, 'raw_author_name': 'Yoshinao Oda', 'raw_affiliation_strings': ['Department of Anatomic Pathology, Graduate School of Medical Sciences, Kyushu University, 3-1-1 Maidashi, Higashi-ku, Fukuoka, 812-8582, Japan'], 'affiliations': [{'raw_affiliation_string': 'Department of Anatomic Pathology, Graduate School of Medical Sciences, Kyushu University, 3-1-1 Maidashi, Higashi-ku, Fukuoka, 812-8582, Japan', 'institution_ids': ['https://openalex.org/I135598925']}]}], 'countries_distinct_count': 1, 'institutions_distinct_count': 2, 'corresponding_author_ids': [], 'corresponding_institution_ids': [], 'apc_list': {'value': 1790, 'currency': 'GBP', 'value_usd': 2195, 'provenance': 'doaj'}, 'apc_paid': {'value': 1790, 'currency': 'GBP', 'value_usd': 2195, 'provenance': 'doaj'}, 'fwci': 0.995, 'has_fulltext': True, 'fulltext_origin': 'ngrams', 'cited_by_count': 17, 'citation_normalized_percentile': {'value': 0.846214, 'is_in_top_1_percent': False, 'is_in_top_10_percent': False}, 'cited_by_percentile_year': {'min': 90, 'max': 91}, 'biblio': {'volume': '16', 'issue': '1', 'first_page': None, 'last_page': None}, 'is_retracted': False, 'is_paratext': False, 'primary_topic': {'id': 'https://openalex.org/T12835', 'display_name': 'Regulation and Functions of FoxO Transcription Factors', 'score': 0.9999, 'subfield': {'id': 'https://openalex.org/subfields/1312', 'display_name': 'Molecular Biology'}, 'field': {'id': 'https://openalex.org/fields/13', 'display_name': 'Biochemistry, Genetics and Molecular Biology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}, 'topics': [{'id': 'https://openalex.org/T12835', 'display_name': 'Regulation and Functions of FoxO Transcription Factors', 'score': 0.9999, 'subfield': {'id': 'https://openalex.org/subfields/1312', 'display_name': 'Molecular Biology'}, 'field': {'id': 'https://openalex.org/fields/13', 'display_name': 'Biochemistry, Genetics and Molecular Biology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}, {'id': 'https://openalex.org/T13779', 'display_name': 'Role of Pim Oncogenes in Tumorigenesis', 'score': 0.9898, 'subfield': {'id': 'https://openalex.org/subfields/2734', 'display_name': 'Pathology and Forensic Medicine'}, 'field': {'id': 'https://openalex.org/fields/27', 'display_name': 'Medicine'}, 'domain': {'id': 'https://openalex.org/domains/4', 'display_name': 'Health Sciences'}}, {'id': 'https://openalex.org/T12620', 'display_name': 'Calcineurin-NFAT Signaling in Transcriptional Regulation', 'score': 0.9866, 'subfield': {'id': 'https://openalex.org/subfields/1312', 'display_name': 'Molecular Biology'}, 'field': {'id': 'https://openalex.org/fields/13', 'display_name': 'Biochemistry, Genetics and Molecular Biology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}], 'keywords': [{'id': 'https://openalex.org/keywords/foxm1', 'display_name': 'FOXM1', 'score': 0.95768535}, {'id': 'https://openalex.org/keywords/thiostrepton', 'display_name': 'Thiostrepton', 'score': 0.8652413}, {'id': 'https://openalex.org/keywords/synovial-sarcoma', 'display_name': 'Synovial sarcoma', 'score': 0.6943947}, {'id': 'https://openalex.org/keywords/surgical-oncology', 'display_name': 'Surgical oncology', 'score': 0.56926674}, {'id': 'https://openalex.org/keywords/cancer', 'display_name': 'Cancer', 'score': 0.485572}], 'concepts': [{'id': 'https://openalex.org/C170240278', 'wikidata': 'https://www.wikidata.org/wiki/Q17928773', 'display_name': 'FOXM1', 'level': 4, 'score': 0.95768535}, {'id': 'https://openalex.org/C2777578258', 'wikidata': 'https://www.wikidata.org/wiki/Q7784698', 'display_name': 'Thiostrepton', 'level': 5, 'score': 0.8652413}, {'id': 'https://openalex.org/C2776910622', 'wikidata': 'https://www.wikidata.org/wiki/Q2619315', 'display_name': 'Synovial sarcoma', 'level': 3, 'score': 0.6943947}, {'id': 'https://openalex.org/C502942594', 'wikidata': 'https://www.wikidata.org/wiki/Q3421914', 'display_name': 'Cancer research', 'level': 1, 'score': 0.6159245}, {'id': 'https://openalex.org/C2781303535', 'wikidata': 'https://www.wikidata.org/wiki/Q18936', 'display_name': 'Doxorubicin', 'level': 3, 'score': 0.6096013}, {'id': 'https://openalex.org/C2780140570', 'wikidata': 'https://www.wikidata.org/wiki/Q3545481', 'display_name': 'Surgical oncology', 'level': 2, 'score': 0.56926674}, {'id': 'https://openalex.org/C204232928', 'wikidata': 'https://www.wikidata.org/wiki/Q899285', 'display_name': 'Immunohistochemistry', 'level': 2, 'score': 0.50166655}, {'id': 'https://openalex.org/C2778256501', 'wikidata': 'https://www.wikidata.org/wiki/Q223911', 'display_name': 'Sarcoma', 'level': 2, 'score': 0.46690255}, {'id': 'https://openalex.org/C71924100', 'wikidata': 'https://www.wikidata.org/wiki/Q11190', 'display_name': 'Medicine', 'level': 0, 'score': 0.46047392}, {'id': 'https://openalex.org/C86803240', 'wikidata': 'https://www.wikidata.org/wiki/Q420', 'display_name': 'Biology', 'level': 0, 'score': 0.3770092}, {'id': 'https://openalex.org/C143998085', 'wikidata': 'https://www.wikidata.org/wiki/Q162555', 'display_name': 'Oncology', 'level': 1, 'score': 0.3695106}, {'id': 'https://openalex.org/C29537977', 'wikidata': 'https://www.wikidata.org/wiki/Q188941', 'display_name': 'Cell cycle', 'level': 3, 'score': 0.349806}, {'id': 'https://openalex.org/C142724271', 'wikidata': 'https://www.wikidata.org/wiki/Q7208', 'display_name': 'Pathology', 'level': 1, 'score': 0.30439696}, {'id': 'https://openalex.org/C2776694085', 'wikidata': 'https://www.wikidata.org/wiki/Q974135', 'display_name': 'Chemotherapy', 'level': 2, 'score': 0.2683278}, {'id': 'https://openalex.org/C126322002', 'wikidata': 'https://www.wikidata.org/wiki/Q11180', 'display_name': 'Internal medicine', 'level': 1, 'score': 0.26058328}, {'id': 'https://openalex.org/C121608353', 'wikidata': 'https://www.wikidata.org/wiki/Q12078', 'display_name': 'Cancer', 'level': 2, 'score': 0.23547307}, {'id': 'https://openalex.org/C104317684', 'wikidata': 'https://www.wikidata.org/wiki/Q7187', 'display_name': 'Gene', 'level': 2, 'score': 0.14177167}, {'id': 'https://openalex.org/C67705224', 'wikidata': 'https://www.wikidata.org/wiki/Q11053', 'display_name': 'RNA', 'level': 3, 'score': 0.1366069}, {'id': 'https://openalex.org/C88478588', 'wikidata': 'https://www.wikidata.org/wiki/Q42244', 'display_name': 'Ribosome', 'level': 4, 'score': 0.0}, {'id': 'https://openalex.org/C55493867', 'wikidata': 'https://www.wikidata.org/wiki/Q7094', 'display_name': 'Biochemistry', 'level': 1, 'score': 0.0}], 'mesh': [{'descriptor_ui': 'D000970', 'descriptor_name': 'Antineoplastic Agents', 'qualifier_ui': 'Q000627', 'qualifier_name': 'therapeutic use', 'is_major_topic': True}, {'descriptor_ui': 'D000072278', 'descriptor_name': 'Forkhead Box Protein M1', 'qualifier_ui': 'Q000037', 'qualifier_name': 'antagonists & inhibitors', 'is_major_topic': True}, {'descriptor_ui': 'D015972', 'descriptor_name': 'Gene Expression Regulation, Neoplastic', 'qualifier_ui': 'Q000187', 'qualifier_name': 'drug effects', 'is_major_topic': True}, {'descriptor_ui': 'D013584', 'descriptor_name': 'Sarcoma, Synovial', 'qualifier_ui': 'Q000188', 'qualifier_name': 'drug therapy', 'is_major_topic': True}, {'descriptor_ui': 'D000328', 'descriptor_name': 'Adult', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D000970', 'descriptor_name': 'Antineoplastic Agents', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D014408', 'descriptor_name': 'Biomarkers, Tumor', 'qualifier_ui': 'Q000037', 'qualifier_name': 'antagonists & inhibitors', 'is_major_topic': False}, {'descriptor_ui': 'D014408', 'descriptor_name': 'Biomarkers, Tumor', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': False}, {'descriptor_ui': 'D014408', 'descriptor_name': 'Biomarkers, Tumor', 'qualifier_ui': 'Q000235', 'qualifier_name': 'genetics', 'is_major_topic': False}, {'descriptor_ui': 'D014408', 'descriptor_name': 'Biomarkers, Tumor', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D045744', 'descriptor_name': 'Cell Line, Tumor', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D049109', 'descriptor_name': 'Cell Proliferation', 'qualifier_ui': 'Q000235', 'qualifier_name': 'genetics', 'is_major_topic': False}, {'descriptor_ui': 'D049109', 'descriptor_name': 'Cell Proliferation', 'qualifier_ui': 'Q000187', 'qualifier_name': 'drug effects', 'is_major_topic': False}, {'descriptor_ui': 'D049109', 'descriptor_name': 'Cell Proliferation', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D004317', 'descriptor_name': 'Doxorubicin', 'qualifier_ui': 'Q000627', 'qualifier_name': 'therapeutic use', 'is_major_topic': False}, {'descriptor_ui': 'D004317', 'descriptor_name': 'Doxorubicin', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D005260', 'descriptor_name': 'Female', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D000072278', 'descriptor_name': 'Forkhead Box Protein M1', 'qualifier_ui': 'Q000235', 'qualifier_name': 'genetics', 'is_major_topic': False}, {'descriptor_ui': 'D000072278', 'descriptor_name': 'Forkhead Box Protein M1', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': False}, {'descriptor_ui': 'D000072278', 'descriptor_name': 'Forkhead Box Protein M1', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D020869', 'descriptor_name': 'Gene Expression Profiling', 'qualifier_ui': 'Q000379', 'qualifier_name': 'methods', 'is_major_topic': False}, {'descriptor_ui': 'D020869', 'descriptor_name': 'Gene Expression Profiling', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D015972', 'descriptor_name': 'Gene Expression Regulation, Neoplastic', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D006801', 'descriptor_name': 'Humans', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D007150', 'descriptor_name': 'Immunohistochemistry', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D053208', 'descriptor_name': 'Kaplan-Meier Estimate', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D008297', 'descriptor_name': 'Male', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D058990', 'descriptor_name': 'Molecular Targeted Therapy', 'qualifier_ui': 'Q000379', 'qualifier_name': 'methods', 'is_major_topic': False}, {'descriptor_ui': 'D058990', 'descriptor_name': 'Molecular Targeted Therapy', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D015514', 'descriptor_name': 'Oncogene Proteins, Fusion', 'qualifier_ui': 'Q000235', 'qualifier_name': 'genetics', 'is_major_topic': False}, {'descriptor_ui': 'D015514', 'descriptor_name': 'Oncogene Proteins, Fusion', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D011379', 'descriptor_name': 'Prognosis', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D034622', 'descriptor_name': 'RNA Interference', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D020133', 'descriptor_name': 'Reverse Transcriptase Polymerase Chain Reaction', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D013584', 'descriptor_name': 'Sarcoma, Synovial', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': False}, {'descriptor_ui': 'D013584', 'descriptor_name': 'Sarcoma, Synovial', 'qualifier_ui': 'Q000235', 'qualifier_name': 'genetics', 'is_major_topic': False}, {'descriptor_ui': 'D013584', 'descriptor_name': 'Sarcoma, Synovial', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D013883', 'descriptor_name': 'Thiostrepton', 'qualifier_ui': 'Q000627', 'qualifier_name': 'therapeutic use', 'is_major_topic': False}, {'descriptor_ui': 'D013883', 'descriptor_name': 'Thiostrepton', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D055815', 'descriptor_name': 'Young Adult', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}], 'locations_count': 3, 'locations': [{'is_oa': True, 'landing_page_url': 'https://doi.org/10.1186/s12885-016-2542-4', 'pdf_url': 'https://bmccancer.biomedcentral.com/track/pdf/10.1186/s12885-016-2542-4', 'source': {'id': 'https://openalex.org/S192926780', 'display_name': 'BMC Cancer', 'issn_l': '1471-2407', 'issn': ['1471-2407'], 'is_oa': True, 'is_in_doaj': True, 'is_core': True, 'host_organization': 'https://openalex.org/P4310320256', 'host_organization_name': 'BioMed Central', 'host_organization_lineage': ['https://openalex.org/P4310319965', 'https://openalex.org/P4310320256'], 'host_organization_lineage_names': ['Springer Nature', 'BioMed Central'], 'type': 'journal'}, 'license': 'cc-by', 'license_id': 'https://openalex.org/licenses/cc-by', 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, {'is_oa': True, 'landing_page_url': 'https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4955131', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S2764455111', 'display_name': 'PubMed Central', 'issn_l': None, 'issn': None, 'is_oa': True, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1299303238', 'host_organization_name': 'National Institutes of Health', 'host_organization_lineage': ['https://openalex.org/I1299303238'], 'host_organization_lineage_names': ['National Institutes of Health'], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, {'is_oa': False, 'landing_page_url': 'https://pubmed.ncbi.nlm.nih.gov/27439614', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S4306525036', 'display_name': 'PubMed', 'issn_l': None, 'issn': None, 'is_oa': False, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1299303238', 'host_organization_name': 'National Institutes of Health', 'host_organization_lineage': ['https://openalex.org/I1299303238'], 'host_organization_lineage_names': ['National Institutes of Health'], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}], 'best_oa_location': {'is_oa': True, 'landing_page_url': 'https://doi.org/10.1186/s12885-016-2542-4', 'pdf_url': 'https://bmccancer.biomedcentral.com/track/pdf/10.1186/s12885-016-2542-4', 'source': {'id': 'https://openalex.org/S192926780', 'display_name': 'BMC Cancer', 'issn_l': '1471-2407', 'issn': ['1471-2407'], 'is_oa': True, 'is_in_doaj': True, 'is_core': True, 'host_organization': 'https://openalex.org/P4310320256', 'host_organization_name': 'BioMed Central', 'host_organization_lineage': ['https://openalex.org/P4310319965', 'https://openalex.org/P4310320256'], 'host_organization_lineage_names': ['Springer Nature', 'BioMed Central'], 'type': 'journal'}, 'license': 'cc-by', 'license_id': 'https://openalex.org/licenses/cc-by', 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, 'sustainable_development_goals': [{'score': 0.58, 'display_name': 'Good health and well-being', 'id': 'https://metadata.un.org/sdg/3'}], 'grants': [{'funder': 'https://openalex.org/F4320334764', 'funder_display_name': 'Japan Society for the Promotion of Science', 'award_id': '2593088'}], 'datasets': [], 'versions': [], 'referenced_works_count': 52, 'referenced_works': ['https://openalex.org/W1489202311', 'https://openalex.org/W1565915668', 'https://openalex.org/W1611604148', 'https://openalex.org/W1742901756', 'https://openalex.org/W1858630497', 'https://openalex.org/W1970041667', 'https://openalex.org/W1972190235', 'https://openalex.org/W1974332510', 'https://openalex.org/W1977144004', 'https://openalex.org/W1985647633', 'https://openalex.org/W1987225288', 'https://openalex.org/W1991603403', 'https://openalex.org/W1992782721', 'https://openalex.org/W1995357936', 'https://openalex.org/W1999959103', 'https://openalex.org/W2001479656', 'https://openalex.org/W2002435345', 'https://openalex.org/W2002512110', 'https://openalex.org/W2005472071', 'https://openalex.org/W2007987759', 'https://openalex.org/W2010139897', 'https://openalex.org/W2014729451', 'https://openalex.org/W2021904420', 'https://openalex.org/W2032481064', 'https://openalex.org/W2033912307', 'https://openalex.org/W2034091087', 'https://openalex.org/W2052146376', 'https://openalex.org/W2059094534', 'https://openalex.org/W2060665573', 'https://openalex.org/W2074651320', 'https://openalex.org/W2101816771', 'https://openalex.org/W2102123859', 'https://openalex.org/W2103953796', 'https://openalex.org/W2119876924', 'https://openalex.org/W2125569277', 'https://openalex.org/W2126141743', 'https://openalex.org/W2128071596', 'https://openalex.org/W2129097501', 'https://openalex.org/W2130236734', 'https://openalex.org/W2132433945', 'https://openalex.org/W2135630561', 'https://openalex.org/W2136923108', 'https://openalex.org/W2141284512', 'https://openalex.org/W2154575661', 'https://openalex.org/W2160196905', 'https://openalex.org/W2165057403', 'https://openalex.org/W2422151218', 'https://openalex.org/W2502134830', 'https://openalex.org/W4250252470', 'https://openalex.org/W4255398094', 'https://openalex.org/W81826961', 'https://openalex.org/W97469372'], 'related_works': ['https://openalex.org/W609527359', 'https://openalex.org/W2961633759', 'https://openalex.org/W2587281793', 'https://openalex.org/W2504543139', 'https://openalex.org/W2038626783', 'https://openalex.org/W2002512110', 'https://openalex.org/W1994401890', 'https://openalex.org/W1978326263', 'https://openalex.org/W1976577016', 'https://openalex.org/W1970041667'], 'abstract_inverted_index': {'Synovial': [0], 'sarcoma': [1, 7], '(SS)': [2], 'is': [3, 44, 216, 223], 'a': [4, 217, 224], 'soft': [5], 'tissue': [6], 'of': [8, 41, 51, 66, 91, 100, 111, 121, 141, 145, 176], 'unknown': [9], 'histogenesis.': [10], 'Most': [11], 'metastatic': [12], 'or': [13], 'unresectable': [14], 'cases': [15], 'are': [16, 24, 70], 'incurable.': [17], 'Novel': [18], 'antitumor': [19, 119, 191], 'agents': [20], 'and': [21, 57, 63, 81, 83, 86, 126, 148, 151, 220], 'precise': [22], 'prognostication': [23], 'needed': [25], 'for': [26, 207, 228], 'SS': [27, 69, 96, 133, 195, 211], 'patients.': [28], 'The': [29, 165], 'protein': [30], 'forkhead': [31], 'box': [32], 'M1': [33], '(FOXM1),': [34], 'which': [35], 'belongs': [36], 'to': [37, 46, 106], 'the': [38, 60, 76, 89, 118, 122, 139, 142, 174, 194, 205], 'FOX': [39], 'family': [40], 'transcription': [42], 'factors,': [43, 85], 'considered': [45], 'be': [47], 'an': [48], 'independent': [49], 'predictor': [50], 'poor': [52, 161], 'survival': [53], 'in': [54, 68, 95, 114, 163, 198, 209], 'many': [55], 'cancers': [56], 'sarcomas,': [58], 'but': [59], 'prognostic': [61, 84], 'implications': [62], 'oncogenic': [64], 'roles': [65], 'FOXM1': [67, 79, 92, 123, 156, 183, 185, 200, 214], 'poorly': [71], 'understood.': [72], 'Here': [73], 'we': [74, 87], 'examined': [75, 117], 'correlation': [77], 'between': [78], 'expression': [80, 110, 157, 175, 215], 'clinicopathologic': [82], 'investigated': [88], 'efficacy': [90, 140], 'target': [93], 'therapy': [94], 'cases.': [97], 'Immunohistochemical': [98], 'study': [99, 116], '106': [101], 'tumor': [102], 'specimens': [103], 'was': [104, 158, 180], 'conducted': [105], 'evaluate': [107], 'their': [108], 'immunohistochemical': [109], 'FOXM1.': [112], 'An': [113], 'vitro': [115], 'effect': [120], 'inhibitor': [124], 'thiostrepton': [125, 188], 'small': [127], 'interference': [128], 'RNA': [129], '(siRNA)': [130], 'on': [131, 193], 'two': [132], 'cell': [134, 177, 196, 212], 'lines.': [135, 213], 'We': [136], 'also': [137], 'assessed': [138], 'combined': [143], 'use': [144], 'doxorubicin': [146], '(DOX)': [147], 'thiostrepton.': [149], 'Univariate': [150], 'multivariate': [152], 'analyses': [153], 'revealed': [154, 172], 'that': [155, 173], 'associated': [159], 'with': [160, 182], 'prognosis': [162], 'SS.': [164, 229], 'cDNA': [166], 'microarray': [167], 'analysis': [168], 'using': [169], 'clinical': [170], 'samples': [171], 'cycle-associated': [178], 'genes': [179], 'correlated': [181], 'expression.': [184], 'inhibition': [186, 222], 'by': [187, 202], 'showed': [189], 'significant': [190], 'activity': [192], 'lines': [197], 'vitro.': [199], 'interruption': [201], 'siRNA': [203], 'increased': [204], 'chemosensitivity': [206], 'DOX': [208], 'both': [210], 'novel': [218], 'biomarker,': [219], 'its': [221], 'potential': [225], 'treatment': [226], 'option': [227]}, 'cited_by_api_url': 'https://api.openalex.org/works?filter=cites:W2504543139', 'counts_by_year': [{'year': 2024, 'cited_by_count': 3}, {'year': 2022, 'cited_by_count': 1}, {'year': 2021, 'cited_by_count': 1}, {'year': 2020, 'cited_by_count': 4}, {'year': 2019, 'cited_by_count': 1}, {'year': 2018, 'cited_by_count': 2}, {'year': 2017, 'cited_by_count': 4}, {'year': 2016, 'cited_by_count': 1}], 'updated_date': '2024-08-15T14:33:23.697191', 'created_date': '2016-08-23'}