Title: Silibinin in Skin Health: Efficacy and Mechanism of Action
Abstract: Publisher Summary Silibinin, a flavolignan, is one of the active ingredients of milk thistle extract, which is rich in a complex mixture of flavonoids such as silydianin, silychristin, isosilybin, and dehydrosilybin. Based on numerous studies, it seems that silibinin can be effectively used in improving skin health in general, and reduction of skin cancer risk in particular. More interestingly, silibinin has shown efficacy against UV-induced skin damage when applied topically, as well as when supplemented in the diet in various preclinical models. Thus, it has a strong potential to be developed as a chemopreventive agent against skin cancer and photoaging and is already being marketed in improved bioavailable forms. The important role for silibinin in managing skin health along with the chemoprevention of skin cancer is discussed in detail in this chapter. Silibinin has been shown to inhibit the proliferation of human colon cancer cells via the inhibition of cell cycle progression by modulating the levels of cyclins and cyclin-dependent kinases. Phytochemicals play an important role in skin health and chemoprevention of skin cancer. This chapter also discuses the mechanisms of silibinin action that include anti-inflammatory action, antiproliferative action, pro- or antiapoptotic action, modulation of aberrant mitogenic signaling, antiangiogenic action, and repair of UV-induced DNA damage.
Publication Year: 2009
Publication Date: 2009-01-01
Language: en
Type: book-chapter
Indexed In: ['crossref']
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Cited By Count: 3
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