Get quick answers to your questions about the article from our AI researcher chatbot
{'id': 'https://openalex.org/W2501166177', 'doi': 'https://doi.org/10.1007/s10544-016-0095-6', 'title': 'Assessment of whole blood thrombosis in a microfluidic device lined by fixed human endothelium', 'display_name': 'Assessment of whole blood thrombosis in a microfluidic device lined by fixed human endothelium', 'publication_year': 2016, 'publication_date': '2016-07-27', 'ids': {'openalex': 'https://openalex.org/W2501166177', 'doi': 'https://doi.org/10.1007/s10544-016-0095-6', 'mag': '2501166177', 'pmid': 'https://pubmed.ncbi.nlm.nih.gov/27464497', 'pmcid': 'https://www.ncbi.nlm.nih.gov/pmc/articles/4963439'}, 'language': 'en', 'primary_location': {'is_oa': True, 'landing_page_url': 'https://doi.org/10.1007/s10544-016-0095-6', 'pdf_url': 'https://link.springer.com/content/pdf/10.1007%2Fs10544-016-0095-6.pdf', 'source': {'id': 'https://openalex.org/S173545647', 'display_name': 'Biomedical Microdevices', 'issn_l': '1387-2176', 'issn': ['1387-2176', '1572-8781'], 'is_oa': False, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310319900', 'host_organization_name': 'Springer Science+Business Media', 'host_organization_lineage': ['https://openalex.org/P4310319965', 'https://openalex.org/P4310319900'], 'host_organization_lineage_names': ['Springer Nature', 'Springer Science+Business Media'], 'type': 'journal'}, 'license': 'cc-by', 'license_id': 'https://openalex.org/licenses/cc-by', 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, 'type': 'article', 'type_crossref': 'journal-article', 'indexed_in': ['crossref', 'pubmed'], 'open_access': {'is_oa': True, 'oa_status': 'hybrid', 'oa_url': 'https://link.springer.com/content/pdf/10.1007%2Fs10544-016-0095-6.pdf', 'any_repository_has_fulltext': True}, 'authorships': [{'author_position': 'first', 'author': {'id': 'https://openalex.org/A5037955730', 'display_name': 'Abhishek Jain', 'orcid': 'https://orcid.org/0000-0003-2235-5139'}, 'institutions': [{'id': 'https://openalex.org/I1316535847', 'display_name': 'Beth Israel Deaconess Medical Center', 'ror': 'https://ror.org/04drvxt59', 'country_code': 'US', 'type': 'healthcare', 'lineage': ['https://openalex.org/I1316535847']}, {'id': 'https://openalex.org/I136199984', 'display_name': 'Harvard University', 'ror': 'https://ror.org/03vek6s52', 'country_code': 'US', 'type': 'education', 'lineage': ['https://openalex.org/I136199984']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'Abhishek Jain', 'raw_affiliation_strings': ['Division of Hemostasis and Thrombosis, Department of Medicine, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA, USA'], 'affiliations': [{'raw_affiliation_string': 'Division of Hemostasis and Thrombosis, Department of Medicine, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA, USA', 'institution_ids': ['https://openalex.org/I1316535847', 'https://openalex.org/I136199984']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5034743017', 'display_name': 'Andries D. van der Meer', 'orcid': 'https://orcid.org/0000-0002-8761-4077'}, 'institutions': [{'id': 'https://openalex.org/I136199984', 'display_name': 'Harvard University', 'ror': 'https://ror.org/03vek6s52', 'country_code': 'US', 'type': 'education', 'lineage': ['https://openalex.org/I136199984']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'Andries D. van der Meer', 'raw_affiliation_strings': ['Wyss Institute for Biologically Inspired Engineering, Harvard University, 3 Blackfan Circle, CLSB 5, Boston, MA, 02115, USA'], 'affiliations': [{'raw_affiliation_string': 'Wyss Institute for Biologically Inspired Engineering, Harvard University, 3 Blackfan Circle, CLSB 5, Boston, MA, 02115, USA', 'institution_ids': ['https://openalex.org/I136199984']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5043109186', 'display_name': 'Anne‐Laure Papa', 'orcid': 'https://orcid.org/0000-0001-8282-5564'}, 'institutions': [{'id': 'https://openalex.org/I136199984', 'display_name': 'Harvard University', 'ror': 'https://ror.org/03vek6s52', 'country_code': 'US', 'type': 'education', 'lineage': ['https://openalex.org/I136199984']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'Anne-Laure Papa', 'raw_affiliation_strings': ['Wyss Institute for Biologically Inspired Engineering, Harvard University, 3 Blackfan Circle, CLSB 5, Boston, MA, 02115, USA'], 'affiliations': [{'raw_affiliation_string': 'Wyss Institute for Biologically Inspired Engineering, Harvard University, 3 Blackfan Circle, CLSB 5, Boston, MA, 02115, USA', 'institution_ids': ['https://openalex.org/I136199984']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5004776840', 'display_name': 'Riccardo Barrile', 'orcid': 'https://orcid.org/0000-0002-7301-3959'}, 'institutions': [{'id': 'https://openalex.org/I136199984', 'display_name': 'Harvard University', 'ror': 'https://ror.org/03vek6s52', 'country_code': 'US', 'type': 'education', 'lineage': ['https://openalex.org/I136199984']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'Riccardo Barrile', 'raw_affiliation_strings': ['Wyss Institute for Biologically Inspired Engineering, Harvard University, 3 Blackfan Circle, CLSB 5, Boston, MA, 02115, USA'], 'affiliations': [{'raw_affiliation_string': 'Wyss Institute for Biologically Inspired Engineering, Harvard University, 3 Blackfan Circle, CLSB 5, Boston, MA, 02115, USA', 'institution_ids': ['https://openalex.org/I136199984']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5081873818', 'display_name': 'Angela Lai', 'orcid': 'https://orcid.org/0000-0003-4912-3629'}, 'institutions': [{'id': 'https://openalex.org/I74973139', 'display_name': 'Carnegie Mellon University', 'ror': 'https://ror.org/05x2bcf33', 'country_code': 'US', 'type': 'education', 'lineage': ['https://openalex.org/I74973139']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'Angela Lai', 'raw_affiliation_strings': ['Department of Biomedical Engineering, Carnegie Mellon University, Pittsburgh, PA, USA'], 'affiliations': [{'raw_affiliation_string': 'Department of Biomedical Engineering, Carnegie Mellon University, Pittsburgh, PA, USA', 'institution_ids': ['https://openalex.org/I74973139']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5062338114', 'display_name': 'Benjamin L. Schlechter', 'orcid': 'https://orcid.org/0000-0002-1529-3278'}, 'institutions': [{'id': 'https://openalex.org/I1316535847', 'display_name': 'Beth Israel Deaconess Medical Center', 'ror': 'https://ror.org/04drvxt59', 'country_code': 'US', 'type': 'healthcare', 'lineage': ['https://openalex.org/I1316535847']}, {'id': 'https://openalex.org/I136199984', 'display_name': 'Harvard University', 'ror': 'https://ror.org/03vek6s52', 'country_code': 'US', 'type': 'education', 'lineage': ['https://openalex.org/I136199984']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'Benjamin L. Schlechter', 'raw_affiliation_strings': ['Division of Hematology and Oncology, Department of Medicine, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA, USA'], 'affiliations': [{'raw_affiliation_string': 'Division of Hematology and Oncology, Department of Medicine, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA, USA', 'institution_ids': ['https://openalex.org/I1316535847', 'https://openalex.org/I136199984']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5050880886', 'display_name': 'Monicah A. Otieno', 'orcid': 'https://orcid.org/0000-0001-6473-5979'}, 'institutions': [{'id': 'https://openalex.org/I4210151386', 'display_name': 'Janssen (United States)', 'ror': 'https://ror.org/05af73403', 'country_code': 'US', 'type': 'company', 'lineage': ['https://openalex.org/I1330063522', 'https://openalex.org/I4210151386']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'Monicah A. Otieno', 'raw_affiliation_strings': ['Janssen Pharmaceutical Research and Development, Pre-Clinical Development and Safety, Spring House, PA, USA'], 'affiliations': [{'raw_affiliation_string': 'Janssen Pharmaceutical Research and Development, Pre-Clinical Development and Safety, Spring House, PA, USA', 'institution_ids': ['https://openalex.org/I4210151386']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5001706891', 'display_name': 'Calvert Louden', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I4210151386', 'display_name': 'Janssen (United States)', 'ror': 'https://ror.org/05af73403', 'country_code': 'US', 'type': 'company', 'lineage': ['https://openalex.org/I1330063522', 'https://openalex.org/I4210151386']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'Calvert S. Louden', 'raw_affiliation_strings': ['Janssen Pharmaceutical Research and Development, Pre-Clinical Development and Safety, Spring House, PA, USA'], 'affiliations': [{'raw_affiliation_string': 'Janssen Pharmaceutical Research and Development, Pre-Clinical Development and Safety, Spring House, PA, USA', 'institution_ids': ['https://openalex.org/I4210151386']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5081783044', 'display_name': 'Kyung‐Jin Jang', 'orcid': 'https://orcid.org/0000-0001-7872-1703'}, 'institutions': [{'id': 'https://openalex.org/I136199984', 'display_name': 'Harvard University', 'ror': 'https://ror.org/03vek6s52', 'country_code': 'US', 'type': 'education', 'lineage': ['https://openalex.org/I136199984']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'Geraldine A. Hamilton', 'raw_affiliation_strings': ['Wyss Institute for Biologically Inspired Engineering, Harvard University, 3 Blackfan Circle, CLSB 5, Boston, MA, 02115, USA'], 'affiliations': [{'raw_affiliation_string': 'Wyss Institute for Biologically Inspired Engineering, Harvard University, 3 Blackfan Circle, CLSB 5, Boston, MA, 02115, USA', 'institution_ids': ['https://openalex.org/I136199984']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5049630475', 'display_name': 'Alan D. Michelson', 'orcid': 'https://orcid.org/0000-0002-1746-4819'}, 'institutions': [{'id': 'https://openalex.org/I4210117453', 'display_name': 'Dana-Farber Cancer Institute', 'ror': 'https://ror.org/02jzgtq86', 'country_code': 'US', 'type': 'facility', 'lineage': ['https://openalex.org/I4210117453']}, {'id': 'https://openalex.org/I136199984', 'display_name': 'Harvard University', 'ror': 'https://ror.org/03vek6s52', 'country_code': 'US', 'type': 'education', 'lineage': ['https://openalex.org/I136199984']}, {'id': 'https://openalex.org/I1288882113', 'display_name': "Boston Children's Hospital", 'ror': 'https://ror.org/00dvg7y05', 'country_code': 'US', 'type': 'healthcare', 'lineage': ['https://openalex.org/I1288882113']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'Alan D. Michelson', 'raw_affiliation_strings': ['Center for Platelet Research Studies, Division of Hematology/Oncology, Boston Children’s Hospital, Dana-Farber Cancer Institute, Harvard Medical School, Boston, MA, USA'], 'affiliations': [{'raw_affiliation_string': 'Center for Platelet Research Studies, Division of Hematology/Oncology, Boston Children’s Hospital, Dana-Farber Cancer Institute, Harvard Medical School, Boston, MA, USA', 'institution_ids': ['https://openalex.org/I4210117453', 'https://openalex.org/I136199984', 'https://openalex.org/I1288882113']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5067192657', 'display_name': 'Andrew L. Frelinger', 'orcid': 'https://orcid.org/0000-0002-6871-7441'}, 'institutions': [{'id': 'https://openalex.org/I1288882113', 'display_name': "Boston Children's Hospital", 'ror': 'https://ror.org/00dvg7y05', 'country_code': 'US', 'type': 'healthcare', 'lineage': ['https://openalex.org/I1288882113']}, {'id': 'https://openalex.org/I4210117453', 'display_name': 'Dana-Farber Cancer Institute', 'ror': 'https://ror.org/02jzgtq86', 'country_code': 'US', 'type': 'facility', 'lineage': ['https://openalex.org/I4210117453']}, {'id': 'https://openalex.org/I136199984', 'display_name': 'Harvard University', 'ror': 'https://ror.org/03vek6s52', 'country_code': 'US', 'type': 'education', 'lineage': ['https://openalex.org/I136199984']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'Andrew L. Frelinger', 'raw_affiliation_strings': ['Center for Platelet Research Studies, Division of Hematology/Oncology, Boston Children’s Hospital, Dana-Farber Cancer Institute, Harvard Medical School, Boston, MA, USA'], 'affiliations': [{'raw_affiliation_string': 'Center for Platelet Research Studies, Division of Hematology/Oncology, Boston Children’s Hospital, Dana-Farber Cancer Institute, Harvard Medical School, Boston, MA, USA', 'institution_ids': ['https://openalex.org/I1288882113', 'https://openalex.org/I4210117453', 'https://openalex.org/I136199984']}]}, {'author_position': 'last', 'author': {'id': 'https://openalex.org/A5005669988', 'display_name': 'Donald E. Ingber', 'orcid': 'https://orcid.org/0000-0002-4319-6520'}, 'institutions': [], 'countries': ['US'], 'is_corresponding': True, 'raw_author_name': 'Donald E. Ingber', 'raw_affiliation_strings': ['Harvard John A. Paulson School of Engineering and Applied Sciences, Cambridge, MA, USA'], 'affiliations': [{'raw_affiliation_string': 'Harvard John A. Paulson School of Engineering and Applied Sciences, Cambridge, MA, USA', 'institution_ids': []}]}], 'countries_distinct_count': 1, 'institutions_distinct_count': 6, 'corresponding_author_ids': ['https://openalex.org/A5005669988'], 'corresponding_institution_ids': [], 'apc_list': {'value': 2890, 'currency': 'EUR', 'value_usd': 3690, 'provenance': 'doaj'}, 'apc_paid': {'value': 2890, 'currency': 'EUR', 'value_usd': 3690, 'provenance': 'doaj'}, 'fwci': 6.9, 'has_fulltext': True, 'fulltext_origin': 'pdf', 'cited_by_count': 120, 'citation_normalized_percentile': {'value': 0.999975, 'is_in_top_1_percent': True, 'is_in_top_10_percent': True}, 'cited_by_percentile_year': {'min': 98, 'max': 99}, 'biblio': {'volume': '18', 'issue': '4', 'first_page': None, 'last_page': None}, 'is_retracted': False, 'is_paratext': False, 'primary_topic': {'id': 'https://openalex.org/T11190', 'display_name': '3D Bioprinting Technology', 'score': 0.9984, 'subfield': {'id': 'https://openalex.org/subfields/2204', 'display_name': 'Biomedical Engineering'}, 'field': {'id': 'https://openalex.org/fields/22', 'display_name': 'Engineering'}, 'domain': {'id': 'https://openalex.org/domains/3', 'display_name': 'Physical Sciences'}}, 'topics': [{'id': 'https://openalex.org/T11190', 'display_name': '3D Bioprinting Technology', 'score': 0.9984, 'subfield': {'id': 'https://openalex.org/subfields/2204', 'display_name': 'Biomedical Engineering'}, 'field': {'id': 'https://openalex.org/fields/22', 'display_name': 'Engineering'}, 'domain': {'id': 'https://openalex.org/domains/3', 'display_name': 'Physical Sciences'}}, {'id': 'https://openalex.org/T10746', 'display_name': 'Platelet Disorders and Thrombosis Mechanisms', 'score': 0.9973, 'subfield': {'id': 'https://openalex.org/subfields/2720', 'display_name': 'Hematology'}, 'field': {'id': 'https://openalex.org/fields/27', 'display_name': 'Medicine'}, 'domain': {'id': 'https://openalex.org/domains/4', 'display_name': 'Health Sciences'}}, {'id': 'https://openalex.org/T11407', 'display_name': 'Droplet Microfluidics Technology', 'score': 0.9845, 'subfield': {'id': 'https://openalex.org/subfields/2204', 'display_name': 'Biomedical Engineering'}, 'field': {'id': 'https://openalex.org/fields/22', 'display_name': 'Engineering'}, 'domain': {'id': 'https://openalex.org/domains/3', 'display_name': 'Physical Sciences'}}], 'keywords': [{'id': 'https://openalex.org/keywords/microfluidic-devices', 'display_name': 'Microfluidic Devices', 'score': 0.536908}, {'id': 'https://openalex.org/keywords/microfluidics', 'display_name': 'Microfluidics', 'score': 0.510694}, {'id': 'https://openalex.org/keywords/point-of-care', 'display_name': 'Point of care', 'score': 0.41432828}], 'concepts': [{'id': 'https://openalex.org/C2778589496', 'wikidata': 'https://www.wikidata.org/wiki/Q487937', 'display_name': 'Hemostasis', 'level': 2, 'score': 0.78471804}, {'id': 'https://openalex.org/C2776992346', 'wikidata': 'https://www.wikidata.org/wiki/Q111140', 'display_name': 'Endothelium', 'level': 2, 'score': 0.77120435}, {'id': 'https://openalex.org/C89560881', 'wikidata': 'https://www.wikidata.org/wiki/Q101026', 'display_name': 'Platelet', 'level': 2, 'score': 0.7201713}, {'id': 'https://openalex.org/C2781362458', 'wikidata': 'https://www.wikidata.org/wiki/Q1588755', 'display_name': 'Thrombus', 'level': 2, 'score': 0.714481}, {'id': 'https://openalex.org/C136229726', 'wikidata': 'https://www.wikidata.org/wiki/Q327092', 'display_name': 'Biomedical engineering', 'level': 1, 'score': 0.66283095}, {'id': 'https://openalex.org/C2780868729', 'wikidata': 'https://www.wikidata.org/wiki/Q261327', 'display_name': 'Thrombosis', 'level': 2, 'score': 0.5979837}, {'id': 'https://openalex.org/C123012128', 'wikidata': 'https://www.wikidata.org/wiki/Q5376430', 'display_name': 'Endothelial stem cell', 'level': 3, 'score': 0.4561429}, {'id': 'https://openalex.org/C158846371', 'wikidata': 'https://www.wikidata.org/wiki/Q1642137', 'display_name': 'Blood flow', 'level': 2, 'score': 0.43869197}, {'id': 'https://openalex.org/C1621761', 'wikidata': 'https://www.wikidata.org/wiki/Q7997549', 'display_name': 'Whole blood', 'level': 2, 'score': 0.42493206}, {'id': 'https://openalex.org/C51915194', 'wikidata': 'https://www.wikidata.org/wiki/Q17075487', 'display_name': 'Point of care', 'level': 2, 'score': 0.41432828}, {'id': 'https://openalex.org/C192562407', 'wikidata': 'https://www.wikidata.org/wiki/Q228736', 'display_name': 'Materials science', 'level': 0, 'score': 0.39832827}, {'id': 'https://openalex.org/C71924100', 'wikidata': 'https://www.wikidata.org/wiki/Q11190', 'display_name': 'Medicine', 'level': 0, 'score': 0.35663527}, {'id': 'https://openalex.org/C164705383', 'wikidata': 'https://www.wikidata.org/wiki/Q10379', 'display_name': 'Cardiology', 'level': 1, 'score': 0.35346505}, {'id': 'https://openalex.org/C202751555', 'wikidata': 'https://www.wikidata.org/wiki/Q221681', 'display_name': 'In vitro', 'level': 2, 'score': 0.34261256}, {'id': 'https://openalex.org/C86803240', 'wikidata': 'https://www.wikidata.org/wiki/Q420', 'display_name': 'Biology', 'level': 0, 'score': 0.27275586}, {'id': 'https://openalex.org/C142724271', 'wikidata': 'https://www.wikidata.org/wiki/Q7208', 'display_name': 'Pathology', 'level': 1, 'score': 0.26554814}, {'id': 'https://openalex.org/C126322002', 'wikidata': 'https://www.wikidata.org/wiki/Q11180', 'display_name': 'Internal medicine', 'level': 1, 'score': 0.24704444}, {'id': 'https://openalex.org/C55493867', 'wikidata': 'https://www.wikidata.org/wiki/Q7094', 'display_name': 'Biochemistry', 'level': 1, 'score': 0.07605687}], 'mesh': [{'descriptor_ui': 'D004730', 'descriptor_name': 'Endothelium, Vascular', 'qualifier_ui': 'Q000187', 'qualifier_name': 'drug effects', 'is_major_topic': True}, {'descriptor_ui': 'D056656', 'descriptor_name': 'Lab-On-A-Chip Devices', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': True}, {'descriptor_ui': 'D013927', 'descriptor_name': 'Thrombosis', 'qualifier_ui': 'Q000175', 'qualifier_name': 'diagnosis', 'is_major_topic': True}, {'descriptor_ui': 'D001792', 'descriptor_name': 'Blood Platelets', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D001792', 'descriptor_name': 'Blood Platelets', 'qualifier_ui': 'Q000187', 'qualifier_name': 'drug effects', 'is_major_topic': False}, {'descriptor_ui': 'D042783', 'descriptor_name': 'Endothelial Cells', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D042783', 'descriptor_name': 'Endothelial Cells', 'qualifier_ui': 'Q000187', 'qualifier_name': 'drug effects', 'is_major_topic': False}, {'descriptor_ui': 'D004730', 'descriptor_name': 'Endothelium, Vascular', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D005337', 'descriptor_name': 'Fibrin', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': False}, {'descriptor_ui': 'D005337', 'descriptor_name': 'Fibrin', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D061307', 'descriptor_name': 'Human Umbilical Vein Endothelial Cells', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D006801', 'descriptor_name': 'Humans', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D010975', 'descriptor_name': 'Platelet Aggregation Inhibitors', 'qualifier_ui': 'Q000494', 'qualifier_name': 'pharmacology', 'is_major_topic': False}, {'descriptor_ui': 'D010975', 'descriptor_name': 'Platelet Aggregation Inhibitors', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D019095', 'descriptor_name': 'Point-of-Care Systems', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D013314', 'descriptor_name': 'Stress, Mechanical', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D013927', 'descriptor_name': 'Thrombosis', 'qualifier_ui': 'Q000097', 'qualifier_name': 'blood', 'is_major_topic': False}, {'descriptor_ui': 'D013927', 'descriptor_name': 'Thrombosis', 'qualifier_ui': 'Q000188', 'qualifier_name': 'drug therapy', 'is_major_topic': False}, {'descriptor_ui': 'D013927', 'descriptor_name': 'Thrombosis', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}], 'locations_count': 6, 'locations': [{'is_oa': True, 'landing_page_url': 'https://doi.org/10.1007/s10544-016-0095-6', 'pdf_url': 'https://link.springer.com/content/pdf/10.1007%2Fs10544-016-0095-6.pdf', 'source': {'id': 'https://openalex.org/S173545647', 'display_name': 'Biomedical Microdevices', 'issn_l': '1387-2176', 'issn': ['1387-2176', '1572-8781'], 'is_oa': False, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310319900', 'host_organization_name': 'Springer Science+Business Media', 'host_organization_lineage': ['https://openalex.org/P4310319965', 'https://openalex.org/P4310319900'], 'host_organization_lineage_names': ['Springer Nature', 'Springer Science+Business Media'], 'type': 'journal'}, 'license': 'cc-by', 'license_id': 'https://openalex.org/licenses/cc-by', 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, {'is_oa': True, 'landing_page_url': 'https://europepmc.org/articles/pmc4963439', 'pdf_url': 'https://europepmc.org/articles/pmc4963439?pdf=render', 'source': {'id': 'https://openalex.org/S4306400806', 'display_name': 'Europe PMC (PubMed Central)', 'issn_l': None, 'issn': None, 'is_oa': True, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1303153112', 'host_organization_name': 'European Bioinformatics Institute', 'host_organization_lineage': ['https://openalex.org/I1303153112'], 'host_organization_lineage_names': ['European Bioinformatics Institute'], 'type': 'repository'}, 'license': 'cc-by', 'license_id': 'https://openalex.org/licenses/cc-by', 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, {'is_oa': True, 'landing_page_url': 'http://nrs.harvard.edu/urn-3:HUL.InstRepos:29002611', 'pdf_url': 'https://dash.harvard.edu/bitstream/1/29002611/1/4963439.pdf', 'source': {'id': 'https://openalex.org/S4306401540', 'display_name': 'Digital Access to Scholarship at Harvard (DASH) (Harvard University)', 'issn_l': None, 'issn': None, 'is_oa': True, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I136199984', 'host_organization_name': 'Harvard University', 'host_organization_lineage': ['https://openalex.org/I136199984'], 'host_organization_lineage_names': ['Harvard University'], 'type': 'repository'}, 'license': 'cc-by', 'license_id': 'https://openalex.org/licenses/cc-by', 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, {'is_oa': True, 'landing_page_url': 'https://research.utwente.nl/en/publications/6c4337d3-844d-4fc9-8910-75df62a9a91d', 'pdf_url': 'https://research.utwente.nl/files/7003489/art%253A10.1007%252Fs10544-016-0095-6.pdf', 'source': {'id': 'https://openalex.org/S4306401843', 'display_name': 'Data Archiving and Networked Services (DANS)', 'issn_l': None, 'issn': None, 'is_oa': True, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1322597698', 'host_organization_name': 'Royal Netherlands Academy of Arts and Sciences', 'host_organization_lineage': ['https://openalex.org/I1322597698'], 'host_organization_lineage_names': ['Royal Netherlands Academy of Arts and Sciences'], 'type': 'repository'}, 'license': 'cc-by', 'license_id': 'https://openalex.org/licenses/cc-by', 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, {'is_oa': True, 'landing_page_url': 'https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4963439', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S2764455111', 'display_name': 'PubMed Central', 'issn_l': None, 'issn': None, 'is_oa': True, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1299303238', 'host_organization_name': 'National Institutes of Health', 'host_organization_lineage': ['https://openalex.org/I1299303238'], 'host_organization_lineage_names': ['National Institutes of Health'], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, {'is_oa': False, 'landing_page_url': 'https://pubmed.ncbi.nlm.nih.gov/27464497', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S4306525036', 'display_name': 'PubMed', 'issn_l': None, 'issn': None, 'is_oa': False, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1299303238', 'host_organization_name': 'National Institutes of Health', 'host_organization_lineage': ['https://openalex.org/I1299303238'], 'host_organization_lineage_names': ['National Institutes of Health'], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}], 'best_oa_location': {'is_oa': True, 'landing_page_url': 'https://doi.org/10.1007/s10544-016-0095-6', 'pdf_url': 'https://link.springer.com/content/pdf/10.1007%2Fs10544-016-0095-6.pdf', 'source': {'id': 'https://openalex.org/S173545647', 'display_name': 'Biomedical Microdevices', 'issn_l': '1387-2176', 'issn': ['1387-2176', '1572-8781'], 'is_oa': False, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310319900', 'host_organization_name': 'Springer Science+Business Media', 'host_organization_lineage': ['https://openalex.org/P4310319965', 'https://openalex.org/P4310319900'], 'host_organization_lineage_names': ['Springer Nature', 'Springer Science+Business Media'], 'type': 'journal'}, 'license': 'cc-by', 'license_id': 'https://openalex.org/licenses/cc-by', 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, 'sustainable_development_goals': [], 'grants': [{'funder': 'https://openalex.org/F4320332180', 'funder_display_name': 'Defense Advanced Research Projects Agency', 'award_id': 'HR0011-13-C-0025'}, {'funder': 'https://openalex.org/F4320332180', 'funder_display_name': 'Defense Advanced Research Projects Agency', 'award_id': 'N66001-11-1-4180'}, {'funder': 'https://openalex.org/F4320337601', 'funder_display_name': 'Janssen Pharmaceuticals', 'award_id': None}], 'datasets': [], 'versions': [], 'referenced_works_count': 32, 'referenced_works': ['https://openalex.org/W1532897607', 'https://openalex.org/W1936028382', 'https://openalex.org/W1970959706', 'https://openalex.org/W1986162817', 'https://openalex.org/W2005111715', 'https://openalex.org/W2012860339', 'https://openalex.org/W2020702043', 'https://openalex.org/W2023122926', 'https://openalex.org/W2023252309', 'https://openalex.org/W2026908430', 'https://openalex.org/W2028237251', 'https://openalex.org/W2031994999', 'https://openalex.org/W2041777103', 'https://openalex.org/W2048380290', 'https://openalex.org/W2065593094', 'https://openalex.org/W2076922024', 'https://openalex.org/W2077105092', 'https://openalex.org/W2088606003', 'https://openalex.org/W2091551811', 'https://openalex.org/W2100984089', 'https://openalex.org/W2102075858', 'https://openalex.org/W2114696177', 'https://openalex.org/W2119824111', 'https://openalex.org/W2125150716', 'https://openalex.org/W2126254515', 'https://openalex.org/W2134766290', 'https://openalex.org/W2151132808', 'https://openalex.org/W2158220412', 'https://openalex.org/W2165265464', 'https://openalex.org/W2256963343', 'https://openalex.org/W2343360984', 'https://openalex.org/W2601589642'], 'related_works': ['https://openalex.org/W4205156913', 'https://openalex.org/W3113380241', 'https://openalex.org/W3003900439', 'https://openalex.org/W2909538255', 'https://openalex.org/W2739633251', 'https://openalex.org/W2387103638', 'https://openalex.org/W2363073319', 'https://openalex.org/W2114926007', 'https://openalex.org/W2043132231', 'https://openalex.org/W2026830088'], 'abstract_inverted_index': {'The': [0, 162], 'vascular': [1], 'endothelium': [2, 48, 77, 107], 'and': [3, 12, 20, 40, 139, 182], 'shear': [4], 'stress': [5], 'are': [6, 61], 'critical': [7], 'determinants': [8], 'of': [9, 99, 110, 116, 131, 153, 164], 'physiological': [10, 117], 'hemostasis': [11, 89], 'platelet': [13, 140], 'function': [14, 28, 141], 'in': [15, 31, 49, 93, 113], 'vivo,': [16], 'yet': [17], 'current': [18], 'diagnostic': [19], 'monitoring': [21], 'devices': [22, 174], 'do': [23], 'not': [24, 62], 'fully': [25], 'incorporate': [26], 'endothelial': [27, 167], 'under': [29, 90], 'flow': [30, 92], 'their': [32], 'assessment': [33], 'and,': [34], 'therefore,': [35], 'they': [36], 'can': [37, 142, 176], 'be': [38, 143, 178], 'unreliable': [39], 'inaccurate.': [41], 'It': [42], 'is': [43, 72, 79], 'challenging': [44], 'to': [45, 87, 120, 171], 'include': [46], 'the': [47, 114, 127], 'assays': [50], 'for': [51, 180], 'clinical': [52, 129], 'laboratories': [53], 'or': [54], 'point-of-care': [55, 183], 'settings': [56], 'because': [57], 'living': [58, 122], 'cell': [59], 'cultures': [60], 'sufficiently': [63], 'robust.': [64], 'Here,': [65], 'we': [66], 'describe': [67], 'a': [68, 75, 105, 121, 148, 165], 'microfluidic': [69], 'device': [70, 102, 133], 'that': [71, 78, 136, 175], 'lined': [73, 103], 'by': [74, 134], 'human': [76], 'chemically': [80], 'fixed,': [81], 'but': [82], 'still': [83], 'retains': [84], 'its': [85], 'ability': [86], 'modulate': [88], 'continuous': [91], 'vitro': [94], 'even': [95], 'after': [96], 'few': [97], 'days': [98], 'storage.': [100], 'This': [101], 'with': [104], 'fixed': [106, 166], 'supports': [108], 'formation': [109, 138], 'platelet-rich': [111], 'thrombi': [112], 'presence': [115], 'shear,': [118], 'similar': [119], 'arterial': [123], 'vessel.': [124], 'We': [125], 'demonstrate': [126], 'potential': [128], 'value': [130], 'this': [132], 'showing': [135], 'thrombus': [137], 'measured': [144], 'within': [145], 'minutes': [146], 'using': [147], 'small': [149], 'volume': [150], '(0.5': [151], 'mL)': [152], 'whole': [154], 'blood': [155], 'taken': [156], 'from': [157], 'subjects': [158], 'receiving': [159], 'antiplatelet': [160], 'medications.': [161], 'inclusion': [163], 'microvessel': [168], 'will': [169], 'lead': [170], 'biomimetic': [172], 'analytical': [173], 'potentially': [177], 'used': [179], 'diagnostics': [181], 'applications.': [184]}, 'cited_by_api_url': 'https://api.openalex.org/works?filter=cites:W2501166177', 'counts_by_year': [{'year': 2024, 'cited_by_count': 11}, {'year': 2023, 'cited_by_count': 13}, {'year': 2022, 'cited_by_count': 15}, {'year': 2021, 'cited_by_count': 18}, {'year': 2020, 'cited_by_count': 15}, {'year': 2019, 'cited_by_count': 22}, {'year': 2018, 'cited_by_count': 12}, {'year': 2017, 'cited_by_count': 13}, {'year': 2016, 'cited_by_count': 1}], 'updated_date': '2024-09-13T12:47:17.359130', 'created_date': '2016-08-23'}