Title: Anticonvulsant Effects of Phencyclidine and PCP-like Drugs on Audiogenic Seizures Induced by Metaphit in Mice
Abstract: Phencyclidine (PCP), at low doses (0.3–3 mg/kg), selectively delayed the onset or prevented the occurrence of pentylenetetrazol (PTZ)-induced tonic, but not clonic seizures. However, at a dose of 10 mg/kg it acted as a convulsant agent (Hayes and Balster, 1985). PCP-like drugs, when evaluated with respect to potential anti/pro-convulsant actions, demonstrated only anticonvulsant properties. Modulation of the N-methyl-D-aspartate (NMDA) receptor site by PCP and PCP-like compounds as a mechanism of anticonvulsant activity has been suggested by Leander et al. (1988), in which a strong correlation was demonstrated between the anticonvulsant activity of PCP/PCP-like compounds and the minimal effective dose which blocks NMDA receptor-mediated NMDA-induced lethality.
Publication Year: 1992
Publication Date: 1992-01-01
Language: en
Type: book-chapter
Indexed In: ['crossref']
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