Get quick answers to your questions about the article from our AI researcher chatbot
{'id': 'https://openalex.org/W2498826978', 'doi': 'https://doi.org/10.1177/1753465816661091', 'title': 'Nivolumab in the treatment of metastatic squamous non-small cell lung cancer: a review of the evidence', 'display_name': 'Nivolumab in the treatment of metastatic squamous non-small cell lung cancer: a review of the evidence', 'publication_year': 2016, 'publication_date': '2016-08-03', 'ids': {'openalex': 'https://openalex.org/W2498826978', 'doi': 'https://doi.org/10.1177/1753465816661091', 'mag': '2498826978', 'pmid': 'https://pubmed.ncbi.nlm.nih.gov/27480166', 'pmcid': 'https://www.ncbi.nlm.nih.gov/pmc/articles/5933620'}, 'language': 'en', 'primary_location': {'is_oa': True, 'landing_page_url': 'https://doi.org/10.1177/1753465816661091', 'pdf_url': 'https://journals.sagepub.com/doi/pdf/10.1177/1753465816661091', 'source': {'id': 'https://openalex.org/S83029640', 'display_name': 'Therapeutic Advances in Respiratory Disease', 'issn_l': '1753-4658', 'issn': ['1753-4658', '1753-4666'], 'is_oa': True, 'is_in_doaj': True, 'is_core': True, 'host_organization': 'https://openalex.org/P4310320017', 'host_organization_name': 'SAGE Publishing', 'host_organization_lineage': ['https://openalex.org/P4310320017'], 'host_organization_lineage_names': ['SAGE Publishing'], 'type': 'journal'}, 'license': 'cc-by-nc', 'license_id': 'https://openalex.org/licenses/cc-by-nc', 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, 'type': 'review', 'type_crossref': 'journal-article', 'indexed_in': ['crossref', 'doaj', 'pubmed'], 'open_access': {'is_oa': True, 'oa_status': 'hybrid', 'oa_url': 'https://journals.sagepub.com/doi/pdf/10.1177/1753465816661091', 'any_repository_has_fulltext': True}, 'authorships': [{'author_position': 'first', 'author': {'id': 'https://openalex.org/A5027873167', 'display_name': 'Joline S.J. Lim', 'orcid': 'https://orcid.org/0000-0001-8979-8597'}, 'institutions': [{'id': 'https://openalex.org/I4210103786', 'display_name': 'National University Cancer Institute, Singapore', 'ror': 'https://ror.org/025yypj46', 'country_code': 'SG', 'type': 'education', 'lineage': ['https://openalex.org/I4210103786', 'https://openalex.org/I4210150261']}, {'id': 'https://openalex.org/I165932596', 'display_name': 'National University of Singapore', 'ror': 'https://ror.org/01tgyzw49', 'country_code': 'SG', 'type': 'education', 'lineage': ['https://openalex.org/I165932596']}], 'countries': ['SG'], 'is_corresponding': False, 'raw_author_name': 'Joline S. J. Lim', 'raw_affiliation_strings': ['Cancer Science Institute of Singapore, National University of Singapore, Singapore'], 'affiliations': [{'raw_affiliation_string': 'Cancer Science Institute of Singapore, National University of Singapore, Singapore', 'institution_ids': ['https://openalex.org/I4210103786', 'https://openalex.org/I165932596']}]}, {'author_position': 'last', 'author': {'id': 'https://openalex.org/A5032293215', 'display_name': 'Ross A. Soo', 'orcid': 'https://orcid.org/0000-0002-3053-3997'}, 'institutions': [{'id': 'https://openalex.org/I4210150261', 'display_name': 'National University Health System', 'ror': 'https://ror.org/05tjjsh18', 'country_code': 'SG', 'type': 'education', 'lineage': ['https://openalex.org/I4210150261']}, {'id': 'https://openalex.org/I4210103786', 'display_name': 'National University Cancer Institute, Singapore', 'ror': 'https://ror.org/025yypj46', 'country_code': 'SG', 'type': 'education', 'lineage': ['https://openalex.org/I4210103786', 'https://openalex.org/I4210150261']}], 'countries': ['SG'], 'is_corresponding': True, 'raw_author_name': 'Ross A. Soo', 'raw_affiliation_strings': ['Department of Haematology–Oncology, National University Cancer Institute, National University Health System, 1E Kent Ridge Road, NUHS Tower Block Level 7, Singapore 119228'], 'affiliations': [{'raw_affiliation_string': 'Department of Haematology–Oncology, National University Cancer Institute, National University Health System, 1E Kent Ridge Road, NUHS Tower Block Level 7, Singapore 119228', 'institution_ids': ['https://openalex.org/I4210150261', 'https://openalex.org/I4210103786']}]}], 'countries_distinct_count': 1, 'institutions_distinct_count': 3, 'corresponding_author_ids': ['https://openalex.org/A5032293215'], 'corresponding_institution_ids': ['https://openalex.org/I4210150261', 'https://openalex.org/I4210103786'], 'apc_list': {'value': 2300, 'currency': 'USD', 'value_usd': 2300, 'provenance': 'doaj'}, 'apc_paid': {'value': 2300, 'currency': 'USD', 'value_usd': 2300, 'provenance': 'doaj'}, 'fwci': 0.648, 'has_fulltext': True, 'fulltext_origin': 'ngrams', 'cited_by_count': 30, 'citation_normalized_percentile': {'value': 0.646444, 'is_in_top_1_percent': False, 'is_in_top_10_percent': False}, 'cited_by_percentile_year': {'min': 94, 'max': 95}, 'biblio': {'volume': '10', 'issue': '5', 'first_page': '444', 'last_page': '454'}, 'is_retracted': False, 'is_paratext': False, 'primary_topic': {'id': 'https://openalex.org/T10158', 'display_name': 'Cancer Immunotherapy', 'score': 1.0, 'subfield': {'id': 'https://openalex.org/subfields/2730', 'display_name': 'Oncology'}, 'field': {'id': 'https://openalex.org/fields/27', 'display_name': 'Medicine'}, 'domain': {'id': 'https://openalex.org/domains/4', 'display_name': 'Health Sciences'}}, 'topics': [{'id': 'https://openalex.org/T10158', 'display_name': 'Cancer Immunotherapy', 'score': 1.0, 'subfield': {'id': 'https://openalex.org/subfields/2730', 'display_name': 'Oncology'}, 'field': {'id': 'https://openalex.org/fields/27', 'display_name': 'Medicine'}, 'domain': {'id': 'https://openalex.org/domains/4', 'display_name': 'Health Sciences'}}, {'id': 'https://openalex.org/T10417', 'display_name': 'Advancements in Lung Cancer Research', 'score': 0.9988, 'subfield': {'id': 'https://openalex.org/subfields/2740', 'display_name': 'Pulmonary and Respiratory Medicine'}, 'field': {'id': 'https://openalex.org/fields/27', 'display_name': 'Medicine'}, 'domain': {'id': 'https://openalex.org/domains/4', 'display_name': 'Health Sciences'}}, {'id': 'https://openalex.org/T10231', 'display_name': 'Pancreatic Cancer Research and Treatment', 'score': 0.9978, 'subfield': {'id': 'https://openalex.org/subfields/2730', 'display_name': 'Oncology'}, 'field': {'id': 'https://openalex.org/fields/27', 'display_name': 'Medicine'}, 'domain': {'id': 'https://openalex.org/domains/4', 'display_name': 'Health Sciences'}}], 'keywords': [{'id': 'https://openalex.org/keywords/tolerability', 'display_name': 'Tolerability', 'score': 0.69620323}, {'id': 'https://openalex.org/keywords/biomarkers-for-immunotherapy', 'display_name': 'Biomarkers for Immunotherapy', 'score': 0.489746}], 'concepts': [{'id': 'https://openalex.org/C2780030458', 'wikidata': 'https://www.wikidata.org/wiki/Q7041828', 'display_name': 'Nivolumab', 'level': 4, 'score': 0.97533524}, {'id': 'https://openalex.org/C71924100', 'wikidata': 'https://www.wikidata.org/wiki/Q11190', 'display_name': 'Medicine', 'level': 0, 'score': 0.90319604}, {'id': 'https://openalex.org/C143998085', 'wikidata': 'https://www.wikidata.org/wiki/Q162555', 'display_name': 'Oncology', 'level': 1, 'score': 0.74573433}, {'id': 'https://openalex.org/C2781190966', 'wikidata': 'https://www.wikidata.org/wiki/Q420436', 'display_name': 'Docetaxel', 'level': 3, 'score': 0.70550233}, {'id': 'https://openalex.org/C2778375690', 'wikidata': 'https://www.wikidata.org/wiki/Q7814214', 'display_name': 'Tolerability', 'level': 3, 'score': 0.69620323}, {'id': 'https://openalex.org/C2776256026', 'wikidata': 'https://www.wikidata.org/wiki/Q47912', 'display_name': 'Lung cancer', 'level': 2, 'score': 0.6206876}, {'id': 'https://openalex.org/C126322002', 'wikidata': 'https://www.wikidata.org/wiki/Q11180', 'display_name': 'Internal medicine', 'level': 1, 'score': 0.619999}, {'id': 'https://openalex.org/C2776694085', 'wikidata': 'https://www.wikidata.org/wiki/Q974135', 'display_name': 'Chemotherapy', 'level': 2, 'score': 0.4352992}, {'id': 'https://openalex.org/C2777701055', 'wikidata': 'https://www.wikidata.org/wiki/Q1427096', 'display_name': 'Immunotherapy', 'level': 3, 'score': 0.388488}, {'id': 'https://openalex.org/C121608353', 'wikidata': 'https://www.wikidata.org/wiki/Q12078', 'display_name': 'Cancer', 'level': 2, 'score': 0.3765667}, {'id': 'https://openalex.org/C197934379', 'wikidata': 'https://www.wikidata.org/wiki/Q2047938', 'display_name': 'Adverse effect', 'level': 2, 'score': 0.1404404}], 'mesh': [{'descriptor_ui': 'D000911', 'descriptor_name': 'Antibodies, Monoclonal', 'qualifier_ui': 'Q000627', 'qualifier_name': 'therapeutic use', 'is_major_topic': True}, {'descriptor_ui': 'D002289', 'descriptor_name': 'Carcinoma, Non-Small-Cell Lung', 'qualifier_ui': 'Q000188', 'qualifier_name': 'drug therapy', 'is_major_topic': True}, {'descriptor_ui': 'D008175', 'descriptor_name': 'Lung Neoplasms', 'qualifier_ui': 'Q000188', 'qualifier_name': 'drug therapy', 'is_major_topic': True}, {'descriptor_ui': 'D000911', 'descriptor_name': 'Antibodies, Monoclonal', 'qualifier_ui': 'Q000494', 'qualifier_name': 'pharmacology', 'is_major_topic': False}, {'descriptor_ui': 'D000911', 'descriptor_name': 'Antibodies, Monoclonal', 'qualifier_ui': 'Q000009', 'qualifier_name': 'adverse effects', 'is_major_topic': False}, {'descriptor_ui': 'D000911', 'descriptor_name': 'Antibodies, Monoclonal', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D000970', 'descriptor_name': 'Antineoplastic Agents', 'qualifier_ui': 'Q000494', 'qualifier_name': 'pharmacology', 'is_major_topic': False}, {'descriptor_ui': 'D000970', 'descriptor_name': 'Antineoplastic Agents', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D000970', 'descriptor_name': 'Antineoplastic Agents', 'qualifier_ui': 'Q000009', 'qualifier_name': 'adverse effects', 'is_major_topic': False}, {'descriptor_ui': 'D000970', 'descriptor_name': 'Antineoplastic Agents', 'qualifier_ui': 'Q000627', 'qualifier_name': 'therapeutic use', 'is_major_topic': False}, {'descriptor_ui': 'D002289', 'descriptor_name': 'Carcinoma, Non-Small-Cell Lung', 'qualifier_ui': 'Q000473', 'qualifier_name': 'pathology', 'is_major_topic': False}, {'descriptor_ui': 'D002289', 'descriptor_name': 'Carcinoma, Non-Small-Cell Lung', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D002294', 'descriptor_name': 'Carcinoma, Squamous Cell', 'qualifier_ui': 'Q000188', 'qualifier_name': 'drug therapy', 'is_major_topic': False}, {'descriptor_ui': 'D002294', 'descriptor_name': 'Carcinoma, Squamous Cell', 'qualifier_ui': 'Q000473', 'qualifier_name': 'pathology', 'is_major_topic': False}, {'descriptor_ui': 'D002294', 'descriptor_name': 'Carcinoma, Squamous Cell', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D018572', 'descriptor_name': 'Disease-Free Survival', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D006801', 'descriptor_name': 'Humans', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D008175', 'descriptor_name': 'Lung Neoplasms', 'qualifier_ui': 'Q000473', 'qualifier_name': 'pathology', 'is_major_topic': False}, {'descriptor_ui': 'D008175', 'descriptor_name': 'Lung Neoplasms', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D009362', 'descriptor_name': 'Neoplasm Metastasis', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D009367', 'descriptor_name': 'Neoplasm Staging', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D000077594', 'descriptor_name': 'Nivolumab', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D016032', 'descriptor_name': 'Randomized Controlled Trials as Topic', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D015996', 'descriptor_name': 'Survival Rate', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}], 'locations_count': 5, 'locations': [{'is_oa': True, 'landing_page_url': 'https://doi.org/10.1177/1753465816661091', 'pdf_url': 'https://journals.sagepub.com/doi/pdf/10.1177/1753465816661091', 'source': {'id': 'https://openalex.org/S83029640', 'display_name': 'Therapeutic Advances in Respiratory Disease', 'issn_l': '1753-4658', 'issn': ['1753-4658', '1753-4666'], 'is_oa': True, 'is_in_doaj': True, 'is_core': True, 'host_organization': 'https://openalex.org/P4310320017', 'host_organization_name': 'SAGE Publishing', 'host_organization_lineage': ['https://openalex.org/P4310320017'], 'host_organization_lineage_names': ['SAGE Publishing'], 'type': 'journal'}, 'license': 'cc-by-nc', 'license_id': 'https://openalex.org/licenses/cc-by-nc', 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, {'is_oa': False, 'landing_page_url': 'https://doaj.org/article/6cbf38cb38ce4e21be00822d5802c7b3', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S4306401280', 'display_name': 'DOAJ (DOAJ: Directory of Open Access Journals)', 'issn_l': None, 'issn': None, 'is_oa': True, 'is_in_doaj': False, 'is_core': False, 'host_organization': None, 'host_organization_name': None, 'host_organization_lineage': [], 'host_organization_lineage_names': [], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}, {'is_oa': True, 'landing_page_url': 'https://europepmc.org/articles/pmc5933620', 'pdf_url': 'https://europepmc.org/articles/pmc5933620?pdf=render', 'source': {'id': 'https://openalex.org/S4306400806', 'display_name': 'Europe PMC (PubMed Central)', 'issn_l': None, 'issn': None, 'is_oa': True, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1303153112', 'host_organization_name': 'European Bioinformatics Institute', 'host_organization_lineage': ['https://openalex.org/I1303153112'], 'host_organization_lineage_names': ['European Bioinformatics Institute'], 'type': 'repository'}, 'license': 'cc-by-nc', 'license_id': 'https://openalex.org/licenses/cc-by-nc', 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, {'is_oa': True, 'landing_page_url': 'https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5933620', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S2764455111', 'display_name': 'PubMed Central', 'issn_l': None, 'issn': None, 'is_oa': True, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1299303238', 'host_organization_name': 'National Institutes of Health', 'host_organization_lineage': ['https://openalex.org/I1299303238'], 'host_organization_lineage_names': ['National Institutes of Health'], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, {'is_oa': False, 'landing_page_url': 'https://pubmed.ncbi.nlm.nih.gov/27480166', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S4306525036', 'display_name': 'PubMed', 'issn_l': None, 'issn': None, 'is_oa': False, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1299303238', 'host_organization_name': 'National Institutes of Health', 'host_organization_lineage': ['https://openalex.org/I1299303238'], 'host_organization_lineage_names': ['National Institutes of Health'], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}], 'best_oa_location': {'is_oa': True, 'landing_page_url': 'https://doi.org/10.1177/1753465816661091', 'pdf_url': 'https://journals.sagepub.com/doi/pdf/10.1177/1753465816661091', 'source': {'id': 'https://openalex.org/S83029640', 'display_name': 'Therapeutic Advances in Respiratory Disease', 'issn_l': '1753-4658', 'issn': ['1753-4658', '1753-4666'], 'is_oa': True, 'is_in_doaj': True, 'is_core': True, 'host_organization': 'https://openalex.org/P4310320017', 'host_organization_name': 'SAGE Publishing', 'host_organization_lineage': ['https://openalex.org/P4310320017'], 'host_organization_lineage_names': ['SAGE Publishing'], 'type': 'journal'}, 'license': 'cc-by-nc', 'license_id': 'https://openalex.org/licenses/cc-by-nc', 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, 'sustainable_development_goals': [{'display_name': 'Good health and well-being', 'id': 'https://metadata.un.org/sdg/3', 'score': 0.86}], 'grants': [], 'datasets': [], 'versions': [], 'referenced_works_count': 36, 'referenced_works': ['https://openalex.org/W1584673858', 'https://openalex.org/W2010121426', 'https://openalex.org/W2011458181', 'https://openalex.org/W2024492396', 'https://openalex.org/W2065477010', 'https://openalex.org/W2071865120', 'https://openalex.org/W2083455294', 'https://openalex.org/W2099609050', 'https://openalex.org/W2099803791', 'https://openalex.org/W2104347254', 'https://openalex.org/W2106511606', 'https://openalex.org/W2112601576', 'https://openalex.org/W2122553809', 'https://openalex.org/W2123918574', 'https://openalex.org/W2128204411', 'https://openalex.org/W2130652363', 'https://openalex.org/W2137043950', 'https://openalex.org/W2139192665', 'https://openalex.org/W2140980839', 'https://openalex.org/W2143488876', 'https://openalex.org/W2156353875', 'https://openalex.org/W2160834915', 'https://openalex.org/W2167599107', 'https://openalex.org/W2170030318', 'https://openalex.org/W2177405394', 'https://openalex.org/W2180481128', 'https://openalex.org/W2237385549', 'https://openalex.org/W2259730793', 'https://openalex.org/W2275877493', 'https://openalex.org/W2526642223', 'https://openalex.org/W2560367415', 'https://openalex.org/W2572174216', 'https://openalex.org/W2599175392', 'https://openalex.org/W2616535253', 'https://openalex.org/W3154037044', 'https://openalex.org/W865168492'], 'related_works': ['https://openalex.org/W4311628015', 'https://openalex.org/W3147275309', 'https://openalex.org/W3095184244', 'https://openalex.org/W2947088833', 'https://openalex.org/W2515537233', 'https://openalex.org/W236807388', 'https://openalex.org/W2201793188', 'https://openalex.org/W2139614539', 'https://openalex.org/W2129685713', 'https://openalex.org/W2081815287'], 'abstract_inverted_index': {'Progress': [0], 'in': [1, 21, 29, 57, 122], 'the': [2, 22, 30, 33, 52, 58, 95, 118, 123], 'treatment': [3, 59, 124], 'of': [4, 24, 32, 60, 78, 120, 125], 'patients': [5, 61, 100], 'with': [6, 62, 102, 127], 'advanced': [7, 63], 'stage': [8, 64], 'squamous': [9, 65], 'cell': [10, 12, 66], 'non-small': [11], 'lung': [13], 'cancer': [14], '(NSCLC)': [15], 'has': [16, 27], 'been': [17], 'limited.': [18], 'An': [19], 'improvement': [20], 'understanding': [23], 'tumor': [25], 'immunosurveillance': [26], 'resulted': [28], 'development': [31], 'immune': [34], 'checkpoint': [35], 'inhibitors': [36], 'such': [37], 'as': [38], 'nivolumab.': [39, 103], 'Nivolumab': [40], '(Opdivo(®)),': [41], 'a': [42, 73], 'human': [43], 'immunoglobulin': [44], '(Ig)G4': [45], 'anti-programmed': [46], 'death': [47], '(PD)-1': [48], 'monoclonal': [49], 'antibody,': [50], 'was': [51], 'first': [53], 'PD-1': [54], 'inhibitor': [55], 'approved': [56], 'NSCLC': [67, 126], 'following': [68], 'platinum-based': [69], 'chemotherapy.': [70], 'CHECKMATE': [71], '017,': [72], 'randomized': [74], 'phase': [75], 'III': [76], 'study': [77], 'second-line': [79], 'nivolumab': [80, 121], 'versus': [81], 'docetaxel,': [82], 'significantly': [83], 'improved': [84], 'overall': [85], 'survival': [86, 89], '(OS),': [87], 'progression-free': [88], '(PFS),': [90], 'patient': [91], 'reported': [92], 'outcomes': [93], 'and': [94, 97, 139], 'safety': [96], 'tolerability': [98], 'favored': [99], 'treated': [101], 'The': [104], 'ligand': [105], '(PD-L1)': [106], 'expression': [107], 'did': [108], 'not': [109], 'predict': [110], 'for': [111], 'outcome.': [112], 'In': [113], 'this': [114], 'paper,': [115], 'we': [116], 'review': [117], 'role': [119], 'particular': [128], 'attention': [129], 'on': [130], 'recent': [131], 'studies,': [132, 135], 'ongoing': [133], 'combination': [134], 'toxicity': [136], 'profile,': [137], 'current': [138], 'potential': [140], 'predictive': [141], 'biomarkers.': [142]}, 'cited_by_api_url': 'https://api.openalex.org/works?filter=cites:W2498826978', 'counts_by_year': [{'year': 2024, 'cited_by_count': 2}, {'year': 2023, 'cited_by_count': 3}, {'year': 2022, 'cited_by_count': 3}, {'year': 2021, 'cited_by_count': 1}, {'year': 2020, 'cited_by_count': 6}, {'year': 2019, 'cited_by_count': 4}, {'year': 2018, 'cited_by_count': 5}, {'year': 2017, 'cited_by_count': 5}], 'updated_date': '2024-09-13T12:47:11.279399', 'created_date': '2016-08-23'}