Abstract: 1.Reginster JY, Neuprez A, Beaudart C, Lecart MP, Sarlet N, Bernard D, Disteche S, Bruyere O. Antiresorptive drugs beyond bisphosphonates and selective oestrogen receptor modulators for the management of postmenopausal osteoporosis. Drugs Aging. 31:413-24, 2014. http://dx.doi.org/10.1007/s40266-014-0179-zThis article discusses the mode of action of denosumab and the trials leading up to its approval for clinical use. The mode of action of denosumab is contrasted with those of bisphosphonates.2.O'Halloran M, Boyd N, Smith A. Denosumab and osteonecrosis of the jaws - the pharmacology, pathogenesis and a report of two cases. Aust Dent J. 2014 Aug 16. http://dx.doi.org/10.1111/adj.12217An account of two cases of osteonecrosis of the jaws related to denosumab and a good description of the pharmokinetics of denosumab as compared with the bisphosphonates.3.Neuprez A, Coste S, Rompen E, Crielaard JM, Reginster JY. Osteonecrosis of the jaw in a male osteoporotic patient treated with denosumab. Osteoporos Int. 25:393-5, 2014. http://dx.doi.org/10.1007/s00198-013-2437-z. Epub 2013 Jul 9The first case of osteonecrosis in a male patient treated with denosumab. The denosumab was in the form of Prolia given by subcutaneous injection for osteoporosis.4.Neuprez A, Rompen E, Crielaard JM, Reginster JY. Teriparatide therapy for denosumab-induced osteonecrosis of the jaw in a male osteoporotic patient. Calcif Tissue Int. 95:94-6, 2014. http://dx.doi.org/10.1007/s00223-014-9858-3. Epub 2014 May 8A follow-up article on the patient in reference #3 after he was treated with Forteo (teriparatide).5.Schreuder WH, Coumou AW, Kessler PA, de Lange J. Alternative pharmacologic therapy for aggressive central giant cell granuloma: denosumab. J Oral Maxillofac Surg. 72:1301-9, 2014. http://dx.doi.org/10.1016/j.joms.2014.02.017. Epub 2014 Feb 18An account by a team from the Netherlands who have reported on multiple treatments for central giant cell granulomas of the jaws. In this article, they describe the use of denosumab to cause improvement in the lesion where other pharmacological agents (including calcitonin) have failed.6.Purdue E. Aneurysmal bone cysts: denosumab extends its reach. Transl Res. 164:135-8, 2014. http://dx.doi.org/10.1016/j.trsl.2014.04.013. Epub 2014 Apr 30This article describes the use of denosumab to cause resolution of an aneurysmal bone cyst presumably acting in the same way as it does against central giant cell granulomas.7.Niibe K, Ouchi T, Iwasaki R, Nakagawa T, Horie N. Osteonecrosis of the jaw in patients with dental prostheses being treated with bisphosphonates or denosumab. J Prosthodont Res. 2014 Sep 8. pii: S1883-1958(14)00091-7. http://dx.doi.org/10.1016/j.jpor.2014.08.001This article documents seven cases of osteonecrosis in patients taking denosumab that may be related to the use of a dental prosthesis rather than a surgical procedure.8.Benhamou J, Gensburger D, Chapurlat R. Transient improvement of severe pain from fibrous dysplasia of bone with denosumab treatment. Joint Bone Spine. 2014 Jun 21. pii: S1297-319X(14)00133-X. http://dx.doi.org/10.1016/j.jbspin.2014.04.013This article describes the use of denosumab to alleviate the pain caused by active fibrous dysplasia. Bisphosphonates have also been used for the same purpose.9.Khan AA, Leslie WD, Lentle B, Iles S, Kaiser SM, Frame H, Burrell S, Cheung AM. Atypical Femoral Fractures: A Teaching Perspective. Can Assoc Radiol J. 2014 Jul 19. pii: S0846-5371(14)00007-2. http://dx.doi.org/10.1016/j.carj.2014.01.002. ReviewAn article describing the appearance of atypical femur fractures in patients taking antiresorbative therapy and some ideas on the mechanism involved.10.Khow KS, Yong TY. Atypical femoral fracture in a patient treated with denosumab. J Bone Miner Metab. 2014 Jul 5 http://dx.doi.org/10.1007/s00774-014-0606-6Description of an atypical femur fracture in a patient who was taking denosumab, to show that this phenomenon may occur with multiple antiresorbative agents.
Publication Year: 2016
Publication Date: 2016-08-01
Language: en
Type: article
Indexed In: ['crossref']
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