Abstract: In its clinical use a drug is intended to have a therapeutic action, but it can also promote toxic reactions and have side effects. The latter can reflect deficiencies in a drug's selectivity and may even occur at the same time or with smaller doses than those that are therapeutically effective. Side effects can also result from excessive doses of drugs, which are then said to be at toxic concentrations and ultimately may even result in death. Such toxic effects are often merely extensions of therapeutic effects. Drug concentrations in the blood provide a convenient way of predicting drug effects. Concentrations can be divided into four general levels: the concentration of the drug that is the threshold of the therapeutic response, the maximal concentration for a therapeutic effect, the concentration where toxic effects may be expected to occur, and the lethal concentration.
Publication Year: 1981
Publication Date: 1981-08-31
Language: en
Type: book-chapter
Indexed In: ['crossref']
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