Title: Mechanisms involved in the regulation of calcium metabolism by secretagogues in the exocrine pancreas
Abstract:Calcium is an important intracellular messenger for stimulation of enzyme secretion from the exocrine pancreas. Evidence suggests that a rise of intracellular free Ca2+ concentration is at least one s...Calcium is an important intracellular messenger for stimulation of enzyme secretion from the exocrine pancreas. Evidence suggests that a rise of intracellular free Ca2+ concentration is at least one step in the sequence of events leading from secretagogue-receptor interaction to exocytosis in pancreatic acinar cells (Gardner, 1979; Schulz, 1980; Petersen, 1982). Secretagogue-induced increase in cytosolic free Ca concentration is due both to Ca2+ release from intracellular organelles as well as Ca2+ influx into the cells(Schulz, 1980). This results in a biphasic Ca2+net flux: an initial Ca2+ efflux followed by Ca2+ influx and ATP-dependent Ca2+ uptake into intracellular stores (Wakasugi et al., 1982). Isolated pancreatic acinar cells with highly permeable plasma membranes regulate, in the presence of MgATP with or without mitochondrial inhibitors, a free Ca2+ concentration of 4 x 10-7 mol l-1 in the surrounding medium (Streb & Schulz, 1983). Changes in the medium free [Ca2+] by addition of Ca2+ or EGTA are buffered by cellular Ca2+ uptake or Ca2+ release, respectively, until the previous steady state is re-established.Read More
Publication Year: 1984
Publication Date: 1984-01-01
Language: en
Type: book-chapter
Indexed In: ['crossref']
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