Get quick answers to your questions about the article from our AI researcher chatbot
{'id': 'https://openalex.org/W2488033279', 'doi': 'https://doi.org/10.1177/1087054716661235', 'title': 'Non-Linear Pharmacokinetics of Atomoxetine in Adult Japanese Patients With ADHD', 'display_name': 'Non-Linear Pharmacokinetics of Atomoxetine in Adult Japanese Patients With ADHD', 'publication_year': 2016, 'publication_date': '2016-07-28', 'ids': {'openalex': 'https://openalex.org/W2488033279', 'doi': 'https://doi.org/10.1177/1087054716661235', 'mag': '2488033279', 'pmid': 'https://pubmed.ncbi.nlm.nih.gov/27474159'}, 'language': 'en', 'primary_location': {'is_oa': False, 'landing_page_url': 'https://doi.org/10.1177/1087054716661235', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S4019948', 'display_name': 'Journal of Attention Disorders', 'issn_l': '1087-0547', 'issn': ['1087-0547', '1557-1246'], 'is_oa': False, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310320017', 'host_organization_name': 'SAGE Publishing', 'host_organization_lineage': ['https://openalex.org/P4310320017'], 'host_organization_lineage_names': ['SAGE Publishing'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}, 'type': 'article', 'type_crossref': 'journal-article', 'indexed_in': ['crossref', 'pubmed'], 'open_access': {'is_oa': False, 'oa_status': 'closed', 'oa_url': None, 'any_repository_has_fulltext': False}, 'authorships': [{'author_position': 'first', 'author': {'id': 'https://openalex.org/A5079093223', 'display_name': 'Atsunori Sugimoto', 'orcid': 'https://orcid.org/0000-0002-6684-0016'}, 'institutions': [{'id': 'https://openalex.org/I71395657', 'display_name': 'Niigata University', 'ror': 'https://ror.org/04ww21r56', 'country_code': 'JP', 'type': 'education', 'lineage': ['https://openalex.org/I71395657']}], 'countries': ['JP'], 'is_corresponding': False, 'raw_author_name': 'Atsunori Sugimoto', 'raw_affiliation_strings': ['Niigata University, Japan'], 'affiliations': [{'raw_affiliation_string': 'Niigata University, Japan', 'institution_ids': ['https://openalex.org/I71395657']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5054653407', 'display_name': 'Yutaro Suzuki', 'orcid': 'https://orcid.org/0000-0001-7977-8517'}, 'institutions': [{'id': 'https://openalex.org/I71395657', 'display_name': 'Niigata University', 'ror': 'https://ror.org/04ww21r56', 'country_code': 'JP', 'type': 'education', 'lineage': ['https://openalex.org/I71395657']}], 'countries': ['JP'], 'is_corresponding': True, 'raw_author_name': 'Yutaro Suzuki', 'raw_affiliation_strings': ['Niigata University, Japan'], 'affiliations': [{'raw_affiliation_string': 'Niigata University, Japan', 'institution_ids': ['https://openalex.org/I71395657']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5033404299', 'display_name': 'Naoki Orime', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I71395657', 'display_name': 'Niigata University', 'ror': 'https://ror.org/04ww21r56', 'country_code': 'JP', 'type': 'education', 'lineage': ['https://openalex.org/I71395657']}], 'countries': ['JP'], 'is_corresponding': False, 'raw_author_name': 'Naoki Orime', 'raw_affiliation_strings': ['Niigata University, Japan'], 'affiliations': [{'raw_affiliation_string': 'Niigata University, Japan', 'institution_ids': ['https://openalex.org/I71395657']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5047902422', 'display_name': 'Taketsugu Hayashi', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I71395657', 'display_name': 'Niigata University', 'ror': 'https://ror.org/04ww21r56', 'country_code': 'JP', 'type': 'education', 'lineage': ['https://openalex.org/I71395657']}], 'countries': ['JP'], 'is_corresponding': False, 'raw_author_name': 'Taketsugu Hayashi', 'raw_affiliation_strings': ['Niigata University, Japan'], 'affiliations': [{'raw_affiliation_string': 'Niigata University, Japan', 'institution_ids': ['https://openalex.org/I71395657']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5076989359', 'display_name': 'Jun Egawa', 'orcid': 'https://orcid.org/0000-0003-1346-4042'}, 'institutions': [{'id': 'https://openalex.org/I71395657', 'display_name': 'Niigata University', 'ror': 'https://ror.org/04ww21r56', 'country_code': 'JP', 'type': 'education', 'lineage': ['https://openalex.org/I71395657']}], 'countries': ['JP'], 'is_corresponding': False, 'raw_author_name': 'Jun Egawa', 'raw_affiliation_strings': ['Niigata University, Japan'], 'affiliations': [{'raw_affiliation_string': 'Niigata University, Japan', 'institution_ids': ['https://openalex.org/I71395657']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5109245593', 'display_name': 'Takuro Sugai', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I71395657', 'display_name': 'Niigata University', 'ror': 'https://ror.org/04ww21r56', 'country_code': 'JP', 'type': 'education', 'lineage': ['https://openalex.org/I71395657']}], 'countries': ['JP'], 'is_corresponding': False, 'raw_author_name': 'Takuro Sugai', 'raw_affiliation_strings': ['Niigata University, Japan'], 'affiliations': [{'raw_affiliation_string': 'Niigata University, Japan', 'institution_ids': ['https://openalex.org/I71395657']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5072652662', 'display_name': 'Yoshimasa Inoue', 'orcid': 'https://orcid.org/0000-0003-0245-5570'}, 'institutions': [{'id': 'https://openalex.org/I78274823', 'display_name': 'Dokkyo Medical University', 'ror': 'https://ror.org/05k27ay38', 'country_code': 'JP', 'type': 'education', 'lineage': ['https://openalex.org/I78274823']}], 'countries': ['JP'], 'is_corresponding': False, 'raw_author_name': 'Yoshimasa Inoue', 'raw_affiliation_strings': ['Dokkyo Medical University, Shimotsuga, Japan'], 'affiliations': [{'raw_affiliation_string': 'Dokkyo Medical University, Shimotsuga, Japan', 'institution_ids': ['https://openalex.org/I78274823']}]}, {'author_position': 'last', 'author': {'id': 'https://openalex.org/A5044283342', 'display_name': 'Toshiyuki Someya', 'orcid': 'https://orcid.org/0000-0003-2505-4470'}, 'institutions': [{'id': 'https://openalex.org/I71395657', 'display_name': 'Niigata University', 'ror': 'https://ror.org/04ww21r56', 'country_code': 'JP', 'type': 'education', 'lineage': ['https://openalex.org/I71395657']}], 'countries': ['JP'], 'is_corresponding': False, 'raw_author_name': 'Toshiyuki Someya', 'raw_affiliation_strings': ['Niigata University, Japan'], 'affiliations': [{'raw_affiliation_string': 'Niigata University, Japan', 'institution_ids': ['https://openalex.org/I71395657']}]}], 'institution_assertions': [], 'countries_distinct_count': 1, 'institutions_distinct_count': 2, 'corresponding_author_ids': ['https://openalex.org/A5054653407'], 'corresponding_institution_ids': ['https://openalex.org/I71395657'], 'apc_list': None, 'apc_paid': None, 'fwci': 0.0, 'has_fulltext': True, 'fulltext_origin': 'ngrams', 'cited_by_count': 4, 'citation_normalized_percentile': {'value': 0.620112, 'is_in_top_1_percent': False, 'is_in_top_10_percent': False}, 'cited_by_percentile_year': {'min': 79, 'max': 81}, 'biblio': {'volume': '24', 'issue': '3', 'first_page': '490', 'last_page': '493'}, 'is_retracted': False, 'is_paratext': False, 'primary_topic': {'id': 'https://openalex.org/T10537', 'display_name': 'Attention Deficit Hyperactivity Disorder', 'score': 1.0, 'subfield': {'id': 'https://openalex.org/subfields/2738', 'display_name': 'Psychiatry and Mental health'}, 'field': {'id': 'https://openalex.org/fields/27', 'display_name': 'Medicine'}, 'domain': {'id': 'https://openalex.org/domains/4', 'display_name': 'Health Sciences'}}, 'topics': [{'id': 'https://openalex.org/T10537', 'display_name': 'Attention Deficit Hyperactivity Disorder', 'score': 1.0, 'subfield': {'id': 'https://openalex.org/subfields/2738', 'display_name': 'Psychiatry and Mental health'}, 'field': {'id': 'https://openalex.org/fields/27', 'display_name': 'Medicine'}, 'domain': {'id': 'https://openalex.org/domains/4', 'display_name': 'Health Sciences'}}, {'id': 'https://openalex.org/T12547', 'display_name': 'Pharmaceutical studies and practices', 'score': 0.9704, 'subfield': {'id': 'https://openalex.org/subfields/2735', 'display_name': 'Pediatrics, Perinatology and Child Health'}, 'field': {'id': 'https://openalex.org/fields/27', 'display_name': 'Medicine'}, 'domain': {'id': 'https://openalex.org/domains/4', 'display_name': 'Health Sciences'}}, {'id': 'https://openalex.org/T11071', 'display_name': 'Treatment of Major Depression', 'score': 0.9682, 'subfield': {'id': 'https://openalex.org/subfields/2736', 'display_name': 'Pharmacology'}, 'field': {'id': 'https://openalex.org/fields/27', 'display_name': 'Medicine'}, 'domain': {'id': 'https://openalex.org/domains/4', 'display_name': 'Health Sciences'}}], 'keywords': [{'id': 'https://openalex.org/keywords/atomoxetine-hydrochloride', 'display_name': 'Atomoxetine hydrochloride', 'score': 0.67558587}, {'id': 'https://openalex.org/keywords/blood-concentration', 'display_name': 'Blood concentration', 'score': 0.46815303}], 'concepts': [{'id': 'https://openalex.org/C2778781522', 'wikidata': 'https://www.wikidata.org/wiki/Q417240', 'display_name': 'Atomoxetine', 'level': 4, 'score': 0.9638442}, {'id': 'https://openalex.org/C112705442', 'wikidata': 'https://www.wikidata.org/wiki/Q323936', 'display_name': 'Pharmacokinetics', 'level': 2, 'score': 0.836163}, {'id': 'https://openalex.org/C2909253567', 'wikidata': 'https://www.wikidata.org/wiki/Q417240', 'display_name': 'Atomoxetine hydrochloride', 'level': 5, 'score': 0.67558587}, {'id': 'https://openalex.org/C185592680', 'wikidata': 'https://www.wikidata.org/wiki/Q2329', 'display_name': 'Chemistry', 'level': 0, 'score': 0.49991083}, {'id': 'https://openalex.org/C3020580990', 'wikidata': 'https://www.wikidata.org/wiki/Q3918988', 'display_name': 'Blood concentration', 'level': 2, 'score': 0.46815303}, {'id': 'https://openalex.org/C3018023364', 'wikidata': 'https://www.wikidata.org/wiki/Q425265', 'display_name': 'Significant difference', 'level': 2, 'score': 0.46184653}, {'id': 'https://openalex.org/C3020079912', 'wikidata': 'https://www.wikidata.org/wiki/Q3918988', 'display_name': 'Plasma concentration', 'level': 2, 'score': 0.449551}, {'id': 'https://openalex.org/C98274493', 'wikidata': 'https://www.wikidata.org/wiki/Q128406', 'display_name': 'Pharmacology', 'level': 1, 'score': 0.32848442}, {'id': 'https://openalex.org/C126322002', 'wikidata': 'https://www.wikidata.org/wiki/Q11180', 'display_name': 'Internal medicine', 'level': 1, 'score': 0.29557174}, {'id': 'https://openalex.org/C71924100', 'wikidata': 'https://www.wikidata.org/wiki/Q11190', 'display_name': 'Medicine', 'level': 0, 'score': 0.24134898}, {'id': 'https://openalex.org/C2780783007', 'wikidata': 'https://www.wikidata.org/wiki/Q181923', 'display_name': 'Attention deficit hyperactivity disorder', 'level': 2, 'score': 0.21827957}, {'id': 'https://openalex.org/C118552586', 'wikidata': 'https://www.wikidata.org/wiki/Q7867', 'display_name': 'Psychiatry', 'level': 1, 'score': 0.08215469}, {'id': 'https://openalex.org/C2777112843', 'wikidata': 'https://www.wikidata.org/wiki/Q422112', 'display_name': 'Methylphenidate', 'level': 3, 'score': 0.0}], 'mesh': [{'descriptor_ui': 'D001289', 'descriptor_name': 'Attention Deficit Disorder with Hyperactivity', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': True}, {'descriptor_ui': 'D018759', 'descriptor_name': 'Adrenergic Uptake Inhibitors', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D000328', 'descriptor_name': 'Adult', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D000069445', 'descriptor_name': 'Atomoxetine Hydrochloride', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D001289', 'descriptor_name': 'Attention Deficit Disorder with Hyperactivity', 'qualifier_ui': 'Q000188', 'qualifier_name': 'drug therapy', 'is_major_topic': False}, {'descriptor_ui': 'D004305', 'descriptor_name': 'Dose-Response Relationship, Drug', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D006801', 'descriptor_name': 'Humans', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D007564', 'descriptor_name': 'Japan', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D011437', 'descriptor_name': 'Propylamines', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}], 'locations_count': 2, 'locations': [{'is_oa': False, 'landing_page_url': 'https://doi.org/10.1177/1087054716661235', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S4019948', 'display_name': 'Journal of Attention Disorders', 'issn_l': '1087-0547', 'issn': ['1087-0547', '1557-1246'], 'is_oa': False, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310320017', 'host_organization_name': 'SAGE Publishing', 'host_organization_lineage': ['https://openalex.org/P4310320017'], 'host_organization_lineage_names': ['SAGE Publishing'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}, {'is_oa': False, 'landing_page_url': 'https://pubmed.ncbi.nlm.nih.gov/27474159', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S4306525036', 'display_name': 'PubMed', 'issn_l': None, 'issn': None, 'is_oa': False, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1299303238', 'host_organization_name': 'National Institutes of Health', 'host_organization_lineage': ['https://openalex.org/I1299303238'], 'host_organization_lineage_names': ['National Institutes of Health'], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}], 'best_oa_location': None, 'sustainable_development_goals': [{'score': 0.58, 'display_name': 'Good health and well-being', 'id': 'https://metadata.un.org/sdg/3'}], 'grants': [], 'datasets': [], 'versions': [], 'referenced_works_count': 17, 'referenced_works': ['https://openalex.org/W1492384425', 'https://openalex.org/W1596190251', 'https://openalex.org/W1958017720', 'https://openalex.org/W1970212093', 'https://openalex.org/W2001524406', 'https://openalex.org/W2014756391', 'https://openalex.org/W2016311788', 'https://openalex.org/W2066906758', 'https://openalex.org/W2074792668', 'https://openalex.org/W2109376915', 'https://openalex.org/W2121027929', 'https://openalex.org/W2122518346', 'https://openalex.org/W2184940291', 'https://openalex.org/W2219150984', 'https://openalex.org/W2924885896', 'https://openalex.org/W4238234479', 'https://openalex.org/W4247665917'], 'related_works': ['https://openalex.org/W3215949594', 'https://openalex.org/W2488033279', 'https://openalex.org/W2372322332', 'https://openalex.org/W2366708379', 'https://openalex.org/W2363747314', 'https://openalex.org/W2349785452', 'https://openalex.org/W2109376915', 'https://openalex.org/W2030105938', 'https://openalex.org/W1970212093', 'https://openalex.org/W1964759623'], 'abstract_inverted_index': {'Objective:': [0], 'The': [1, 30, 107], 'objective': [2], 'was': [3, 127], 'to': [4], 'reveal': [5], 'the': [6, 56, 78, 81, 94, 97, 100, 125, 131], 'relationship': [7], 'between': [8, 77], 'dose': [9, 82, 147], 'and': [10, 40, 52, 55, 65, 80, 88, 111, 120], 'concentration': [11, 79], 'of': [12, 18, 47, 83], 'atomoxetine.': [13], 'Method:': [14], 'Fifty-five': [15], 'blood': [16], 'samples': [17], '33': [19], 'patients': [20], 'with': [21], 'ADHD': [22], 'were': [23, 33, 58, 116], 'examined': [24], 'using': [25], 'high-performance': [26], 'liquid': [27], 'chromatography.': [28], 'Results:': [29], 'plasma': [31], 'concentrations': [32], '53.2': [34], '±': [35, 38, 42, 60, 63, 67, 118, 122], '67.0,': [36], '298.0': [37], '390.5,': [39], '639.3': [41], '831.9': [43], 'ng/mL': [44], 'at': [45, 109], 'doses': [46], '40': [48, 110], 'mg,': [49, 51, 54], '80': [50, 112], '120': [53, 114], 'concentration/dose': [57, 98, 108], '1.33': [59, 117], '1.67,': [61], '3.73': [62], '4.88,': [64], '5.33': [66], '6.93': [68], 'ng/mL/mg,': [69, 124], 'respectively.': [70], 'Statistical': [71], 'analyses': [72], 'revealed': [73], 'a': [74, 89], 'significant': [75], 'correlation': [76], 'atomoxetine': [84, 148], '(p': [85, 104, 133], '=': [86, 105, 134], '.004),': [87], 'trending': [90], 'toward': [91], 'significance': [92], 'in': [93, 96, 99, 145], 'difference': [95], 'three': [101], 'dosage': [102], 'groups': [103], '.064).': [106], '+': [113], 'mg/day': [115], '1.67': [119], '4.22': [121], '5.53': [123], 'latter': [126], 'significantly': [128], 'higher': [129], 'than': [130], 'former': [132], '.006),': [135], 'which': [136], 'suggested': [137], 'non-linear': [138], 'pharmacokinetics.': [139], 'Conclusion:': [140], 'Clinicians': [141], 'should': [142], 'carefully': [143], 'titrate': [144], 'high': [146], 'treatment.': [149]}, 'cited_by_api_url': 'https://api.openalex.org/works?filter=cites:W2488033279', 'counts_by_year': [{'year': 2024, 'cited_by_count': 1}, {'year': 2023, 'cited_by_count': 2}, {'year': 2021, 'cited_by_count': 1}], 'updated_date': '2024-12-08T05:27:11.381707', 'created_date': '2016-08-23'}