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3549, 3771, 4232, 4388], 'examined': [557, 1159, 2399, 3149], '41': [558, 1258, 2411, 3156], 'cases': [559, 2487, 2706, 3309, 3607], 'using': [562, 1345, 1522, 1693, 1879, 1912, 2167, 2337, 2357, 2375, 2414, 4173], 'immunohistochemistry': [563], 'macrophage': [567, 1733, 2939, 3680], '(TAM)': [568], 'markers': [569, 690, 3752, 3777, 3896, 3960, 3976], 'CD68,': [570, 2406, 2476, 2692, 3572, 3591], 'CD163,': [571, 2407, 2477, 2693, 3573, 3592], 'CD204,': [573, 2478], 'fibroblast': [577, 4064], '(CAF)': [578], 'marker,': [579], 'alpha': [580], 'smooth': [581, 3191], 'muscle': [582, 3192], 'actin': [583], '(αSMA).': [584], 'Each': [585, 1331], 'case': [586, 1382], 'was': [587, 709, 982, 1227, 1291, 1333, 1383, 1397, 1483, 1492, 1503, 1541, 1607, 1787, 1889, 1910, 1978, 2181, 2232, 2278, 2355, 2366, 2389, 2972, 2991, 3030, 3043, 3124, 3253, 3487, 3506, 3745, 3998, 4092, 4171, 4248, 4267, 4403, 4414, 4434], 'assigned': [588, 1384], 'low/high': [590], 'groups': [591, 602, 1360, 2562, 3230, 3465, 3723], 'on': [592, 603, 672, 822, 1012, 1369, 1518, 2209, 3004, 3231, 3519, 4215, 4240, 4298, 4336, 4395], 'basis': [594, 605, 3233], 'number': [597, 614, 1097, 1471, 2386, 2567, 2603, 2687, 3022, 3039, 3129, 3555], 'TAMs': [599, 616, 793, 1070, 1100, 1118, 1134, 1166, 1185, 2388, 3131, 3529, 3541, 3557], 'or': [600, 1279, 1441, 1443, 1791, 1806, 1827, 1855, 1928, 1961, 1997, 2028, 2057, 2349, 2937, 3678, 4096, 4446], 'three': [601, 1359, 1461, 1477, 3229, 3464, 3722, 3943, 4139], 'αSMA-staining': [608], 'area': [609, 619, 1434, 1452, 1487, 1499, 1513, 1517, 2541, 3208, 3215, 3237, 3250, 3448, 3560, 3706], 'CAFs.': [611], 'Both': [612], 'significantly': [623, 695, 3076, 3254, 3815], 'correlated': [624, 2614, 3044, 3126, 3255], 'clinical': [626, 868, 885, 2619, 3260], 'stage,': [627], 'MYCN': [628, 2629, 2788, 3066, 3122, 3265, 3355], 'amplification,': [629], 'bone': [630, 673, 1176, 3027, 3270], 'marrow': [631, 2830, 3028, 3271, 3381], 'metastasis,': [632], 'histological': [633, 635, 892, 2650, 2660, 3053, 3276, 3281], 'classification,': [634], 'type,': [636], 'risk': [638, 1377, 1391, 2672, 2902, 3288, 3426], 'classification.': [639], 'Furthermore,': [640, 1225], 'TAM': [641, 689, 3751, 3764, 3776, 3842, 3895], 'settled': [642], 'vicinity': [645, 3533], 'CAF': [648, 1433, 1486, 3236, 3297, 3310, 3447, 3580, 3596, 3603, 3705, 3959, 3975, 3994, 4060], 'area,': [649], 'suggesting': [650], 'their': [651, 884, 958, 1013, 1297, 3817], 'close': [652, 1072], 'interaction': [653], 'within': [654, 1001, 2017, 2101, 2946, 3454, 3687, 3712], 'We': [658, 1113, 1170, 1568, 1620, 1681, 2398, 3147, 3204, 3964, 4029, 4487], 'next': [659, 3148, 3965], 'determined': [660, 3908, 4127], 'effects': [662, 4236, 4294, 4391], 'conditioned': [664, 1189, 2015, 2099, 3848], 'medium': [665, 1190, 1618, 1636, 1646, 1786, 2027, 3849, 4091], 'cell': [669, 683, 932, 1124, 1195, 1538, 1799, 1868, 1874, 1980, 3853, 4216, 4241], 'line': [670, 1196, 1539, 3854], '(NBCM)': [671, 1197, 1619], 'marrow-derived': [674, 1177], 'mesenchymal': [675, 1178], 'stem': [676, 1179], '(BM-MSCs)': [678, 1181], 'peripheral': [680], 'blood': [681], 'mononuclear': [682], '(PBMC)-derived': [684], 'vitro.': [687, 1199], 'CD163': [691, 1442, 2427, 2493, 2513, 3793, 3897], 'CD204': [693, 1444, 2409, 2495, 2515, 2695, 3575, 3594, 3795, 3899], 'up-regulated': [696], 'PBMC-derived': [698, 780, 1173, 3754, 3779, 3798, 3809, 3901, 3924], 'treated': [700, 2029, 3811, 3846, 3865, 4074], 'NBCM.': [702, 4076], 'expression': [704, 959, 3774, 3796, 3818, 3921, 3973, 3991, 4018, 4105, 4114], 'αSMA': [706, 2497, 2517, 3185, 3996, 4014, 4033, 4102, 4110], 'BM-MSCs': [708, 717, 755, 783, 1221, 1571, 1680, 1767, 1807, 1945, 1998, 2059, 3963, 3984, 4011, 4041, 4073, 4079, 4116, 4157, 4197, 4266, 4303, 4344, 4431, 4448], 'increased': [710, 1222, 4013], 'NBCM-treated': [712], 'Co-culturing': [714], 'CAF-like': [716, 1220, 1679, 1763, 1825, 1949, 1962, 2058, 4251, 4410, 4447, 4458], 'did': [718], 'not': [719, 746, 3826, 3999, 4254, 4404], 'enhance': [720], 'invasive': [722, 749, 1209, 1238, 4219, 4287, 4338, 4396], 'ability': [723, 1239, 4220, 4288, 4339], 'but': [724, 756, 3825, 4253, 4412], 'supported': [725], 'proliferation': [727, 759, 1216, 1869, 4244, 4264], 'cells,': [730, 3193, 4231], 'whereas': [731, 1219, 3118], 'co-cultured': [734, 1243], 'TAM-like': [736, 743, 765, 1205, 1245, 1676, 1748, 1823, 1939, 4255, 4274, 4420, 4444, 4479], 'had': [738, 2155], 'opposite': [740], 'effect.': [741], 'Intriguingly,': [742, 3248], 'enhanced': [745, 1207, 3816, 4000, 4249, 4268, 4405, 4415, 4435, 4481], 'only': [747, 3045], 'abilities': [750, 1210], 'also': [757, 996, 1202, 2458, 3060, 3125, 3170, 4030], 'BM-MSCs.': [761], 'CXCL2': [762, 1590, 2310, 4476], 'secreted': [763, 4477], 'from': [764, 835, 955, 1192, 1268, 1293, 1543, 1572, 1593, 1609, 1684, 3216, 4478], 'plays': [767], 'an': [768, 1694, 1880, 3790, 3822], 'important': [769], 'role': [770, 1235], 'invasiveness.': [773], 'Taken': [774], 'together,': [775], 'these': [776, 1148, 2081], 'results': [777, 2334, 2342, 3059, 3788], 'indicate': [778, 2534], 'that': [779, 907, 939, 976, 1095, 1116, 1131, 1172, 1204, 1229, 2154, 3062, 3121, 3184, 4032], 'recruited': [785], 'site': [789], 'activated': [791, 935, 945, 951, 1025, 1031, 1183], 'into': [792, 874, 1019, 1184, 1358, 1966, 2062, 2558, 2955, 3228, 3463, 3696, 3721], 'CAFs,': [795], 'respectively,': [796], 'followed': [797], 'formation': [800], 'favourable': [802], 'environments': [803], 'progression.': [806, 1169], '©': [807], 'Authors.': [810], 'published': [815], 'John': [817], '&': [819], 'Sons': [820], 'Ltd': [821], 'behalf': [823], 'Pathological': [825], 'Society': [826], 'Great': [828], 'Britain': [829], 'Ireland.': [831], 'Introduction': [832], 'originating': [834], 'neural': [836], 'crest-derived': [837], 'precursor': [838], 'cause': [850], '15%': [852], 'cancer-related': [854], 'deaths': [855], '1.': [858, 2509, 2683], 'Such': [859], 'neuroblastomas': [860, 887, 901, 2397, 3064, 3602], 'characterized': [862, 1037, 1056], 'broad': [865], 'spectrum': [866], 'behaviours': [869], 'including': [870, 2618, 3259], 'spontaneous': [871], 'regression,': [872], 'maturation': [873], 'benign': [876], 'tumour,': [877], 'life-threatening': [879], 'aggressiveness.': [880], 'In': [881, 1154, 1744, 1901, 3035, 3807], 'association': [882, 1162, 2595, 3242, 3552], 'behaviours,': [886], 'exhibit': [888], 'variety': [890], 'types,': [893], 'namely': [894], 'ganglioneuroblastomas,': [895], 'differentiating': [896], 'neuroblastomas,': [897], 'poorly': [899, 1362], 'differentiated': [900, 1937, 1947], '2.': [902, 3294], 'It': [903], 'well': [905, 1717, 1776], 'known': [906, 964, 1005, 3183], 'non-tumour': [908, 930, 4229], 'critical': [912, 1234], 'various': [915, 1102], 'aspects': [916], '3.': [920, 3585], 'Cancer-associated': [921], '(CAFs),': [923], 'which': [924, 1044], 'primary': [927, 1259, 2241, 2287], 'components': [928], 'populations,': [933], 'forms': [936], 'similarities': [941], 'wound': [947], 'healing': [948], '4.': [949, 2529], 'These': [950], 'distinct': [954, 1021], 'αSMA,': [961, 2479, 4062, 4192], 'promote': [966], 'growth': [968, 4217, 4285], 'progression': [970, 1089, 1379], '5,': [971], '6.': [972], 'Some': [973, 1127], 'studies': [974, 1092], 'showed': [975, 3075, 4012], 'population': [978, 1371, 3006, 3521], 'αSMA-positive': [980, 1510, 3153, 3167, 3218, 3545], 'poor': [985, 1109], 'prognosis': [986, 1110], 'several': [988], 'types': [989], 'tumours': [991, 1002, 1103, 1354, 3176], '7,': [992], '8.': [993], 'Macrophages': [994], 'major': [998], 'component': [1000], 'as': [1006, 1064, 1408, 1505, 1736, 1857, 1876, 2030, 2183, 2234, 2280, 2345, 3950, 3985, 4146, 4321, 4377], '(TAMs)': [1009], '9.': [1010], 'Based': [1011, 3003, 3518], 'functions,': [1014], 'broadly': [1017], 'two': [1020], 'types:': [1022], 'classically': [1024], '(M1)': [1026], 'type': [1027, 2661, 3054, 3282], 'alternatively': [1030], '(M2)': [1032], 'type.': [1033], 'M1': [1034], 'production': [1040, 1059], 'pro-inflammatory': [1042, 3830], 'cytokines,': [1043], 'capacity': [1047], 'bactericidal': [1049], 'tumour-suppressive': [1051], 'activities.': [1052], 'M2': [1053, 1076], 'anti-inflammatory': [1061, 3823], 'cytokines': [1062], 'such': [1063], 'IL4,': [1065], 'IL10,': [1066, 1082, 3820], 'TGFβ': [1068], '10.': [1069], 'character': [1074], 'macrophages;': [1077], 'they': [1078, 4467], 'express': [1079], 'IL4': [1080], 'play': [1084], 'significant': [1085, 3016], '11.': [1090], 'Clinicopathological': [1091], 'shown': [1094], 'CD163-positive': [1099, 2576, 2607, 3024, 3080], '(including': [1104], 'neuroblastomas)': [1105], '12,': [1111], '13.': [1112], 'recently': [1114], 'reported': [1115, 2417], 'CD204-positive': [1117, 2455, 2584, 3041], 'accumulated': [1119], 'progressive': [1121], 'oesophageal': [1122], 'squamous': [1123], 'carcinoma': [1125], '14.': [1126], 'reports': [1128], 'indicated': [1130, 1858, 2031, 4124, 4204], 'synergistically': [1136], 'prognostic': [1139], 'significance': [1140, 2354], '15-17.': [1141], 'However,': [1142], 'precise': [1144], 'mechanisms': [1145], 'invoked': [1146], 'between': [1147, 2329, 2685, 3019, 3296, 3553, 3587, 4225], 'remain': [1150], 'be': [1152], 'revealed.': [1153], 'present': [1156], 'study,': [1157], 'clinicopathological': [1161, 2330, 2393, 2597, 2700, 3143, 3244, 3303], 'observed': [1171, 3031, 3120, 3163, 3577], 'taken': [1191], 'Our': [1200, 3058], 'findings': [1201], 'revealed': [1203, 3061], 'surrounding': [1212], 'BM-MSCs,': [1218, 1826, 4252, 4411], 'growth.': [1224], 'it': [1226, 3181, 4413], 'clarified': [1228], 'CXCL2/CXCR2': [1230, 4485], 'signalling': [1231, 4486], 'has': [1232], 'macrophages.': [1246, 1468], 'Materials': [1247], 'methods': [1249], 'Tissue': [1250], 'samples': [1251, 1265, 2413, 2433, 2437, 2464, 2557, 3158, 3227], 'immunohistochemical': [1253, 2333], 'analyses': [1254, 2371], 'A': [1255, 1602, 2361, 2601], 'total': [1256, 1516], 'ganglioneuroblastoma': [1262], '(intermixed)': [1263], 'tissue': [1264], 'obtained': [1267, 1292, 1592, 1682], 'Hospital': [1271, 1304], '(Kobe,': [1272], 'Japan)': [1273, 1407, 1563], 'before': [1274, 1972], 'administration': [1276], 'chemotherapy': [1278], 'radiotherapy': [1280], 'patients': [1283, 1295, 2954, 3096, 3462, 3695, 3720], '(see': [1284], 'supplementary': [1285, 1426, 2197, 2299], 'material,': [1286, 1427, 2198, 2300], 'Table': [1287, 1428, 2199, 2250, 2301, 2682, 3293, 3584], 'S1).': [1288], 'Informed': [1289], 'consent': [1290], 'all': [1294], 'and/or': [1296], 'guardians,': [1298], 'both': [1300, 4270, 4437], 'Institutional': [1305, 1312], 'Review': [1306, 1313], 'Board': [1307, 1314], 'approved': [1315], 'study.': [1317], 'All': [1318, 2261, 2369], 'resected': [1319], 'specimens': [1320], 'fixed': [1322, 2221], '10%': [1324, 1566, 1584, 1651], 'formalin': [1325], 'embedded': [1327], 'paraffin': [1329], 'wax.': [1330], 'sample': [1332], 'categorized': [1334, 1357], 'according': [1335, 1739, 1896, 2320, 2563], 'International': [1338, 1347, 2980, 3495], 'Committee': [1341], '(INPC)': [1342], 'staged': [1344], 'Staging': [1349, 2982, 3497], 'System': [1350, 2983, 3498], '18,': [1351], '19.': [1352, 2984, 3499], 'further': [1356], '–': [1361, 1367], 'differentiated,': [1363], 'differentiating,': [1364], 'ganglioneuroblastomas': [1366], 'based': [1368], 'each': [1381, 2543], 'Oncology': [1388], 'group': [1389], '(COG)': [1390], 'classification': [1392, 2651, 2673, 2852, 3277, 3289, 3395], 'scheme': [1393], '20,': [1394], '21.': [1395], 'Immunohistochemistry': [1396], 'performed': [1398, 1911, 2182, 2279, 4172], 'Labelled': [1401], 'Streptavidin-Biotin': [1402], 'kit': [1403, 2171], '(Dako': [1404], 'Japan,': [1405], 'Kyoto,': [1406], 'described': [1409, 2184, 2235, 2281], 'elsewhere': [1410], '22.': [1411, 2186, 2237], 'Details': [1412, 2238, 2284], 'antibodies,': [1414], 'antigen': [1415], 'retrieval,': [1416], 'antibody': [1417, 1604, 3197], 'dilution,': [1418], 'secondary': [1420, 2243, 2290], 'layers': [1421], 'given': [1423, 2194], 'S2.': [1429, 2302], 'Macrophage': [1430], 'count': [1431], 'calculation': [1435], 'Round': [1436], 'positive': [1438, 2404, 2423, 2690, 3017, 3589], 'CD68': [1440, 2425, 2491, 2511], 'identified': [1446], 'screening': [1448], 'entire': [1450], 'low-power': [1455], 'field': [1456], '(100×': [1457], 'field)': [1458, 1482], 'selecting': [1460], 'areas': [1462, 2948, 3456, 3581, 3689, 3714], 'highest': [1465], 'density': [1466], 'mean': [1470, 2346, 3941, 3951, 4137, 4147, 4314, 4322, 4370, 4378], 'counted': [1474, 1491, 2166, 2992, 3507, 4361], 'independent': [1478], 'high-power': [1479], 'fields': [1480], '(400×': [1481], 'calculated.': [1484], 'where': [1488], 'assessed': [1493, 1867, 4306, 4488], 'at': [1494, 1671, 1709, 1891, 2130, 2225, 3070, 3086, 3098, 3110], '200×': [1495], 'overall': [1496], 'magnification.': [1497], 'fraction': [1500], 'defined': [1504], 'ratio': [1507], 'h-caldesmon-negative': [1512], 'microscopic': [1520], 'field,': [1521], 'ImageJ': [1523], 'software': [1524], 'ver.': [1525, 2378], '1.48': [1526], '(National': [1527], 'Institutes': [1528], 'Health,': [1530], 'Bethesda,': [1531], 'MD,': [1532, 1657], 'USA).': [1533, 1614, 1658, 1887, 1923, 2383], 'Cell': [1534], 'cultures': [1535], 'BE(2)-C': [1540, 1629], 'purchased': [1542, 1569, 1608], 'American': [1545], 'Type': [1546], 'Culture': [1547], 'Collection': [1548], '(ATCC;': [1549], 'Manassas,': [1550], 'VA,': [1551], 'USA)': [1552, 2218], 'cultured': [1554, 1719, 1752, 1778, 1809, 4042], 'DMEM': [1556, 1580, 1648], "Ham's": [1558], 'F-12': [1559], '(DMEM/F-12;': [1560], 'Wako,': [1561], 'Osaka,': [1562], 'supplemented': [1564, 1582, 1649], 'FBS.': [1567, 1585], 'human': [1570, 1587, 1652, 1721, 1766, 2315, 3870, 3962, 3978, 3983, 4003, 4010, 4040, 4069], 'ATCC': [1574], 'maintained': [1576], 'them': [1577, 3200], 'low-glucose': [1579], '(Wako)': [1581], 'Recombinant': [1586], 'CXCL1': [1588, 2308], 'R&D': [1594, 1726], 'Systems': [1595], '(Minneapolis,': [1596], 'MN,': [1597], 'USA;': [1598], '275-GR': [1599], '276-GB).': [1601], 'CXCR2-specific': [1603], 'neutralization': [1606], 'Abcam': [1610], '(ab10401;': [1611], 'Cambridge,': [1612], 'MA,': [1613, 1922], 'Preparation': [1615, 1674], 'neuroblastoma-conditioned': [1617], 'prepared': [1621], 'NBCM': [1623, 1757, 1781, 3749, 3784, 3803, 3814, 3884, 3906, 3929, 3957, 3969, 4045, 4084, 4121, 4162], 'plating': [1625], '5': [1626, 1932, 1956, 1992, 2041, 2052, 2069, 2786, 2807, 2819, 2847, 2870, 2895, 2897, 2906, 2916, 2920, 3366, 3387, 3400, 3417, 3657, 3661, 3669], '×': [1627, 1711, 1772, 1802, 1821, 1933, 1957, 1993, 2042, 2053, 2070, 2551], '106': [1628], '10': [1632, 2229, 3354, 3379], 'ml': [1633], 'culture': [1635, 1952], '100-mm': [1638], 'dishes': [1639, 1953], '24': [1641, 1970, 2066, 2833, 3384], 'h,': [1642, 1865], 'thereafter': [1643], 'changing': [1644], 'AB': [1653], 'serum': [1654], '(Lonza,': [1655], 'Walkersville,': [1656], 'After': [1659, 1703, 1849, 2113, 3220, 4166], 'days,': [1661], 'supernatants': [1663], 'collected,': [1665], 'centrifuged,': [1666], 'stored': [1668], 'aliquots': [1670], '−80': [1672], '°C.': [1673], 'PBMCs': [1683, 1690, 1935, 2044, 2072, 3845, 3858, 4347, 4433, 4453, 4463], 'healthy': [1685], 'volunteer': [1686], 'donors.': [1687], 'CD14-positive': [1689, 3857], 'purified': [1692], 'autoMACS': [1695], 'Pro': [1696], 'Separator': [1697], '(Miltenyi': [1698], 'Biotec,': [1699], 'Bergisch': [1700], 'Gladbach,': [1701], 'Germany).': [1702, 2273], 'purification,': [1704], 'plated': [1708, 1769], '1': [1710, 1771, 1801, 1820, 2802, 2804, 2880, 2926, 3315, 3391, 3404, 3412, 3422, 3437, 3650, 3655], '105': [1712, 1773, 1803, 1822], 'cells/ml': [1713, 1774], 'per': [1714, 1775], '30': [1715], 'mm': [1716], 'M-CSF': [1722, 3871], '(hM-CSF)': [1723], '(25': [1724], 'ng/ml;': [1725], 'Systems)': [1727], '6': [1729, 2775, 2803, 2805, 2813, 2816, 2845, 2849, 2859, 2891, 2892, 3330, 3337, 3353, 3372, 3405, 3423, 3430, 3441, 3659, 3873], 'days': [1730, 3874, 4048, 4125, 4205], 'induce': [1732, 1747, 3876, 3971], 'differentiation,': [1734, 3878], 'regarded': [1735], 'M0': [1737, 1753], 'recommendation': [1742], '23.': [1743], 'order': [1745], 'macrophages,': [1749, 1824], 'then': [1751, 1955, 2080, 2145, 2220, 2592, 3205, 3239, 3864, 3880], '50%': [1756, 1780, 3783, 3802, 3813, 3883, 3905, 3928, 3968, 4021, 4044, 4083, 4120, 4161, 4200], 'days.': [1760, 1784, 1793, 3887, 4089, 4098, 4165], 'For': [1761, 1796, 2036], 'BM-MSC': [1764, 1929, 4459], 'preparation,': [1765], '7': [1783, 2751, 2760, 2772, 2801, 2827, 2856, 2879, 2899, 2912, 2915, 3332, 3336, 3338, 3363, 3386, 3392, 3411, 3418, 3434, 4047, 4088, 4164], 'changed': [1788, 2024, 4093], 'every': [1789, 4094], '3': [1790, 2782, 2866, 2890, 2909, 2919, 3665, 3667, 4086, 4095], '4': [1792, 2431, 2445, 2768, 2780, 2888, 2918, 2928, 3175, 3343, 3348, 3350, 3373, 3377, 3431, 3435, 4097], 'Proliferation': [1794], 'assays': [1795, 1904], 'assessment': [1797], 'proliferation,': [1800], 'bottom': [1812, 2021, 2105], 'chamber': [1813, 1918, 2211, 4356], '24-well': [1816, 1914], 'insert': [1817], 'plate.': [1818], 'Then': [1819], 'seeded': [1831, 1965, 2000], 'upper': [1834, 1844, 2003, 2049, 2077, 2115, 2142], '0.4-µm': [1835], 'pore-size': [1836], 'insert.': [1837], 'There': [1838, 1977], 'no': [1840, 1979], 'inserts': [1845, 1974, 2007, 2019, 2050, 2078, 2082, 2091, 2103, 2116, 2143], 'control': [1847, 1986], 'wells.': [1848, 1987], 'co-culture': [1850, 4213, 4238, 4290, 4296, 4334, 4393, 4407, 4417, 4438, 4460, 4472], 'serum-free': [1853, 2026, 2110], 'conditions': [1854, 4214, 4239, 4297, 4335, 4394, 4408, 4418, 4439, 4473], 'treatment': [1856], 'Results': [1861, 2034, 2384], 'section': [1862], '48': [1864, 2128], 'increase': [1872, 3791], 'number,': [1875], 'estimated': [1877, 2336], 'MTS': [1881, 4309], 'colourimetric': [1882], 'assay': [1883, 1909, 2305], '(Promega,': [1884], 'Madison,': [1885], 'WI,': [1886], 'Absorbance': [1888], '405': [1892], '492': [1894], 'nm': [1895], "manufacturer's": [1899, 2323], 'instructions.': [1900, 2324], 'vitro': [1902, 1907], 'invasion': [1903, 1908, 1917, 1930, 2039, 4355, 4399, 4429], 'BioCoat': [1915, 4353], 'Matrigel': [1916, 4354], '(BD': [1919], 'Biosciences,': [1920], 'Bedford,': [1921], 'Prior': [1924], 'assay,': [1931, 2040], '104': [1934, 1958, 1994, 2043, 2054, 2071], 'lower': [1943, 1968, 1983, 2012, 2064, 2087, 2096, 2121, 2159], 'chambers.': [1944, 2065, 2088], 'chambers': [1969, 1984, 2022, 2106], 'h': [1971, 2067, 2129], 'exposed.': [1976], 'At': [1988], 'same': [1990], 'time,': [1991], 'inserts.': [2004], 'When': [2005, 2089], 'exposed': [2009, 2084, 2093, 2118, 3781, 3881, 4081], 'chambers,': [2013, 2097, 2122], 'media': [2016, 2100], 'section.': [2035], 'PBMC': [2038], 'separated': [2046], 'divided': [2061, 2555, 3224], 'later,': [2068], 'distributed': [2074], 'onto': [2075, 2157], 'replaced': [2108], 'RPMI-1640': [2111], '(Wako).': [2112, 2260], 'incubated': [2126], '37': [2131], '°C': [2132, 2227], 'CO2': [2135], 'incubator.': [2136], 'remaining': [2139], 'removed': [2146], 'cotton': [2149], 'swab.': [2150], 'Thereafter,': [2151], 'invaded': [2156, 4454, 4468], 'surface': [2160], 'Matrigel-coated': [2163], 'membrane': [2164], 'Diff-Quik': [2169], 'staining': [2170, 2474], '(Sysmex,': [2172], 'Japan).': [2174], 'Reverse': [2175], 'transcription': [2176], 'quantitative': [2177], 'PCR': [2178], '(RT-qPCR)': [2179], 'RT-qPCR': [2180], 'previously': [2185, 2236, 2282], 'primer': [2188], 'sequences': [2189], 'detailed': [2191], 'procedures': [2192], 'S3': [2200], 'Figure': [2202, 2468, 3835, 4052, 4278], 'S1.': [2203], 'Immunofluorescence': [2204, 2231], 'grown': [2208], 'Lab-Tek': [2210], 'slides': [2212], '(Nalge': [2213], 'Nunc': [2214], 'International,': [2215], 'Rochester,': [2216], 'NY,': [2217], '100%': [2223], 'methanol': [2224], '−20': [2226], 'min.': [2230], 'conducted': [2233], 'fluorescein': [2244], 'conjugated': [2245], 'antibodies': [2246, 2288, 2294], 'listed': [2248], 'S2': [2251], '(supplementary': [2252], 'material).': [2253], 'nuclei': [2255], 'stained': [2257, 2503, 2523], 'DAPI': [2259, 4179], 'images': [2262], 'acquired': [2264], 'confocal': [2266], 'microscopy': [2267], '(LSM': [2268], '700;': [2269], 'Carl': [2270], 'Zeiss,': [2271], 'Oberkochen,': [2272], 'Western': [2274, 2276], 'blotting': [2275, 2277], '24.': [2283], 'horseradish': [2291], 'peroxidase': [2292], '(HRP)-conjugated': [2293], 'provided': [2296, 4181], 'Enzyme-linked': [2303], 'immunosorbent': [2304], '(ELISA)': [2306], 'Human': [2307], 'concentrations': [2311], 'measured': [2313], 'SimpleStep': [2316], 'ELISA': [2317], 'kits': [2318], '(Abcam)': [2319], 'Statistical': [2325], 'analysis': [2326], 'relationships': [2328], 'factors': [2331], "Fisher's": [2338, 2965, 3480, 3738], 'test.': [2340], 'expressed': [2344, 3187, 3949, 4145, 4320, 4376], '±': [2347, 3952, 4148, 4323, 4379], 'SD': [2348, 3953, 4149], 'SEM,': [2350], 'statistical': [2353, 2370], 'analysed': [2356, 2593, 2963, 3240, 3478, 3736, 3931, 4234, 4350, 4389], 'two-sided': [2358], "Student's": [2359], 't-tests.': [2360], 'p-value': [2362], 'less': [2363], 'than': [2364], '0.05': [2365, 2971, 3486, 3744], 'considered': [2367, 2973, 3488, 3746], 'significant.': [2368, 2975, 3490, 3748], 'carried': [2373], 'out': [2374], 'SPSS': [2376], 'Statistics': [2377], '22': [2379, 2822, 3376], '(IBM,': [2380], 'Chicago,': [2381], 'IL,': [2382], 'closely': [2390, 2613, 3140], 'features': [2394, 2598, 2701, 3144, 3245, 3304], 'existence': [2401, 3151], 'immunohistochemistry.': [2415, 3160], 'As': [2416, 3161, 3540], 'before,': [2418], 'there': [2419], 'stage': [2430, 2444, 2508, 2528, 2620, 3174, 3261], '(metastatic)': [2432], 'compared': [2434, 3082], 'stages': [2440], '(i.e.': [2441], 'non-metastatic': [2442, 2506], 's,': [2446], 'spontaneously': [2447], 'regressive': [2448], 'stage)': [2449], '(Figure': [2450, 2465, 3177, 3201, 3547, 3785, 3804, 3832, 4007, 4027, 4049, 4257, 4276, 4422, 4449, 4474], '1A,': [2451], 'B,': [2452], 'G,': [2453], 'H).': [2454], 'frequently': [2459], 'detected': [2460], 'aggressive-stage': [2463], '1C,': [2466], 'I).': [2467], '1Open': [2469], 'figure': [2471, 3838, 4055, 4281], 'viewerPowerPoint': [2472, 3839, 4056, 4282], 'Immunohistochemical': [2473], 'h-caldesmon': [2481, 2500, 2520, 3196], 'samples.': [2484], 'Two': [2485], 'representative': [2486], 'shown.': [2489], '(A–F)': [2490], '(A),': [2492, 4108], '(B),': [2494], '(C),': [2496, 4343], '(D),': [2498, 4345], '(E)': [2501, 4348], 'case,': [2507, 2527], '(G–L)': [2510], '(G),': [2512], '(H),': [2514], '(I),': [2516], '(J),': [2518], '(K)': [2521], 'metastatic': [2526], 'insets': [2531], 'G–L': [2533], 'high': [2535, 2559, 2602, 2956, 3021, 3038, 3697], 'magnification': [2536], 'views': [2537], 'boxed': [2540], 'panel.': [2544], 'magnification:': [2546, 2549, 4185], '100×.': [2547], 'Inset': [2548], '400': [2550], '.': [2552], 'Next,': [2553], 'low': [2561, 2958, 3699], 'median': [2566, 2932, 3673], 'CD68-positive': [2569, 2605], '(26;': [2571], 'range': [2572, 2579, 2587], '9.3': [2573], '−': [2574, 2581, 2589], '92.3),': [2575], '(24.3;': [2578], '1.7': [2580], '97.7),': [2582], '(17.3;': [2586], '2.3': [2588], '56.3),': [2590], '(Table': [2599, 3246, 3582], '1).': [2600], 'phenotypes': [2617, 3258], '(p': [2621, 2631, 2641, 2652, 2662, 2674, 3032, 3049, 3055, 3262, 3267, 3273, 3278, 3283, 3290], '=': [2622, 2632, 2636, 2642, 2646, 2653, 2663, 2667, 2675, 2720, 2723, 2728, 2731, 2736, 2739, 3012, 3033, 3050, 3056, 3263, 3268, 3274, 3279, 3291, 3318, 3321, 3324, 3527, 3627, 3630, 3633, 3636, 3639, 3642], '0.001': [2623, 2654, 2664, 2676, 2773, 2857, 2878, 2881, 2907, 3349, 3651], 'p': [2625, 2635, 2645, 2656, 2666, 2678, 2725, 2733, 2741, 2969, 3115, 3312, 3484, 3616, 3620, 3624, 3742], '<': [2626, 2657, 2679, 2970, 3088, 3112, 3116, 3284, 3485, 3743, 3955, 4151, 4154, 4326, 4329, 4382, 4385], '0.001,': [2627, 2658, 2668, 2680], 'respectively),': [2628, 2638, 2648, 2659], 'amplification': [2630, 3068, 3123, 3266], '0.045': [2633, 2793, 2796, 3361], '0.045,': [2637], 'Ki-67': [2639, 2808, 2990, 3047, 3367, 3505], 'index': [2640, 3048], '0.041': [2643, 2814, 2817], '0.041,': [2647], 'INPC': [2649, 2851, 3394], 'respectively)': [2669], 'COG': [2671, 2901, 3287, 3425], 'respectively).': [2681], 'Correlation': [2684, 3295, 3586], 'stroma': [2698, 2945, 3301, 3453, 3600, 3686, 3711], 'macrophages*': [2709, 3612, 3613], 'CD68+': [2710, 3608], 'CD163+': [2711, 2936, 3609, 3677], 'CD204+': [2712, 2938, 3610, 3679], 'Low': [2713, 2715, 2717, 2903, 3427, 3614, 3618, 3622], 'High': [2714, 2716, 2718, 2922, 3438, 3615, 3619, 3623], '(n': [2719, 2722, 2727, 2730, 2735, 2738, 3317, 3320, 3323, 3626, 3629, 3632, 3635, 3638, 3641], '21)': [2721, 2729, 2737, 3628, 3634, 3640], '20)': [2724, 2732, 2740, 3631, 3637, 3643], 'value†': [2726, 2734, 2742, 3313], 'Age': [2743, 3326], '(months)': [2744, 3327], '<18': [2745, 3328], '21': [2746, 2894, 3329, 3421], '12': [2747, 2754, 2762, 2848, 2886, 2911, 3359, 3385, 3398, 3416, 3649], '9': [2748, 2753, 2758, 2778, 2835, 2841, 2862, 2889, 3360, 3371, 3393, 3406, 3429, 3442, 3658, 3662, 3670], '0.538': [2749], '14': [2750, 2785, 2792, 2795, 2818, 2824, 2826, 2869, 2900, 2905, 2927, 3106, 3424, 3656, 3664], '0.063': [2752], '0.354': [2755], '≥18': [2756, 3334], '20': [2757, 2791, 2794, 3335], '11': [2759, 2787, 2846, 2850, 2871, 2929, 3652, 3666, 3668], '13': [2761, 2783, 2812, 2815, 2867, 2925, 3346, 3358, 3645, 3646], '8': [2763, 2823, 2825, 2838, 2875, 2876, 2882, 2887, 3331, 3347, 3378, 3399, 3410, 3660], 'Stage‡': [2764, 3339], '1,': [2765, 3340, 3470, 3728], '2,': [2766, 3341, 3473, 3731], '3,': [2767, 3342], 's': [2769, 3344], '25': [2770, 2854, 3345, 3397, 3867], '19': [2774, 2797, 2811, 2858, 2904, 3370, 3428], '<0.001': [2776, 2860, 2910, 3414, 3648], '16': [2777, 2781, 2837, 2861, 2865, 2896, 2898, 2908, 3351, 3403], '0.058': [2779, 2863], 'Non-amplified': [2789, 3356], '34': [2790, 3357], '15': [2798, 2828, 2834, 2840, 2923, 3439], '0.238': [2799], 'Amplified': [2800, 3362], 'index§': [2809, 3368], '≤5%': [2810, 3369], '0.007': [2820], '>5%': [2821, 3375], 'Bone': [2829, 3380], 'metastasis': [2831, 3029, 3272, 3382], 'Negative': [2832, 3383], '0.118': [2836, 2842], '0.028': [2839], 'Positive': [2843, 3389], '17': [2844, 3390], 'Favourable': [2853, 3396], 'Unfavourable': [2864, 3402], 'Histological': [2872, 3407], 'type||': [2873, 3408], 'GNB': [2874, 3011, 3409, 3526], '0': [2877, 2883, 3314, 3352, 3364, 3413, 3419, 3440, 3644, 3647], '0.006': [2884], 'Differentiating': [2885, 3415], 'Poorly': [2893, 3420], '0.054': [2913], 'Intermediate': [2914, 3433], '*': [2930, 3443, 3671], 'values': [2933, 3674], 'CD68+,': [2935, 3676], 'numbers': [2940, 3078, 3568, 3681], 'nests': [2943, 3451, 3684, 3709], 'used': [2950, 3195, 3458, 3691, 3716], 'divide': [2952, 3460, 3693, 3718], 'groups.': [2959, 3700], '†': [2960, 3475, 3701], 'Data': [2961, 3476, 3734], 'test': [2967, 3482, 3740], 'statistically': [2974, 3489, 3747], '‡': [2976, 3491, 3733], 'According': [2977, 3492], '§': [2985, 3500], 'presence': [2987, 3502], 'nuclear': [2989, 3504, 4182], '1000': [2994, 3509], 'ten': [2998, 3513], 'randomly': [2999, 3514, 4364], 'selected': [3000, 3515, 3860], 'fields.': [3001, 3516, 4366], '||': [3002, 3517], 'ganglioneuroblastoma.': [3013, 3528], 'Interestingly,': [3014, 3566, 4452], 'correlation': [3018], '0.028).': [3034], 'contrast,': [3036], '0.007)': [3051], '0.006).': [3057], 'without': [3065], 'proto-oncogene': [3067], 'diagnosed': [3069, 3085, 3097, 3109], 'age': [3071, 3087, 3099, 3111], '≥': [3072, 3100], 'months': [3074, 3090], 'larger': [3077], 'those': [3084], '(ten': [3091], '‘high’': [3092, 3104], 'six': [3094], '‘low’': [3095, 3107], 'months;': [3102, 3114], 'four': [3103, 4316, 4372], '0.035),': [3117], 'neuroblastomas.': [3134, 3565], 'grades': [3136, 3298, 3445, 3597, 3703], 'TAMs,': [3166], 'dominant': [3171], '1D,': [3178], 'J).': [3179], 'Since': [3180], 'normal': [3189], 'vascular': [3190], 'detect': [3199], '1E,': [3202], 'K).': [3203], 'calculated': [3206], 'subtracting': [3212], 'h-caldesmon-positive': [3214], 'area.': [3219], 'calculation,': [3222], '2).': [3247], '0.001),': [3264, 3285], '0.045),': [3269], '0.009),': [3275], '0.01),': [3280], '0.013).': [3292], 'grades*': [3311], '13)': [3319], '14)': [3322, 3325], '0.844': [3333], '0.101': [3374], '0.009': [3388], '0.01': [3401], '0.013': [3432], '(grade': [3466, 3724], '0,': [3467, 3725], 'low;': [3468, 3726], 'grade': [3469, 3472, 3727, 3730], 'intermediate;': [3471, 3729], 'high).': [3474, 3732], 'resided': [3530], 'tissues': [3539], 'adjacent': [3543], '1G–J),': [3548], 'investigated': [3550, 3966], 'higher': [3567, 3579], 'expressing': [3571], '3).': [3583], 'grade†': [3604], 'macrophages†': [3611], 'value‡': [3617, 3621, 3625], '0.014': [3654], 'induced': [3750, 3958, 4038], 'To': [3756, 4221], 'investigate': [3757, 4222], 'whether': [3758, 3967], 'able': [3761], 'acquire': [3763], 'characteristics': [3765, 3843], 'under': [3766, 4289, 4406, 4416, 4436], 'microenvironment,': [3770], 'evaluated': [3772], '2A).': [3786], 'confirmed': [3789, 4031], 'effected': [3800], '2B,': [3805], 'C).': [3806], 'addition,': [3808], 'encoding': [3821, 3828], 'cytokine,': [3824], 'IL12,': [3827], 'cytokine': [3831], '2D,': [3833], 'E).': [3834, 4451], '2Open': [3836], 'Acquisition': [3840], '(NBCM).': [3855], '(A)': [3856, 4301], 'MACS': [3862], 'ng/ml': [3868], 'recombinant': [3869], 'macrophage-like': [3877], '(B,': [3888], 'C)': [3889], 'mRNA': [3891, 3920, 4017, 4104, 4113, 4490], 'levels': [3892, 4190, 4491], 'stimulated': [3903, 3926, 4118, 4159, 4198], 'RT-qPCR,': [3910, 3933, 4129], 'normalized': [3911, 3934, 4130], 'GAPDH.': [3913], '(D,': [3914], 'E)': [3915], 'IL10': [3917], 'IL12': [3919], 'patterns': [3922], 'GAPDH': [3936, 4132], 'expression.': [3937, 4133], 'Values': [3938, 4134, 4311, 4367], 'represent': [3939, 4135, 4312], 'experiments': [3944, 4140, 4317, 4373], 'duplicate': [3946, 4142], '(**p': [3954], '0.01).': [3956, 4155, 4330, 4386], 'would': [3970], 'neonate': [3979, 4004, 4070], 'dermal': [3980, 4005], 'examples': [3986], 'marker': [3995], '(ACTA2)': [3997, 4103], '3A),': [4008], 'FAP': [4016, 4035, 4112], 'when': [4019, 4466], 'NBCM,': [4022], 'time-dependent': [4025], 'manner': [4026], '3B).': [4028], 'proteins': [4036], '3C,': [4050], 'D).': [4051], '3Open': [4053], 'induction': [4058], 'markers,': [4061], 'activation': [4065], 'protein': [4066, 4189], '(FAP)': [4067], 'Fibroblasts': [4077], '(A,': [4099], 'B)': [4100], '(B)': [4117, 4304], '(*p': [4150, 4325, 4381], '0.05;': [4152, 4327, 4383], '**p': [4153, 4328, 4384], '(C)': [4156], 'stimulation,': [4168], 'double': [4169], 'immunofluorescence': [4170], 'anti-αSMA': [4174], '(red)': [4175], 'anti-FAP': [4177], '(green).': [4178], '(blue)': [4180], 'counterstaining.': [4183], '200×.': [4186], '(D)': [4187], 'FAP,': [4193], 'β-actin': [4195], 'NBC': [4201], 'quantified': [4207], 'western': [4209], 'blotting.': [4210], 'Effects': [4211, 4331], 'relationship': [4224], 'first': [4233], 'proliferation.': [4242], '4A).': [4258], 'On': [4259, 4424], 'hand,': [4262, 4427], '4B).': [4277], '4Open': [4279], 'Induction': [4283], 'conditions.': [4291], 'growth-promoting': [4293], 'assay.': [4310, 4357], 'SEM': [4324, 4380], 'Invading': [4358], 'five': [4363], 'chosen': [4365], 'Second,': [4387], 'ability.': [4397], '4C).': [4423], '4D,': [4450], 'individually': [4455], 'conditions,': [4461], 'while': [4462], 'formed': [4464], 'clusters': [4465], '4E).': [4475], 'invasiveness': [4483], 'through': [4484], 'MMPs,': [4493], 'CC/CXC': [4494], 'chemokines,': [4495]}, 'cited_by_api_url': 'https://api.openalex.org/works?filter=cites:W2487956862', 'counts_by_year': [{'year': 2024, 'cited_by_count': 15}, {'year': 2023, 'cited_by_count': 19}, {'year': 2022, 'cited_by_count': 26}, {'year': 2021, 'cited_by_count': 25}, {'year': 2020, 'cited_by_count': 22}, {'year': 2019, 'cited_by_count': 19}, {'year': 2018, 'cited_by_count': 12}, {'year': 2017, 'cited_by_count': 7}, {'year': 2016, 'cited_by_count': 3}], 'updated_date': '2024-09-15T13:32:45.741325', 'created_date': '2016-08-23'}