Title: 22aAR-2 Analysis of molecular crowding effect in signal transduction process on cell membrane by molecular dynamics simulations II
Abstract: Cells can sense the environmental variations by their signal transduction processes. Such processes start with the activation of receptors and signaling protein on the cell membrane. Recent studies suggest that various macromolecules are crowded in the cell and their excluded volumes often affect several biochemical reactions. For example, a recent experiment of mouse retina cell suggest the signal transduction of wild-type cells with dense photoreceptors on the cell membrane is slower than that of the mutants with half of the density of photoreceptors. Then, we investigated the influences of the molecular crowding using a coarse-grained molecular model of signal transduction on the membrane of retina cell. By simulations, we found the crowding of receptors slow down the signal transduction as expected from the experiment.
Publication Year: 2015
Publication Date: 2015-03-21
Language: en
Type: article
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