Get quick answers to your questions about the article from our AI researcher chatbot
{'id': 'https://openalex.org/W2486055736', 'doi': 'https://doi.org/10.18632/oncotarget.10670', 'title': 'Treatment with an SLC12A1 antagonist inhibits tumorigenesis in a subset of hepatocellular carcinomas', 'display_name': 'Treatment with an SLC12A1 antagonist inhibits tumorigenesis in a subset of hepatocellular carcinomas', 'publication_year': 2016, 'publication_date': '2016-07-18', 'ids': {'openalex': 'https://openalex.org/W2486055736', 'doi': 'https://doi.org/10.18632/oncotarget.10670', 'mag': '2486055736', 'pmid': 'https://pubmed.ncbi.nlm.nih.gov/27447551', 'pmcid': 'https://www.ncbi.nlm.nih.gov/pmc/articles/5288206'}, 'language': 'en', 'primary_location': {'is_oa': True, 'landing_page_url': 'https://doi.org/10.18632/oncotarget.10670', 'pdf_url': 'http://www.oncotarget.com/index.php?journal=oncotarget&page=article&op=view&path%5B%5D=10670&path%5B%5D=33781', 'source': {'id': 'https://openalex.org/S126644158', 'display_name': 'Oncotarget', 'issn_l': '1949-2553', 'issn': ['1949-2553'], 'is_oa': True, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310316297', 'host_organization_name': 'Impact Journals LLC', 'host_organization_lineage': ['https://openalex.org/P4310316297'], 'host_organization_lineage_names': ['Impact Journals LLC'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, 'type': 'review', 'type_crossref': 'journal-article', 'indexed_in': ['crossref', 'pubmed'], 'open_access': {'is_oa': True, 'oa_status': 'gold', 'oa_url': 'http://www.oncotarget.com/index.php?journal=oncotarget&page=article&op=view&path%5B%5D=10670&path%5B%5D=33781', 'any_repository_has_fulltext': True}, 'authorships': [{'author_position': 'first', 'author': {'id': 'https://openalex.org/A5100647688', 'display_name': 'Fei Teng', 'orcid': 'https://orcid.org/0000-0001-9076-8862'}, 'institutions': [{'id': 'https://openalex.org/I177933477', 'display_name': 'Second Military Medical University', 'ror': 'https://ror.org/04tavpn47', 'country_code': 'CN', 'type': 'education', 'lineage': ['https://openalex.org/I177933477']}], 'countries': ['CN'], 'is_corresponding': False, 'raw_author_name': 'Fei Teng', 'raw_affiliation_strings': ['Department of Liver Surgery and Organ Transplantation, Changzheng Hospital, Second Military Medical University, Shanghai 200003, China'], 'affiliations': [{'raw_affiliation_string': 'Department of Liver Surgery and Organ Transplantation, Changzheng Hospital, Second Military Medical University, Shanghai 200003, China', 'institution_ids': ['https://openalex.org/I177933477']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5101531901', 'display_name': 'Meng Guo', 'orcid': 'https://orcid.org/0000-0001-7395-3863'}, 'institutions': [{'id': 'https://openalex.org/I177933477', 'display_name': 'Second Military Medical University', 'ror': 'https://ror.org/04tavpn47', 'country_code': 'CN', 'type': 'education', 'lineage': ['https://openalex.org/I177933477']}], 'countries': ['CN'], 'is_corresponding': False, 'raw_author_name': 'Meng Guo', 'raw_affiliation_strings': ['Department of Liver Surgery and Organ Transplantation, Changzheng Hospital, Second Military Medical University, Shanghai 200003, China'], 'affiliations': [{'raw_affiliation_string': 'Department of Liver Surgery and Organ Transplantation, Changzheng Hospital, Second Military Medical University, Shanghai 200003, China', 'institution_ids': ['https://openalex.org/I177933477']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5100453097', 'display_name': 'Fang Liu', 'orcid': 'https://orcid.org/0000-0002-9918-2945'}, 'institutions': [{'id': 'https://openalex.org/I177933477', 'display_name': 'Second Military Medical University', 'ror': 'https://ror.org/04tavpn47', 'country_code': 'CN', 'type': 'education', 'lineage': ['https://openalex.org/I177933477']}], 'countries': ['CN'], 'is_corresponding': False, 'raw_author_name': 'Fang Liu', 'raw_affiliation_strings': ['Department of Liver Surgery and Organ Transplantation, Changzheng Hospital, Second Military Medical University, Shanghai 200003, China'], 'affiliations': [{'raw_affiliation_string': 'Department of Liver Surgery and Organ Transplantation, Changzheng Hospital, Second Military Medical University, Shanghai 200003, China', 'institution_ids': ['https://openalex.org/I177933477']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5100600887', 'display_name': 'Ce Wang', 'orcid': 'https://orcid.org/0000-0001-7465-796X'}, 'institutions': [{'id': 'https://openalex.org/I177933477', 'display_name': 'Second Military Medical University', 'ror': 'https://ror.org/04tavpn47', 'country_code': 'CN', 'type': 'education', 'lineage': ['https://openalex.org/I177933477']}], 'countries': ['CN'], 'is_corresponding': False, 'raw_author_name': 'Ce Wang', 'raw_affiliation_strings': ['Department of Orthopaedics, Changzheng Hospital, Second Military Medical University, Shanghai 200003, China'], 'affiliations': [{'raw_affiliation_string': 'Department of Orthopaedics, Changzheng Hospital, Second Military Medical University, Shanghai 200003, China', 'institution_ids': ['https://openalex.org/I177933477']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5008408463', 'display_name': 'Jiayong Dong', 'orcid': 'https://orcid.org/0000-0002-6659-3553'}, 'institutions': [{'id': 'https://openalex.org/I177933477', 'display_name': 'Second Military Medical University', 'ror': 'https://ror.org/04tavpn47', 'country_code': 'CN', 'type': 'education', 'lineage': ['https://openalex.org/I177933477']}], 'countries': ['CN'], 'is_corresponding': False, 'raw_author_name': 'Jiayong Dong', 'raw_affiliation_strings': ['Department of Liver Surgery and Organ Transplantation, Changzheng Hospital, Second Military Medical University, Shanghai 200003, China'], 'affiliations': [{'raw_affiliation_string': 'Department of Liver Surgery and Organ Transplantation, Changzheng Hospital, Second Military Medical University, Shanghai 200003, China', 'institution_ids': ['https://openalex.org/I177933477']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5100434072', 'display_name': 'Lei Zhang', 'orcid': 'https://orcid.org/0009-0008-9783-092X'}, 'institutions': [{'id': 'https://openalex.org/I177933477', 'display_name': 'Second Military Medical University', 'ror': 'https://ror.org/04tavpn47', 'country_code': 'CN', 'type': 'education', 'lineage': ['https://openalex.org/I177933477']}], 'countries': ['CN'], 'is_corresponding': False, 'raw_author_name': 'Lei Zhang', 'raw_affiliation_strings': ['Department of Liver Surgery and Organ Transplantation, Changzheng Hospital, Second Military Medical University, Shanghai 200003, China'], 'affiliations': [{'raw_affiliation_string': 'Department of Liver Surgery and Organ Transplantation, Changzheng Hospital, Second Military Medical University, Shanghai 200003, China', 'institution_ids': ['https://openalex.org/I177933477']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5102361701', 'display_name': 'You Zou', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I177933477', 'display_name': 'Second Military Medical University', 'ror': 'https://ror.org/04tavpn47', 'country_code': 'CN', 'type': 'education', 'lineage': ['https://openalex.org/I177933477']}], 'countries': ['CN'], 'is_corresponding': False, 'raw_author_name': 'You Zou', 'raw_affiliation_strings': ['Department of Liver Surgery and Organ Transplantation, Changzheng Hospital, Second Military Medical University, Shanghai 200003, China'], 'affiliations': [{'raw_affiliation_string': 'Department of Liver Surgery and Organ Transplantation, Changzheng Hospital, Second Military Medical University, Shanghai 200003, China', 'institution_ids': ['https://openalex.org/I177933477']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5100403693', 'display_name': 'Rui Chen', 'orcid': 'https://orcid.org/0000-0003-3728-2577'}, 'institutions': [{'id': 'https://openalex.org/I177933477', 'display_name': 'Second Military Medical University', 'ror': 'https://ror.org/04tavpn47', 'country_code': 'CN', 'type': 'education', 'lineage': ['https://openalex.org/I177933477']}], 'countries': ['CN'], 'is_corresponding': False, 'raw_author_name': 'Rui Chen', 'raw_affiliation_strings': ['Department of Liver Surgery and Organ Transplantation, Changzheng Hospital, Second Military Medical University, Shanghai 200003, China'], 'affiliations': [{'raw_affiliation_string': 'Department of Liver Surgery and Organ Transplantation, Changzheng Hospital, Second Military Medical University, Shanghai 200003, China', 'institution_ids': ['https://openalex.org/I177933477']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5040956923', 'display_name': 'Ke-Yan Sun', 'orcid': 'https://orcid.org/0000-0002-7909-2029'}, 'institutions': [{'id': 'https://openalex.org/I177933477', 'display_name': 'Second Military Medical University', 'ror': 'https://ror.org/04tavpn47', 'country_code': 'CN', 'type': 'education', 'lineage': ['https://openalex.org/I177933477']}], 'countries': ['CN'], 'is_corresponding': False, 'raw_author_name': 'Keyan Sun', 'raw_affiliation_strings': ['Department of Liver Surgery and Organ Transplantation, Changzheng Hospital, Second Military Medical University, Shanghai 200003, China'], 'affiliations': [{'raw_affiliation_string': 'Department of Liver Surgery and Organ Transplantation, Changzheng Hospital, Second Military Medical University, Shanghai 200003, China', 'institution_ids': ['https://openalex.org/I177933477']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5100624057', 'display_name': 'Hong Fu', 'orcid': 'https://orcid.org/0000-0003-0223-1905'}, 'institutions': [{'id': 'https://openalex.org/I177933477', 'display_name': 'Second Military Medical University', 'ror': 'https://ror.org/04tavpn47', 'country_code': 'CN', 'type': 'education', 'lineage': ['https://openalex.org/I177933477']}], 'countries': ['CN'], 'is_corresponding': False, 'raw_author_name': 'Hong Fu', 'raw_affiliation_strings': ['Department of Liver Surgery and Organ Transplantation, Changzheng Hospital, Second Military Medical University, Shanghai 200003, China'], 'affiliations': [{'raw_affiliation_string': 'Department of Liver Surgery and Organ Transplantation, Changzheng Hospital, Second Military Medical University, Shanghai 200003, China', 'institution_ids': ['https://openalex.org/I177933477']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5002798633', 'display_name': 'Zhiren Fu', 'orcid': 'https://orcid.org/0000-0001-7288-6769'}, 'institutions': [{'id': 'https://openalex.org/I177933477', 'display_name': 'Second Military Medical University', 'ror': 'https://ror.org/04tavpn47', 'country_code': 'CN', 'type': 'education', 'lineage': ['https://openalex.org/I177933477']}], 'countries': ['CN'], 'is_corresponding': False, 'raw_author_name': 'Zhiren Fu', 'raw_affiliation_strings': ['Department of Liver Surgery and Organ Transplantation, Changzheng Hospital, Second Military Medical University, Shanghai 200003, China'], 'affiliations': [{'raw_affiliation_string': 'Department of Liver Surgery and Organ Transplantation, Changzheng Hospital, Second Military Medical University, Shanghai 200003, China', 'institution_ids': ['https://openalex.org/I177933477']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5100773828', 'display_name': 'Wenyuan Guo', 'orcid': 'https://orcid.org/0000-0003-3313-3881'}, 'institutions': [{'id': 'https://openalex.org/I177933477', 'display_name': 'Second Military Medical University', 'ror': 'https://ror.org/04tavpn47', 'country_code': 'CN', 'type': 'education', 'lineage': ['https://openalex.org/I177933477']}], 'countries': ['CN'], 'is_corresponding': False, 'raw_author_name': 'Wenyuan Guo', 'raw_affiliation_strings': ['Department of Liver Surgery and Organ Transplantation, Changzheng Hospital, Second Military Medical University, Shanghai 200003, China'], 'affiliations': [{'raw_affiliation_string': 'Department of Liver Surgery and Organ Transplantation, Changzheng Hospital, Second Military Medical University, Shanghai 200003, China', 'institution_ids': ['https://openalex.org/I177933477']}]}, {'author_position': 'last', 'author': {'id': 'https://openalex.org/A5100641878', 'display_name': 'Guoshan Ding', 'orcid': 'https://orcid.org/0000-0001-8917-969X'}, 'institutions': [{'id': 'https://openalex.org/I177933477', 'display_name': 'Second Military Medical University', 'ror': 'https://ror.org/04tavpn47', 'country_code': 'CN', 'type': 'education', 'lineage': ['https://openalex.org/I177933477']}], 'countries': ['CN'], 'is_corresponding': True, 'raw_author_name': 'Guoshan Ding', 'raw_affiliation_strings': ['Department of Liver Surgery and Organ Transplantation, Changzheng Hospital, Second Military Medical University, Shanghai 200003, China'], 'affiliations': [{'raw_affiliation_string': 'Department of Liver Surgery and Organ Transplantation, Changzheng Hospital, Second Military Medical University, Shanghai 200003, China', 'institution_ids': ['https://openalex.org/I177933477']}]}], 'institution_assertions': [], 'countries_distinct_count': 1, 'institutions_distinct_count': 1, 'corresponding_author_ids': ['https://openalex.org/A5100641878'], 'corresponding_institution_ids': ['https://openalex.org/I177933477'], 'apc_list': None, 'apc_paid': None, 'fwci': 0.108, 'has_fulltext': True, 'fulltext_origin': 'pdf', 'cited_by_count': 15, 'citation_normalized_percentile': {'value': 0.273528, 'is_in_top_1_percent': False, 'is_in_top_10_percent': False}, 'cited_by_percentile_year': {'min': 89, 'max': 90}, 'biblio': {'volume': '7', 'issue': '33', 'first_page': '53571', 'last_page': '53582'}, 'is_retracted': False, 'is_paratext': False, 'primary_topic': {'id': 'https://openalex.org/T10604', 'display_name': 'RNA Research and Splicing', 'score': 0.9965, 'subfield': {'id': 'https://openalex.org/subfields/1312', 'display_name': 'Molecular Biology'}, 'field': {'id': 'https://openalex.org/fields/13', 'display_name': 'Biochemistry, Genetics and Molecular Biology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}, 'topics': [{'id': 'https://openalex.org/T10604', 'display_name': 'RNA Research and Splicing', 'score': 0.9965, 'subfield': {'id': 'https://openalex.org/subfields/1312', 'display_name': 'Molecular Biology'}, 'field': {'id': 'https://openalex.org/fields/13', 'display_name': 'Biochemistry, Genetics and Molecular Biology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}, {'id': 'https://openalex.org/T10887', 'display_name': 'Bioinformatics and Genomic Networks', 'score': 0.9961, 'subfield': {'id': 'https://openalex.org/subfields/1312', 'display_name': 'Molecular Biology'}, 'field': {'id': 'https://openalex.org/fields/13', 'display_name': 'Biochemistry, Genetics and Molecular Biology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}, {'id': 'https://openalex.org/T10222', 'display_name': 'Genomics and Chromatin Dynamics', 'score': 0.9949, 'subfield': {'id': 'https://openalex.org/subfields/1312', 'display_name': 'Molecular Biology'}, 'field': {'id': 'https://openalex.org/fields/13', 'display_name': 'Biochemistry, Genetics and Molecular Biology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}], 'keywords': [{'id': 'https://openalex.org/keywords/hccs', 'display_name': 'HCCS', 'score': 0.6969855}], 'concepts': [{'id': 'https://openalex.org/C502942594', 'wikidata': 'https://www.wikidata.org/wiki/Q3421914', 'display_name': 'Cancer research', 'level': 1, 'score': 0.70403117}, {'id': 'https://openalex.org/C555283112', 'wikidata': 'https://www.wikidata.org/wiki/Q1637543', 'display_name': 'Carcinogenesis', 'level': 3, 'score': 0.7037698}, {'id': 'https://openalex.org/C2778019345', 'wikidata': 'https://www.wikidata.org/wiki/Q1148337', 'display_name': 'Hepatocellular carcinoma', 'level': 2, 'score': 0.698874}, {'id': 'https://openalex.org/C2779314089', 'wikidata': 'https://www.wikidata.org/wiki/Q18026830', 'display_name': 'HCCS', 'level': 3, 'score': 0.6969855}, {'id': 'https://openalex.org/C127561419', 'wikidata': 'https://www.wikidata.org/wiki/Q224527', 'display_name': 'Downregulation and upregulation', 'level': 3, 'score': 0.5003836}, {'id': 'https://openalex.org/C86803240', 'wikidata': 'https://www.wikidata.org/wiki/Q420', 'display_name': 'Biology', 'level': 0, 'score': 0.4341703}, {'id': 'https://openalex.org/C71924100', 'wikidata': 'https://www.wikidata.org/wiki/Q11190', 'display_name': 'Medicine', 'level': 0, 'score': 0.42845643}, {'id': 'https://openalex.org/C121608353', 'wikidata': 'https://www.wikidata.org/wiki/Q12078', 'display_name': 'Cancer', 'level': 2, 'score': 0.42504743}, {'id': 'https://openalex.org/C186836561', 'wikidata': 'https://www.wikidata.org/wiki/Q1931516', 'display_name': 'Microarray', 'level': 4, 'score': 0.4158428}, {'id': 'https://openalex.org/C150194340', 'wikidata': 'https://www.wikidata.org/wiki/Q26972', 'display_name': 'Gene expression', 'level': 3, 'score': 0.3180198}, {'id': 'https://openalex.org/C126322002', 'wikidata': 'https://www.wikidata.org/wiki/Q11180', 'display_name': 'Internal medicine', 'level': 1, 'score': 0.25211763}, {'id': 'https://openalex.org/C104317684', 'wikidata': 'https://www.wikidata.org/wiki/Q7187', 'display_name': 'Gene', 'level': 2, 'score': 0.22569767}, {'id': 'https://openalex.org/C54355233', 'wikidata': 'https://www.wikidata.org/wiki/Q7162', 'display_name': 'Genetics', 'level': 1, 'score': 0.09858978}], 'mesh': [{'descriptor_ui': 'D002034', 'descriptor_name': 'Bumetanide', 'qualifier_ui': 'Q000494', 'qualifier_name': 'pharmacology', 'is_major_topic': True}, {'descriptor_ui': 'D006528', 'descriptor_name': 'Carcinoma, Hepatocellular', 'qualifier_ui': 'Q000473', 'qualifier_name': 'pathology', 'is_major_topic': True}, {'descriptor_ui': 'D008113', 'descriptor_name': 'Liver Neoplasms', 'qualifier_ui': 'Q000473', 'qualifier_name': 'pathology', 'is_major_topic': True}, {'descriptor_ui': 'D049994', 'descriptor_name': 'Sodium Potassium Chloride Symporter Inhibitors', 'qualifier_ui': 'Q000494', 'qualifier_name': 'pharmacology', 'is_major_topic': True}, {'descriptor_ui': 'D064466', 'descriptor_name': 'Solute Carrier Family 12, Member 1', 'qualifier_ui': 'Q000037', 'qualifier_name': 'antagonists & inhibitors', 'is_major_topic': True}, {'descriptor_ui': 'D000818', 'descriptor_name': 'Animals', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D002034', 'descriptor_name': 'Bumetanide', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D006528', 'descriptor_name': 'Carcinoma, Hepatocellular', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D030541', 'descriptor_name': 'Databases, Genetic', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D006801', 'descriptor_name': 'Humans', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D008113', 'descriptor_name': 'Liver Neoplasms', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D051379', 'descriptor_name': 'Mice', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D049994', 'descriptor_name': 'Sodium Potassium Chloride Symporter Inhibitors', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D064466', 'descriptor_name': 'Solute Carrier Family 12, Member 1', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D023041', 'descriptor_name': 'Xenograft Model Antitumor Assays', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}], 'locations_count': 4, 'locations': [{'is_oa': True, 'landing_page_url': 'https://doi.org/10.18632/oncotarget.10670', 'pdf_url': 'http://www.oncotarget.com/index.php?journal=oncotarget&page=article&op=view&path%5B%5D=10670&path%5B%5D=33781', 'source': {'id': 'https://openalex.org/S126644158', 'display_name': 'Oncotarget', 'issn_l': '1949-2553', 'issn': ['1949-2553'], 'is_oa': True, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310316297', 'host_organization_name': 'Impact Journals LLC', 'host_organization_lineage': ['https://openalex.org/P4310316297'], 'host_organization_lineage_names': ['Impact Journals LLC'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, {'is_oa': True, 'landing_page_url': 'https://europepmc.org/articles/pmc5288206', 'pdf_url': 'https://europepmc.org/articles/pmc5288206?pdf=render', 'source': {'id': 'https://openalex.org/S4306400806', 'display_name': 'Europe PMC (PubMed Central)', 'issn_l': None, 'issn': None, 'is_oa': True, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1303153112', 'host_organization_name': 'European Bioinformatics Institute', 'host_organization_lineage': ['https://openalex.org/I1303153112'], 'host_organization_lineage_names': ['European Bioinformatics Institute'], 'type': 'repository'}, 'license': 'cc-by', 'license_id': 'https://openalex.org/licenses/cc-by', 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, {'is_oa': True, 'landing_page_url': 'https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5288206', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S2764455111', 'display_name': 'PubMed Central', 'issn_l': None, 'issn': None, 'is_oa': True, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1299303238', 'host_organization_name': 'National Institutes of Health', 'host_organization_lineage': ['https://openalex.org/I1299303238'], 'host_organization_lineage_names': ['National Institutes of Health'], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, {'is_oa': False, 'landing_page_url': 'https://pubmed.ncbi.nlm.nih.gov/27447551', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S4306525036', 'display_name': 'PubMed', 'issn_l': None, 'issn': None, 'is_oa': False, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1299303238', 'host_organization_name': 'National Institutes of Health', 'host_organization_lineage': ['https://openalex.org/I1299303238'], 'host_organization_lineage_names': ['National Institutes of Health'], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}], 'best_oa_location': {'is_oa': True, 'landing_page_url': 'https://doi.org/10.18632/oncotarget.10670', 'pdf_url': 'http://www.oncotarget.com/index.php?journal=oncotarget&page=article&op=view&path%5B%5D=10670&path%5B%5D=33781', 'source': {'id': 'https://openalex.org/S126644158', 'display_name': 'Oncotarget', 'issn_l': '1949-2553', 'issn': ['1949-2553'], 'is_oa': True, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310316297', 'host_organization_name': 'Impact Journals LLC', 'host_organization_lineage': ['https://openalex.org/P4310316297'], 'host_organization_lineage_names': ['Impact Journals LLC'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, 'sustainable_development_goals': [{'display_name': 'Good health and well-being', 'id': 'https://metadata.un.org/sdg/3', 'score': 0.77}], 'grants': [], 'datasets': [], 'versions': [], 'referenced_works_count': 48, 'referenced_works': ['https://openalex.org/W1493453469', 'https://openalex.org/W1757204763', 'https://openalex.org/W178461477', 'https://openalex.org/W1897112873', 'https://openalex.org/W1908445139', 'https://openalex.org/W1968244525', 'https://openalex.org/W1973562447', 'https://openalex.org/W1976625175', 'https://openalex.org/W1992781992', 'https://openalex.org/W1994912', 'https://openalex.org/W2006682339', 'https://openalex.org/W2018762599', 'https://openalex.org/W2019937297', 'https://openalex.org/W2031211461', 'https://openalex.org/W2031374290', 'https://openalex.org/W2035443856', 'https://openalex.org/W2036922484', 'https://openalex.org/W2037470216', 'https://openalex.org/W2039210770', 'https://openalex.org/W2039394834', 'https://openalex.org/W2048141509', 'https://openalex.org/W2058128032', 'https://openalex.org/W2061602742', 'https://openalex.org/W2064946020', 'https://openalex.org/W2068856879', 'https://openalex.org/W2073604155', 'https://openalex.org/W2075261741', 'https://openalex.org/W2081436697', 'https://openalex.org/W2082668371', 'https://openalex.org/W2086399544', 'https://openalex.org/W2088629624', 'https://openalex.org/W2101746550', 'https://openalex.org/W2103413154', 'https://openalex.org/W2108900994', 'https://openalex.org/W2121691257', 'https://openalex.org/W2126922455', 'https://openalex.org/W2128823699', 'https://openalex.org/W2136415416', 'https://openalex.org/W2137052325', 'https://openalex.org/W2159405409', 'https://openalex.org/W2159444131', 'https://openalex.org/W2161641966', 'https://openalex.org/W2163173465', 'https://openalex.org/W2172151601', 'https://openalex.org/W2239511084', 'https://openalex.org/W2265630203', 'https://openalex.org/W2305012816', 'https://openalex.org/W2949840706'], 'related_works': ['https://openalex.org/W4390228625', 'https://openalex.org/W3161864617', 'https://openalex.org/W2462437421', 'https://openalex.org/W2388153334', 'https://openalex.org/W2375390396', 'https://openalex.org/W2188205072', 'https://openalex.org/W2117410915', 'https://openalex.org/W2035703032', 'https://openalex.org/W1992314595', 'https://openalex.org/W1911027473'], 'abstract_inverted_index': {'//': [0], 'Fei': [1], 'Teng': [2], '1,': [3, 8, 13], '*': [4, 9, 14, 85], ',': [5, 10, 15, 19, 23, 27, 31, 35, 39, 43, 47, 51], 'Meng': [6], 'Guo': [7, 49], 'Fang': [11], 'Liu': [12], 'Ce': [16], 'Wang': [17], '2': [18, 72], 'Jiayong': [20], 'Dong': [21], '1': [22, 26, 30, 34, 38, 42, 46, 50, 54, 55], 'Lei': [24], 'Zhang': [25], 'You': [28], 'Zou': [29], 'Rui': [32], 'Chen': [33], 'Keyan': [36], 'Sun': [37], 'Hong': [40], 'Fu': [41, 45], 'Zhiren': [44], 'Wenyuan': [48, 100], 'Guoshan': [52, 96], 'Ding': [53], 'Department': [56, 73], 'of': [57, 74, 152, 162, 230, 248, 283], 'Liver': [58], 'Surgery': [59], 'and': [60, 144, 164, 221, 241, 266], 'Organ': [61], 'Transplantation,': [62], 'Changzheng': [63, 76], 'Hospital,': [64, 77], 'Second': [65, 78], 'Military': [66, 79], 'Medical': [67, 80], 'University,': [68, 81], 'Shanghai': [69, 82], '200003,': [70, 83], 'China': [71, 84], 'Orthopaedics,': [75], 'These': [86], 'authors': [87], 'have': [88], 'contributed': [89], 'equally': [90], 'to': [91, 134, 174, 288], 'this': [92, 182], 'work': [93], 'Correspondence': [94], 'to:': [95], 'Ding,': [97], 'email:': [98, 102], 'dingguoshanmail@163.com': [99], 'Guo,': [101], 'gwyuan7502@aliyun.com': [103], 'Keywords:': [104], 'HCC,': [105], 'liver': [106], 'cancer,': [107], 'SLC12A1,': [108], 'cancer': [109, 131], 'outlier': [110], 'profile': [111], 'analysis,': [112], 'Bumetanide': [113, 262], 'Received:': [114], 'October': [115], '02,': [116], '2015': [117], 'Accepted:': [118], 'July': [119, 123], '06,': [120], '2016': [121, 125], 'Published:': [122], '18,': [124], 'ABSTRACT': [126], 'A': [127], 'central': [128], 'aim': [129], 'in': [130, 141, 148, 160, 209, 254, 272], 'research': [132, 278], 'is': [133, 244], 'identify': [135, 175], 'genes': [136], 'with': [137, 215, 253, 258], 'altered': [138], 'expression': [139, 179], 'patterns': [140], 'tumor': [142, 264, 270], 'specimens': [143], 'their': [145], 'potential': [146], 'role': [147], 'tumorigenesis.': [149], 'Most': [150], 'types': [151], 'tumors,': [153], 'including': [154], 'hepatocellular': [155], 'carcinoma': [156], '(HCC),': [157], 'are': [158, 286], 'heterogeneous': [159], 'terms': [161], 'genotype': [163], 'phenotype.': [165], 'Thus,': [166], 'traditional': [167], 'analytical': [168], 'methods': [169], 'like': [170], 'the': [171, 199, 210, 228, 249, 259], 't-test': [172], 'fail': [173], 'all': [176], 'oncogenes': [177], 'from': [178, 198], 'profiles.': [180], 'In': [181, 275], 'study,': [183], 'we': [184], 'performed': [185], 'a': [186, 245, 280, 294], 'meta-Cancer': [187], 'Outlier': [188], 'Profile': [189], 'Analysis': [190], '(meta-COPA)': [191], 'across': [192], 'six': [193], 'microarray': [194], 'datasets': [195], 'for': [196, 297], 'HCC': [197, 218, 299], 'GEO': [200], 'database.': [201], 'We': [202, 224], 'found': [203, 226], 'that': [204, 227, 242, 285], 'gene': [205], 'SLC12A1': [206, 231, 243, 260, 289], 'was': [207, 232], 'overexpressed': [208], 'Hep3B': [211, 268], 'cell': [212, 219, 269], 'line,': [213], 'compared': [214], 'five': [216], 'other': [217], 'lines': [220], 'L02': [222], 'cells.': [223], 'also': [225], 'upregulation': [229], 'mediated': [233], 'by': [234], 'histone': [235], 'methylation': [236], 'within': [237], 'its': [238], 'promoter': [239], 'region,': [240], 'positive': [246], 'regulator': [247], 'WNK1/ERK5': [250], 'pathway.': [251], 'Consistent': [252], 'vitro': [255], 'results,': [256], 'treatment': [257], 'antagonist': [261, 290], 'delayed': [263], 'formation': [265], 'reduced': [267], 'size': [271], 'mouse': [273], 'xenografts.': [274], 'summary,': [276], 'our': [277], 'reveals': [279], 'novel': [281], 'subset': [282], 'HCCs': [284], 'sensitive': [287], 'treatment,': [291], 'thereby': [292], 'offering': [293], 'new': [295], 'strategy': [296], 'precision': [298], 'treatment.': [300]}, 'cited_by_api_url': 'https://api.openalex.org/works?filter=cites:W2486055736', 'counts_by_year': [{'year': 2024, 'cited_by_count': 2}, {'year': 2023, 'cited_by_count': 2}, {'year': 2022, 'cited_by_count': 1}, {'year': 2021, 'cited_by_count': 2}, {'year': 2020, 'cited_by_count': 5}, {'year': 2019, 'cited_by_count': 3}], 'updated_date': '2025-01-12T17:38:26.111974', 'created_date': '2016-08-23'}