Title: Changes In Serum Lipid Profiles And Heart Rate In Rats Treated With Aqueous Garlic Extract
Abstract: The serum lipid profiles and heart rate in rats treated with aqueous garlic extract were estimated in 24 Wistar albino rats. The rats were divided into four groups of 6 rats each. Group A received water and standard feeds for 6 weeks. Group B was fed with hyperlipidaemic diets for 6 weeks, while groups C and D had the hyperlipidaemic diets for 3 weeks and in addition administered 100 and 200 mg/kg aqueous garlic extract for another 3 weeks respectively. The body weights of the animals were simultaneously estimated. The results showed that the rats in all the groups gained weight: 0.03% for group A (negative Control), 6.2% for group B (positive Control), and 1.9 and 2.1% for groups C and D respectively. At the 6th week, the serum levels of Tc, Tg and LDL-c decreased significantly (P<0.05). but the HDL-c value increased significantly (P<0.05) too. The atherogenic risk predictor ratios also increased. The changes in groups C and D followed a dose-related pattern. Garlic extracts are reported to inhibit 3-hydroxy-3-methoxy-butyryl-CoA reduetase. This could help to explain the decrease in serum lipid indices. The increase in aterogenic risk ratio confirms the beneficial use of the aqueous garlic extract in traditional medicine practice to manage hypertension and some cardiovascular related problems. The restoration of heart rate by the two doses of the extract tend to validate the hypolipidaemic and antiarrythmic potentials of the garlic extract.
Publication Year: 2007
Publication Date: 2007-01-01
Language: en
Type: article
Indexed In: ['crossref']
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Cited By Count: 8
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