Publication Information

{'id': 'https://openalex.org/W2481659380', 'doi': 'https://doi.org/10.1042/bcj20160387', 'title': "Gsk3β and Tomm20 are substrates of the SCFFbxo7/PARK15 ubiquitin ligase associated with Parkinson's disease", 'display_name': "Gsk3β and Tomm20 are substrates of the SCFFbxo7/PARK15 ubiquitin ligase associated with Parkinson's disease", 'publication_year': 2016, 'publication_date': '2016-08-09', 'ids': {'openalex': 'https://openalex.org/W2481659380', 'doi': 'https://doi.org/10.1042/bcj20160387', 'mag': '2481659380', 'pmid': 'https://pubmed.ncbi.nlm.nih.gov/27503909', 'pmcid': 'https://www.ncbi.nlm.nih.gov/pmc/articles/5260939'}, 'language': 'en', 'primary_location': {'is_oa': True, 'landing_page_url': 'https://doi.org/10.1042/bcj20160387', 'pdf_url': 'https://portlandpress.com/biochemj/article-pdf/473/20/3563/689287/bcj-2016-0387.pdf', 'source': {'id': 'https://openalex.org/S44425019', 'display_name': 'Biochemical Journal', 'issn_l': '0264-6021', 'issn': ['0264-6021', '1470-8728'], 'is_oa': False, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310311608', 'host_organization_name': 'Portland Press', 'host_organization_lineage': ['https://openalex.org/P4310311715', 'https://openalex.org/P4310311608'], 'host_organization_lineage_names': ['Biochemical Society', 'Portland Press'], 'type': 'journal'}, 'license': 'cc-by', 'license_id': 'https://openalex.org/licenses/cc-by', 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, 'type': 'article', 'type_crossref': 'journal-article', 'indexed_in': ['crossref', 'pubmed'], 'open_access': {'is_oa': True, 'oa_status': 'hybrid', 'oa_url': 'https://portlandpress.com/biochemj/article-pdf/473/20/3563/689287/bcj-2016-0387.pdf', 'any_repository_has_fulltext': True}, 'authorships': [{'author_position': 'first', 'author': {'id': 'https://openalex.org/A5004148807', 'display_name': 'Felipe R. Teixeira', 'orcid': 'https://orcid.org/0000-0003-0251-2686'}, 'institutions': [{'id': 'https://openalex.org/I17974374', 'display_name': 'Universidade de São Paulo', 'ror': 'https://ror.org/036rp1748', 'country_code': 'BR', 'type': 'education', 'lineage': ['https://openalex.org/I17974374']}, {'id': 'https://openalex.org/I241749', 'display_name': 'University of Cambridge', 'ror': 'https://ror.org/013meh722', 'country_code': 'GB', 'type': 'education', 'lineage': ['https://openalex.org/I241749']}], 'countries': ['BR', 'GB'], 'is_corresponding': False, 'raw_author_name': 'Felipe Roberti Teixeira', 'raw_affiliation_strings': ['Department of Biochemistry and Immunology, Ribeirão Preto Medical School, University of São Paulo, Ribeirão Preto, Brazil', 'Department of Pathology, University of Cambridge, Tennis Court Road, Cambridge CB2 1QP, U.K.'], 'affiliations': [{'raw_affiliation_string': 'Department of Biochemistry and Immunology, Ribeirão Preto Medical School, University of São Paulo, Ribeirão Preto, Brazil', 'institution_ids': ['https://openalex.org/I17974374']}, {'raw_affiliation_string': 'Department of Pathology, University of Cambridge, Tennis Court Road, Cambridge CB2 1QP, U.K.', 'institution_ids': ['https://openalex.org/I241749', 'https://openalex.org/I241749']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5070927371', 'display_name': 'Suzanne J. Randle', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I241749', 'display_name': 'University of Cambridge', 'ror': 'https://ror.org/013meh722', 'country_code': 'GB', 'type': 'education', 'lineage': ['https://openalex.org/I241749']}], 'countries': ['GB'], 'is_corresponding': False, 'raw_author_name': 'Suzanne J. Randle', 'raw_affiliation_strings': ['Department of Pathology, University of Cambridge, Tennis Court Road, Cambridge CB2 1QP, U.K.'], 'affiliations': [{'raw_affiliation_string': 'Department of Pathology, University of Cambridge, Tennis Court Road, Cambridge CB2 1QP, U.K.', 'institution_ids': ['https://openalex.org/I241749']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5102250933', 'display_name': 'Shachi P. Patel', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I241749', 'display_name': 'University of Cambridge', 'ror': 'https://ror.org/013meh722', 'country_code': 'GB', 'type': 'education', 'lineage': ['https://openalex.org/I241749']}], 'countries': ['GB'], 'is_corresponding': False, 'raw_author_name': 'Shachi P. Patel', 'raw_affiliation_strings': ['Department of Pathology, University of Cambridge, Tennis Court Road, Cambridge CB2 1QP, U.K.'], 'affiliations': [{'raw_affiliation_string': 'Department of Pathology, University of Cambridge, Tennis Court Road, Cambridge CB2 1QP, U.K.', 'institution_ids': ['https://openalex.org/I241749']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5081354649', 'display_name': 'Tycho E.T. Mevissen', 'orcid': 'https://orcid.org/0000-0002-2324-5292'}, 'institutions': [{'id': 'https://openalex.org/I170203145', 'display_name': 'MRC Laboratory of Molecular Biology', 'ror': 'https://ror.org/00tw3jy02', 'country_code': 'GB', 'type': 'facility', 'lineage': ['https://openalex.org/I170203145', 'https://openalex.org/I4210087105', 'https://openalex.org/I90344618']}], 'countries': ['GB'], 'is_corresponding': False, 'raw_author_name': 'Tycho E.T. Mevissen', 'raw_affiliation_strings': ['MRC Laboratory of Molecular Biology, Francis Crick Avenue, Cambridge Biomedical Campus, Cambridge CB2 0QH, U.K.'], 'affiliations': [{'raw_affiliation_string': 'MRC Laboratory of Molecular Biology, Francis Crick Avenue, Cambridge Biomedical Campus, Cambridge CB2 0QH, U.K.', 'institution_ids': ['https://openalex.org/I170203145']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5034653114', 'display_name': 'Grasilda Zenkevičiūtė', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I241749', 'display_name': 'University of Cambridge', 'ror': 'https://ror.org/013meh722', 'country_code': 'GB', 'type': 'education', 'lineage': ['https://openalex.org/I241749']}], 'countries': ['GB'], 'is_corresponding': False, 'raw_author_name': 'Grasilda Zenkeviciute', 'raw_affiliation_strings': ['Department of Pathology, University of Cambridge, Tennis Court Road, Cambridge CB2 1QP, U.K.'], 'affiliations': [{'raw_affiliation_string': 'Department of Pathology, University of Cambridge, Tennis Court Road, Cambridge CB2 1QP, U.K.', 'institution_ids': ['https://openalex.org/I241749']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5010317899', 'display_name': 'Tie Koide', 'orcid': 'https://orcid.org/0000-0003-4760-2423'}, 'institutions': [{'id': 'https://openalex.org/I17974374', 'display_name': 'Universidade de São Paulo', 'ror': 'https://ror.org/036rp1748', 'country_code': 'BR', 'type': 'education', 'lineage': ['https://openalex.org/I17974374']}], 'countries': ['BR'], 'is_corresponding': False, 'raw_author_name': 'Tie Koide', 'raw_affiliation_strings': ['Department of Biochemistry and Immunology, Ribeirão Preto Medical School, University of São Paulo, Ribeirão Preto, Brazil'], 'affiliations': [{'raw_affiliation_string': 'Department of Biochemistry and Immunology, Ribeirão Preto Medical School, University of São Paulo, Ribeirão Preto, Brazil', 'institution_ids': ['https://openalex.org/I17974374']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5086480636', 'display_name': 'David Komander', 'orcid': 'https://orcid.org/0000-0002-8092-4320'}, 'institutions': [{'id': 'https://openalex.org/I170203145', 'display_name': 'MRC Laboratory of Molecular Biology', 'ror': 'https://ror.org/00tw3jy02', 'country_code': 'GB', 'type': 'facility', 'lineage': ['https://openalex.org/I170203145', 'https://openalex.org/I4210087105', 'https://openalex.org/I90344618']}], 'countries': ['GB'], 'is_corresponding': False, 'raw_author_name': 'David Komander', 'raw_affiliation_strings': ['MRC Laboratory of Molecular Biology, Francis Crick Avenue, Cambridge Biomedical Campus, Cambridge CB2 0QH, U.K.'], 'affiliations': [{'raw_affiliation_string': 'MRC Laboratory of Molecular Biology, Francis Crick Avenue, Cambridge Biomedical Campus, Cambridge CB2 0QH, U.K.', 'institution_ids': ['https://openalex.org/I170203145']}]}, {'author_position': 'last', 'author': {'id': 'https://openalex.org/A5045006704', 'display_name': 'Heike Laman', 'orcid': 'https://orcid.org/0000-0002-6089-171X'}, 'institutions': [{'id': 'https://openalex.org/I241749', 'display_name': 'University of Cambridge', 'ror': 'https://ror.org/013meh722', 'country_code': 'GB', 'type': 'education', 'lineage': ['https://openalex.org/I241749']}], 'countries': ['GB'], 'is_corresponding': False, 'raw_author_name': 'Heike Laman', 'raw_affiliation_strings': ['Department of Pathology, University of Cambridge, Tennis Court Road, Cambridge CB2 1QP, U.K.'], 'affiliations': [{'raw_affiliation_string': 'Department of Pathology, University of Cambridge, Tennis Court Road, Cambridge CB2 1QP, U.K.', 'institution_ids': ['https://openalex.org/I241749']}]}], 'institution_assertions': [], 'countries_distinct_count': 2, 'institutions_distinct_count': 3, 'corresponding_author_ids': [], 'corresponding_institution_ids': [], 'apc_list': None, 'apc_paid': {'value': 2099, 'currency': 'EUR', 'value_usd': 2263, 'provenance': 'openapc'}, 'fwci': 1.306, 'has_fulltext': True, 'fulltext_origin': 'ngrams', 'cited_by_count': 43, 'citation_normalized_percentile': {'value': 0.833945, 'is_in_top_1_percent': False, 'is_in_top_10_percent': False}, 'cited_by_percentile_year': {'min': 95, 'max': 96}, 'biblio': {'volume': '473', 'issue': '20', 'first_page': '3563', 'last_page': '3580'}, 'is_retracted': False, 'is_paratext': False, 'primary_topic': {'id': 'https://openalex.org/T11041', 'display_name': 'Ubiquitin and proteasome pathways', 'score': 0.9999, 'subfield': {'id': 'https://openalex.org/subfields/1312', 'display_name': 'Molecular Biology'}, 'field': {'id': 'https://openalex.org/fields/13', 'display_name': 'Biochemistry, Genetics and Molecular Biology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}, 'topics': [{'id': 'https://openalex.org/T11041', 'display_name': 'Ubiquitin and proteasome pathways', 'score': 0.9999, 'subfield': {'id': 'https://openalex.org/subfields/1312', 'display_name': 'Molecular Biology'}, 'field': {'id': 'https://openalex.org/fields/13', 'display_name': 'Biochemistry, Genetics and Molecular Biology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}, {'id': 'https://openalex.org/T10587', 'display_name': 'Autophagy in Disease and Therapy', 'score': 0.9998, 'subfield': {'id': 'https://openalex.org/subfields/2713', 'display_name': 'Epidemiology'}, 'field': {'id': 'https://openalex.org/fields/27', 'display_name': 'Medicine'}, 'domain': {'id': 'https://openalex.org/domains/4', 'display_name': 'Health Sciences'}}, {'id': 'https://openalex.org/T11772', 'display_name': 'Genetics and Neurodevelopmental Disorders', 'score': 0.9991, 'subfield': {'id': 'https://openalex.org/subfields/1311', 'display_name': 'Genetics'}, 'field': {'id': 'https://openalex.org/fields/13', 'display_name': 'Biochemistry, Genetics and Molecular Biology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}], 'keywords': [{'id': 'https://openalex.org/keywords/translocase', 'display_name': 'Translocase', 'score': 0.6995746}, {'id': 'https://openalex.org/keywords/deubiquitinating-enzyme', 'display_name': 'Deubiquitinating enzyme', 'score': 0.60134894}, {'id': 'https://openalex.org/keywords/ubiquitin-conjugating-enzyme', 'display_name': 'Ubiquitin-conjugating enzyme', 'score': 0.41070944}], 'concepts': [{'id': 'https://openalex.org/C25602115', 'wikidata': 'https://www.wikidata.org/wiki/Q407111', 'display_name': 'Ubiquitin', 'level': 3, 'score': 0.8374579}, {'id': 'https://openalex.org/C134459356', 'wikidata': 'https://www.wikidata.org/wiki/Q4274835', 'display_name': 'Ubiquitin ligase', 'level': 4, 'score': 0.8300918}, {'id': 'https://openalex.org/C2779324830', 'wikidata': 'https://www.wikidata.org/wiki/Q1806192', 'display_name': 'Mitophagy', 'level': 4, 'score': 0.75435346}, {'id': 'https://openalex.org/C113035283', 'wikidata': 'https://www.wikidata.org/wiki/Q909555', 'display_name': 'Translocase', 'level': 4, 'score': 0.6995746}, {'id': 'https://openalex.org/C102658986', 'wikidata': 'https://www.wikidata.org/wiki/Q5266092', 'display_name': 'Deubiquitinating enzyme', 'level': 4, 'score': 0.60134894}, {'id': 'https://openalex.org/C86803240', 'wikidata': 'https://www.wikidata.org/wiki/Q420', 'display_name': 'Biology', 'level': 0, 'score': 0.5772052}, {'id': 'https://openalex.org/C95444343', 'wikidata': 'https://www.wikidata.org/wiki/Q7141', 'display_name': 'Cell biology', 'level': 1, 'score': 0.5035636}, {'id': 'https://openalex.org/C27740335', 'wikidata': 'https://www.wikidata.org/wiki/Q14878333', 'display_name': 'Proteasome', 'level': 2, 'score': 0.50336975}, {'id': 'https://openalex.org/C203522944', 'wikidata': 'https://www.wikidata.org/wiki/Q288322', 'display_name': 'Autophagy', 'level': 3, 'score': 0.4511227}, {'id': 'https://openalex.org/C28859421', 'wikidata': 'https://www.wikidata.org/wiki/Q39572', 'display_name': 'Mitochondrion', 'level': 2, 'score': 0.44147524}, {'id': 'https://openalex.org/C175114707', 'wikidata': 'https://www.wikidata.org/wiki/Q408483', 'display_name': 'DNA ligase', 'level': 3, 'score': 0.4229687}, {'id': 'https://openalex.org/C182561583', 'wikidata': 'https://www.wikidata.org/wiki/Q7876535', 'display_name': 'Ubiquitin-conjugating enzyme', 'level': 5, 'score': 0.41070944}, {'id': 'https://openalex.org/C55493867', 'wikidata': 'https://www.wikidata.org/wiki/Q7094', 'display_name': 'Biochemistry', 'level': 1, 'score': 0.32856143}, {'id': 'https://openalex.org/C190283241', 'wikidata': 'https://www.wikidata.org/wiki/Q14599311', 'display_name': 'Apoptosis', 'level': 2, 'score': 0.26130903}, {'id': 'https://openalex.org/C104317684', 'wikidata': 'https://www.wikidata.org/wiki/Q7187', 'display_name': 'Gene', 'level': 2, 'score': 0.1517843}, {'id': 'https://openalex.org/C138626823', 'wikidata': 'https://www.wikidata.org/wiki/Q916504', 'display_name': 'Chromosomal translocation', 'level': 3, 'score': 0.13426498}], 'mesh': [{'descriptor_ui': 'D044783', 'descriptor_name': 'F-Box Proteins', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': True}, {'descriptor_ui': 'D026901', 'descriptor_name': 'Membrane Transport Proteins', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': True}, {'descriptor_ui': 'D010300', 'descriptor_name': 'Parkinson Disease', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': True}, {'descriptor_ui': 'D010300', 'descriptor_name': 'Parkinson Disease', 'qualifier_ui': 'Q000201', 'qualifier_name': 'enzymology', 'is_major_topic': True}, {'descriptor_ui': 'D011956', 'descriptor_name': 'Receptors, Cell Surface', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': True}, {'descriptor_ui': 'D000951', 'descriptor_name': 'Antigens, Neoplasm', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D000951', 'descriptor_name': 'Antigens, Neoplasm', 'qualifier_ui': 'Q000235', 'qualifier_name': 'genetics', 'is_major_topic': False}, {'descriptor_ui': 'D000951', 'descriptor_name': 'Antigens, Neoplasm', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': False}, {'descriptor_ui': 'D018797', 'descriptor_name': 'Cell Cycle Proteins', 'qualifier_ui': 'Q000235', 'qualifier_name': 'genetics', 'is_major_topic': False}, {'descriptor_ui': 'D018797', 'descriptor_name': 'Cell Cycle Proteins', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': False}, {'descriptor_ui': 'D018797', 'descriptor_name': 'Cell Cycle Proteins', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D045744', 'descriptor_name': 'Cell Line, Tumor', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D044783', 'descriptor_name': 'F-Box Proteins', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D044783', 'descriptor_name': 'F-Box Proteins', 'qualifier_ui': 'Q000235', 'qualifier_name': 'genetics', 'is_major_topic': False}, {'descriptor_ui': 'D005455', 'descriptor_name': 'Fluorescent Antibody Technique', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D000071679', 'descriptor_name': 'Glycogen Synthase Kinase 3 beta', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D057809', 'descriptor_name': 'HEK293 Cells', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D006801', 'descriptor_name': 'Humans', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D047468', 'descriptor_name': 'Immunoprecipitation', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D051034', 'descriptor_name': 'Inhibitor of Apoptosis Proteins', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D051034', 'descriptor_name': 'Inhibitor of Apoptosis Proteins', 'qualifier_ui': 'Q000235', 'qualifier_name': 'genetics', 'is_major_topic': False}, {'descriptor_ui': 'D051034', 'descriptor_name': 'Inhibitor of Apoptosis Proteins', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': False}, {'descriptor_ui': 'D026901', 'descriptor_name': 'Membrane Transport Proteins', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D026901', 'descriptor_name': 'Membrane Transport Proteins', 'qualifier_ui': 'Q000235', 'qualifier_name': 'genetics', 'is_major_topic': False}, {'descriptor_ui': 'D000090622', 'descriptor_name': 'Mitochondrial Precursor Protein Import Complex Proteins', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D009363', 'descriptor_name': 'Neoplasm Proteins', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D009363', 'descriptor_name': 'Neoplasm Proteins', 'qualifier_ui': 'Q000235', 'qualifier_name': 'genetics', 'is_major_topic': False}, {'descriptor_ui': 'D009363', 'descriptor_name': 'Neoplasm Proteins', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': False}, {'descriptor_ui': 'D010300', 'descriptor_name': 'Parkinson Disease', 'qualifier_ui': 'Q000235', 'qualifier_name': 'genetics', 'is_major_topic': False}, {'descriptor_ui': 'D010300', 'descriptor_name': 'Parkinson Disease', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D017354', 'descriptor_name': 'Point Mutation', 'qualifier_ui': 'Q000235', 'qualifier_name': 'genetics', 'is_major_topic': False}, {'descriptor_ui': 'D017354', 'descriptor_name': 'Point Mutation', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D020641', 'descriptor_name': 'Polymorphism, Single Nucleotide', 'qualifier_ui': 'Q000235', 'qualifier_name': 'genetics', 'is_major_topic': False}, {'descriptor_ui': 'D020641', 'descriptor_name': 'Polymorphism, Single Nucleotide', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D011956', 'descriptor_name': 'Receptors, Cell Surface', 'qualifier_ui': 'Q000235', 'qualifier_name': 'genetics', 'is_major_topic': False}, {'descriptor_ui': 'D011956', 'descriptor_name': 'Receptors, Cell Surface', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D044843', 'descriptor_name': 'SKP Cullin F-Box Protein Ligases', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': False}, {'descriptor_ui': 'D044843', 'descriptor_name': 'SKP Cullin F-Box Protein Ligases', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D044843', 'descriptor_name': 'SKP Cullin F-Box Protein Ligases', 'qualifier_ui': 'Q000235', 'qualifier_name': 'genetics', 'is_major_topic': False}, {'descriptor_ui': 'D047992', 'descriptor_name': 'TNF Receptor-Associated Factor 2', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D047992', 'descriptor_name': 'TNF Receptor-Associated Factor 2', 'qualifier_ui': 'Q000235', 'qualifier_name': 'genetics', 'is_major_topic': False}, {'descriptor_ui': 'D047992', 'descriptor_name': 'TNF Receptor-Associated Factor 2', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': False}, {'descriptor_ui': 'D054875', 'descriptor_name': 'Ubiquitination', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D054875', 'descriptor_name': 'Ubiquitination', 'qualifier_ui': 'Q000502', 'qualifier_name': 'physiology', 'is_major_topic': False}, {'descriptor_ui': 'D054875', 'descriptor_name': 'Ubiquitination', 'qualifier_ui': 'Q000235', 'qualifier_name': 'genetics', 'is_major_topic': False}], 'locations_count': 5, 'locations': [{'is_oa': True, 'landing_page_url': 'https://doi.org/10.1042/bcj20160387', 'pdf_url': 'https://portlandpress.com/biochemj/article-pdf/473/20/3563/689287/bcj-2016-0387.pdf', 'source': {'id': 'https://openalex.org/S44425019', 'display_name': 'Biochemical Journal', 'issn_l': '0264-6021', 'issn': ['0264-6021', '1470-8728'], 'is_oa': False, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310311608', 'host_organization_name': 'Portland Press', 'host_organization_lineage': ['https://openalex.org/P4310311715', 'https://openalex.org/P4310311608'], 'host_organization_lineage_names': ['Biochemical Society', 'Portland Press'], 'type': 'journal'}, 'license': 'cc-by', 'license_id': 'https://openalex.org/licenses/cc-by', 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, {'is_oa': True, 'landing_page_url': 'https://www.repository.cam.ac.uk/handle/1810/260441', 'pdf_url': 'https://www.repository.cam.ac.uk/bitstreams/57d5f526-7344-48f5-a88c-4211ff8d7348/download', 'source': {'id': 'https://openalex.org/S4306401777', 'display_name': 'Apollo (University of Cambridge)', 'issn_l': None, 'issn': None, 'is_oa': True, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I241749', 'host_organization_name': 'University of Cambridge', 'host_organization_lineage': ['https://openalex.org/I241749'], 'host_organization_lineage_names': ['University of Cambridge'], 'type': 'repository'}, 'license': 'cc-by', 'license_id': 'https://openalex.org/licenses/cc-by', 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, {'is_oa': True, 'landing_page_url': 'https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5260939', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S2764455111', 'display_name': 'PubMed Central', 'issn_l': None, 'issn': None, 'is_oa': True, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1299303238', 'host_organization_name': 'National Institutes of Health', 'host_organization_lineage': ['https://openalex.org/I1299303238'], 'host_organization_lineage_names': ['National Institutes of Health'], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, {'is_oa': True, 'landing_page_url': 'https://europepmc.org/articles/pmc5260939', 'pdf_url': 'https://europepmc.org/articles/pmc5260939?pdf=render', 'source': {'id': 'https://openalex.org/S4306400806', 'display_name': 'Europe PMC (PubMed Central)', 'issn_l': None, 'issn': None, 'is_oa': True, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1303153112', 'host_organization_name': 'European Bioinformatics Institute', 'host_organization_lineage': ['https://openalex.org/I1303153112'], 'host_organization_lineage_names': ['European Bioinformatics Institute'], 'type': 'repository'}, 'license': 'cc-by', 'license_id': 'https://openalex.org/licenses/cc-by', 'version': 'acceptedVersion', 'is_accepted': True, 'is_published': False}, {'is_oa': False, 'landing_page_url': 'https://pubmed.ncbi.nlm.nih.gov/27503909', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S4306525036', 'display_name': 'PubMed', 'issn_l': None, 'issn': None, 'is_oa': False, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1299303238', 'host_organization_name': 'National Institutes of Health', 'host_organization_lineage': ['https://openalex.org/I1299303238'], 'host_organization_lineage_names': ['National Institutes of Health'], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}], 'best_oa_location': {'is_oa': True, 'landing_page_url': 'https://doi.org/10.1042/bcj20160387', 'pdf_url': 'https://portlandpress.com/biochemj/article-pdf/473/20/3563/689287/bcj-2016-0387.pdf', 'source': {'id': 'https://openalex.org/S44425019', 'display_name': 'Biochemical Journal', 'issn_l': '0264-6021', 'issn': ['0264-6021', '1470-8728'], 'is_oa': False, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310311608', 'host_organization_name': 'Portland Press', 'host_organization_lineage': ['https://openalex.org/P4310311715', 'https://openalex.org/P4310311608'], 'host_organization_lineage_names': ['Biochemical Society', 'Portland Press'], 'type': 'journal'}, 'license': 'cc-by', 'license_id': 'https://openalex.org/licenses/cc-by', 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, 'sustainable_development_goals': [{'score': 0.79, 'display_name': 'Good health and well-being', 'id': 'https://metadata.un.org/sdg/3'}], 'grants': [], 'datasets': [], 'versions': [], 'referenced_works_count': 73, 'referenced_works': ['https://openalex.org/W1487848458', 'https://openalex.org/W1926695909', 'https://openalex.org/W1928600912', 'https://openalex.org/W1929625487', 'https://openalex.org/W1965205650', 'https://openalex.org/W1965641455', 'https://openalex.org/W1968428382', 'https://openalex.org/W1969074927', 'https://openalex.org/W1971428500', 'https://openalex.org/W1971476169', 'https://openalex.org/W1972626651', 'https://openalex.org/W1977413934', 'https://openalex.org/W1980697072', 'https://openalex.org/W1985005169', 'https://openalex.org/W1989411375', 'https://openalex.org/W1991533918', 'https://openalex.org/W1995740655', 'https://openalex.org/W1997173534', 'https://openalex.org/W2006850044', 'https://openalex.org/W2006869862', 'https://openalex.org/W2011139151', 'https://openalex.org/W2017321408', 'https://openalex.org/W2020783045', 'https://openalex.org/W2022283793', 'https://openalex.org/W2033228162', 'https://openalex.org/W2033679556', 'https://openalex.org/W2035099971', 'https://openalex.org/W2036776072', 'https://openalex.org/W2043792709', 'https://openalex.org/W2047868774', 'https://openalex.org/W2058065156', 'https://openalex.org/W2062934426', 'https://openalex.org/W2070143179', 'https://openalex.org/W2070463829', 'https://openalex.org/W2076465180', 'https://openalex.org/W2081985759', 'https://openalex.org/W2090375541', 'https://openalex.org/W2092261702', 'https://openalex.org/W2095143806', 'https://openalex.org/W2095591220', 'https://openalex.org/W2097132970', 'https://openalex.org/W2104029014', 'https://openalex.org/W2104115143', 'https://openalex.org/W2104793324', 'https://openalex.org/W2109955944', 'https://openalex.org/W2118669458', 'https://openalex.org/W2129584348', 'https://openalex.org/W2129840287', 'https://openalex.org/W2129905273', 'https://openalex.org/W2130979925', 'https://openalex.org/W2134095164', 'https://openalex.org/W2140529212', 'https://openalex.org/W2141387804', 'https://openalex.org/W2141721028', 'https://openalex.org/W2144425803', 'https://openalex.org/W2144993348', 'https://openalex.org/W2146812359', 'https://openalex.org/W2147078172', 'https://openalex.org/W2147917253', 'https://openalex.org/W2149430751', 'https://openalex.org/W2152026276', 'https://openalex.org/W2157923296', 'https://openalex.org/W2158217645', 'https://openalex.org/W2158698427', 'https://openalex.org/W2161992291', 'https://openalex.org/W2164963523', 'https://openalex.org/W2169543816', 'https://openalex.org/W2169589032', 'https://openalex.org/W2171213306', 'https://openalex.org/W2186992748', 'https://openalex.org/W2224015589', 'https://openalex.org/W2336790540', 'https://openalex.org/W4248721357'], 'related_works': ['https://openalex.org/W4239766472', 'https://openalex.org/W3033898885', 'https://openalex.org/W2980489405', 'https://openalex.org/W2894596463', 'https://openalex.org/W2811116997', 'https://openalex.org/W2770653741', 'https://openalex.org/W2047507923', 'https://openalex.org/W2034346780', 'https://openalex.org/W2017177922', 'https://openalex.org/W1980936182'], 'abstract_inverted_index': {'Fbxo7': [0, 208, 218, 231, 239, 251], 'is': [1], 'a': [2, 103, 145, 185, 242], 'clinically': [3], 'relevant': [4], 'F-box': [5, 40], 'protein,': [6], 'associated': [7], 'with': [8, 21, 238], 'both': [9, 196], 'cancer': [10], 'and': [11, 42, 84, 96, 163, 177, 199, 234], "Parkinson's": [12], 'disease': [13], '(PD).': [14], 'Additionally,': [15], 'SNPs': [16], 'within': [17, 30, 33], 'FBXO7': [18, 31], 'are': [19, 55, 99], 'correlated': [20, 237], 'alterations': [22], 'in': [23, 50, 81, 140, 197, 200, 250, 268], 'red': [24], 'blood': [25], 'cell': [26, 128], 'parameters.': [27], 'Point': [28], 'mutations': [29, 249], 'map': [32], 'specific': [34], 'functional': [35], 'domains,': [36, 46], 'including': [37], 'near': [38], 'its': [39, 43, 225, 235], 'domain': [41], 'substrate': [44], 'recruiting': [45], 'suggesting': [47], 'that': [48, 207, 217, 258], 'deficiencies': [49], 'SCFFbxo7/PARK15': [51], 'ubiquitin': [52], 'ligase': [53, 68], 'activity': [54], 'mechanistically': [56], 'linked': [57, 113], 'to': [58, 115, 151, 272], 'early-onset': [59], 'PD.': [60, 273], 'To': [61, 131], 'date,': [62], 'relatively': [63], 'few': [64], 'substrates': [65, 110, 134, 195], 'of': [66, 87, 105, 108, 135, 157, 179, 246], 'the': [67, 247], 'have': [69, 111], 'been': [70, 112, 120], 'identified.': [71], 'These': [72], 'include': [73], 'HURP': [74], '(hepatoma': [75], 'up-regulated': [76], 'protein),': [77], 'whose': [78], 'ubiquitination': [79], 'results': [80, 215], 'proteasome-mediated': [82], 'degradation,': [83], 'c-IAP1': [85], '(inhibitor': [86], 'apoptosis': [88], 'protein': [89, 149], '1),': [90], 'TNF': [91], 'receptor-associated': [92], 'factor': [93], '2': [94], '(TRAF2),': [95], 'NRAGE,': [97], 'which': [98, 173], 'not': [100], 'destabilized': [101], 'as': [102, 193], 'result': [104], 'ubiquitination.': [106, 254], 'None': [107, 245], 'these': [109, 165], 'directly': [114, 125, 139, 263], 'PD,': [116], 'nor': [117], 'has': [118, 260], 'it': [119], 'determined': [121], 'whether': [122], 'they': [123], 'would': [124], 'engage': [126], 'neuronal': [127], 'death': [129], 'pathways.': [130], 'discover': [132], 'ubiquitinated': [133, 232], 'SCFFbxo7': [136, 194, 259], 'implicated': [137, 267], 'more': [138], 'PD': [141], 'aetiology,': [142], 'we': [143, 166], 'conducted': [144], 'high-throughput': [146], 'screen': [147], 'using': [148, 211], 'arrays': [150], 'identify': [152], 'new': [153, 159], 'candidates.': [154], 'A': [155], 'total': [156], '338': [158], 'targets': [160], 'were': [161], 'identified': [162], 'from': [164], 'validated': [167], 'glycogen': [168], 'synthase': [169], 'kinase': [170], '3β': [171], '(Gsk3β),': [172], 'can': [174], 'phosphorylate': [175], 'α-synuclein,': [176], 'translocase': [178, 187], 'outer': [180], 'mitochondrial': [181, 186], 'membrane': [182], '20': [183], '(Tomm20),': [184], 'that,': [188], 'when': [189], 'ubiquitinated,': [190], 'promotes': [191], 'mitophagy,': [192], 'vitro': [198], 'vivo': [201], 'Ubiquitin': [202], 'chain': [203], 'restriction': [204], 'analyses': [205], 'revealed': [206], 'modified': [209], 'Gsk3β': [210, 221], 'K63': [212], 'linkages.': [213], 'Our': [214, 255], 'indicate': [216], 'negatively': [219], 'regulates': [220], 'activity,': [222], 'rather': [223], 'than': [224], 'levels': [226, 236], 'or': [227], 'localization.': [228], 'In': [229], 'addition,': [230], 'Tomm20,': [233], 'expression,': [240], 'indicating': [241], 'stabilizing': [243], 'effect.': [244], 'PD-associated': [248], 'impaired': [252], 'Tomm20': [253], 'findings': [256], 'demonstrate': [257], 'an': [261], 'impact': [262], 'on': [264], 'two': [265], 'proteins': [266], 'pathological': [269], 'processes': [270], 'leading': [271]}, 'cited_by_api_url': 'https://api.openalex.org/works?filter=cites:W2481659380', 'counts_by_year': [{'year': 2024, 'cited_by_count': 4}, {'year': 2023, 'cited_by_count': 6}, {'year': 2022, 'cited_by_count': 8}, {'year': 2021, 'cited_by_count': 8}, {'year': 2020, 'cited_by_count': 6}, {'year': 2019, 'cited_by_count': 5}, {'year': 2018, 'cited_by_count': 1}, {'year': 2017, 'cited_by_count': 5}], 'updated_date': '2024-12-30T19:25:05.501984', 'created_date': '2016-08-23'}