Get quick answers to your questions about the article from our AI researcher chatbot
{'id': 'https://openalex.org/W2480841917', 'doi': 'https://doi.org/10.1016/s1470-2045(16)30249-2', 'title': 'Biochemical and imaging surveillance in germline TP53 mutation carriers with Li-Fraumeni syndrome: 11 year follow-up of a prospective observational study', 'display_name': 'Biochemical and imaging surveillance in germline TP53 mutation carriers with Li-Fraumeni syndrome: 11 year follow-up of a prospective observational study', 'publication_year': 2016, 'publication_date': '2016-09-01', 'ids': {'openalex': 'https://openalex.org/W2480841917', 'doi': 'https://doi.org/10.1016/s1470-2045(16)30249-2', 'mag': '2480841917', 'pmid': 'https://pubmed.ncbi.nlm.nih.gov/27501770'}, 'language': 'en', 'primary_location': {'is_oa': False, 'landing_page_url': 'https://doi.org/10.1016/s1470-2045(16)30249-2', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S116900674', 'display_name': 'The Lancet Oncology', 'issn_l': '1470-2045', 'issn': ['1470-2045', '1474-5488'], 'is_oa': False, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310320990', 'host_organization_name': 'Elsevier BV', 'host_organization_lineage': ['https://openalex.org/P4310320990'], 'host_organization_lineage_names': ['Elsevier BV'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}, 'type': 'article', 'type_crossref': 'journal-article', 'indexed_in': ['crossref', 'pubmed'], 'open_access': {'is_oa': False, 'oa_status': 'closed', 'oa_url': None, 'any_repository_has_fulltext': False}, 'authorships': [{'author_position': 'first', 'author': {'id': 'https://openalex.org/A5001213402', 'display_name': 'Anita Villani', 'orcid': 'https://orcid.org/0000-0003-3283-2197'}, 'institutions': [{'id': 'https://openalex.org/I185261750', 'display_name': 'University of Toronto', 'ror': 'https://ror.org/03dbr7087', 'country_code': 'CA', 'type': 'education', 'lineage': ['https://openalex.org/I185261750']}], 'countries': ['CA'], 'is_corresponding': False, 'raw_author_name': 'Anita Villani', 'raw_affiliation_strings': ['Department of Pediatrics, University of Toronto, Toronto, ON, Canada', 'Division of Hematology/Oncology, University of Toronto, Toronto, ON, Canada', 'Genetics & Genomic Biology Program, University of Toronto, Toronto, ON, Canada'], 'affiliations': [{'raw_affiliation_string': 'Department of Pediatrics, University of Toronto, Toronto, ON, Canada', 'institution_ids': ['https://openalex.org/I185261750']}, {'raw_affiliation_string': 'Genetics & Genomic Biology Program, University of Toronto, Toronto, ON, Canada', 'institution_ids': ['https://openalex.org/I185261750']}, {'raw_affiliation_string': 'Division of Hematology/Oncology, University of Toronto, Toronto, ON, Canada', 'institution_ids': ['https://openalex.org/I185261750']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5080660540', 'display_name': 'Ari Shore', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I185261750', 'display_name': 'University of Toronto', 'ror': 'https://ror.org/03dbr7087', 'country_code': 'CA', 'type': 'education', 'lineage': ['https://openalex.org/I185261750']}], 'countries': ['CA'], 'is_corresponding': False, 'raw_author_name': 'Ari Shore', 'raw_affiliation_strings': ['Genetics & Genomic Biology Program, University of Toronto, Toronto, ON, Canada'], 'affiliations': [{'raw_affiliation_string': 'Genetics & Genomic Biology Program, University of Toronto, Toronto, ON, Canada', 'institution_ids': ['https://openalex.org/I185261750']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5051856483', 'display_name': 'Jonathan D. Wasserman', 'orcid': 'https://orcid.org/0000-0001-7088-8146'}, 'institutions': [{'id': 'https://openalex.org/I185261750', 'display_name': 'University of Toronto', 'ror': 'https://ror.org/03dbr7087', 'country_code': 'CA', 'type': 'education', 'lineage': ['https://openalex.org/I185261750']}], 'countries': ['CA'], 'is_corresponding': False, 'raw_author_name': 'Jonathan D Wasserman', 'raw_affiliation_strings': ['Department of Pediatrics, University of Toronto, Toronto, ON, Canada', 'Division of Endocrinology, University of Toronto, Toronto, ON, Canada', 'Genetics & Genomic Biology Program, University of Toronto, Toronto, ON, Canada'], 'affiliations': [{'raw_affiliation_string': 'Genetics & Genomic Biology Program, University of Toronto, Toronto, ON, Canada', 'institution_ids': ['https://openalex.org/I185261750']}, {'raw_affiliation_string': 'Division of Endocrinology, University of Toronto, Toronto, ON, Canada', 'institution_ids': ['https://openalex.org/I185261750']}, {'raw_affiliation_string': 'Department of Pediatrics, University of Toronto, Toronto, ON, Canada', 'institution_ids': ['https://openalex.org/I185261750']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5005366116', 'display_name': 'Derek Stephens', 'orcid': 'https://orcid.org/0000-0001-8083-8230'}, 'institutions': [{'id': 'https://openalex.org/I185261750', 'display_name': 'University of Toronto', 'ror': 'https://ror.org/03dbr7087', 'country_code': 'CA', 'type': 'education', 'lineage': ['https://openalex.org/I185261750']}], 'countries': ['CA'], 'is_corresponding': False, 'raw_author_name': 'Derek Stephens', 'raw_affiliation_strings': ['Division of Biostatistics, Design and Analysis, University of Toronto, Toronto, ON, Canada'], 'affiliations': [{'raw_affiliation_string': 'Division of Biostatistics, Design and Analysis, University of Toronto, Toronto, ON, Canada', 'institution_ids': ['https://openalex.org/I185261750']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5058511034', 'display_name': 'Raymond H. Kim', 'orcid': 'https://orcid.org/0000-0002-2147-8674'}, 'institutions': [{'id': 'https://openalex.org/I2802654988', 'display_name': 'Princess Margaret Cancer Centre', 'ror': 'https://ror.org/03zayce58', 'country_code': 'CA', 'type': 'healthcare', 'lineage': ['https://openalex.org/I1325899441', 'https://openalex.org/I2802654988']}, {'id': 'https://openalex.org/I185261750', 'display_name': 'University of Toronto', 'ror': 'https://ror.org/03dbr7087', 'country_code': 'CA', 'type': 'education', 'lineage': ['https://openalex.org/I185261750']}, {'id': 'https://openalex.org/I2801317318', 'display_name': 'Hospital for Sick Children', 'ror': 'https://ror.org/057q4rt57', 'country_code': 'CA', 'type': 'healthcare', 'lineage': ['https://openalex.org/I2801317318']}, {'id': 'https://openalex.org/I4210141030', 'display_name': 'SickKids Foundation', 'ror': 'https://ror.org/04374qe70', 'country_code': 'CA', 'type': 'nonprofit', 'lineage': ['https://openalex.org/I4210141030']}], 'countries': ['CA'], 'is_corresponding': False, 'raw_author_name': 'Raymond H Kim', 'raw_affiliation_strings': ['The Hospital for Sick Children, and Department of Medicine and Division of Medical Oncology and Hematology, Princess Margaret Cancer Center, University of Toronto, Toronto, ON, Canada'], 'affiliations': [{'raw_affiliation_string': 'The Hospital for Sick Children, and Department of Medicine and Division of Medical Oncology and Hematology, Princess Margaret Cancer Center, University of Toronto, Toronto, ON, Canada', 'institution_ids': ['https://openalex.org/I2802654988', 'https://openalex.org/I185261750', 'https://openalex.org/I2801317318', 'https://openalex.org/I4210141030']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5013098987', 'display_name': 'Harriet Druker', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I185261750', 'display_name': 'University of Toronto', 'ror': 'https://ror.org/03dbr7087', 'country_code': 'CA', 'type': 'education', 'lineage': ['https://openalex.org/I185261750']}], 'countries': ['CA'], 'is_corresponding': False, 'raw_author_name': 'Harriet Druker', 'raw_affiliation_strings': ['Department of Genetic Counselling and Department of Molecular Genetics, University of Toronto, Toronto, ON, Canada', 'Division of Hematology/Oncology, University of Toronto, Toronto, ON, Canada'], 'affiliations': [{'raw_affiliation_string': 'Division of Hematology/Oncology, University of Toronto, Toronto, ON, Canada', 'institution_ids': ['https://openalex.org/I185261750']}, {'raw_affiliation_string': 'Department of Genetic Counselling and Department of Molecular Genetics, University of Toronto, Toronto, ON, Canada', 'institution_ids': ['https://openalex.org/I185261750']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5090578274', 'display_name': 'Bailey Gallinger', 'orcid': 'https://orcid.org/0000-0003-0039-3652'}, 'institutions': [{'id': 'https://openalex.org/I185261750', 'display_name': 'University of Toronto', 'ror': 'https://ror.org/03dbr7087', 'country_code': 'CA', 'type': 'education', 'lineage': ['https://openalex.org/I185261750']}], 'countries': ['CA'], 'is_corresponding': False, 'raw_author_name': 'Bailey Gallinger', 'raw_affiliation_strings': ['Department of Genetic Counselling and Department of Molecular Genetics, University of Toronto, Toronto, ON, Canada', 'Genetics & Genomic Biology Program, University of Toronto, Toronto, ON, Canada'], 'affiliations': [{'raw_affiliation_string': 'Genetics & Genomic Biology Program, University of Toronto, Toronto, ON, Canada', 'institution_ids': ['https://openalex.org/I185261750']}, {'raw_affiliation_string': 'Department of Genetic Counselling and Department of Molecular Genetics, University of Toronto, Toronto, ON, Canada', 'institution_ids': ['https://openalex.org/I185261750']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5052190190', 'display_name': 'Anne Naumer', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I2801159745', 'display_name': 'Huntsman Cancer Institute', 'ror': 'https://ror.org/03v7tx966', 'country_code': 'US', 'type': 'healthcare', 'lineage': ['https://openalex.org/I2801159745', 'https://openalex.org/I4210148268']}, {'id': 'https://openalex.org/I223532165', 'display_name': 'University of Utah', 'ror': 'https://ror.org/03r0ha626', 'country_code': 'US', 'type': 'education', 'lineage': ['https://openalex.org/I223532165']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'Anne Naumer', 'raw_affiliation_strings': ['Division of Pediatric Hematology/Oncology, Huntsman Cancer Institute, University of Utah, Salt Lake City, UT, USA'], 'affiliations': [{'raw_affiliation_string': 'Division of Pediatric Hematology/Oncology, Huntsman Cancer Institute, University of Utah, Salt Lake City, UT, USA', 'institution_ids': ['https://openalex.org/I2801159745', 'https://openalex.org/I223532165']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5058251924', 'display_name': 'Wendy Kohlmann', 'orcid': 'https://orcid.org/0000-0002-9134-9640'}, 'institutions': [{'id': 'https://openalex.org/I223532165', 'display_name': 'University of Utah', 'ror': 'https://ror.org/03r0ha626', 'country_code': 'US', 'type': 'education', 'lineage': ['https://openalex.org/I223532165']}, {'id': 'https://openalex.org/I2801159745', 'display_name': 'Huntsman Cancer Institute', 'ror': 'https://ror.org/03v7tx966', 'country_code': 'US', 'type': 'healthcare', 'lineage': ['https://openalex.org/I2801159745', 'https://openalex.org/I4210148268']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'Wendy Kohlmann', 'raw_affiliation_strings': ['Division of Pediatric Hematology/Oncology, Huntsman Cancer Institute, University of Utah, Salt Lake City, UT, USA'], 'affiliations': [{'raw_affiliation_string': 'Division of Pediatric Hematology/Oncology, Huntsman Cancer Institute, University of Utah, Salt Lake City, UT, USA', 'institution_ids': ['https://openalex.org/I223532165', 'https://openalex.org/I2801159745']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5090784401', 'display_name': 'Ana Novokmet', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I185261750', 'display_name': 'University of Toronto', 'ror': 'https://ror.org/03dbr7087', 'country_code': 'CA', 'type': 'education', 'lineage': ['https://openalex.org/I185261750']}], 'countries': ['CA'], 'is_corresponding': False, 'raw_author_name': 'Ana Novokmet', 'raw_affiliation_strings': ['Division of Hematology/Oncology, University of Toronto, Toronto, ON, Canada', 'Genetics & Genomic Biology Program, University of Toronto, Toronto, ON, Canada'], 'affiliations': [{'raw_affiliation_string': 'Genetics & Genomic Biology Program, University of Toronto, Toronto, ON, Canada', 'institution_ids': ['https://openalex.org/I185261750']}, {'raw_affiliation_string': 'Division of Hematology/Oncology, University of Toronto, Toronto, ON, Canada', 'institution_ids': ['https://openalex.org/I185261750']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5010939758', 'display_name': 'Uri Tabori', 'orcid': 'https://orcid.org/0000-0002-5019-2683'}, 'institutions': [{'id': 'https://openalex.org/I185261750', 'display_name': 'University of Toronto', 'ror': 'https://ror.org/03dbr7087', 'country_code': 'CA', 'type': 'education', 'lineage': ['https://openalex.org/I185261750']}], 'countries': ['CA'], 'is_corresponding': False, 'raw_author_name': 'Uri Tabori', 'raw_affiliation_strings': ['Department of Pediatrics, University of Toronto, Toronto, ON, Canada', 'Division of Hematology/Oncology, University of Toronto, Toronto, ON, Canada', 'Genetics & Genomic Biology Program, University of Toronto, Toronto, ON, Canada'], 'affiliations': [{'raw_affiliation_string': 'Genetics & Genomic Biology Program, University of Toronto, Toronto, ON, Canada', 'institution_ids': ['https://openalex.org/I185261750']}, {'raw_affiliation_string': 'Division of Hematology/Oncology, University of Toronto, Toronto, ON, Canada', 'institution_ids': ['https://openalex.org/I185261750']}, {'raw_affiliation_string': 'Department of Pediatrics, University of Toronto, Toronto, ON, Canada', 'institution_ids': ['https://openalex.org/I185261750']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5031436967', 'display_name': 'M. Bueno', 'orcid': 'https://orcid.org/0000-0002-9694-2523'}, 'institutions': [{'id': 'https://openalex.org/I185261750', 'display_name': 'University of Toronto', 'ror': 'https://ror.org/03dbr7087', 'country_code': 'CA', 'type': 'education', 'lineage': ['https://openalex.org/I185261750']}], 'countries': ['CA'], 'is_corresponding': False, 'raw_author_name': 'Marta Tijerin', 'raw_affiliation_strings': ['Department of Medical Imaging, University of Toronto, Toronto, ON, Canada'], 'affiliations': [{'raw_affiliation_string': 'Department of Medical Imaging, University of Toronto, Toronto, ON, Canada', 'institution_ids': ['https://openalex.org/I185261750']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5018395025', 'display_name': 'Mary-Louise C. Greer', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I185261750', 'display_name': 'University of Toronto', 'ror': 'https://ror.org/03dbr7087', 'country_code': 'CA', 'type': 'education', 'lineage': ['https://openalex.org/I185261750']}], 'countries': ['CA'], 'is_corresponding': False, 'raw_author_name': 'Mary-Louise C Greer', 'raw_affiliation_strings': ['Department of Medical Imaging, University of Toronto, Toronto, ON, Canada'], 'affiliations': [{'raw_affiliation_string': 'Department of Medical Imaging, University of Toronto, Toronto, ON, Canada', 'institution_ids': ['https://openalex.org/I185261750']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5072346018', 'display_name': 'Jonathan L. Finlay', 'orcid': 'https://orcid.org/0000-0002-8312-6586'}, 'institutions': [{'id': 'https://openalex.org/I1314135232', 'display_name': "Nationwide Children's Hospital", 'ror': 'https://ror.org/003rfsp33', 'country_code': 'US', 'type': 'healthcare', 'lineage': ['https://openalex.org/I1314135232']}, {'id': 'https://openalex.org/I52357470', 'display_name': 'The Ohio State University', 'ror': 'https://ror.org/00rs6vg23', 'country_code': 'US', 'type': 'education', 'lineage': ['https://openalex.org/I52357470']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'Jonathan L Finlay', 'raw_affiliation_strings': ["Division of Hematology/Oncology, Nationwide Children's Hospital, The Ohio State University, Columbus, OH, USA"], 'affiliations': [{'raw_affiliation_string': "Division of Hematology/Oncology, Nationwide Children's Hospital, The Ohio State University, Columbus, OH, USA", 'institution_ids': ['https://openalex.org/I1314135232', 'https://openalex.org/I52357470']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5028302740', 'display_name': 'Joshua D. Schiffman', 'orcid': 'https://orcid.org/0000-0002-6968-7694'}, 'institutions': [{'id': 'https://openalex.org/I2801159745', 'display_name': 'Huntsman Cancer Institute', 'ror': 'https://ror.org/03v7tx966', 'country_code': 'US', 'type': 'healthcare', 'lineage': ['https://openalex.org/I2801159745', 'https://openalex.org/I4210148268']}, {'id': 'https://openalex.org/I223532165', 'display_name': 'University of Utah', 'ror': 'https://ror.org/03r0ha626', 'country_code': 'US', 'type': 'education', 'lineage': ['https://openalex.org/I223532165']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'Joshua D Schiffman', 'raw_affiliation_strings': ['Division of Pediatric Hematology/Oncology, Huntsman Cancer Institute, University of Utah, Salt Lake City, UT, USA'], 'affiliations': [{'raw_affiliation_string': 'Division of Pediatric Hematology/Oncology, Huntsman Cancer Institute, University of Utah, Salt Lake City, UT, USA', 'institution_ids': ['https://openalex.org/I2801159745', 'https://openalex.org/I223532165']}]}, {'author_position': 'last', 'author': {'id': 'https://openalex.org/A5090452550', 'display_name': 'David Malkin', 'orcid': 'https://orcid.org/0000-0001-5752-9763'}, 'institutions': [{'id': 'https://openalex.org/I185261750', 'display_name': 'University of Toronto', 'ror': 'https://ror.org/03dbr7087', 'country_code': 'CA', 'type': 'education', 'lineage': ['https://openalex.org/I185261750']}], 'countries': ['CA'], 'is_corresponding': True, 'raw_author_name': 'David Malkin', 'raw_affiliation_strings': ['Department of Pediatrics, University of Toronto, Toronto, ON, Canada', 'Division of Hematology/Oncology, University of Toronto, Toronto, ON, Canada', 'Genetics & Genomic Biology Program, University of Toronto, Toronto, ON, Canada'], 'affiliations': [{'raw_affiliation_string': 'Genetics & Genomic Biology Program, University of Toronto, Toronto, ON, Canada', 'institution_ids': ['https://openalex.org/I185261750']}, {'raw_affiliation_string': 'Division of Hematology/Oncology, University of Toronto, Toronto, ON, Canada', 'institution_ids': ['https://openalex.org/I185261750']}, {'raw_affiliation_string': 'Department of Pediatrics, University of Toronto, Toronto, ON, Canada', 'institution_ids': ['https://openalex.org/I185261750']}]}], 'countries_distinct_count': 2, 'institutions_distinct_count': 8, 'corresponding_author_ids': ['https://openalex.org/A5090452550'], 'corresponding_institution_ids': ['https://openalex.org/I185261750'], 'apc_list': {'value': 6300, 'currency': 'USD', 'value_usd': 6300, 'provenance': 'doaj'}, 'apc_paid': None, 'fwci': 24.149, 'has_fulltext': True, 'fulltext_origin': 'ngrams', 'cited_by_count': 411, 'citation_normalized_percentile': {'value': 0.999955, 'is_in_top_1_percent': True, 'is_in_top_10_percent': True}, 'cited_by_percentile_year': {'min': 99, 'max': 100}, 'biblio': {'volume': '17', 'issue': '9', 'first_page': '1295', 'last_page': '1305'}, 'is_retracted': False, 'is_paratext': False, 'primary_topic': {'id': 'https://openalex.org/T10583', 'display_name': 'The p53 Signaling Network in Cancer Research', 'score': 1.0, 'subfield': {'id': 'https://openalex.org/subfields/2730', 'display_name': 'Oncology'}, 'field': {'id': 'https://openalex.org/fields/27', 'display_name': 'Medicine'}, 'domain': {'id': 'https://openalex.org/domains/4', 'display_name': 'Health Sciences'}}, 'topics': [{'id': 'https://openalex.org/T10583', 'display_name': 'The p53 Signaling Network in Cancer Research', 'score': 1.0, 'subfield': {'id': 'https://openalex.org/subfields/2730', 'display_name': 'Oncology'}, 'field': {'id': 'https://openalex.org/fields/27', 'display_name': 'Medicine'}, 'domain': {'id': 'https://openalex.org/domains/4', 'display_name': 'Health Sciences'}}, {'id': 'https://openalex.org/T11287', 'display_name': 'Genomic Landscape of Cancer and Mutational Signatures', 'score': 0.9964, 'subfield': {'id': 'https://openalex.org/subfields/1306', 'display_name': 'Cancer Research'}, 'field': {'id': 'https://openalex.org/fields/13', 'display_name': 'Biochemistry, Genetics and Molecular Biology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}, {'id': 'https://openalex.org/T10231', 'display_name': 'Pancreatic Cancer Research and Treatment', 'score': 0.9949, 'subfield': {'id': 'https://openalex.org/subfields/2730', 'display_name': 'Oncology'}, 'field': {'id': 'https://openalex.org/fields/27', 'display_name': 'Medicine'}, 'domain': {'id': 'https://openalex.org/domains/4', 'display_name': 'Health Sciences'}}], 'keywords': [{'id': 'https://openalex.org/keywords/tumor-microenvironment', 'display_name': 'Tumor Microenvironment', 'score': 0.510017}, {'id': 'https://openalex.org/keywords/p53', 'display_name': 'p53', 'score': 0.501425}], 'concepts': [{'id': 'https://openalex.org/C71924100', 'wikidata': 'https://www.wikidata.org/wiki/Q11190', 'display_name': 'Medicine', 'level': 0, 'score': 0.8073721}, {'id': 'https://openalex.org/C2777910003', 'wikidata': 'https://www.wikidata.org/wiki/Q1707292', 'display_name': 'Asymptomatic', 'level': 2, 'score': 0.6445507}, {'id': 'https://openalex.org/C23131810', 'wikidata': 'https://www.wikidata.org/wiki/Q818574', 'display_name': 'Observational study', 'level': 2, 'score': 0.56925505}, {'id': 'https://openalex.org/C188816634', 'wikidata': 'https://www.wikidata.org/wiki/Q2113324', 'display_name': 'Prospective cohort study', 'level': 2, 'score': 0.4642753}, {'id': 'https://openalex.org/C2778435480', 'wikidata': 'https://www.wikidata.org/wiki/Q840387', 'display_name': 'Colonoscopy', 'level': 4, 'score': 0.4115614}, {'id': 'https://openalex.org/C187212893', 'wikidata': 'https://www.wikidata.org/wiki/Q123028', 'display_name': 'Pediatrics', 'level': 1, 'score': 0.38220158}, {'id': 'https://openalex.org/C121608353', 'wikidata': 'https://www.wikidata.org/wiki/Q12078', 'display_name': 'Cancer', 'level': 2, 'score': 0.3787804}, {'id': 'https://openalex.org/C526805850', 'wikidata': 'https://www.wikidata.org/wiki/Q188874', 'display_name': 'Colorectal cancer', 'level': 3, 'score': 0.36382103}, {'id': 'https://openalex.org/C126322002', 'wikidata': 'https://www.wikidata.org/wiki/Q11180', 'display_name': 'Internal medicine', 'level': 1, 'score': 0.35541975}], 'mesh': [{'descriptor_ui': 'D014408', 'descriptor_name': 'Biomarkers, Tumor', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': True}, {'descriptor_ui': 'D018095', 'descriptor_name': 'Germ-Line Mutation', 'qualifier_ui': 'Q000235', 'qualifier_name': 'genetics', 'is_major_topic': True}, {'descriptor_ui': 'D016864', 'descriptor_name': 'Li-Fraumeni Syndrome', 'qualifier_ui': 'Q000235', 'qualifier_name': 'genetics', 'is_major_topic': True}, {'descriptor_ui': 'D064847', 'descriptor_name': 'Multimodal Imaging', 'qualifier_ui': 'Q000379', 'qualifier_name': 'methods', 'is_major_topic': True}, {'descriptor_ui': 'D009369', 'descriptor_name': 'Neoplasms', 'qualifier_ui': 'Q000235', 'qualifier_name': 'genetics', 'is_major_topic': True}, {'descriptor_ui': 'D011159', 'descriptor_name': 'Population Surveillance', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': True}, {'descriptor_ui': 'D016159', 'descriptor_name': 'Tumor Suppressor Protein p53', 'qualifier_ui': 'Q000235', 'qualifier_name': 'genetics', 'is_major_topic': True}, {'descriptor_ui': 'D000293', 'descriptor_name': 'Adolescent', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D000328', 'descriptor_name': 'Adult', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D000368', 'descriptor_name': 'Aged', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D014408', 'descriptor_name': 'Biomarkers, Tumor', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D002648', 'descriptor_name': 'Child', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D002675', 'descriptor_name': 'Child, Preschool', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D005260', 'descriptor_name': 'Female', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D005500', 'descriptor_name': 'Follow-Up Studies', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D020022', 'descriptor_name': 'Genetic Predisposition to Disease', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D018095', 'descriptor_name': 'Germ-Line Mutation', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D006579', 'descriptor_name': 'Heterozygote', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D006801', 'descriptor_name': 'Humans', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D007223', 'descriptor_name': 'Infant', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D007231', 'descriptor_name': 'Infant, Newborn', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D016864', 'descriptor_name': 'Li-Fraumeni Syndrome', 'qualifier_ui': 'Q000473', 'qualifier_name': 'pathology', 'is_major_topic': False}, {'descriptor_ui': 'D016864', 'descriptor_name': 'Li-Fraumeni Syndrome', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': False}, {'descriptor_ui': 'D016864', 'descriptor_name': 'Li-Fraumeni Syndrome', 'qualifier_ui': 'Q000000981', 'qualifier_name': 'diagnostic imaging', 'is_major_topic': False}, {'descriptor_ui': 'D016864', 'descriptor_name': 'Li-Fraumeni Syndrome', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D008297', 'descriptor_name': 'Male', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D008875', 'descriptor_name': 'Middle Aged', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D064847', 'descriptor_name': 'Multimodal Imaging', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D009367', 'descriptor_name': 'Neoplasm Staging', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D009369', 'descriptor_name': 'Neoplasms', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': False}, {'descriptor_ui': 'D009369', 'descriptor_name': 'Neoplasms', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D009369', 'descriptor_name': 'Neoplasms', 'qualifier_ui': 'Q000000981', 'qualifier_name': 'diagnostic imaging', 'is_major_topic': False}, {'descriptor_ui': 'D009369', 'descriptor_name': 'Neoplasms', 'qualifier_ui': 'Q000473', 'qualifier_name': 'pathology', 'is_major_topic': False}, {'descriptor_ui': 'D011379', 'descriptor_name': 'Prognosis', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D011446', 'descriptor_name': 'Prospective Studies', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D015996', 'descriptor_name': 'Survival Rate', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D016159', 'descriptor_name': 'Tumor Suppressor Protein p53', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D055815', 'descriptor_name': 'Young Adult', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}], 'locations_count': 2, 'locations': [{'is_oa': False, 'landing_page_url': 'https://doi.org/10.1016/s1470-2045(16)30249-2', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S116900674', 'display_name': 'The Lancet Oncology', 'issn_l': '1470-2045', 'issn': ['1470-2045', '1474-5488'], 'is_oa': False, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310320990', 'host_organization_name': 'Elsevier BV', 'host_organization_lineage': ['https://openalex.org/P4310320990'], 'host_organization_lineage_names': ['Elsevier BV'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}, {'is_oa': False, 'landing_page_url': 'https://pubmed.ncbi.nlm.nih.gov/27501770', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S4306525036', 'display_name': 'PubMed', 'issn_l': None, 'issn': None, 'is_oa': False, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1299303238', 'host_organization_name': 'National Institutes of Health', 'host_organization_lineage': ['https://openalex.org/I1299303238'], 'host_organization_lineage_names': ['National Institutes of Health'], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}], 'best_oa_location': None, 'sustainable_development_goals': [{'display_name': 'Good health and well-being', 'id': 'https://metadata.un.org/sdg/3', 'score': 0.59}], 'grants': [], 'datasets': [], 'versions': [], 'referenced_works_count': 22, 'referenced_works': ['https://openalex.org/W1896259395', 'https://openalex.org/W1938158279', 'https://openalex.org/W1977610165', 'https://openalex.org/W1996809856', 'https://openalex.org/W1996877697', 'https://openalex.org/W2015785607', 'https://openalex.org/W2043881730', 'https://openalex.org/W2095770043', 'https://openalex.org/W2097132292', 'https://openalex.org/W2104524209', 'https://openalex.org/W2112008163', 'https://openalex.org/W2117264741', 'https://openalex.org/W2120218419', 'https://openalex.org/W2134026526', 'https://openalex.org/W2145459015', 'https://openalex.org/W2157618054', 'https://openalex.org/W2157727387', 'https://openalex.org/W2160956320', 'https://openalex.org/W2162723956', 'https://openalex.org/W2165854883', 'https://openalex.org/W2290344319', 'https://openalex.org/W577324554'], 'related_works': ['https://openalex.org/W3028983594', 'https://openalex.org/W3016587774', 'https://openalex.org/W2999920852', 'https://openalex.org/W2781494228', 'https://openalex.org/W2381279477', 'https://openalex.org/W2097753790', 'https://openalex.org/W2088704621', 'https://openalex.org/W2049776456', 'https://openalex.org/W2006998504', 'https://openalex.org/W1627705222'], 'abstract_inverted_index': {'Background': [0], 'Carriers': [1], 'of': [2, 13, 24, 26, 50, 65, 98, 130, 136, 166, 217, 225, 252, 261, 275, 322, 338, 352, 429, 435], 'a': [3, 9, 20, 33, 183, 250, 259, 349, 399], 'germline': [4], 'TP53': [5, 131, 137, 218, 411], 'pathogenic': [6, 132, 219, 410], 'variant': [7], 'have': [8, 269], 'substantial': [10], 'lifetime': [11], 'risk': [12], 'developing': [14], 'cancer.': [15], 'In': [16], '2011,': [17], 'we': [18, 60, 213], 'did': [19], 'prospective': [21], 'observational': [22], 'study': [23, 59], 'members': [25], 'families': [27], 'who': [28, 71, 278, 307, 329, 344], 'chose': [29, 141, 146], 'to': [30, 46, 142, 148, 230, 245], 'either': [31, 140], 'undergo': [32, 143, 149], 'comprehensive': [34, 400], 'surveillance': [35, 54, 81, 86, 144, 170, 231, 247, 257, 287, 328, 343, 361, 381, 401, 421], 'protocol': [36, 87, 402], 'for': [37, 128, 258, 357, 366, 403, 444, 458], 'individuals': [38, 255, 306, 325, 341, 408], 'with': [39, 335, 398, 409, 424], 'Li-Fraumeni': [40], 'syndrome': [41], 'or': [42, 145], 'not.': [43], 'We': [44, 196], 'sought': [45], 'update': [47, 77], 'our': [48], 'assessment': [49], 'and': [51, 68, 91, 94, 107, 110, 121, 209, 232, 291, 362, 383, 415, 456], 'modify': [52], 'the': [53, 78, 122, 188, 243, 246, 304, 323, 339, 380, 387], 'protocol,': [55], 'so': [56], 'in': [57, 119, 221, 272, 316, 379, 386, 407], 'this': [58, 430], 'report': [61], 'both': [62], 'longer': [63], 'follow-up': [64, 351], 'these': [66, 436], 'patients': [67, 70, 239, 277, 437], 'additional': [69, 282], 'underwent': [72, 279], 'surveillance,': [73, 310], 'as': [74, 76], 'well': [75], 'originally': [79], 'presented': [80], 'protocol.': [82], 'Methods': [83], 'A': [84], 'clinical': [85, 433], 'using': [88, 200], 'physical': [89], 'examination': [90], 'frequent': [92], 'biochemical': [93], 'imaging': [95], 'studies': [96], '(consisting': [97], 'whole-body': [99], 'MRI,': [100, 102, 104], 'brain': [101], 'breast': [103], 'mammography,': [105], 'abdominal': [106], 'pelvic': [108], 'ultrasound,': [109], 'colonoscopy)': [111], 'was': [112, 164, 176, 374], 'introduced': [113], 'at': [114, 157], 'three': [115], 'tertiary': [116], 'care': [117], 'centres': [118], 'Canada': [120], 'USA': [123], 'on': [124, 298, 327, 360, 368], 'Jan': [125, 206], '1,': [126, 207, 211], '2004,': [127, 208], 'carriers': [129, 216], 'variants.': [133], 'After': [134], 'confirmation': [135], 'mutation,': [138], 'participants': [139], 'not': [147, 326, 359], 'surveillance.': [150, 195, 236, 280, 369], 'Patients': [151], 'could': [152], 'cross': [153], 'over': [154, 241], 'between': [155, 286], 'groups': [156], 'any': [158], 'time.': [159], 'The': [160, 172], 'primary': [161], 'outcome': [162, 174], 'measure': [163, 175], 'detection': [165, 406, 419], 'asymptomatic': [167, 267], 'tumours': [168, 268, 313], 'by': [169, 194], 'investigations.': [171], 'secondary': [173], '5': [177, 370], 'year': [178, 371], 'overall': [179, 372], 'survival': [180, 198, 373], 'established': [181], 'from': [182, 242], 'tumour': [184, 405, 418], 'diagnosed': [185, 193, 285, 315], 'symptomatically': [186], '(in': [187], 'non-surveillance': [189, 244, 388], 'group)': [190], 'versus': [191], 'one': [192], 'completed': [197], 'analyses': [199], 'an': [201], 'as-treated': [202], 'approach.': [203], 'Findings': [204], 'Between': [205], 'July': [210], '2015,': [212], 'identified': [214], '89': [215], 'variants': [220, 412], '39': [222], 'unrelated': [223], 'families,': [224], 'whom': [226], '40': [227, 266], '(45%)': [228], 'agreed': [229], '49': [233, 305], '(55%)': [234], 'declined': [235, 309], '19': [237, 273, 340], '(21%)': [238], 'crossed': [240], 'group,': [248], 'giving': [249], 'total': [251], '59': [253, 276], '(66%)': [254], 'undergoing': [256, 342], 'median': [260, 350], '32': [262], 'months': [263, 354, 364], '(IQR': [264, 355], '12–87).': [265], 'been': [270], 'detected': [271], '(32%)': [274], 'Two': [281], 'cancers': [283], 'were': [284, 295, 314, 332], 'assessments': [288], '(false': [289, 301], 'negatives)': [290], 'two': [292], 'biopsied': [293], 'lesions': [294], 'non-neoplastic': [296], 'entities': [297], 'pathological': [299], 'review': [300], 'positives).': [302], 'Among': [303], 'initially': [308], '61': [311], 'symptomatic': [312], '43': [317, 324], '(88%)': [318], 'patients.': [319], '21': [320], '(49%)': [321], 'developed': [330, 345], 'cancer': [331, 346], 'alive': [333], 'compared': [334], '16': [336], '(84%)': [337], '(p=0·012)': [347], 'after': [348], '46': [353], '22–72)': [356], 'those': [358, 367], '38': [363], '(12–86)': [365], '88·8%': [375], '(95%': [376], 'CI': [377], '78·7–100)': [378], 'group': [382, 389], '59·6%': [384], '(47·2–75·2)': [385], '(p=0·0132).': [390], 'Interpretation': [391], 'Our': [392], 'findings': [393], 'show': [394], 'that': [395, 416], 'long-term': [396, 426], 'compliance': [397], 'early': [404, 417], 'is': [413, 422], 'feasible': [414], 'through': [420], 'associated': [423], 'improved': [425], 'survival.': [427], 'Incorporation': [428], 'approach': [431], 'into': [432], 'management': [434], 'should': [438], 'be': [439], 'considered.': [440], 'Funding': [441], 'Canadian': [442, 447], 'Institutes': [443], 'Heath': [445], 'Research,': [446], 'Cancer': [448], 'Society,': [449], 'Terry': [450], 'Fox': [451], 'Research': [452], 'Institute,': [453], 'SickKids': [454], 'Foundation,': [455], 'Soccer': [457], 'Hope': [459], 'Foundation.': [460]}, 'cited_by_api_url': 'https://api.openalex.org/works?filter=cites:W2480841917', 'counts_by_year': [{'year': 2024, 'cited_by_count': 36}, {'year': 2023, 'cited_by_count': 38}, {'year': 2022, 'cited_by_count': 42}, {'year': 2021, 'cited_by_count': 53}, {'year': 2020, 'cited_by_count': 80}, {'year': 2019, 'cited_by_count': 53}, {'year': 2018, 'cited_by_count': 50}, {'year': 2017, 'cited_by_count': 48}, {'year': 2016, 'cited_by_count': 9}], 'updated_date': '2024-09-11T19:29:30.840524', 'created_date': '2016-08-23'}