Get quick answers to your questions about the article from our AI researcher chatbot
{'id': 'https://openalex.org/W2479607776', 'doi': 'https://doi.org/10.1142/9789812810557_0015', 'title': 'THE ROLES OF CARBONIC ANHYDRASE ISOZYMES IN CANCER', 'display_name': 'THE ROLES OF CARBONIC ANHYDRASE ISOZYMES IN CANCER', 'publication_year': 2001, 'publication_date': '2001-06-01', 'ids': {'openalex': 'https://openalex.org/W2479607776', 'doi': 'https://doi.org/10.1142/9789812810557_0015', 'mag': '2479607776'}, 'language': 'en', 'primary_location': {'is_oa': False, 'landing_page_url': 'https://doi.org/10.1142/9789812810557_0015', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S4306464320', 'display_name': 'WORLD SCIENTIFIC eBooks', 'issn_l': None, 'issn': None, 'is_oa': False, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/P4310319815', 'host_organization_name': 'World Scientific', 'host_organization_lineage': ['https://openalex.org/P4310319815'], 'host_organization_lineage_names': ['World Scientific'], 'type': 'ebook platform'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}, 'type': 'book-chapter', 'type_crossref': 'book-chapter', 'indexed_in': ['crossref'], 'open_access': {'is_oa': False, 'oa_status': 'closed', 'oa_url': None, 'any_repository_has_fulltext': False}, 'authorships': [{'author_position': 'first', 'author': {'id': 'https://openalex.org/A5049293051', 'display_name': 'W. Richard Chegwidden', 'orcid': 'https://orcid.org/0000-0001-9517-0034'}, 'institutions': [{'id': 'https://openalex.org/I18241798', 'display_name': 'Lake Erie College of Osteopathic Medicine', 'ror': 'https://ror.org/04679fh62', 'country_code': 'US', 'type': 'education', 'lineage': ['https://openalex.org/I18241798']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'W. RICHARD CHEGWIDDEN', 'raw_affiliation_strings': ['Lake Erie College of Osteopathic Medicine, 1858 West Grandview Boulevard, Erie, PA 16509, U.S.A.'], 'affiliations': [{'raw_affiliation_string': 'Lake Erie College of Osteopathic Medicine, 1858 West Grandview Boulevard, Erie, PA 16509, U.S.A.', 'institution_ids': ['https://openalex.org/I18241798']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5016003090', 'display_name': 'Ian M. Spencer', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I71422933', 'display_name': 'Sheffield Hallam University', 'ror': 'https://ror.org/019wt1929', 'country_code': 'GB', 'type': 'education', 'lineage': ['https://openalex.org/I71422933']}], 'countries': ['GB'], 'is_corresponding': False, 'raw_author_name': 'IAN M. SPENCER', 'raw_affiliation_strings': ['Division of Biomedical Sciences, Sheffield Hallam University, Sheffield, S1 1WB, UK'], 'affiliations': [{'raw_affiliation_string': 'Division of Biomedical Sciences, Sheffield Hallam University, Sheffield, S1 1WB, UK', 'institution_ids': ['https://openalex.org/I71422933']}]}, {'author_position': 'last', 'author': {'id': 'https://openalex.org/A5035013697', 'display_name': 'Claudiu T. Supuran', 'orcid': 'https://orcid.org/0000-0003-4262-0323'}, 'institutions': [], 'countries': ['IT'], 'is_corresponding': False, 'raw_author_name': 'CLAUDIU T. SUPURAN', 'raw_affiliation_strings': ['Universita degli Studi, Laboratorio di Chimica Inorganica e Bioinorganica, Via Gino Capponi 7, I-501221, Florence, Italy'], 'affiliations': [{'raw_affiliation_string': 'Universita degli Studi, Laboratorio di Chimica Inorganica e Bioinorganica, Via Gino Capponi 7, I-501221, Florence, Italy', 'institution_ids': []}]}], 'institution_assertions': [], 'countries_distinct_count': 3, 'institutions_distinct_count': 2, 'corresponding_author_ids': [], 'corresponding_institution_ids': [], 'apc_list': None, 'apc_paid': None, 'fwci': 33.636, 'has_fulltext': False, 'cited_by_count': 14, 'citation_normalized_percentile': {'value': 0.947526, 'is_in_top_1_percent': False, 'is_in_top_10_percent': True}, 'cited_by_percentile_year': {'min': 82, 'max': 83}, 'biblio': {'volume': None, 'issue': None, 'first_page': '157', 'last_page': '169'}, 'is_retracted': False, 'is_paratext': False, 'primary_topic': {'id': 'https://openalex.org/T13434', 'display_name': 'Cancer Research and Treatment', 'score': 0.5794, 'subfield': {'id': 'https://openalex.org/subfields/2730', 'display_name': 'Oncology'}, 'field': {'id': 'https://openalex.org/fields/27', 'display_name': 'Medicine'}, 'domain': {'id': 'https://openalex.org/domains/4', 'display_name': 'Health Sciences'}}, 'topics': [{'id': 'https://openalex.org/T13434', 'display_name': 'Cancer Research and Treatment', 'score': 0.5794, 'subfield': {'id': 'https://openalex.org/subfields/2730', 'display_name': 'Oncology'}, 'field': {'id': 'https://openalex.org/fields/27', 'display_name': 'Medicine'}, 'domain': {'id': 'https://openalex.org/domains/4', 'display_name': 'Health Sciences'}}, {'id': 'https://openalex.org/T13775', 'display_name': "Hydrogen's biological and therapeutic effects", 'score': 0.5704, 'subfield': {'id': 'https://openalex.org/subfields/2746', 'display_name': 'Surgery'}, 'field': {'id': 'https://openalex.org/fields/27', 'display_name': 'Medicine'}, 'domain': {'id': 'https://openalex.org/domains/4', 'display_name': 'Health Sciences'}}, {'id': 'https://openalex.org/T12963', 'display_name': 'Anesthesia and Neurotoxicity Research', 'score': 0.5328, 'subfield': {'id': 'https://openalex.org/subfields/2806', 'display_name': 'Developmental Neuroscience'}, 'field': {'id': 'https://openalex.org/fields/28', 'display_name': 'Neuroscience'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}], 'keywords': [], 'concepts': [{'id': 'https://openalex.org/C119795356', 'wikidata': 'https://www.wikidata.org/wiki/Q407801', 'display_name': 'Isozyme', 'level': 3, 'score': 0.88016427}, {'id': 'https://openalex.org/C2775914622', 'wikidata': 'https://www.wikidata.org/wiki/Q284089', 'display_name': 'Carbonic anhydrase', 'level': 3, 'score': 0.7934109}, {'id': 'https://openalex.org/C121608353', 'wikidata': 'https://www.wikidata.org/wiki/Q12078', 'display_name': 'Cancer', 'level': 2, 'score': 0.48249316}, {'id': 'https://openalex.org/C55493867', 'wikidata': 'https://www.wikidata.org/wiki/Q7094', 'display_name': 'Biochemistry', 'level': 1, 'score': 0.42892215}, {'id': 'https://openalex.org/C86803240', 'wikidata': 'https://www.wikidata.org/wiki/Q420', 'display_name': 'Biology', 'level': 0, 'score': 0.34836626}, {'id': 'https://openalex.org/C185592680', 'wikidata': 'https://www.wikidata.org/wiki/Q2329', 'display_name': 'Chemistry', 'level': 0, 'score': 0.3259644}, {'id': 'https://openalex.org/C181199279', 'wikidata': 'https://www.wikidata.org/wiki/Q8047', 'display_name': 'Enzyme', 'level': 2, 'score': 0.2801869}, {'id': 'https://openalex.org/C54355233', 'wikidata': 'https://www.wikidata.org/wiki/Q7162', 'display_name': 'Genetics', 'level': 1, 'score': 0.18094453}], 'mesh': [], 'locations_count': 1, 'locations': [{'is_oa': False, 'landing_page_url': 'https://doi.org/10.1142/9789812810557_0015', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S4306464320', 'display_name': 'WORLD SCIENTIFIC eBooks', 'issn_l': None, 'issn': None, 'is_oa': False, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/P4310319815', 'host_organization_name': 'World Scientific', 'host_organization_lineage': ['https://openalex.org/P4310319815'], 'host_organization_lineage_names': ['World Scientific'], 'type': 'ebook platform'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}], 'best_oa_location': None, 'sustainable_development_goals': [], 'grants': [], 'datasets': [], 'versions': [], 'referenced_works_count': 0, 'referenced_works': [], 'related_works': ['https://openalex.org/W2950491884', 'https://openalex.org/W2892378433', 'https://openalex.org/W2269746293', 'https://openalex.org/W2183866633', 'https://openalex.org/W2084788967', 'https://openalex.org/W2059446431', 'https://openalex.org/W1980370145', 'https://openalex.org/W1976629605', 'https://openalex.org/W1872389956', 'https://openalex.org/W1160988677'], 'abstract_inverted_index': {'Gene': [0, 451], 'Families,': [1], 'pp.': [2], '157-169': [3], '(2001)': [4], 'No': [5], 'AccessTHE': [6], 'ROLES': [7], 'OF': [8], 'CARBONIC': [9], 'ANHYDRASE': [10], 'ISOZYMES': [11], 'IN': [12], 'CANCERW.': [13], 'RICHARD': [14, 23], 'CHEGWIDDEN,': [15], 'IAN': [16, 38], 'M.': [17, 39], 'SPENCER,': [18], 'and': [19, 51, 94, 129, 139, 164, 185, 188, 237, 260, 269, 276, 293, 307, 316, 329, 340, 354, 356, 370, 382, 396, 398, 413, 425, 438], 'CLAUDIU': [20, 52], 'T.': [21, 53, 331, 434], 'SUPURANW.': [22], 'CHEGWIDDENLake': [24], 'Erie': [25], 'College': [26], 'of': [27, 41, 87, 98, 101, 112, 137, 148, 156, 209, 252, 337, 350, 379, 392, 422], 'Osteopathic': [28], 'Medicine,': [29], '1858': [30], 'West': [31], 'Grandview': [32], 'Boulevard,': [33], 'Erie,': [34], 'PA': [35], '16509,': [36], 'U.S.A.,': [37], 'SPENCERDivision': [40], 'Biomedical': [42], 'Sciences,': [43], 'Sheffield': [44], 'Hallam': [45], 'University,': [46], 'Sheffield,': [47], 'S1': [48], '1WB,': [49], 'UK,': [50], 'SUPURANUniversita': [54], 'degli': [55], 'Studi,': [56], 'Laboratorio': [57], 'di': [58], 'Chimica': [59], 'Inorganica': [60], 'e': [61], 'Bioinorganica,': [62], 'Via': [63], 'Gino': [64], 'Capponi': [65], '7,': [66], 'I-501221,': [67], 'Florence,': [68], 'Italyhttps://doi.org/10.1142/9789812810557_0015Cited': [69], 'by:7': [70], 'PreviousNext': [71], 'AboutSectionsPDF/EPUB': [72], 'ToolsAdd': [73], 'to': [74, 78, 192], 'favoritesDownload': [75], 'CitationsTrack': [76], 'CitationsRecommend': [77], 'Library': [79], 'ShareShare': [80], 'onFacebookTwitterLinked': [81], 'InRedditEmail': [82], 'Abstract:': [83], 'Specific': [84], 'sulphonamide': [85], 'inhibitors': [86], 'carbonic': [88, 213], 'anhydrase': [89, 289, 432], 'also': [90], 'inhibit': [91], 'the': [92, 96, 125, 135, 157, 219, 223], 'growth,': [93], 'suppress': [95], 'invasion,': [97], 'certain': [99], 'types': [100], 'cancer': [102, 109], 'cells': [103], 'in': [104, 121, 168, 266, 295], 'culture,': [105], 'suggesting': [106], 'potential': [107], 'for': [108, 134, 181, 202, 222], 'therapy.': [110], 'Inhibition': [111, 339, 349, 381, 391, 424], 'cell': [113, 141, 159, 184], 'growth': [114, 264], 'may': [115, 151, 176, 197], 'be': [116, 152, 177, 198], 'mediated': [117, 153], 'through': [118, 154], 'a': [119, 169, 178, 189, 199], 'reduction': [120], 'bicarbonate': [122], 'provision': [123], 'by': [124], 'cytosolic': [126], 'CA': [127, 131, 162, 165, 174, 195], 'II': [128, 290, 355, 397], 'mitochondrial': [130], 'V': [132], 'isozymes,': [133, 161], 'synthesis': [136], 'nucleotides': [138], 'other': [140], 'components.': [142], 'It': [143], 'is': [144], 'hypothesized': [145], 'that': [146], 'suppression': [147], 'invasive': [149], 'properties': [150], 'inhibition': [155, 265], 'cancer-associated,': [158], 'surface': [160], 'IX': [163, 175, 360, 402], 'XII,': [166], 'resulting': [167], 'less': [170], 'acidic': [171], 'extracellular': [172], 'pH.': [173], 'useful': [179, 200], 'marker': [180, 201], 'renal': [182], 'clear': [183], 'cervical': [186], 'carcinomas': [187], 'valuable': [190], 'adjunct': [191], 'PAP': [193], 'screening.': [194], 'XII': [196], 'colorectal': [203], 'tumours.': [204], 'FiguresReferencesRelatedDetailsCited': [205], 'By': [206], '7Computational': [207], 'evaluation': [208], '2-amino-5-sulphonamido-1,3,4-thiadiazoles': [210], 'as': [211], 'human': [212], 'anhydrase-IX': [214], 'inhibitors:': [215], 'an': [216], 'insight': [217], 'into': [218], 'structural': [220], 'requirement': [221], 'anticancer': [224, 261], 'activity': [225, 262], 'against': [226], 'HEK': [227], '293Mahavir': [228], 'Chhajed,': [229, 234, 272], 'Anil': [230, 273], 'K.': [231], 'Shrivastava,': [232], 'Atika': [233], 'Vijay': [235, 277], 'Taile': [236], 'Sumeet': [238], 'Prachand': [239], 'et': [240, 310, 373, 416], 'al.30': [241], 'May': [242], '2017': [243], '|': [244, 281, 314, 335, 377, 420, 443], 'Medicinal': [245, 282, 341, 383, 426, 444], 'Chemistry': [246, 283], 'Research,': [247, 284], 'Vol.': [248, 285, 319, 343, 385, 428, 447], '26,': [249], 'No.': [250, 287, 321, 345, 387, 430, 449], '10Synthesis': [251], '5-arylidine': [253], 'amino-1,3,4-thiadiazol-2-[(N-substituted': [254], 'benzyol)]sulphonamides': [255], 'endowed': [256], 'with': [257, 361, 403], 'potent': [258], 'antioxidants': [259], 'induces': [263], 'HEK293,': [267], 'BT474': [268], 'NCI-H226': [270], 'cellsMahavir': [271], 'Kumar': [274], 'Shrivastava': [275], 'Taile27': [278], 'December': [279], '2013': [280], '23,': [286, 448], '6Carbonic': [288], 'gene': [291], 'upregulation': [292], 'tumorigenesis': [294], 'Lewis': [296], 'lung': [297], 'carcinoma-bearing': [298], 'miceSeung-Hyeok': [299], 'Seok,': [300], 'Min-Won': [301], 'Baek,': [302], 'Hui-Young': [303], 'Lee,': [304], 'Dong-Jae': [305], 'Kim': [306], 'Kiho': [308], 'Cho': [309], 'al.1': [311], 'Mar': [312, 441], '2008': [313, 334, 376, 419], 'Basic': [315], 'Applied': [317], 'Pathology,': [318], '1,': [320], '1Review': [322], 'ArticleSilvia': [323], 'Pastorekova,': [324], 'Seppo': [325], 'Parkkila,': [326], 'Jaromir': [327, 368, 411], 'Pastorek': [328, 369, 412], 'Claudiu': [330], 'Supuran30': [332], 'September': [333], 'Journal': [336, 378, 421], 'Enzyme': [338, 380, 423], 'Chemistry,': [342, 384, 427], '19,': [344], '3Carbonic': [346], 'Anhydrase': [347, 389], 'Inhibitors.': [348, 390], 'Cytosolic': [351, 393], 'Isozymes': [352, 394], 'I': [353, 395], 'Transmembrane,': [357, 399], 'Cancer-associated': [358, 400], 'Isozyme': [359, 401], 'AnionsDaniela': [362], 'Vullo,': [363, 408], 'Marco': [364], 'Franchi,': [365, 406], 'Enzo': [366, 409], 'Gallori,': [367, 410], 'Andrea': [371, 436], 'Scozzafava': [372, 437], 'al.3': [374, 417], 'October': [375, 418], '18,': [386, 429], '5Carbonic': [388], 'Lipophilic': [404], 'SulfonamidesMarco': [405], 'Daniela': [407], 'Antonella': [414], 'Russo': [415], '4Carbonic': [431], 'inhibitorsClaudiu': [433], 'Supuran,': [435], 'Angela': [439], 'Casini1': [440], '2003': [442], 'Research': [445], 'Reviews,': [446], '2': [450], 'FamiliesMetrics': [452], 'History': [453], 'PDF': [454], 'download': [455]}, 'cited_by_api_url': 'https://api.openalex.org/works?filter=cites:W2479607776', 'counts_by_year': [{'year': 2017, 'cited_by_count': 1}, {'year': 2013, 'cited_by_count': 1}], 'updated_date': '2024-12-16T00:06:39.833609', 'created_date': '2016-08-23'}