Title: THE ROLES OF CARBONIC ANHYDRASE ISOZYMES IN CANCER
Abstract: Gene Families, pp. 157-169 (2001) No AccessTHE ROLES OF CARBONIC ANHYDRASE ISOZYMES IN CANCERW. RICHARD CHEGWIDDEN, IAN M. SPENCER, and CLAUDIU T. SUPURANW. RICHARD CHEGWIDDENLake Erie College of Osteopathic Medicine, 1858 West Grandview Boulevard, Erie, PA 16509, U.S.A., IAN M. SPENCERDivision of Biomedical Sciences, Sheffield Hallam University, Sheffield, S1 1WB, UK, and CLAUDIU T. SUPURANUniversita degli Studi, Laboratorio di Chimica Inorganica e Bioinorganica, Via Gino Capponi 7, I-501221, Florence, Italyhttps://doi.org/10.1142/9789812810557_0015Cited by:7 PreviousNext AboutSectionsPDF/EPUB ToolsAdd to favoritesDownload CitationsTrack CitationsRecommend to Library ShareShare onFacebookTwitterLinked InRedditEmail Abstract: Specific sulphonamide inhibitors of carbonic anhydrase also inhibit the growth, and suppress the invasion, of certain types of cancer cells in culture, suggesting potential for cancer therapy. Inhibition of cell growth may be mediated through a reduction in bicarbonate provision by the cytosolic CA II and mitochondrial CA V isozymes, for the synthesis of nucleotides and other cell components. It is hypothesized that suppression of invasive properties may be mediated through inhibition of the cancer-associated, cell surface isozymes, CA IX and CA XII, resulting in a less acidic extracellular pH. CA IX may be a useful marker for renal clear cell and cervical carcinomas and a valuable adjunct to PAP screening. CA XII may be a useful marker for colorectal tumours. FiguresReferencesRelatedDetailsCited By 7Computational evaluation of 2-amino-5-sulphonamido-1,3,4-thiadiazoles as human carbonic anhydrase-IX inhibitors: an insight into the structural requirement for the anticancer activity against HEK 293Mahavir Chhajed, Anil K. Shrivastava, Atika Chhajed, Vijay Taile and Sumeet Prachand et al.30 May 2017 | Medicinal Chemistry Research, Vol. 26, No. 10Synthesis of 5-arylidine amino-1,3,4-thiadiazol-2-[(N-substituted benzyol)]sulphonamides endowed with potent antioxidants and anticancer activity induces growth inhibition in HEK293, BT474 and NCI-H226 cellsMahavir Chhajed, Anil Kumar Shrivastava and Vijay Taile27 December 2013 | Medicinal Chemistry Research, Vol. 23, No. 6Carbonic anhydrase II gene upregulation and tumorigenesis in Lewis lung carcinoma-bearing miceSeung-Hyeok Seok, Min-Won Baek, Hui-Young Lee, Dong-Jae Kim and Kiho Cho et al.1 Mar 2008 | Basic and Applied Pathology, Vol. 1, No. 1Review ArticleSilvia Pastorekova, Seppo Parkkila, Jaromir Pastorek and Claudiu T. Supuran30 September 2008 | Journal of Enzyme Inhibition and Medicinal Chemistry, Vol. 19, No. 3Carbonic Anhydrase Inhibitors. Inhibition of Cytosolic Isozymes I and II and Transmembrane, Cancer-associated Isozyme IX with AnionsDaniela Vullo, Marco Franchi, Enzo Gallori, Jaromir Pastorek and Andrea Scozzafava et al.3 October 2008 | Journal of Enzyme Inhibition and Medicinal Chemistry, Vol. 18, No. 5Carbonic Anhydrase Inhibitors. Inhibition of Cytosolic Isozymes I and II and Transmembrane, Cancer-associated Isozyme IX with Lipophilic SulfonamidesMarco Franchi, Daniela Vullo, Enzo Gallori, Jaromir Pastorek and Antonella Russo et al.3 October 2008 | Journal of Enzyme Inhibition and Medicinal Chemistry, Vol. 18, No. 4Carbonic anhydrase inhibitorsClaudiu T. Supuran, Andrea Scozzafava and Angela Casini1 Mar 2003 | Medicinal Research Reviews, Vol. 23, No. 2 Gene FamiliesMetrics History PDF download
Publication Year: 2001
Publication Date: 2001-06-01
Language: en
Type: book-chapter
Indexed In: ['crossref']
Access and Citation
Cited By Count: 14
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