Publication Information

{'id': 'https://openalex.org/W2478023009', 'doi': 'https://doi.org/10.18632/oncotarget.10658', 'title': 'Oncogenic Ras triggers hyperproliferation and impairs polarized colonic morphogenesis by autocrine ErbB3 signaling', 'display_name': 'Oncogenic Ras triggers hyperproliferation and impairs polarized colonic morphogenesis by autocrine ErbB3 signaling', 'publication_year': 2016, 'publication_date': '2016-07-18', 'ids': {'openalex': 'https://openalex.org/W2478023009', 'doi': 'https://doi.org/10.18632/oncotarget.10658', 'mag': '2478023009', 'pmid': 'https://pubmed.ncbi.nlm.nih.gov/27447549', 'pmcid': 'https://www.ncbi.nlm.nih.gov/pmc/articles/5288203'}, 'language': 'en', 'primary_location': {'is_oa': True, 'landing_page_url': 'https://doi.org/10.18632/oncotarget.10658', 'pdf_url': 'http://www.oncotarget.com/index.php?journal=oncotarget&page=article&op=download&path%5B%5D=10658&path%5B%5D=42937', 'source': {'id': 'https://openalex.org/S126644158', 'display_name': 'Oncotarget', 'issn_l': '1949-2553', 'issn': ['1949-2553'], 'is_oa': True, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310316297', 'host_organization_name': 'Impact Journals LLC', 'host_organization_lineage': ['https://openalex.org/P4310316297'], 'host_organization_lineage_names': ['Impact Journals LLC'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, 'type': 'article', 'type_crossref': 'journal-article', 'indexed_in': ['crossref', 'pubmed'], 'open_access': {'is_oa': True, 'oa_status': 'gold', 'oa_url': 'http://www.oncotarget.com/index.php?journal=oncotarget&page=article&op=download&path%5B%5D=10658&path%5B%5D=42937', 'any_repository_has_fulltext': True}, 'authorships': [{'author_position': 'first', 'author': {'id': 'https://openalex.org/A5110967392', 'display_name': 'Yvonne Möller', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I100066346', 'display_name': 'University of Stuttgart', 'ror': 'https://ror.org/04vnq7t77', 'country_code': 'DE', 'type': 'education', 'lineage': ['https://openalex.org/I100066346']}], 'countries': ['DE'], 'is_corresponding': False, 'raw_author_name': 'Yvonne Möller', 'raw_affiliation_strings': ['Institute of Cell Biology and Immunology, University of Stuttgart, Stuttgart, Germany'], 'affiliations': [{'raw_affiliation_string': 'Institute of Cell Biology and Immunology, University of Stuttgart, Stuttgart, Germany', 'institution_ids': ['https://openalex.org/I100066346']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5005238604', 'display_name': 'Markus Morkel', 'orcid': 'https://orcid.org/0000-0002-2553-9999'}, 'institutions': [{'id': 'https://openalex.org/I7877124', 'display_name': 'Charité - Universitätsmedizin Berlin', 'ror': 'https://ror.org/001w7jn25', 'country_code': 'DE', 'type': 'healthcare', 'lineage': ['https://openalex.org/I7877124']}], 'countries': ['DE'], 'is_corresponding': False, 'raw_author_name': 'Markus Morkel', 'raw_affiliation_strings': ['Laboratory of Molecular Tumor Pathology and Systems Biology, Institute of Pathology, Charité Universitätsmedizin Berlin, Berlin, Germany'], 'affiliations': [{'raw_affiliation_string': 'Laboratory of Molecular Tumor Pathology and Systems Biology, Institute of Pathology, Charité Universitätsmedizin Berlin, Berlin, Germany', 'institution_ids': ['https://openalex.org/I7877124']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5025096132', 'display_name': 'Jens O. Schmid', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I4210120009', 'display_name': 'Dr. Margarete Fischer-Bosch-Institute of Clinical Pharmacology', 'ror': 'https://ror.org/02pnjnj33', 'country_code': 'DE', 'type': 'facility', 'lineage': ['https://openalex.org/I2802101015', 'https://openalex.org/I4210120009', 'https://openalex.org/I4403386655']}, {'id': 'https://openalex.org/I8087733', 'display_name': 'University of Tübingen', 'ror': 'https://ror.org/03a1kwz48', 'country_code': 'DE', 'type': 'education', 'lineage': ['https://openalex.org/I8087733']}], 'countries': ['DE'], 'is_corresponding': False, 'raw_author_name': 'Jens Schmid', 'raw_affiliation_strings': ['Dr. Margarete Fischer-Bosch Institute of Clinical Pharmacology and University of Tübingen, Stuttgart, Germany'], 'affiliations': [{'raw_affiliation_string': 'Dr. Margarete Fischer-Bosch Institute of Clinical Pharmacology and University of Tübingen, Stuttgart, Germany', 'institution_ids': ['https://openalex.org/I4210120009', 'https://openalex.org/I8087733']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5060882767', 'display_name': 'Sven Beyes', 'orcid': 'https://orcid.org/0000-0002-7665-6829'}, 'institutions': [{'id': 'https://openalex.org/I161046081', 'display_name': 'University of Freiburg', 'ror': 'https://ror.org/0245cg223', 'country_code': 'DE', 'type': 'education', 'lineage': ['https://openalex.org/I161046081']}, {'id': 'https://openalex.org/I100066346', 'display_name': 'University of Stuttgart', 'ror': 'https://ror.org/04vnq7t77', 'country_code': 'DE', 'type': 'education', 'lineage': ['https://openalex.org/I100066346']}], 'countries': ['DE'], 'is_corresponding': False, 'raw_author_name': 'Sven Beyes', 'raw_affiliation_strings': ['Current address: Institute of Molecular Medicine and Cell Research, Faculty of Biology, Albert-Ludwigs-University, Freiburg, Germany', 'Institute of Cell Biology and Immunology, University of Stuttgart, Stuttgart, Germany'], 'affiliations': [{'raw_affiliation_string': 'Current address: Institute of Molecular Medicine and Cell Research, Faculty of Biology, Albert-Ludwigs-University, Freiburg, Germany', 'institution_ids': ['https://openalex.org/I161046081']}, {'raw_affiliation_string': 'Institute of Cell Biology and Immunology, University of Stuttgart, Stuttgart, Germany', 'institution_ids': ['https://openalex.org/I100066346']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5042904190', 'display_name': 'Janina Hendrick', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I100066346', 'display_name': 'University of Stuttgart', 'ror': 'https://ror.org/04vnq7t77', 'country_code': 'DE', 'type': 'education', 'lineage': ['https://openalex.org/I100066346']}], 'countries': ['DE'], 'is_corresponding': False, 'raw_author_name': 'Janina Hendrick', 'raw_affiliation_strings': ['Institute of Cell Biology and Immunology, University of Stuttgart, Stuttgart, Germany'], 'affiliations': [{'raw_affiliation_string': 'Institute of Cell Biology and Immunology, University of Stuttgart, Stuttgart, Germany', 'institution_ids': ['https://openalex.org/I100066346']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5066554531', 'display_name': 'Michaela Strotbek', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I100066346', 'display_name': 'University of Stuttgart', 'ror': 'https://ror.org/04vnq7t77', 'country_code': 'DE', 'type': 'education', 'lineage': ['https://openalex.org/I100066346']}], 'countries': ['DE'], 'is_corresponding': False, 'raw_author_name': 'Michaela Strotbek', 'raw_affiliation_strings': ['Institute of Cell Biology and Immunology, University of Stuttgart, Stuttgart, Germany'], 'affiliations': [{'raw_affiliation_string': 'Institute of Cell Biology and Immunology, University of Stuttgart, Stuttgart, Germany', 'institution_ids': ['https://openalex.org/I100066346']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5013064739', 'display_name': 'Pamela Riemer', 'orcid': 'https://orcid.org/0000-0003-3231-7056'}, 'institutions': [{'id': 'https://openalex.org/I7877124', 'display_name': 'Charité - Universitätsmedizin Berlin', 'ror': 'https://ror.org/001w7jn25', 'country_code': 'DE', 'type': 'healthcare', 'lineage': ['https://openalex.org/I7877124']}, {'id': 'https://openalex.org/I4391767962', 'display_name': 'Deutschen Konsortium für Translationale Krebsforschung', 'ror': 'https://ror.org/02pqn3g31', 'country_code': None, 'type': 'facility', 'lineage': ['https://openalex.org/I4391767962']}], 'countries': ['DE'], 'is_corresponding': False, 'raw_author_name': 'Pamela Riemer', 'raw_affiliation_strings': ['DKTK, German Cancer Consortium, Partner site Charité, Berlin, Germany', 'Laboratory of Molecular Tumor Pathology and Systems Biology, Institute of Pathology, Charité Universitätsmedizin Berlin, Berlin, Germany'], 'affiliations': [{'raw_affiliation_string': 'DKTK, German Cancer Consortium, Partner site Charité, Berlin, Germany', 'institution_ids': ['https://openalex.org/I7877124', 'https://openalex.org/I4391767962']}, {'raw_affiliation_string': 'Laboratory of Molecular Tumor Pathology and Systems Biology, Institute of Pathology, Charité Universitätsmedizin Berlin, Berlin, Germany', 'institution_ids': ['https://openalex.org/I7877124']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5051104177', 'display_name': 'Simone Schmid', 'orcid': 'https://orcid.org/0000-0002-5787-7343'}, 'institutions': [{'id': 'https://openalex.org/I100066346', 'display_name': 'University of Stuttgart', 'ror': 'https://ror.org/04vnq7t77', 'country_code': 'DE', 'type': 'education', 'lineage': ['https://openalex.org/I100066346']}], 'countries': ['DE'], 'is_corresponding': False, 'raw_author_name': 'Simone Schmid', 'raw_affiliation_strings': ['Institute of Cell Biology and Immunology, University of Stuttgart, Stuttgart, Germany'], 'affiliations': [{'raw_affiliation_string': 'Institute of Cell Biology and Immunology, University of Stuttgart, Stuttgart, Germany', 'institution_ids': ['https://openalex.org/I100066346']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5024171545', 'display_name': 'Lisa C. Schmitt', 'orcid': 'https://orcid.org/0000-0003-2593-1285'}, 'institutions': [{'id': 'https://openalex.org/I100066346', 'display_name': 'University of Stuttgart', 'ror': 'https://ror.org/04vnq7t77', 'country_code': 'DE', 'type': 'education', 'lineage': ['https://openalex.org/I100066346']}], 'countries': ['DE'], 'is_corresponding': False, 'raw_author_name': 'Lisa C. Schmitt', 'raw_affiliation_strings': ['Institute of Cell Biology and Immunology, University of Stuttgart, Stuttgart, Germany'], 'affiliations': [{'raw_affiliation_string': 'Institute of Cell Biology and Immunology, University of Stuttgart, Stuttgart, Germany', 'institution_ids': ['https://openalex.org/I100066346']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5082328991', 'display_name': 'Roland E. Kontermann', 'orcid': 'https://orcid.org/0000-0001-7139-1350'}, 'institutions': [{'id': 'https://openalex.org/I100066346', 'display_name': 'University of Stuttgart', 'ror': 'https://ror.org/04vnq7t77', 'country_code': 'DE', 'type': 'education', 'lineage': ['https://openalex.org/I100066346']}], 'countries': ['DE'], 'is_corresponding': False, 'raw_author_name': 'Roland Kontermann', 'raw_affiliation_strings': ['Institute of Cell Biology and Immunology, University of Stuttgart, Stuttgart, Germany', 'Stuttgart Research Center Systems Biology (SRCSB), University of Stuttgart, Stuttgart, Germany'], 'affiliations': [{'raw_affiliation_string': 'Stuttgart Research Center Systems Biology (SRCSB), University of Stuttgart, Stuttgart, Germany', 'institution_ids': ['https://openalex.org/I100066346']}, {'raw_affiliation_string': 'Institute of Cell Biology and Immunology, University of Stuttgart, Stuttgart, Germany', 'institution_ids': ['https://openalex.org/I100066346']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5044993303', 'display_name': 'Thomas E. Mürdter', 'orcid': 'https://orcid.org/0000-0002-8786-8122'}, 'institutions': [{'id': 'https://openalex.org/I4210120009', 'display_name': 'Dr. Margarete Fischer-Bosch-Institute of Clinical Pharmacology', 'ror': 'https://ror.org/02pnjnj33', 'country_code': 'DE', 'type': 'facility', 'lineage': ['https://openalex.org/I2802101015', 'https://openalex.org/I4210120009', 'https://openalex.org/I4403386655']}, {'id': 'https://openalex.org/I8087733', 'display_name': 'University of Tübingen', 'ror': 'https://ror.org/03a1kwz48', 'country_code': 'DE', 'type': 'education', 'lineage': ['https://openalex.org/I8087733']}], 'countries': ['DE'], 'is_corresponding': False, 'raw_author_name': 'Thomas Mürdter', 'raw_affiliation_strings': ['Dr. Margarete Fischer-Bosch Institute of Clinical Pharmacology and University of Tübingen, Stuttgart, Germany'], 'affiliations': [{'raw_affiliation_string': 'Dr. Margarete Fischer-Bosch Institute of Clinical Pharmacology and University of Tübingen, Stuttgart, Germany', 'institution_ids': ['https://openalex.org/I4210120009', 'https://openalex.org/I8087733']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5057183308', 'display_name': 'Matthias Schwab', 'orcid': 'https://orcid.org/0000-0002-9984-075X'}, 'institutions': [{'id': 'https://openalex.org/I4210125796', 'display_name': "University Children's Hospital Tübingen", 'ror': 'https://ror.org/03esvmb28', 'country_code': 'DE', 'type': 'healthcare', 'lineage': ['https://openalex.org/I4210094118', 'https://openalex.org/I4210125796']}, {'id': 'https://openalex.org/I8087733', 'display_name': 'University of Tübingen', 'ror': 'https://ror.org/03a1kwz48', 'country_code': 'DE', 'type': 'education', 'lineage': ['https://openalex.org/I8087733']}, {'id': 'https://openalex.org/I4210120009', 'display_name': 'Dr. Margarete Fischer-Bosch-Institute of Clinical Pharmacology', 'ror': 'https://ror.org/02pnjnj33', 'country_code': 'DE', 'type': 'facility', 'lineage': ['https://openalex.org/I2802101015', 'https://openalex.org/I4210120009', 'https://openalex.org/I4403386655']}], 'countries': ['DE'], 'is_corresponding': False, 'raw_author_name': 'Matthias Schwab', 'raw_affiliation_strings': ['Department of Biochemistry and Pharmacy, University of Tübingen, Tübingen, Germany', 'Department of Clinical Pharmacology, University Hospital, Tübingen, Germany', 'Dr. Margarete Fischer-Bosch Institute of Clinical Pharmacology and University of Tübingen, Stuttgart, Germany'], 'affiliations': [{'raw_affiliation_string': 'Department of Clinical Pharmacology, University Hospital, Tübingen, Germany', 'institution_ids': ['https://openalex.org/I4210125796']}, {'raw_affiliation_string': 'Department of Biochemistry and Pharmacy, University of Tübingen, Tübingen, Germany', 'institution_ids': ['https://openalex.org/I8087733']}, {'raw_affiliation_string': 'Dr. Margarete Fischer-Bosch Institute of Clinical Pharmacology and University of Tübingen, Stuttgart, Germany', 'institution_ids': ['https://openalex.org/I4210120009', 'https://openalex.org/I8087733']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5002711674', 'display_name': 'Christine Sers', 'orcid': 'https://orcid.org/0000-0002-6219-1514'}, 'institutions': [{'id': 'https://openalex.org/I7877124', 'display_name': 'Charité - Universitätsmedizin Berlin', 'ror': 'https://ror.org/001w7jn25', 'country_code': 'DE', 'type': 'healthcare', 'lineage': ['https://openalex.org/I7877124']}, {'id': 'https://openalex.org/I4391767962', 'display_name': 'Deutschen Konsortium für Translationale Krebsforschung', 'ror': 'https://ror.org/02pqn3g31', 'country_code': None, 'type': 'facility', 'lineage': ['https://openalex.org/I4391767962']}], 'countries': ['DE'], 'is_corresponding': False, 'raw_author_name': 'Christine Sers', 'raw_affiliation_strings': ['DKTK, German Cancer Consortium, Partner site Charité, Berlin, Germany', 'Laboratory of Molecular Tumor Pathology and Systems Biology, Institute of Pathology, Charité Universitätsmedizin Berlin, Berlin, Germany'], 'affiliations': [{'raw_affiliation_string': 'Laboratory of Molecular Tumor Pathology and Systems Biology, Institute of Pathology, Charité Universitätsmedizin Berlin, Berlin, Germany', 'institution_ids': ['https://openalex.org/I7877124']}, {'raw_affiliation_string': 'DKTK, German Cancer Consortium, Partner site Charité, Berlin, Germany', 'institution_ids': ['https://openalex.org/I7877124', 'https://openalex.org/I4391767962']}]}, {'author_position': 'last', 'author': {'id': 'https://openalex.org/A5037484088', 'display_name': 'Monilola A. Olayioye', 'orcid': 'https://orcid.org/0000-0003-1093-263X'}, 'institutions': [{'id': 'https://openalex.org/I100066346', 'display_name': 'University of Stuttgart', 'ror': 'https://ror.org/04vnq7t77', 'country_code': 'DE', 'type': 'education', 'lineage': ['https://openalex.org/I100066346']}], 'countries': ['DE'], 'is_corresponding': True, 'raw_author_name': 'Monilola A. Olayioye', 'raw_affiliation_strings': ['Institute of Cell Biology and Immunology, University of Stuttgart, Stuttgart, Germany', 'Stuttgart Research Center Systems Biology (SRCSB), University of Stuttgart, Stuttgart, Germany'], 'affiliations': [{'raw_affiliation_string': 'Institute of Cell Biology and Immunology, University of Stuttgart, Stuttgart, Germany', 'institution_ids': ['https://openalex.org/I100066346']}, {'raw_affiliation_string': 'Stuttgart Research Center Systems Biology (SRCSB), University of Stuttgart, Stuttgart, Germany', 'institution_ids': ['https://openalex.org/I100066346']}]}], 'institution_assertions': [], 'countries_distinct_count': 1, 'institutions_distinct_count': 7, 'corresponding_author_ids': ['https://openalex.org/A5037484088'], 'corresponding_institution_ids': ['https://openalex.org/I100066346'], 'apc_list': None, 'apc_paid': None, 'fwci': 0.441, 'has_fulltext': True, 'fulltext_origin': 'pdf', 'cited_by_count': 12, 'citation_normalized_percentile': {'value': 0.753308, 'is_in_top_1_percent': False, 'is_in_top_10_percent': False}, 'cited_by_percentile_year': {'min': 87, 'max': 88}, 'biblio': {'volume': '7', 'issue': '33', 'first_page': '53526', 'last_page': '53539'}, 'is_retracted': False, 'is_paratext': False, 'primary_topic': {'id': 'https://openalex.org/T10755', 'display_name': 'HER2/EGFR in Cancer Research', 'score': 0.9979, 'subfield': {'id': 'https://openalex.org/subfields/2730', 'display_name': 'Oncology'}, 'field': {'id': 'https://openalex.org/fields/27', 'display_name': 'Medicine'}, 'domain': {'id': 'https://openalex.org/domains/4', 'display_name': 'Health Sciences'}}, 'topics': [{'id': 'https://openalex.org/T10755', 'display_name': 'HER2/EGFR in Cancer Research', 'score': 0.9979, 'subfield': {'id': 'https://openalex.org/subfields/2730', 'display_name': 'Oncology'}, 'field': {'id': 'https://openalex.org/fields/27', 'display_name': 'Medicine'}, 'domain': {'id': 'https://openalex.org/domains/4', 'display_name': 'Health Sciences'}}, {'id': 'https://openalex.org/T10336', 'display_name': 'Cancer Cells and Metastasis', 'score': 0.9974, 'subfield': {'id': 'https://openalex.org/subfields/2730', 'display_name': 'Oncology'}, 'field': {'id': 'https://openalex.org/fields/27', 'display_name': 'Medicine'}, 'domain': {'id': 'https://openalex.org/domains/4', 'display_name': 'Health Sciences'}}, {'id': 'https://openalex.org/T11067', 'display_name': 'Colorectal Cancer Treatments and Studies', 'score': 0.996, 'subfield': {'id': 'https://openalex.org/subfields/2730', 'display_name': 'Oncology'}, 'field': {'id': 'https://openalex.org/fields/27', 'display_name': 'Medicine'}, 'domain': {'id': 'https://openalex.org/domains/4', 'display_name': 'Health Sciences'}}], 'keywords': [{'id': 'https://openalex.org/keywords/stuttgart', 'display_name': 'Stuttgart', 'score': 0.43886763}], 'concepts': [{'id': 'https://openalex.org/C128240485', 'wikidata': 'https://www.wikidata.org/wiki/Q786998', 'display_name': 'Autocrine signalling', 'level': 3, 'score': 0.5607615}, {'id': 'https://openalex.org/C101544691', 'wikidata': 'https://www.wikidata.org/wiki/Q420511', 'display_name': 'Receptor tyrosine kinase', 'level': 3, 'score': 0.4755958}, {'id': 'https://openalex.org/C2781287369', 'wikidata': 'https://www.wikidata.org/wiki/Q7629209', 'display_name': 'Stuttgart', 'level': 2, 'score': 0.43886763}, {'id': 'https://openalex.org/C502942594', 'wikidata': 'https://www.wikidata.org/wiki/Q3421914', 'display_name': 'Cancer research', 'level': 1, 'score': 0.39921817}, {'id': 'https://openalex.org/C71924100', 'wikidata': 'https://www.wikidata.org/wiki/Q11190', 'display_name': 'Medicine', 'level': 0, 'score': 0.39446676}, {'id': 'https://openalex.org/C161191863', 'wikidata': 'https://www.wikidata.org/wiki/Q199655', 'display_name': 'Library science', 'level': 1, 'score': 0.3254791}, {'id': 'https://openalex.org/C170493617', 'wikidata': 'https://www.wikidata.org/wiki/Q208467', 'display_name': 'Receptor', 'level': 2, 'score': 0.24290141}, {'id': 'https://openalex.org/C126322002', 'wikidata': 'https://www.wikidata.org/wiki/Q11180', 'display_name': 'Internal medicine', 'level': 1, 'score': 0.21203327}, {'id': 'https://openalex.org/C138885662', 'wikidata': 'https://www.wikidata.org/wiki/Q5891', 'display_name': 'Philosophy', 'level': 0, 'score': 0.1626569}, {'id': 'https://openalex.org/C15708023', 'wikidata': 'https://www.wikidata.org/wiki/Q80083', 'display_name': 'Humanities', 'level': 1, 'score': 0.13447323}, {'id': 'https://openalex.org/C41008148', 'wikidata': 'https://www.wikidata.org/wiki/Q21198', 'display_name': 'Computer science', 'level': 0, 'score': 0.0}], 'mesh': [{'descriptor_ui': 'D019898', 'descriptor_name': 'Autocrine Communication', 'qualifier_ui': 'Q000502', 'qualifier_name': 'physiology', 'is_major_topic': True}, {'descriptor_ui': 'D002471', 'descriptor_name': 'Cell Transformation, Neoplastic', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': True}, {'descriptor_ui': 'D007413', 'descriptor_name': 'Intestinal Mucosa', 'qualifier_ui': 'Q000473', 'qualifier_name': 'pathology', 'is_major_topic': True}, {'descriptor_ui': 'D020893', 'descriptor_name': 'Receptor, ErbB-3', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': True}, {'descriptor_ui': 'D018631', 'descriptor_name': 'ras Proteins', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': True}, {'descriptor_ui': 'D019898', 'descriptor_name': 'Autocrine Communication', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D054337', 'descriptor_name': 'Cell Dedifferentiation', 'qualifier_ui': 'Q000502', 'qualifier_name': 'physiology', 'is_major_topic': False}, {'descriptor_ui': 'D054337', 'descriptor_name': 'Cell Dedifferentiation', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D045744', 'descriptor_name': 'Cell Line, Tumor', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D016764', 'descriptor_name': 'Cell Polarity', 'qualifier_ui': 'Q000502', 'qualifier_name': 'physiology', 'is_major_topic': False}, {'descriptor_ui': 'D016764', 'descriptor_name': 'Cell Polarity', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D049109', 'descriptor_name': 'Cell Proliferation', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D002471', 'descriptor_name': 'Cell Transformation, Neoplastic', 'qualifier_ui': 'Q000473', 'qualifier_name': 'pathology', 'is_major_topic': False}, {'descriptor_ui': 'D002471', 'descriptor_name': 'Cell Transformation, Neoplastic', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D015179', 'descriptor_name': 'Colorectal Neoplasms', 'qualifier_ui': 'Q000473', 'qualifier_name': 'pathology', 'is_major_topic': False}, {'descriptor_ui': 'D015179', 'descriptor_name': 'Colorectal Neoplasms', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': False}, {'descriptor_ui': 'D015179', 'descriptor_name': 'Colorectal Neoplasms', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D006801', 'descriptor_name': 'Humans', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D007413', 'descriptor_name': 'Intestinal Mucosa', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': False}, {'descriptor_ui': 'D007413', 'descriptor_name': 'Intestinal Mucosa', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D009024', 'descriptor_name': 'Morphogenesis', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D009024', 'descriptor_name': 'Morphogenesis', 'qualifier_ui': 'Q000502', 'qualifier_name': 'physiology', 'is_major_topic': False}, {'descriptor_ui': 'D020893', 'descriptor_name': 'Receptor, ErbB-3', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D018631', 'descriptor_name': 'ras Proteins', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}], 'locations_count': 4, 'locations': [{'is_oa': True, 'landing_page_url': 'https://doi.org/10.18632/oncotarget.10658', 'pdf_url': 'http://www.oncotarget.com/index.php?journal=oncotarget&page=article&op=download&path%5B%5D=10658&path%5B%5D=42937', 'source': {'id': 'https://openalex.org/S126644158', 'display_name': 'Oncotarget', 'issn_l': '1949-2553', 'issn': ['1949-2553'], 'is_oa': True, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310316297', 'host_organization_name': 'Impact Journals LLC', 'host_organization_lineage': ['https://openalex.org/P4310316297'], 'host_organization_lineage_names': ['Impact Journals LLC'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, {'is_oa': True, 'landing_page_url': 'https://europepmc.org/articles/pmc5288203', 'pdf_url': 'https://europepmc.org/articles/pmc5288203?pdf=render', 'source': {'id': 'https://openalex.org/S4306400806', 'display_name': 'Europe PMC (PubMed Central)', 'issn_l': None, 'issn': None, 'is_oa': True, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1303153112', 'host_organization_name': 'European Bioinformatics Institute', 'host_organization_lineage': ['https://openalex.org/I1303153112'], 'host_organization_lineage_names': ['European Bioinformatics Institute'], 'type': 'repository'}, 'license': 'cc-by', 'license_id': 'https://openalex.org/licenses/cc-by', 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, {'is_oa': True, 'landing_page_url': 'https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5288203', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S2764455111', 'display_name': 'PubMed Central', 'issn_l': None, 'issn': None, 'is_oa': True, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1299303238', 'host_organization_name': 'National Institutes of Health', 'host_organization_lineage': ['https://openalex.org/I1299303238'], 'host_organization_lineage_names': ['National Institutes of Health'], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, {'is_oa': False, 'landing_page_url': 'https://pubmed.ncbi.nlm.nih.gov/27447549', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S4306525036', 'display_name': 'PubMed', 'issn_l': None, 'issn': None, 'is_oa': False, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1299303238', 'host_organization_name': 'National Institutes of Health', 'host_organization_lineage': ['https://openalex.org/I1299303238'], 'host_organization_lineage_names': ['National Institutes of Health'], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}], 'best_oa_location': {'is_oa': True, 'landing_page_url': 'https://doi.org/10.18632/oncotarget.10658', 'pdf_url': 'http://www.oncotarget.com/index.php?journal=oncotarget&page=article&op=download&path%5B%5D=10658&path%5B%5D=42937', 'source': {'id': 'https://openalex.org/S126644158', 'display_name': 'Oncotarget', 'issn_l': '1949-2553', 'issn': ['1949-2553'], 'is_oa': True, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310316297', 'host_organization_name': 'Impact Journals LLC', 'host_organization_lineage': ['https://openalex.org/P4310316297'], 'host_organization_lineage_names': ['Impact Journals LLC'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, 'sustainable_development_goals': [{'id': 'https://metadata.un.org/sdg/3', 'score': 0.79, 'display_name': 'Good health and well-being'}], 'grants': [], 'datasets': [], 'versions': [], 'referenced_works_count': 52, 'referenced_works': ['https://openalex.org/W1483496013', 'https://openalex.org/W1705959389', 'https://openalex.org/W1964321121', 'https://openalex.org/W1965864591', 'https://openalex.org/W1971086565', 'https://openalex.org/W1990499122', 'https://openalex.org/W1993804787', 'https://openalex.org/W1997114875', 'https://openalex.org/W1997579117', 'https://openalex.org/W1998971866', 'https://openalex.org/W1999615718', 'https://openalex.org/W2002513358', 'https://openalex.org/W2004439203', 'https://openalex.org/W2009457168', 'https://openalex.org/W2014111401', 'https://openalex.org/W2017081079', 'https://openalex.org/W2019323840', 'https://openalex.org/W2032461554', 'https://openalex.org/W2038624343', 'https://openalex.org/W2041919461', 'https://openalex.org/W2049180247', 'https://openalex.org/W2052766930', 'https://openalex.org/W2055992413', 'https://openalex.org/W2057940570', 'https://openalex.org/W2062004524', 'https://openalex.org/W2069526613', 'https://openalex.org/W2085971602', 'https://openalex.org/W2089686819', 'https://openalex.org/W2092897704', 'https://openalex.org/W2093036951', 'https://openalex.org/W2099378655', 'https://openalex.org/W2105437003', 'https://openalex.org/W2106567943', 'https://openalex.org/W2106882655', 'https://openalex.org/W2110245825', 'https://openalex.org/W2110933411', 'https://openalex.org/W2116422989', 'https://openalex.org/W2127362646', 'https://openalex.org/W2129140055', 'https://openalex.org/W2131609666', 'https://openalex.org/W2139444209', 'https://openalex.org/W2145915855', 'https://openalex.org/W2146284460', 'https://openalex.org/W2146942822', 'https://openalex.org/W2152095899', 'https://openalex.org/W2164985111', 'https://openalex.org/W2165200432', 'https://openalex.org/W2168068820', 'https://openalex.org/W2169547107', 'https://openalex.org/W2398213711', 'https://openalex.org/W4232777855', 'https://openalex.org/W56241122'], 'related_works': ['https://openalex.org/W4254139451', 'https://openalex.org/W4214536500', 'https://openalex.org/W4205896539', 'https://openalex.org/W2968144600', 'https://openalex.org/W2952937416', 'https://openalex.org/W2417912960', 'https://openalex.org/W2244368680', 'https://openalex.org/W2114093154', 'https://openalex.org/W2095959177', 'https://openalex.org/W145018159'], 'abstract_inverted_index': {'//': [0], 'Yvonne': [1], 'Möller': [2], '1': [3, 20, 24, 33, 38, 65], ',': [4, 8, 12, 17, 21, 25, 30, 34, 39, 44, 48, 54, 59], 'Markus': [5], 'Morkel': [6], '2': [7, 77], 'Jens': [9], 'Schmid': [10, 32], '3': [11, 47, 94], 'Sven': [13], 'Beyes': [14], '1,': [15, 42, 63], '8': [16, 150], 'Janina': [18], 'Hendrick': [19], 'Michaela': [22], 'Strotbek': [23], 'Pamela': [26], 'Riemer': [27], '2,': [28, 57], '4': [29, 58, 108], 'Simone': [31], 'Lisa': [35], 'C.': [36], 'Schmitt': [37], 'Roland': [40], 'Kontermann': [41], '5': [43, 64, 118], 'Thomas': [45], 'Mürdter': [46], 'Matthias': [49], 'Schwab': [50], '3,': [51], '6,': [52], '7': [53, 139], 'Christine': [55], 'Sers': [56], 'Monilola': [60, 168], 'A.': [61, 169], 'Olayioye': [62], 'Institute': [66, 86, 98, 153], 'of': [67, 73, 79, 87, 99, 104, 126, 132, 141, 146, 154, 161, 201, 211, 222, 280, 316], 'Cell': [68, 158], 'Biology': [69, 123], 'and': [70, 83, 102, 143, 157, 236, 271, 323], 'Immunology,': [71], 'University': [72, 103, 125, 135, 145], 'Stuttgart,': [74, 75, 106, 127, 128], 'Germany': [76, 93, 107, 117, 129, 138, 149, 165], 'Laboratory': [78], 'Molecular': [80, 155], 'Tumor': [81], 'Pathology': [82], 'Systems': [84, 122], 'Biology,': [85, 162], 'Pathology,': [88], 'Charité': [89], 'Universitätsmedizin': [90], 'Berlin,': [91, 92, 116], 'Dr.': [95], 'Margarete': [96], 'Fischer-Bosch': [97], 'Clinical': [100, 133], 'Pharmacology': [101], 'Tübingen,': [105, 137, 147, 148], 'DKTK,': [109], 'German': [110], 'Cancer': [111], 'Consortium,': [112], 'Partner': [113], 'site': [114], 'Charité,': [115], 'Stuttgart': [119], 'Research': [120], 'Center': [121], '(SRCSB),': [124], '6': [130], 'Department': [131, 140], 'Pharmacology,': [134], 'Hospital,': [136], 'Biochemistry': [142], 'Pharmacy,': [144], 'Current': [151], 'address:': [152], 'Medicine': [156], 'Research,': [159], 'Faculty': [160], 'Albert-Ludwigs-University,': [163], 'Freiburg,': [164], 'Correspondence': [166], 'to:': [167], 'Olayioye,': [170], 'email:': [171], '[email protected]': [172], 'Keywords:': [173], 'oncogenic': [174, 203, 241, 307], 'Ras,': [175], 'ErbB3/HER3,': [176], '3D': [177, 238], 'culture,': [178], 'intestinal': [179, 253, 318], 'organoids,': [180], 'apical-basolateral': [181], 'polarity': [182], 'Received:': [183], 'January': [184], '31,': [185], '2016': [186, 190, 194], 'Accepted:': [187], 'July': [188, 192], '09,': [189], 'Published:': [191], '18,': [193], 'ABSTRACT': [195], 'Here': [196], 'we': [197], 'study': [198], 'the': [199, 208, 219, 226, 234, 285, 314, 317], 'effects': [200], 'inducible': [202], 'K-Ras': [204, 242, 276, 308], '(G12V)': [205], 'expression': [206], 'on': [207], 'polarized': [209], 'morphogenesis': [210, 239], 'colonic': [212], 'epithelial': [213], 'cells.': [214], 'We': [215], 'provide': [216, 298], 'evidence': [217], 'that': [218, 311], 'autocrine': [220, 302], 'production': [221], 'heregulins,': [223], 'ligands': [224], 'for': [225, 233, 300], 'ErbB3': [227, 269, 287, 310], 'receptor': [228], 'tyrosine': [229], 'kinase,': [230], 'is': [231, 245, 260], 'responsible': [232], 'hyperproliferation': [235], 'aberrant': [237], 'upon': [240], 'expression.': [243], 'This': [244], 'in': [246, 251, 256, 290], 'line': [247], 'with': [248, 264, 284], 'results': [249], 'obtained': [250], 'primary': [252, 293], 'organoid': [254], 'cultures,': [255], 'which': [257], 'exogenous': [258], 'heregulin': [259, 272], 'shown': [261], 'to': [262, 313], 'interfere': [263], 'normal': [265], 'tissue': [266], 'architecture.': [267], 'Importantly,': [268], 'inhibition': [270], 'gene': [273], 'silencing': [274], 'rescued': [275], 'G12V': [277], '-induced': [278], 'features': [279], 'cell': [281], 'transformation.': [282], 'Together': [283], 'increased': [286], 'positivity': [288], 'detected': [289], 'human': [291], 'high-grade': [292], 'colorectal': [294], 'cancers,': [295], 'our': [296], 'findings': [297], 'support': [299], 'an': [301], 'signaling': [303], 'loop': [304], 'engaged': [305], 'by': [306], 'involving': [309], 'contributes': [312], 'dedifferentiation': [315], 'epithelium': [319], 'during': [320], 'tumor': [321], 'initiation': [322], 'progression.': [324]}, 'cited_by_api_url': 'https://api.openalex.org/works?filter=cites:W2478023009', 'counts_by_year': [{'year': 2023, 'cited_by_count': 1}, {'year': 2022, 'cited_by_count': 4}, {'year': 2020, 'cited_by_count': 1}, {'year': 2019, 'cited_by_count': 1}, {'year': 2018, 'cited_by_count': 1}, {'year': 2017, 'cited_by_count': 1}], 'updated_date': '2024-12-24T22:38:25.777447', 'created_date': '2016-08-23'}