Abstract: Biology and Pathogenesis of Rhabdo- and Filoviruses, pp. 335-351 (2015) No AccessCHAPTER 14: RABIES VIRUS REPLICATION AND PATHOGENESISAndrew W. Hudacek and Matthias J. SchnellAndrew W. HudacekDepartment of Microbiology and Immunology, Thomas Jefferson University, Philadelphia, Pennsylvania, USAMolecular Targeting Technologies, Incorporated, West Chester, Pennsylvania, USA and Matthias J. SchnellDepartment of Microbiology and Immunology, Thomas Jefferson University, Philadelphia, Pennsylvania, USAJefferson Vaccine Center, Thomas Jefferson University, Philadelphia, Pennsylvania, USAhttps://doi.org/10.1142/9789814635349_0014Cited by:0 PreviousNext AboutSectionsPDF/EPUB ToolsAdd to favoritesDownload CitationsTrack CitationsRecommend to Library ShareShare onFacebookTwitterLinked InRedditEmail Abstract: Rabies virus (RABV), a negative sense, single-strand RNA virus of the Rhabdoviridae family causes one of the most lethal zoonotic diseases. It spreads through the neural pathways from the site of infection to the central nervous system and is most often fatal following the initial presentation of symptoms. These symptoms include the classical hydrophobia and increased aggression or hyper-activity, which is associated with the "furious" form of rabies, but can also present as flaccid paralysis associated with the "dumb" form. Depending upon whether the virus is a field/"street" isolate, laboratory adapted/"fixed" isolate or a vaccine strain, infection can result in different outcomes for infected cells. However, natural cases and in vivo experimental models of peripheral infection follow a similar lifecycle. Beginning with initial replication at the site of infection, the virus then travels through peripheral nerves through retrograde rapid axonal transport to the spinal column and central nervous system. Following replication within the CNS, there is centrifugal spread of the virus through nerves to other tissues, including the salivary glands. The major determinant of RABV tropism is the viral membrane glycoprotein (G), which binds to cellular receptors that are generally restricted to neurons. In addition, we will discuss the role of the other viral proteins in RABV replication and pathogenesis. FiguresReferencesRelatedDetails Biology and Pathogenesis of Rhabdo- and FilovirusesMetrics History PDF download
Publication Year: 2014
Publication Date: 2014-12-30
Language: en
Type: book-chapter
Indexed In: ['crossref']
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