Title: CD44 as a Functional Cancer Stem Cell Marker and a Potential Therapeutic Target
Abstract: Progress in Gene TherapyAutologous and Cancer Stem Cell Gene Therapy, pp. 317-334 (2007) No AccessCD44 as a Functional Cancer Stem Cell Marker and a Potential Therapeutic TargetLubna Patrawala and Dean G. TangLubna PatrawalaDepartment of Carcinogenesis, The University of Texas MD Anderson Cancer Center, Science Park–Research Division, Smithville, TX 78957, USA and Dean G. TangDepartment of Carcinogenesis, The University of Texas MD Anderson Cancer Center, Science Park–Research Division, Smithville, TX 78957, USAProgram in Environmental & Molecular Carcinogenesis, Graduate School of Biomedical Sciences (GSBS), Houston, TX 77030, USACorresponding author.https://doi.org/10.1142/9789812775870_0012Cited by:1 PreviousNext AboutSectionsPDF/EPUB ToolsAdd to favoritesDownload CitationsTrack CitationsRecommend to Library ShareShare onFacebookTwitterLinked InRedditEmail Abstract: CD44 is a well-characterized adhesion molecule with multi-faceted biological functions. Earlier studies have implicated CD44 in the invasion and metastasis of multiple human cancers. Newly generated data suggest that tumor cells expressing CD44 may be intrinsically different from the bulk CD44− cells and that its expression may mark a population of tumor-initiating cells called cancer stem cells (CSCs). In this review, we succinctly summarize the evidence of CD44 as a CSC marker and also discuss the possibility of targeting CD44-expressing CSCs. Keywords: CD44tumor-initiating cellscancer stem cellstumor progenitorsmetastasishoming FiguresReferencesRelatedDetailsCited By 1Tumor Dormancy and Slow-Cycling Cancer CellsJohn E. Davis, Jason Kirk, Yibing Ji and Dean G. Tang2 October 2019 Autologous and Cancer Stem Cell Gene TherapyMetrics History KeywordsCD44tumor-initiating cellscancer stem cellstumor progenitorsmetastasishomingPDF download
Publication Year: 2007
Publication Date: 2007-12-01
Language: en
Type: book-chapter
Indexed In: ['crossref']
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Cited By Count: 1
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