Get quick answers to your questions about the article from our AI researcher chatbot
{'id': 'https://openalex.org/W2476210219', 'doi': 'https://doi.org/10.18632/oncotarget.11027', 'title': "Dose-dependent genotype effects of BDNF Val66Met polymorphism on default mode network in early stage Alzheimer's disease", 'display_name': "Dose-dependent genotype effects of BDNF Val66Met polymorphism on default mode network in early stage Alzheimer's disease", 'publication_year': 2016, 'publication_date': '2016-08-02', 'ids': {'openalex': 'https://openalex.org/W2476210219', 'doi': 'https://doi.org/10.18632/oncotarget.11027', 'mag': '2476210219', 'pmid': 'https://pubmed.ncbi.nlm.nih.gov/27494844', 'pmcid': 'https://www.ncbi.nlm.nih.gov/pmc/articles/5342335'}, 'language': 'en', 'primary_location': {'is_oa': True, 'landing_page_url': 'https://doi.org/10.18632/oncotarget.11027', 'pdf_url': 'http://www.oncotarget.com/index.php?journal=oncotarget&page=article&op=download&path%5B%5D=11027&path%5B%5D=34922', 'source': {'id': 'https://openalex.org/S126644158', 'display_name': 'Oncotarget', 'issn_l': '1949-2553', 'issn': ['1949-2553'], 'is_oa': True, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310316297', 'host_organization_name': 'Impact Journals LLC', 'host_organization_lineage': ['https://openalex.org/P4310316297'], 'host_organization_lineage_names': ['Impact Journals LLC'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, 'type': 'article', 'type_crossref': 'journal-article', 'indexed_in': ['crossref', 'pubmed'], 'open_access': {'is_oa': True, 'oa_status': 'gold', 'oa_url': 'http://www.oncotarget.com/index.php?journal=oncotarget&page=article&op=download&path%5B%5D=11027&path%5B%5D=34922', 'any_repository_has_fulltext': True}, 'authorships': [{'author_position': 'first', 'author': {'id': 'https://openalex.org/A5102997773', 'display_name': 'Pin‐Hsuan Lin', 'orcid': 'https://orcid.org/0000-0002-5899-6686'}, 'institutions': [{'id': 'https://openalex.org/I4210108002', 'display_name': 'Min-Hwei College of Health Care Management', 'ror': 'https://ror.org/0109nma88', 'country_code': 'TW', 'type': 'education', 'lineage': ['https://openalex.org/I4210108002']}], 'countries': ['TW'], 'is_corresponding': False, 'raw_author_name': 'Pin-Hsuan Lin', 'raw_affiliation_strings': ['Department of Health and Beauty, Shu-Zen College of Medicine and Management, Kaohsiung, Taiwan'], 'affiliations': [{'raw_affiliation_string': 'Department of Health and Beauty, Shu-Zen College of Medicine and Management, Kaohsiung, Taiwan', 'institution_ids': ['https://openalex.org/I4210108002']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5059032985', 'display_name': 'Shih‐Jen Tsai', 'orcid': 'https://orcid.org/0000-0002-9987-022X'}, 'institutions': [{'id': 'https://openalex.org/I2803004286', 'display_name': 'Taipei Veterans General Hospital', 'ror': 'https://ror.org/03ymy8z76', 'country_code': 'TW', 'type': 'healthcare', 'lineage': ['https://openalex.org/I2803004286']}, {'id': 'https://openalex.org/I148366613', 'display_name': 'National Yang Ming Chiao Tung University', 'ror': 'https://ror.org/00se2k293', 'country_code': 'TW', 'type': 'education', 'lineage': ['https://openalex.org/I148366613']}], 'countries': ['TW'], 'is_corresponding': False, 'raw_author_name': 'Shih-Jen Tsai', 'raw_affiliation_strings': ['Psychiatric Department of Taipei Veterans General Hospital, Taipei, Taiwan', 'Psychiatric Division, School of Medicine, National Yang-Ming University, Taipei, Taiwan'], 'affiliations': [{'raw_affiliation_string': 'Psychiatric Department of Taipei Veterans General Hospital, Taipei, Taiwan', 'institution_ids': ['https://openalex.org/I2803004286']}, {'raw_affiliation_string': 'Psychiatric Division, School of Medicine, National Yang-Ming University, Taipei, Taiwan', 'institution_ids': ['https://openalex.org/I148366613']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5101873260', 'display_name': 'Chi‐Wei Huang', 'orcid': 'https://orcid.org/0000-0002-2868-3961'}, 'institutions': [{'id': 'https://openalex.org/I173093425', 'display_name': 'Chang Gung University', 'ror': 'https://ror.org/00d80zx46', 'country_code': 'TW', 'type': 'education', 'lineage': ['https://openalex.org/I173093425']}, {'id': 'https://openalex.org/I4210108002', 'display_name': 'Min-Hwei College of Health Care Management', 'ror': 'https://ror.org/0109nma88', 'country_code': 'TW', 'type': 'education', 'lineage': ['https://openalex.org/I4210108002']}, {'id': 'https://openalex.org/I4210093821', 'display_name': 'Kaohsiung Chang Gung Memorial Hospital', 'ror': 'https://ror.org/00k194y12', 'country_code': 'TW', 'type': 'healthcare', 'lineage': ['https://openalex.org/I4210093821']}], 'countries': ['TW'], 'is_corresponding': False, 'raw_author_name': 'Chi-Wei Huang', 'raw_affiliation_strings': ['Department of Health and Beauty, Shu-Zen College of Medicine and Management, Kaohsiung, Taiwan', 'Department of Neurology, Cognition and Aging Center, Kaohsiung Chang Gung Memorial Hospital, Chang Gung University College of Medicine, Kaohsiung, Taiwan'], 'affiliations': [{'raw_affiliation_string': 'Department of Neurology, Cognition and Aging Center, Kaohsiung Chang Gung Memorial Hospital, Chang Gung University College of Medicine, Kaohsiung, Taiwan', 'institution_ids': ['https://openalex.org/I173093425', 'https://openalex.org/I4210093821']}, {'raw_affiliation_string': 'Department of Health and Beauty, Shu-Zen College of Medicine and Management, Kaohsiung, Taiwan', 'institution_ids': ['https://openalex.org/I4210108002']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5109330488', 'display_name': 'Mu‐En Liu', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I148366613', 'display_name': 'National Yang Ming Chiao Tung University', 'ror': 'https://ror.org/00se2k293', 'country_code': 'TW', 'type': 'education', 'lineage': ['https://openalex.org/I148366613']}], 'countries': ['TW'], 'is_corresponding': False, 'raw_author_name': 'Liu Mu-En', 'raw_affiliation_strings': ['Psychiatric Division, School of Medicine, National Yang-Ming University, Taipei, Taiwan'], 'affiliations': [{'raw_affiliation_string': 'Psychiatric Division, School of Medicine, National Yang-Ming University, Taipei, Taiwan', 'institution_ids': ['https://openalex.org/I148366613']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5101453486', 'display_name': 'Shih‐Wei Hsu', 'orcid': 'https://orcid.org/0000-0002-3564-1524'}, 'institutions': [{'id': 'https://openalex.org/I4210093821', 'display_name': 'Kaohsiung Chang Gung Memorial Hospital', 'ror': 'https://ror.org/00k194y12', 'country_code': 'TW', 'type': 'healthcare', 'lineage': ['https://openalex.org/I4210093821']}, {'id': 'https://openalex.org/I173093425', 'display_name': 'Chang Gung University', 'ror': 'https://ror.org/00d80zx46', 'country_code': 'TW', 'type': 'education', 'lineage': ['https://openalex.org/I173093425']}], 'countries': ['TW'], 'is_corresponding': False, 'raw_author_name': 'Shih-Wei Hsu', 'raw_affiliation_strings': ['Department of Radiology, Kaohsiung Chang Gung Memorial Hospital, Chang Gung University College of Medicine, Kaohsiung, Taiwan'], 'affiliations': [{'raw_affiliation_string': 'Department of Radiology, Kaohsiung Chang Gung Memorial Hospital, Chang Gung University College of Medicine, Kaohsiung, Taiwan', 'institution_ids': ['https://openalex.org/I4210093821', 'https://openalex.org/I173093425']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5062303723', 'display_name': 'Chen‐Chang Lee', 'orcid': 'https://orcid.org/0000-0002-8677-9806'}, 'institutions': [{'id': 'https://openalex.org/I4210093821', 'display_name': 'Kaohsiung Chang Gung Memorial Hospital', 'ror': 'https://ror.org/00k194y12', 'country_code': 'TW', 'type': 'healthcare', 'lineage': ['https://openalex.org/I4210093821']}, {'id': 'https://openalex.org/I173093425', 'display_name': 'Chang Gung University', 'ror': 'https://ror.org/00d80zx46', 'country_code': 'TW', 'type': 'education', 'lineage': ['https://openalex.org/I173093425']}], 'countries': ['TW'], 'is_corresponding': False, 'raw_author_name': 'Chen-Chang Lee', 'raw_affiliation_strings': ['Department of Radiology, Kaohsiung Chang Gung Memorial Hospital, Chang Gung University College of Medicine, Kaohsiung, Taiwan'], 'affiliations': [{'raw_affiliation_string': 'Department of Radiology, Kaohsiung Chang Gung Memorial Hospital, Chang Gung University College of Medicine, Kaohsiung, Taiwan', 'institution_ids': ['https://openalex.org/I4210093821', 'https://openalex.org/I173093425']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5005305648', 'display_name': 'Nai-Ching Chen', 'orcid': 'https://orcid.org/0000-0003-2684-0377'}, 'institutions': [{'id': 'https://openalex.org/I4210108002', 'display_name': 'Min-Hwei College of Health Care Management', 'ror': 'https://ror.org/0109nma88', 'country_code': 'TW', 'type': 'education', 'lineage': ['https://openalex.org/I4210108002']}, {'id': 'https://openalex.org/I4210093821', 'display_name': 'Kaohsiung Chang Gung Memorial Hospital', 'ror': 'https://ror.org/00k194y12', 'country_code': 'TW', 'type': 'healthcare', 'lineage': ['https://openalex.org/I4210093821']}, {'id': 'https://openalex.org/I173093425', 'display_name': 'Chang Gung University', 'ror': 'https://ror.org/00d80zx46', 'country_code': 'TW', 'type': 'education', 'lineage': ['https://openalex.org/I173093425']}], 'countries': ['TW'], 'is_corresponding': False, 'raw_author_name': 'Nai-Ching Chen', 'raw_affiliation_strings': ['Department of Health and Beauty, Shu-Zen College of Medicine and Management, Kaohsiung, Taiwan', 'Department of Neurology, Cognition and Aging Center, Kaohsiung Chang Gung Memorial Hospital, Chang Gung University College of Medicine, Kaohsiung, Taiwan'], 'affiliations': [{'raw_affiliation_string': 'Department of Health and Beauty, Shu-Zen College of Medicine and Management, Kaohsiung, Taiwan', 'institution_ids': ['https://openalex.org/I4210108002']}, {'raw_affiliation_string': 'Department of Neurology, Cognition and Aging Center, Kaohsiung Chang Gung Memorial Hospital, Chang Gung University College of Medicine, Kaohsiung, Taiwan', 'institution_ids': ['https://openalex.org/I4210093821', 'https://openalex.org/I173093425']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5031943586', 'display_name': 'Ya‐Ting Chang', 'orcid': 'https://orcid.org/0000-0002-7560-7224'}, 'institutions': [{'id': 'https://openalex.org/I4210093821', 'display_name': 'Kaohsiung Chang Gung Memorial Hospital', 'ror': 'https://ror.org/00k194y12', 'country_code': 'TW', 'type': 'healthcare', 'lineage': ['https://openalex.org/I4210093821']}, {'id': 'https://openalex.org/I4210108002', 'display_name': 'Min-Hwei College of Health Care Management', 'ror': 'https://ror.org/0109nma88', 'country_code': 'TW', 'type': 'education', 'lineage': ['https://openalex.org/I4210108002']}, {'id': 'https://openalex.org/I173093425', 'display_name': 'Chang Gung University', 'ror': 'https://ror.org/00d80zx46', 'country_code': 'TW', 'type': 'education', 'lineage': ['https://openalex.org/I173093425']}], 'countries': ['TW'], 'is_corresponding': False, 'raw_author_name': 'Ya-Ting Chang', 'raw_affiliation_strings': ['Department of Health and Beauty, Shu-Zen College of Medicine and Management, Kaohsiung, Taiwan', 'Department of Neurology, Cognition and Aging Center, Kaohsiung Chang Gung Memorial Hospital, Chang Gung University College of Medicine, Kaohsiung, Taiwan'], 'affiliations': [{'raw_affiliation_string': 'Department of Neurology, Cognition and Aging Center, Kaohsiung Chang Gung Memorial Hospital, Chang Gung University College of Medicine, Kaohsiung, Taiwan', 'institution_ids': ['https://openalex.org/I4210093821', 'https://openalex.org/I173093425']}, {'raw_affiliation_string': 'Department of Health and Beauty, Shu-Zen College of Medicine and Management, Kaohsiung, Taiwan', 'institution_ids': ['https://openalex.org/I4210108002']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5018222984', 'display_name': 'Min‐Yu Lan', 'orcid': 'https://orcid.org/0000-0001-7361-8475'}, 'institutions': [{'id': 'https://openalex.org/I4210093821', 'display_name': 'Kaohsiung Chang Gung Memorial Hospital', 'ror': 'https://ror.org/00k194y12', 'country_code': 'TW', 'type': 'healthcare', 'lineage': ['https://openalex.org/I4210093821']}, {'id': 'https://openalex.org/I173093425', 'display_name': 'Chang Gung University', 'ror': 'https://ror.org/00d80zx46', 'country_code': 'TW', 'type': 'education', 'lineage': ['https://openalex.org/I173093425']}], 'countries': ['TW'], 'is_corresponding': False, 'raw_author_name': 'Min-Yu Lan', 'raw_affiliation_strings': ['Department of Neurology, Cognition and Aging Center, Kaohsiung Chang Gung Memorial Hospital, Chang Gung University College of Medicine, Kaohsiung, Taiwan'], 'affiliations': [{'raw_affiliation_string': 'Department of Neurology, Cognition and Aging Center, Kaohsiung Chang Gung Memorial Hospital, Chang Gung University College of Medicine, Kaohsiung, Taiwan', 'institution_ids': ['https://openalex.org/I4210093821', 'https://openalex.org/I173093425']}]}, {'author_position': 'last', 'author': {'id': 'https://openalex.org/A5101641244', 'display_name': 'Chiung-Chih Chang', 'orcid': 'https://orcid.org/0000-0002-0755-4714'}, 'institutions': [{'id': 'https://openalex.org/I4210093821', 'display_name': 'Kaohsiung Chang Gung Memorial Hospital', 'ror': 'https://ror.org/00k194y12', 'country_code': 'TW', 'type': 'healthcare', 'lineage': ['https://openalex.org/I4210093821']}, {'id': 'https://openalex.org/I173093425', 'display_name': 'Chang Gung University', 'ror': 'https://ror.org/00d80zx46', 'country_code': 'TW', 'type': 'education', 'lineage': ['https://openalex.org/I173093425']}], 'countries': ['TW'], 'is_corresponding': False, 'raw_author_name': 'Chiung-Chih Chang', 'raw_affiliation_strings': ['Department of Neurology, Cognition and Aging Center, Kaohsiung Chang Gung Memorial Hospital, Chang Gung University College of Medicine, Kaohsiung, Taiwan'], 'affiliations': [{'raw_affiliation_string': 'Department of Neurology, Cognition and Aging Center, Kaohsiung Chang Gung Memorial Hospital, Chang Gung University College of Medicine, Kaohsiung, Taiwan', 'institution_ids': ['https://openalex.org/I4210093821', 'https://openalex.org/I173093425']}]}], 'institution_assertions': [], 'countries_distinct_count': 1, 'institutions_distinct_count': 5, 'corresponding_author_ids': [], 'corresponding_institution_ids': [], 'apc_list': None, 'apc_paid': None, 'fwci': 1.472, 'has_fulltext': True, 'fulltext_origin': 'pdf', 'cited_by_count': 17, 'citation_normalized_percentile': {'value': 0.716706, 'is_in_top_1_percent': False, 'is_in_top_10_percent': False}, 'cited_by_percentile_year': {'min': 90, 'max': 91}, 'biblio': {'volume': '7', 'issue': '34', 'first_page': '54200', 'last_page': '54214'}, 'is_retracted': False, 'is_paratext': False, 'primary_topic': {'id': 'https://openalex.org/T10483', 'display_name': 'Nerve injury and regeneration', 'score': 0.9971, 'subfield': {'id': 'https://openalex.org/subfields/2804', 'display_name': 'Cellular and Molecular Neuroscience'}, 'field': {'id': 'https://openalex.org/fields/28', 'display_name': 'Neuroscience'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}, 'topics': [{'id': 'https://openalex.org/T10483', 'display_name': 'Nerve injury and regeneration', 'score': 0.9971, 'subfield': {'id': 'https://openalex.org/subfields/2804', 'display_name': 'Cellular and Molecular Neuroscience'}, 'field': {'id': 'https://openalex.org/fields/28', 'display_name': 'Neuroscience'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}, {'id': 'https://openalex.org/T10608', 'display_name': 'Neurogenesis and neuroplasticity mechanisms', 'score': 0.9902, 'subfield': {'id': 'https://openalex.org/subfields/2806', 'display_name': 'Developmental Neuroscience'}, 'field': {'id': 'https://openalex.org/fields/28', 'display_name': 'Neuroscience'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}, {'id': 'https://openalex.org/T10086', 'display_name': "Alzheimer's disease research and treatments", 'score': 0.99, 'subfield': {'id': 'https://openalex.org/subfields/2737', 'display_name': 'Physiology'}, 'field': {'id': 'https://openalex.org/fields/27', 'display_name': 'Medicine'}, 'domain': {'id': 'https://openalex.org/domains/4', 'display_name': 'Health Sciences'}}], 'keywords': [{'id': 'https://openalex.org/keywords/neurocognitive', 'display_name': 'Neurocognitive', 'score': 0.5405942}, {'id': 'https://openalex.org/keywords/rs6265', 'display_name': 'rs6265', 'score': 0.5290935}], 'concepts': [{'id': 'https://openalex.org/C71924100', 'wikidata': 'https://www.wikidata.org/wiki/Q11190', 'display_name': 'Medicine', 'level': 0, 'score': 0.62799156}, {'id': 'https://openalex.org/C172467417', 'wikidata': 'https://www.wikidata.org/wiki/Q1670397', 'display_name': 'Neurocognitive', 'level': 3, 'score': 0.5405942}, {'id': 'https://openalex.org/C2778163459', 'wikidata': 'https://www.wikidata.org/wiki/Q7375573', 'display_name': 'rs6265', 'level': 5, 'score': 0.5290935}, {'id': 'https://openalex.org/C2778790584', 'wikidata': 'https://www.wikidata.org/wiki/Q123045', 'display_name': 'Brain-derived neurotrophic factor', 'level': 4, 'score': 0.49884224}, {'id': 'https://openalex.org/C141516989', 'wikidata': 'https://www.wikidata.org/wiki/Q1182555', 'display_name': 'Default mode network', 'level': 3, 'score': 0.49036765}, {'id': 'https://openalex.org/C16568411', 'wikidata': 'https://www.wikidata.org/wiki/Q83042', 'display_name': 'Neurology', 'level': 2, 'score': 0.45726383}, {'id': 'https://openalex.org/C126322002', 'wikidata': 'https://www.wikidata.org/wiki/Q11180', 'display_name': 'Internal medicine', 'level': 1, 'score': 0.4558415}, {'id': 'https://openalex.org/C143998085', 'wikidata': 'https://www.wikidata.org/wiki/Q162555', 'display_name': 'Oncology', 'level': 1, 'score': 0.4461108}, {'id': 'https://openalex.org/C2779134260', 'wikidata': 'https://www.wikidata.org/wiki/Q12136', 'display_name': 'Disease', 'level': 2, 'score': 0.41606036}, {'id': 'https://openalex.org/C118552586', 'wikidata': 'https://www.wikidata.org/wiki/Q7867', 'display_name': 'Psychiatry', 'level': 1, 'score': 0.33244097}, {'id': 'https://openalex.org/C160539049', 'wikidata': 'https://www.wikidata.org/wiki/Q3064187', 'display_name': 'Neurotrophic factors', 'level': 3, 'score': 0.32756054}, {'id': 'https://openalex.org/C169900460', 'wikidata': 'https://www.wikidata.org/wiki/Q2200417', 'display_name': 'Cognition', 'level': 2, 'score': 0.275024}, {'id': 'https://openalex.org/C170493617', 'wikidata': 'https://www.wikidata.org/wiki/Q208467', 'display_name': 'Receptor', 'level': 2, 'score': 0.0}], 'mesh': [{'descriptor_ui': 'D000544', 'descriptor_name': 'Alzheimer Disease', 'qualifier_ui': 'Q000235', 'qualifier_name': 'genetics', 'is_major_topic': True}, {'descriptor_ui': 'D019208', 'descriptor_name': 'Brain-Derived Neurotrophic Factor', 'qualifier_ui': 'Q000235', 'qualifier_name': 'genetics', 'is_major_topic': True}, {'descriptor_ui': 'D011110', 'descriptor_name': 'Polymorphism, Genetic', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': True}, {'descriptor_ui': 'D000368', 'descriptor_name': 'Aged', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D000369', 'descriptor_name': 'Aged, 80 and over', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D000544', 'descriptor_name': 'Alzheimer Disease', 'qualifier_ui': 'Q000000981', 'qualifier_name': 'diagnostic imaging', 'is_major_topic': False}, {'descriptor_ui': 'D000544', 'descriptor_name': 'Alzheimer Disease', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D019208', 'descriptor_name': 'Brain-Derived Neurotrophic Factor', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D003071', 'descriptor_name': 'Cognition', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D018728', 'descriptor_name': 'Entorhinal Cortex', 'qualifier_ui': 'Q000000981', 'qualifier_name': 'diagnostic imaging', 'is_major_topic': False}, {'descriptor_ui': 'D018728', 'descriptor_name': 'Entorhinal Cortex', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D005260', 'descriptor_name': 'Female', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D005838', 'descriptor_name': 'Genotype', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D006801', 'descriptor_name': 'Humans', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D008279', 'descriptor_name': 'Magnetic Resonance Imaging', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D008297', 'descriptor_name': 'Male', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D008875', 'descriptor_name': 'Middle Aged', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D013702', 'descriptor_name': 'Temporal Lobe', 'qualifier_ui': 'Q000000981', 'qualifier_name': 'diagnostic imaging', 'is_major_topic': False}, {'descriptor_ui': 'D013702', 'descriptor_name': 'Temporal Lobe', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}], 'locations_count': 4, 'locations': [{'is_oa': True, 'landing_page_url': 'https://doi.org/10.18632/oncotarget.11027', 'pdf_url': 'http://www.oncotarget.com/index.php?journal=oncotarget&page=article&op=download&path%5B%5D=11027&path%5B%5D=34922', 'source': {'id': 'https://openalex.org/S126644158', 'display_name': 'Oncotarget', 'issn_l': '1949-2553', 'issn': ['1949-2553'], 'is_oa': True, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310316297', 'host_organization_name': 'Impact Journals LLC', 'host_organization_lineage': ['https://openalex.org/P4310316297'], 'host_organization_lineage_names': ['Impact Journals LLC'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, {'is_oa': True, 'landing_page_url': 'https://europepmc.org/articles/pmc5342335', 'pdf_url': 'https://europepmc.org/articles/pmc5342335?pdf=render', 'source': {'id': 'https://openalex.org/S4306400806', 'display_name': 'Europe PMC (PubMed Central)', 'issn_l': None, 'issn': None, 'is_oa': True, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1303153112', 'host_organization_name': 'European Bioinformatics Institute', 'host_organization_lineage': ['https://openalex.org/I1303153112'], 'host_organization_lineage_names': ['European Bioinformatics Institute'], 'type': 'repository'}, 'license': 'cc-by', 'license_id': 'https://openalex.org/licenses/cc-by', 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, {'is_oa': True, 'landing_page_url': 'https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5342335', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S2764455111', 'display_name': 'PubMed Central', 'issn_l': None, 'issn': None, 'is_oa': True, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1299303238', 'host_organization_name': 'National Institutes of Health', 'host_organization_lineage': ['https://openalex.org/I1299303238'], 'host_organization_lineage_names': ['National Institutes of Health'], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, {'is_oa': False, 'landing_page_url': 'https://pubmed.ncbi.nlm.nih.gov/27494844', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S4306525036', 'display_name': 'PubMed', 'issn_l': None, 'issn': None, 'is_oa': False, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1299303238', 'host_organization_name': 'National Institutes of Health', 'host_organization_lineage': ['https://openalex.org/I1299303238'], 'host_organization_lineage_names': ['National Institutes of Health'], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}], 'best_oa_location': {'is_oa': True, 'landing_page_url': 'https://doi.org/10.18632/oncotarget.11027', 'pdf_url': 'http://www.oncotarget.com/index.php?journal=oncotarget&page=article&op=download&path%5B%5D=11027&path%5B%5D=34922', 'source': {'id': 'https://openalex.org/S126644158', 'display_name': 'Oncotarget', 'issn_l': '1949-2553', 'issn': ['1949-2553'], 'is_oa': True, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310316297', 'host_organization_name': 'Impact Journals LLC', 'host_organization_lineage': ['https://openalex.org/P4310316297'], 'host_organization_lineage_names': ['Impact Journals LLC'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, 'sustainable_development_goals': [], 'grants': [], 'datasets': [], 'versions': [], 'referenced_works_count': 82, 'referenced_works': ['https://openalex.org/W1530376957', 'https://openalex.org/W1798009377', 'https://openalex.org/W1847168837', 'https://openalex.org/W1855610705', 'https://openalex.org/W1969976272', 'https://openalex.org/W1971964170', 'https://openalex.org/W1975425686', 'https://openalex.org/W1985945455', 'https://openalex.org/W1989535495', 'https://openalex.org/W1990383598', 'https://openalex.org/W1991771535', 'https://openalex.org/W1991952617', 'https://openalex.org/W1994239403', 'https://openalex.org/W1995569163', 'https://openalex.org/W1998046507', 'https://openalex.org/W2000209446', 'https://openalex.org/W2003982930', 'https://openalex.org/W2008854521', 'https://openalex.org/W2013373204', 'https://openalex.org/W2013924694', 'https://openalex.org/W2015262351', 'https://openalex.org/W2016843660', 'https://openalex.org/W2024684743', 'https://openalex.org/W2033333756', 'https://openalex.org/W2044993609', 'https://openalex.org/W2050042714', 'https://openalex.org/W2055186021', 'https://openalex.org/W2058161128', 'https://openalex.org/W2058198040', 'https://openalex.org/W2061196406', 'https://openalex.org/W2069791716', 'https://openalex.org/W2070194921', 'https://openalex.org/W2073644964', 'https://openalex.org/W2077816250', 'https://openalex.org/W2086135754', 'https://openalex.org/W2088351746', 'https://openalex.org/W2094544368', 'https://openalex.org/W2095444577', 'https://openalex.org/W2095847997', 'https://openalex.org/W2099280287', 'https://openalex.org/W2102101813', 'https://openalex.org/W2102569655', 'https://openalex.org/W2104419734', 'https://openalex.org/W2106396500', 'https://openalex.org/W2107001888', 'https://openalex.org/W2109037871', 'https://openalex.org/W2109480636', 'https://openalex.org/W2116584334', 'https://openalex.org/W2116658855', 'https://openalex.org/W2116698967', 'https://openalex.org/W2117785682', 'https://openalex.org/W2117830068', 'https://openalex.org/W2119062449', 'https://openalex.org/W2119848633', 'https://openalex.org/W2129705910', 'https://openalex.org/W2130417276', 'https://openalex.org/W2131221732', 'https://openalex.org/W2134699043', 'https://openalex.org/W2135959376', 'https://openalex.org/W2137526583', 'https://openalex.org/W2139407404', 'https://openalex.org/W2139565721', 'https://openalex.org/W2139967204', 'https://openalex.org/W2140483640', 'https://openalex.org/W2141218863', 'https://openalex.org/W2143285014', 'https://openalex.org/W2143748581', 'https://openalex.org/W2145977758', 'https://openalex.org/W2148080316', 'https://openalex.org/W2151575571', 'https://openalex.org/W2153171432', 'https://openalex.org/W2157110881', 'https://openalex.org/W2158771218', 'https://openalex.org/W2161039995', 'https://openalex.org/W2165942026', 'https://openalex.org/W2167311298', 'https://openalex.org/W2167437140', 'https://openalex.org/W2214005381', 'https://openalex.org/W2218040246', 'https://openalex.org/W2313478468', 'https://openalex.org/W2315045833', 'https://openalex.org/W2603308917'], 'related_works': ['https://openalex.org/W4284968254', 'https://openalex.org/W3093904391', 'https://openalex.org/W2915044328', 'https://openalex.org/W2788661288', 'https://openalex.org/W2732386051', 'https://openalex.org/W2226388873', 'https://openalex.org/W2055656288', 'https://openalex.org/W2052769790', 'https://openalex.org/W2043249788', 'https://openalex.org/W2008064637'], 'abstract_inverted_index': {'//': [0, 118], 'Pin-Hsuan': [1], 'Lin': [2], '1': [3, 40], ',': [4, 8, 12, 16, 20, 24, 28, 32], 'Shih-Jen': [5], 'Tsai': [6], '2,3': [7], 'Chi-Wei': [9], 'Huang': [10], '1,5': [11, 27, 31], 'Liu': [13], 'Mu-En': [14], '3': [15, 64], 'Shih-Wei': [17], 'Hsu': [18], '4': [19, 23, 75], 'Chen-Chang': [21], 'Lee': [22], 'Nai-Ching': [25], 'Chen': [26], 'Ya-Ting': [29], 'Chang': [30, 38, 80, 84, 101, 105], 'Min-Yu': [33], 'Lan': [34], '5': [35, 39, 92], 'and': [36, 44, 50, 97, 168, 184, 204, 235, 293, 314], 'Chiung-Chih': [37, 115], 'Department': [41, 56, 76, 93], 'of': [42, 48, 57, 68, 77, 88, 94, 109, 262, 273], 'Health': [43], 'Beauty,': [45], 'Shu-Zen': [46], 'College': [47, 87, 108], 'Medicine': [49], 'Management,': [51], 'Kaohsiung,': [52, 90, 111], 'Taiwan': [53, 63, 74, 91, 112], '2': [54], 'Psychiatric': [55, 65], 'Taipei': [58], 'Veterans': [59], 'General': [60], 'Hospital,': [61, 83, 104], 'Taipei,': [62, 73], 'Division,': [66], 'School': [67], 'Medicine,': [69, 89, 110], 'National': [70], 'Yang-Ming': [71], 'University,': [72], 'Radiology,': [78], 'Kaohsiung': [79, 100], 'Gung': [81, 85, 102, 106], 'Memorial': [82, 103], 'University': [86, 107], 'Neurology,': [95], 'Cognition': [96], 'Aging': [98], 'Center,': [99], 'Correspondence': [113], 'to:': [114], 'Chang,': [116], 'email:': [117], 'Keywords': [119], ':': [120, 137, 142, 147], "Alzheimer's": [121, 193], 'disease,': [122], 'genetic': [123], 'dosage': [124], 'effect,': [125], 'anatomical': [126], 'structural': [127, 210, 322], 'covariance,': [128], 'default': [129, 263], 'mode': [130, 264], 'network,': [131], 'brain-derived': [132, 154], 'neurotrophic': [133, 155], 'factor,': [134], 'Gerotarget': [135], 'Received': [136], 'June': [138], '10,': [139], '2016': [140, 145, 150], 'Accepted': [141], 'July': [143], '22,': [144], 'Published': [146], 'August': [148], '02,': [149], 'Abstract': [151], 'In': [152, 187], 'humans,': [153], 'factor': [156], '(BDNF)': [157], 'has': [158], 'been': [159], 'shown': [160], 'to': [161, 222], 'play': [162], 'a': [163, 172], 'pivotal': [164], 'role': [165], 'in': [166, 181, 297], 'neurocognition,': [167], 'its': [169], 'gene': [170], 'contains': [171], 'functional': [173], 'polymorphism': [174], '(Val66Met)': [175], 'that': [176, 306, 325], 'may': [177], 'explain': [178], 'individual': [179], 'differences': [180], 'brain': [182], 'volume': [183], 'memory-related': [185], 'activity.': [186], 'this': [188], 'study,': [189], 'we': [190], 'enrolled': [191], '186': [192], 'disease': [194], '(AD)': [195], 'patients': [196, 215], 'who': [197], 'underwent': [198], '3D': [199], 'T1': [200], 'magnetic': [201], 'resonance': [202], 'imaging,': [203], 'explored': [205], 'the': [206, 254, 275, 289, 298, 304, 315, 327], 'gray': [207], 'matter': [208], '(GM)': [209], 'covariance': [211, 323], 'networks': [212], '(SCN).': [213], 'The': [214], 'were': [216, 284], 'divided': [217], 'into': [218], 'three': [219], 'groups': [220], 'according': [221], 'their': [223], 'genotype:': [224], 'Met/Met': [225], '(': [226, 231, 237], 'n': [227, 232, 238], '=': [228, 233, 239], '45),': [229], 'Val/Met': [230], '86)': [234], 'Val/Val': [236], '55).': [240], 'Seed-based': [241], 'analysis': [242], 'was': [243, 318], 'performed': [244], 'focusing': [245], 'on': [246], 'four': [247], 'SCN': [248], 'networks.': [249], 'Neurobehavioral': [250], 'scores': [251, 292], 'served': [252], 'as': [253], 'major': [255], 'outcome': [256], 'factor.': [257], 'Only': [258], 'peak': [259, 277], 'cluster': [260], 'volumes': [261], 'medial': [265], 'temporal': [266], 'lobe': [267], 'network': [268], 'showed': [269, 279], 'significant': [270, 286], 'genotype': [271, 281], 'interactions,': [272], 'which': [274], 'interconnected': [276], 'clusters': [278, 313], 'dose-dependent': [280], 'effects.': [282], 'There': [283], 'also': [285], 'correlations': [287], 'between': [288], 'cognitive': [290, 328], 'test': [291], 'interconnected-cluster': [294], 'volumes,': [295], 'especially': [296], 'orbitofrontal': [299], 'cortex.': [300], 'These': [301], 'findings': [302], 'support': [303], 'hypothesis': [305], 'BDNF': [307], 'rs6265': [308], 'polymorphisms': [309], 'modulate': [310], 'entorhinal': [311], 'cortex-interconnected': [312], 'valine': [316], 'allele': [317], 'associated': [319], 'with': [320], 'stronger': [321], 'patterns': [324], 'determined': [326], 'outcomes.': [329]}, 'cited_by_api_url': 'https://api.openalex.org/works?filter=cites:W2476210219', 'counts_by_year': [{'year': 2024, 'cited_by_count': 1}, {'year': 2023, 'cited_by_count': 1}, {'year': 2022, 'cited_by_count': 2}, {'year': 2020, 'cited_by_count': 2}, {'year': 2019, 'cited_by_count': 2}, {'year': 2018, 'cited_by_count': 6}, {'year': 2017, 'cited_by_count': 3}], 'updated_date': '2024-12-08T05:50:13.397436', 'created_date': '2016-08-23'}