Get quick answers to your questions about the article from our AI researcher chatbot
{'id': 'https://openalex.org/W2475853404', 'doi': 'https://doi.org/10.1155/2016/8797206', 'title': 'HDAC Inhibitors as Epigenetic Regulators of the Immune System: Impacts on Cancer Therapy and Inflammatory Diseases', 'display_name': 'HDAC Inhibitors as Epigenetic Regulators of the Immune System: Impacts on Cancer Therapy and Inflammatory Diseases', 'publication_year': 2016, 'publication_date': '2016-01-01', 'ids': {'openalex': 'https://openalex.org/W2475853404', 'doi': 'https://doi.org/10.1155/2016/8797206', 'mag': '2475853404', 'pmid': 'https://pubmed.ncbi.nlm.nih.gov/27556043', 'pmcid': 'https://www.ncbi.nlm.nih.gov/pmc/articles/4983322'}, 'language': 'en', 'primary_location': {'is_oa': True, 'landing_page_url': 'https://doi.org/10.1155/2016/8797206', 'pdf_url': 'http://downloads.hindawi.com/journals/bmri/2016/8797206.pdf', 'source': {'id': 'https://openalex.org/S1010394304', 'display_name': 'BioMed Research International', 'issn_l': '2314-6133', 'issn': ['2314-6133', '2314-6141'], 'is_oa': True, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310319869', 'host_organization_name': 'Hindawi Publishing Corporation', 'host_organization_lineage': ['https://openalex.org/P4310319869'], 'host_organization_lineage_names': ['Hindawi Publishing Corporation'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, 'type': 'review', 'type_crossref': 'journal-article', 'indexed_in': ['crossref', 'pubmed'], 'open_access': {'is_oa': True, 'oa_status': 'gold', 'oa_url': 'http://downloads.hindawi.com/journals/bmri/2016/8797206.pdf', 'any_repository_has_fulltext': True}, 'authorships': [{'author_position': 'first', 'author': {'id': 'https://openalex.org/A5061463610', 'display_name': 'Elizabeth Hull', 'orcid': 'https://orcid.org/0000-0001-6100-9605'}, 'institutions': [{'id': 'https://openalex.org/I128902783', 'display_name': 'Midwestern University', 'ror': 'https://ror.org/046yatd98', 'country_code': 'US', 'type': 'education', 'lineage': ['https://openalex.org/I128902783']}], 'countries': ['US'], 'is_corresponding': True, 'raw_author_name': 'Elizabeth E. Hull', 'raw_affiliation_strings': ['Biomedical Sciences Program, Midwestern University, 19555 N 59th Avenue, Glendale, AZ 85308, USA'], 'affiliations': [{'raw_affiliation_string': 'Biomedical Sciences Program, Midwestern University, 19555 N 59th Avenue, Glendale, AZ 85308, USA', 'institution_ids': ['https://openalex.org/I128902783']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5035901881', 'display_name': 'McKale R. Montgomery', 'orcid': 'https://orcid.org/0000-0001-5318-6687'}, 'institutions': [{'id': 'https://openalex.org/I128902783', 'display_name': 'Midwestern University', 'ror': 'https://ror.org/046yatd98', 'country_code': 'US', 'type': 'education', 'lineage': ['https://openalex.org/I128902783']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'McKale R. Montgomery', 'raw_affiliation_strings': ['Biomedical Sciences Program, Midwestern University, 19555 N 59th Avenue, Glendale, AZ 85308, USA'], 'affiliations': [{'raw_affiliation_string': 'Biomedical Sciences Program, Midwestern University, 19555 N 59th Avenue, Glendale, AZ 85308, USA', 'institution_ids': ['https://openalex.org/I128902783']}]}, {'author_position': 'last', 'author': {'id': 'https://openalex.org/A5024726928', 'display_name': 'Kathryn J. Leyva', 'orcid': 'https://orcid.org/0000-0001-5093-6315'}, 'institutions': [{'id': 'https://openalex.org/I128902783', 'display_name': 'Midwestern University', 'ror': 'https://ror.org/046yatd98', 'country_code': 'US', 'type': 'education', 'lineage': ['https://openalex.org/I128902783']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'Kathryn J. Leyva', 'raw_affiliation_strings': ['Department of Microbiology & Immunology, Arizona College of Osteopathic Medicine, Midwestern University, 19555 N 59th Avenue, Glendale, AZ 85308, USA'], 'affiliations': [{'raw_affiliation_string': 'Department of Microbiology & Immunology, Arizona College of Osteopathic Medicine, Midwestern University, 19555 N 59th Avenue, Glendale, AZ 85308, USA', 'institution_ids': ['https://openalex.org/I128902783']}]}], 'institution_assertions': [], 'countries_distinct_count': 1, 'institutions_distinct_count': 1, 'corresponding_author_ids': ['https://openalex.org/A5061463610'], 'corresponding_institution_ids': ['https://openalex.org/I128902783'], 'apc_list': {'value': 2400, 'currency': 'USD', 'value_usd': 2400, 'provenance': 'doaj'}, 'apc_paid': {'value': 2400, 'currency': 'USD', 'value_usd': 2400, 'provenance': 'doaj'}, 'fwci': 2.446, 'has_fulltext': True, 'fulltext_origin': 'pdf', 'cited_by_count': 260, 'citation_normalized_percentile': {'value': 0.999737, 'is_in_top_1_percent': True, 'is_in_top_10_percent': True}, 'cited_by_percentile_year': {'min': 99, 'max': 100}, 'biblio': {'volume': '2016', 'issue': None, 'first_page': '1', 'last_page': '15'}, 'is_retracted': False, 'is_paratext': False, 'primary_topic': {'id': 'https://openalex.org/T11736', 'display_name': 'Histone Deacetylase Inhibitors Research', 'score': 1.0, 'subfield': {'id': 'https://openalex.org/subfields/1312', 'display_name': 'Molecular Biology'}, 'field': {'id': 'https://openalex.org/fields/13', 'display_name': 'Biochemistry, Genetics and Molecular Biology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}, 'topics': [{'id': 'https://openalex.org/T11736', 'display_name': 'Histone Deacetylase Inhibitors Research', 'score': 1.0, 'subfield': {'id': 'https://openalex.org/subfields/1312', 'display_name': 'Molecular Biology'}, 'field': {'id': 'https://openalex.org/fields/13', 'display_name': 'Biochemistry, Genetics and Molecular Biology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}, {'id': 'https://openalex.org/T12534', 'display_name': 'Protein Degradation and Inhibitors', 'score': 0.9935, 'subfield': {'id': 'https://openalex.org/subfields/1312', 'display_name': 'Molecular Biology'}, 'field': {'id': 'https://openalex.org/fields/13', 'display_name': 'Biochemistry, Genetics and Molecular Biology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}, {'id': 'https://openalex.org/T12505', 'display_name': 'Peptidase Inhibition and Analysis', 'score': 0.9802, 'subfield': {'id': 'https://openalex.org/subfields/2730', 'display_name': 'Oncology'}, 'field': {'id': 'https://openalex.org/fields/27', 'display_name': 'Medicine'}, 'domain': {'id': 'https://openalex.org/domains/4', 'display_name': 'Health Sciences'}}], 'keywords': [], 'concepts': [{'id': 'https://openalex.org/C2778305200', 'wikidata': 'https://www.wikidata.org/wiki/Q174378', 'display_name': 'Histone deacetylase', 'level': 4, 'score': 0.7682996}, {'id': 'https://openalex.org/C41091548', 'wikidata': 'https://www.wikidata.org/wiki/Q26939', 'display_name': 'Epigenetics', 'level': 3, 'score': 0.7147365}, {'id': 'https://openalex.org/C8891405', 'wikidata': 'https://www.wikidata.org/wiki/Q1059', 'display_name': 'Immune system', 'level': 2, 'score': 0.65439534}, {'id': 'https://openalex.org/C86803240', 'wikidata': 'https://www.wikidata.org/wiki/Q420', 'display_name': 'Biology', 'level': 0, 'score': 0.5087462}, {'id': 'https://openalex.org/C121608353', 'wikidata': 'https://www.wikidata.org/wiki/Q12078', 'display_name': 'Cancer', 'level': 2, 'score': 0.46286994}, {'id': 'https://openalex.org/C502942594', 'wikidata': 'https://www.wikidata.org/wiki/Q3421914', 'display_name': 'Cancer research', 'level': 1, 'score': 0.44934803}, {'id': 'https://openalex.org/C64927066', 'wikidata': 'https://www.wikidata.org/wiki/Q36293', 'display_name': 'Histone', 'level': 3, 'score': 0.4108262}, {'id': 'https://openalex.org/C60644358', 'wikidata': 'https://www.wikidata.org/wiki/Q128570', 'display_name': 'Bioinformatics', 'level': 1, 'score': 0.3478462}, {'id': 'https://openalex.org/C98274493', 'wikidata': 'https://www.wikidata.org/wiki/Q128406', 'display_name': 'Pharmacology', 'level': 1, 'score': 0.33089167}, {'id': 'https://openalex.org/C203014093', 'wikidata': 'https://www.wikidata.org/wiki/Q101929', 'display_name': 'Immunology', 'level': 1, 'score': 0.29814145}, {'id': 'https://openalex.org/C104317684', 'wikidata': 'https://www.wikidata.org/wiki/Q7187', 'display_name': 'Gene', 'level': 2, 'score': 0.17146006}, {'id': 'https://openalex.org/C54355233', 'wikidata': 'https://www.wikidata.org/wiki/Q7162', 'display_name': 'Genetics', 'level': 1, 'score': 0.1028004}], 'mesh': [{'descriptor_ui': 'D044127', 'descriptor_name': 'Epigenesis, Genetic', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': True}, {'descriptor_ui': 'D056572', 'descriptor_name': 'Histone Deacetylase Inhibitors', 'qualifier_ui': 'Q000627', 'qualifier_name': 'therapeutic use', 'is_major_topic': True}, {'descriptor_ui': 'D007107', 'descriptor_name': 'Immune System', 'qualifier_ui': 'Q000187', 'qualifier_name': 'drug effects', 'is_major_topic': True}, {'descriptor_ui': 'D007249', 'descriptor_name': 'Inflammation', 'qualifier_ui': 'Q000188', 'qualifier_name': 'drug therapy', 'is_major_topic': True}, {'descriptor_ui': 'D007249', 'descriptor_name': 'Inflammation', 'qualifier_ui': 'Q000235', 'qualifier_name': 'genetics', 'is_major_topic': True}, {'descriptor_ui': 'D009369', 'descriptor_name': 'Neoplasms', 'qualifier_ui': 'Q000188', 'qualifier_name': 'drug therapy', 'is_major_topic': True}, {'descriptor_ui': 'D009369', 'descriptor_name': 'Neoplasms', 'qualifier_ui': 'Q000276', 'qualifier_name': 'immunology', 'is_major_topic': True}, {'descriptor_ui': 'D000818', 'descriptor_name': 'Animals', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D044127', 'descriptor_name': 'Epigenesis, Genetic', 'qualifier_ui': 'Q000187', 'qualifier_name': 'drug effects', 'is_major_topic': False}, {'descriptor_ui': 'D058685', 'descriptor_name': 'Genetic Pleiotropy', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D058685', 'descriptor_name': 'Genetic Pleiotropy', 'qualifier_ui': 'Q000187', 'qualifier_name': 'drug effects', 'is_major_topic': False}, {'descriptor_ui': 'D056572', 'descriptor_name': 'Histone Deacetylase Inhibitors', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D056572', 'descriptor_name': 'Histone Deacetylase Inhibitors', 'qualifier_ui': 'Q000494', 'qualifier_name': 'pharmacology', 'is_major_topic': False}, {'descriptor_ui': 'D006801', 'descriptor_name': 'Humans', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D007107', 'descriptor_name': 'Immune System', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D007249', 'descriptor_name': 'Inflammation', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D007249', 'descriptor_name': 'Inflammation', 'qualifier_ui': 'Q000276', 'qualifier_name': 'immunology', 'is_major_topic': False}, {'descriptor_ui': 'D009369', 'descriptor_name': 'Neoplasms', 'qualifier_ui': 'Q000235', 'qualifier_name': 'genetics', 'is_major_topic': False}, {'descriptor_ui': 'D009369', 'descriptor_name': 'Neoplasms', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}], 'locations_count': 4, 'locations': [{'is_oa': True, 'landing_page_url': 'https://doi.org/10.1155/2016/8797206', 'pdf_url': 'http://downloads.hindawi.com/journals/bmri/2016/8797206.pdf', 'source': {'id': 'https://openalex.org/S1010394304', 'display_name': 'BioMed Research International', 'issn_l': '2314-6133', 'issn': ['2314-6133', '2314-6141'], 'is_oa': True, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310319869', 'host_organization_name': 'Hindawi Publishing Corporation', 'host_organization_lineage': ['https://openalex.org/P4310319869'], 'host_organization_lineage_names': ['Hindawi Publishing Corporation'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, {'is_oa': True, 'landing_page_url': 'https://europepmc.org/articles/pmc4983322', 'pdf_url': 'https://europepmc.org/articles/pmc4983322?pdf=render', 'source': {'id': 'https://openalex.org/S4306400806', 'display_name': 'Europe PMC (PubMed Central)', 'issn_l': None, 'issn': None, 'is_oa': True, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1303153112', 'host_organization_name': 'European Bioinformatics Institute', 'host_organization_lineage': ['https://openalex.org/I1303153112'], 'host_organization_lineage_names': ['European Bioinformatics Institute'], 'type': 'repository'}, 'license': 'cc-by', 'license_id': 'https://openalex.org/licenses/cc-by', 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, {'is_oa': True, 'landing_page_url': 'https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4983322', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S2764455111', 'display_name': 'PubMed Central', 'issn_l': None, 'issn': None, 'is_oa': True, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1299303238', 'host_organization_name': 'National Institutes of Health', 'host_organization_lineage': ['https://openalex.org/I1299303238'], 'host_organization_lineage_names': ['National Institutes of Health'], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, {'is_oa': False, 'landing_page_url': 'https://pubmed.ncbi.nlm.nih.gov/27556043', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S4306525036', 'display_name': 'PubMed', 'issn_l': None, 'issn': None, 'is_oa': False, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1299303238', 'host_organization_name': 'National Institutes of Health', 'host_organization_lineage': ['https://openalex.org/I1299303238'], 'host_organization_lineage_names': ['National Institutes of Health'], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}], 'best_oa_location': {'is_oa': True, 'landing_page_url': 'https://doi.org/10.1155/2016/8797206', 'pdf_url': 'http://downloads.hindawi.com/journals/bmri/2016/8797206.pdf', 'source': {'id': 'https://openalex.org/S1010394304', 'display_name': 'BioMed Research International', 'issn_l': '2314-6133', 'issn': ['2314-6133', '2314-6141'], 'is_oa': True, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310319869', 'host_organization_name': 'Hindawi Publishing Corporation', 'host_organization_lineage': ['https://openalex.org/P4310319869'], 'host_organization_lineage_names': ['Hindawi Publishing Corporation'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, 'sustainable_development_goals': [{'score': 0.83, 'id': 'https://metadata.un.org/sdg/3', 'display_name': 'Good health and well-being'}], 'grants': [], 'datasets': [], 'versions': [], 'referenced_works_count': 146, 'referenced_works': ['https://openalex.org/W1491173757', 'https://openalex.org/W1519487278', 'https://openalex.org/W1527752038', 'https://openalex.org/W1563624749', 'https://openalex.org/W1626483287', 'https://openalex.org/W1704661134', 'https://openalex.org/W1846801745', 'https://openalex.org/W1876863496', 'https://openalex.org/W1950937581', 'https://openalex.org/W1965294807', 'https://openalex.org/W1967375848', 'https://openalex.org/W1968348056', 'https://openalex.org/W1968972540', 'https://openalex.org/W1970796511', 'https://openalex.org/W1973721788', 'https://openalex.org/W1975692560', 'https://openalex.org/W1977090021', 'https://openalex.org/W1979610433', 'https://openalex.org/W1981301540', 'https://openalex.org/W1984152709', 'https://openalex.org/W1985845937', 'https://openalex.org/W1988351397', 'https://openalex.org/W1995040570', 'https://openalex.org/W1995359023', 'https://openalex.org/W1998281597', 'https://openalex.org/W1998499089', 'https://openalex.org/W1998865079', 'https://openalex.org/W1999782534', 'https://openalex.org/W2001502548', 'https://openalex.org/W2002853429', 'https://openalex.org/W2003692193', 'https://openalex.org/W2006305989', 'https://openalex.org/W2007139310', 'https://openalex.org/W2009826707', 'https://openalex.org/W2010710786', 'https://openalex.org/W2011718960', 'https://openalex.org/W2015592509', 'https://openalex.org/W2018460886', 'https://openalex.org/W2021359605', 'https://openalex.org/W2023401613', 'https://openalex.org/W2027171343', 'https://openalex.org/W2029175848', 'https://openalex.org/W2031671750', 'https://openalex.org/W2032231721', 'https://openalex.org/W2032696829', 'https://openalex.org/W2033282334', 'https://openalex.org/W2038756571', 'https://openalex.org/W2042586741', 'https://openalex.org/W2044784487', 'https://openalex.org/W2046238383', 'https://openalex.org/W2046345187', 'https://openalex.org/W2049763628', 'https://openalex.org/W2049793199', 'https://openalex.org/W2050931169', 'https://openalex.org/W2051709854', 'https://openalex.org/W2054688665', 'https://openalex.org/W2057946453', 'https://openalex.org/W2059683587', 'https://openalex.org/W2064437293', 'https://openalex.org/W2067934742', 'https://openalex.org/W2068367061', 'https://openalex.org/W2068774036', 'https://openalex.org/W2069322435', 'https://openalex.org/W2069885647', 'https://openalex.org/W2071831973', 'https://openalex.org/W2072669480', 'https://openalex.org/W2072922851', 'https://openalex.org/W2073189570', 'https://openalex.org/W2073620078', 'https://openalex.org/W2077928578', 'https://openalex.org/W2078220845', 'https://openalex.org/W2079003739', 'https://openalex.org/W2079102916', 'https://openalex.org/W2080758856', 'https://openalex.org/W2082139701', 'https://openalex.org/W2083124842', 'https://openalex.org/W2088233020', 'https://openalex.org/W2088587086', 'https://openalex.org/W2091041925', 'https://openalex.org/W2092010700', 'https://openalex.org/W2092722802', 'https://openalex.org/W2093169744', 'https://openalex.org/W2097084183', 'https://openalex.org/W2101781631', 'https://openalex.org/W2102685625', 'https://openalex.org/W2102933118', 'https://openalex.org/W2103309832', 'https://openalex.org/W2106505027', 'https://openalex.org/W2108639843', 'https://openalex.org/W2110894784', 'https://openalex.org/W2112351720', 'https://openalex.org/W2112915315', 'https://openalex.org/W2113144329', 'https://openalex.org/W2113195478', 'https://openalex.org/W2113303160', 'https://openalex.org/W2113477304', 'https://openalex.org/W2114138025', 'https://openalex.org/W2114610169', 'https://openalex.org/W2115593774', 'https://openalex.org/W2119079421', 'https://openalex.org/W2121106136', 'https://openalex.org/W2126894693', 'https://openalex.org/W2129078547', 'https://openalex.org/W2130042720', 'https://openalex.org/W2132037667', 'https://openalex.org/W2135751738', 'https://openalex.org/W2139316343', 'https://openalex.org/W2139607151', 'https://openalex.org/W2140089594', 'https://openalex.org/W2140568796', 'https://openalex.org/W2141915880', 'https://openalex.org/W2144929276', 'https://openalex.org/W2145879583', 'https://openalex.org/W2147601959', 'https://openalex.org/W2148232503', 'https://openalex.org/W2149247636', 'https://openalex.org/W2149555430', 'https://openalex.org/W2151071075', 'https://openalex.org/W2151785974', 'https://openalex.org/W2151850046', 'https://openalex.org/W2153162429', 'https://openalex.org/W2156243556', 'https://openalex.org/W2157335263', 'https://openalex.org/W2158892282', 'https://openalex.org/W2161164355', 'https://openalex.org/W2162384900', 'https://openalex.org/W2167415368', 'https://openalex.org/W2168244648', 'https://openalex.org/W2168680690', 'https://openalex.org/W2200391720', 'https://openalex.org/W2200708130', 'https://openalex.org/W2234443850', 'https://openalex.org/W2236089950', 'https://openalex.org/W2263311874', 'https://openalex.org/W2266830368', 'https://openalex.org/W2271364972', 'https://openalex.org/W2273769037', 'https://openalex.org/W2276711051', 'https://openalex.org/W2295131371', 'https://openalex.org/W2394727679', 'https://openalex.org/W2395723336', 'https://openalex.org/W31775548', 'https://openalex.org/W4242388067', 'https://openalex.org/W4249469332', 'https://openalex.org/W4251379070', 'https://openalex.org/W996260659'], 'related_works': ['https://openalex.org/W4387875454', 'https://openalex.org/W4386476622', 'https://openalex.org/W4366603091', 'https://openalex.org/W3000356375', 'https://openalex.org/W2979314934', 'https://openalex.org/W2908166538', 'https://openalex.org/W2770084104', 'https://openalex.org/W2146527561', 'https://openalex.org/W2089484241', 'https://openalex.org/W1989395477'], 'abstract_inverted_index': {'Histone': [0], 'deacetylase': [1], '(HDAC)': [2], 'inhibitors': [3, 26, 116, 150, 160, 181], 'are': [4, 27, 43, 50, 102], 'powerful': [5], 'epigenetic': [6], 'regulators': [7], 'that': [8], 'have': [9, 14, 46, 75], 'enormous': [10], 'therapeutic': [11, 124, 187], 'potential': [12], 'and': [13, 20, 49, 84, 87, 91, 139, 142, 174], 'pleiotropic': [15], 'effects': [16, 97, 173, 178], 'at': [17, 81, 136], 'the': [18, 82, 96, 112, 119, 130, 137, 156, 163, 170], 'cellular': [19, 83, 138], 'systemic': [21, 85, 140], 'levels.': [22], 'To': [23], 'date,': [24], 'HDAC': [25, 64, 99, 115, 133, 149, 159, 180, 190], 'used': [28], 'clinically': [29], 'for': [30, 54, 145, 189], 'a': [31, 183], 'wide': [32], 'variety': [33], 'of': [34, 70, 98, 114, 132, 148, 158, 168, 179], 'disorders': [35], 'ranging': [36], 'from': [37], 'hematopoietic': [38], 'malignancies': [39], 'to': [40, 45, 60, 105, 117, 161], 'psychiatric': [41], 'disorders,': [42], 'known': [44], 'anti-inflammatory': [47], 'properties,': [48], 'in': [51, 89, 151], 'clinical': [52], 'trials': [53], 'several': [55], 'other': [56], 'diseases.': [57], 'In': [58], 'addition': [59], 'influencing': [61], 'gene': [62], 'expression,': [63], 'enzymes': [65], 'also': [66], 'function': [67], 'as': [68], 'part': [69], 'large,': [71], 'multisubunit': [72], 'complexes': [73], 'which': [74], 'many': [76], 'nonhistone': [77], 'targets,': [78], 'alter': [79], 'signaling': [80], 'levels,': [86], 'result': [88], 'divergent': [90], 'cell-type': [92], 'specific': [93], 'effects.': [94], 'Thus,': [95], 'inhibitor': [100, 134, 191], 'treatment': [101, 135], 'too': [103], 'intricate': [104], 'completely': [106], 'understand': [107], 'with': [108], 'current': [109], 'knowledge': [110], 'but': [111], 'ability': [113, 157], 'modulate': [118, 162], 'immune': [120, 164], 'system': [121], 'presents': [122], 'intriguing': [123], 'possibilities.': [125], 'This': [126], 'review': [127], 'will': [128], 'explore': [129], 'complexity': [131], 'levels': [141], 'suggest': [143], 'strategies': [144], 'effective': [146], 'use': [147], 'biomedical': [152], 'research,': [153], 'focusing': [154], 'on': [155], 'system.': [165], 'The': [166], 'possibility': [167], 'combining': [169], 'documented': [171], 'anticancer': [172], 'newly': [175], 'emerging': [176], 'immunomodulatory': [177], 'represents': [182], 'promising': [184], 'new': [185], 'combinatorial': [186], 'approach': [188], 'treatments.': [192]}, 'cited_by_api_url': 'https://api.openalex.org/works?filter=cites:W2475853404', 'counts_by_year': [{'year': 2024, 'cited_by_count': 24}, {'year': 2023, 'cited_by_count': 36}, {'year': 2022, 'cited_by_count': 34}, {'year': 2021, 'cited_by_count': 65}, {'year': 2020, 'cited_by_count': 33}, {'year': 2019, 'cited_by_count': 32}, {'year': 2018, 'cited_by_count': 22}, {'year': 2017, 'cited_by_count': 13}, {'year': 2016, 'cited_by_count': 1}], 'updated_date': '2025-01-11T16:53:47.783598', 'created_date': '2016-08-23'}