Title: Our Mothers’ Antibodies as Guardians of our Commensals
Abstract: Mucosal secretory IgA protects the mammalian body from invasion of commensal bacteria colonizing the intestine. A recent murine study in Cell shows that commensal-specific antibodies of the IgG isotype are also present in the serum and that maternal commensal-specific IgA and IgG are crucial for maintaining host–microbe mutualism in the offspring. Mucosal secretory IgA protects the mammalian body from invasion of commensal bacteria colonizing the intestine. A recent murine study in Cell shows that commensal-specific antibodies of the IgG isotype are also present in the serum and that maternal commensal-specific IgA and IgG are crucial for maintaining host–microbe mutualism in the offspring. Maternal IgG and IgA Antibodies Dampen Mucosal T Helper Cell Responses in Early LifeKoch et al.CellMay 05, 2016In BriefMaternally acquired, commensal-specific IgG antibodies coordinate with IgA to limit mucosal T cell responses and reinforce intestinal immunity in neonates. Full-Text PDF Open Archive
Publication Year: 2016
Publication Date: 2016-09-01
Language: en
Type: letter
Indexed In: ['crossref', 'pubmed']
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Cited By Count: 5
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