Publication Information

{'id': 'https://openalex.org/W2474881968', 'doi': 'https://doi.org/10.1111/bjh.14218', 'title': 'Ibrutinib penetrates the blood brain barrier and shows efficacy in the therapy of Bing Neel syndrome', 'display_name': 'Ibrutinib penetrates the blood brain barrier and shows efficacy in the therapy of Bing Neel syndrome', 'publication_year': 2016, 'publication_date': '2016-07-13', 'ids': {'openalex': 'https://openalex.org/W2474881968', 'doi': 'https://doi.org/10.1111/bjh.14218', 'mag': '2474881968', 'pmid': 'https://pubmed.ncbi.nlm.nih.gov/27409073'}, 'language': 'en', 'primary_location': {'is_oa': True, 'landing_page_url': 'https://doi.org/10.1111/bjh.14218', 'pdf_url': 'https://onlinelibrary.wiley.com/doi/pdfdirect/10.1111/bjh.14218', 'source': {'id': 'https://openalex.org/S153015021', 'display_name': 'British Journal of Haematology', 'issn_l': '0007-1048', 'issn': ['0007-1048', '1365-2141'], 'is_oa': False, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310320595', 'host_organization_name': 'Wiley', 'host_organization_lineage': ['https://openalex.org/P4310320595'], 'host_organization_lineage_names': ['Wiley'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, 'type': 'letter', 'type_crossref': 'journal-article', 'indexed_in': ['crossref', 'pubmed'], 'open_access': {'is_oa': True, 'oa_status': 'bronze', 'oa_url': 'https://onlinelibrary.wiley.com/doi/pdfdirect/10.1111/bjh.14218', 'any_repository_has_fulltext': False}, 'authorships': [{'author_position': 'first', 'author': {'id': 'https://openalex.org/A5103736974', 'display_name': 'Christopher Mason', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I1302444339', 'display_name': 'Northwell Health', 'ror': 'https://ror.org/02bxt4m23', 'country_code': 'US', 'type': 'healthcare', 'lineage': ['https://openalex.org/I1302444339']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'Christopher Mason', 'raw_affiliation_strings': ['Division of Hematology, Northwell Health Cancer Institute, Hofstra Northwell School of Medicine, Lake Success, NY, USA'], 'affiliations': [{'raw_affiliation_string': 'Division of Hematology, Northwell Health Cancer Institute, Hofstra Northwell School of Medicine, Lake Success, NY, USA', 'institution_ids': ['https://openalex.org/I1302444339']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5077073850', 'display_name': 'Steven Savona', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I1302444339', 'display_name': 'Northwell Health', 'ror': 'https://ror.org/02bxt4m23', 'country_code': 'US', 'type': 'healthcare', 'lineage': ['https://openalex.org/I1302444339']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'Steven Savona', 'raw_affiliation_strings': ['Division of Hematology, Northwell Health Cancer Institute, Hofstra Northwell School of Medicine, Lake Success, NY, USA'], 'affiliations': [{'raw_affiliation_string': 'Division of Hematology, Northwell Health Cancer Institute, Hofstra Northwell School of Medicine, Lake Success, NY, USA', 'institution_ids': ['https://openalex.org/I1302444339']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5040343292', 'display_name': 'Josephine N. Rini', 'orcid': 'https://orcid.org/0009-0003-1173-8035'}, 'institutions': [{'id': 'https://openalex.org/I139290212', 'display_name': 'Hofstra University', 'ror': 'https://ror.org/03pm18j10', 'country_code': 'US', 'type': 'education', 'lineage': ['https://openalex.org/I139290212']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'Josephine N. Rini', 'raw_affiliation_strings': ['Department of Radiology Hofstra Northwell School of Medicine Lake Success NY USA', 'Department of Radiology, Hofstra Northwell School of Medicine, Lake Success, NY, USA'], 'affiliations': [{'raw_affiliation_string': 'Department of Radiology, Hofstra Northwell School of Medicine, Lake Success, NY, USA', 'institution_ids': ['https://openalex.org/I139290212']}, {'raw_affiliation_string': 'Department of Radiology Hofstra Northwell School of Medicine Lake Success NY USA', 'institution_ids': ['https://openalex.org/I139290212']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5024726033', 'display_name': 'Jorge J. Castillo', 'orcid': 'https://orcid.org/0000-0001-9490-7532'}, 'institutions': [{'id': 'https://openalex.org/I136199984', 'display_name': 'Harvard University', 'ror': 'https://ror.org/03vek6s52', 'country_code': 'US', 'type': 'education', 'lineage': ['https://openalex.org/I136199984']}, {'id': 'https://openalex.org/I4210117453', 'display_name': 'Dana-Farber Cancer Institute', 'ror': 'https://ror.org/02jzgtq86', 'country_code': 'US', 'type': 'facility', 'lineage': ['https://openalex.org/I4210117453']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'Jorge J. Castillo', 'raw_affiliation_strings': ["Bing Center for Waldenstrom's Macroglobulinemia, Dana Farber Cancer Institute, Harvard Medical School, Boston, MA, USA"], 'affiliations': [{'raw_affiliation_string': "Bing Center for Waldenstrom's Macroglobulinemia, Dana Farber Cancer Institute, Harvard Medical School, Boston, MA, USA", 'institution_ids': ['https://openalex.org/I136199984', 'https://openalex.org/I4210117453']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5110212228', 'display_name': 'Lian Xu', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I4210117453', 'display_name': 'Dana-Farber Cancer Institute', 'ror': 'https://ror.org/02jzgtq86', 'country_code': 'US', 'type': 'facility', 'lineage': ['https://openalex.org/I4210117453']}, {'id': 'https://openalex.org/I136199984', 'display_name': 'Harvard University', 'ror': 'https://ror.org/03vek6s52', 'country_code': 'US', 'type': 'education', 'lineage': ['https://openalex.org/I136199984']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'Lian Xu', 'raw_affiliation_strings': ["Bing Center for Waldenstrom's Macroglobulinemia, Dana Farber Cancer Institute, Harvard Medical School, Boston, MA, USA"], 'affiliations': [{'raw_affiliation_string': "Bing Center for Waldenstrom's Macroglobulinemia, Dana Farber Cancer Institute, Harvard Medical School, Boston, MA, USA", 'institution_ids': ['https://openalex.org/I4210117453', 'https://openalex.org/I136199984']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5026121534', 'display_name': 'Zachary R. Hunter', 'orcid': 'https://orcid.org/0000-0002-1689-1691'}, 'institutions': [{'id': 'https://openalex.org/I4210117453', 'display_name': 'Dana-Farber Cancer Institute', 'ror': 'https://ror.org/02jzgtq86', 'country_code': 'US', 'type': 'facility', 'lineage': ['https://openalex.org/I4210117453']}, {'id': 'https://openalex.org/I136199984', 'display_name': 'Harvard University', 'ror': 'https://ror.org/03vek6s52', 'country_code': 'US', 'type': 'education', 'lineage': ['https://openalex.org/I136199984']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'Zachary R. Hunter', 'raw_affiliation_strings': ["Bing Center for Waldenstrom's Macroglobulinemia, Dana Farber Cancer Institute, Harvard Medical School, Boston, MA, USA"], 'affiliations': [{'raw_affiliation_string': "Bing Center for Waldenstrom's Macroglobulinemia, Dana Farber Cancer Institute, Harvard Medical School, Boston, MA, USA", 'institution_ids': ['https://openalex.org/I4210117453', 'https://openalex.org/I136199984']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5081299017', 'display_name': 'Steven P. Treon', 'orcid': 'https://orcid.org/0000-0001-6393-6154'}, 'institutions': [{'id': 'https://openalex.org/I4210117453', 'display_name': 'Dana-Farber Cancer Institute', 'ror': 'https://ror.org/02jzgtq86', 'country_code': 'US', 'type': 'facility', 'lineage': ['https://openalex.org/I4210117453']}, {'id': 'https://openalex.org/I136199984', 'display_name': 'Harvard University', 'ror': 'https://ror.org/03vek6s52', 'country_code': 'US', 'type': 'education', 'lineage': ['https://openalex.org/I136199984']}], 'countries': ['US'], 'is_corresponding': True, 'raw_author_name': 'Steven P. Treon', 'raw_affiliation_strings': ["Bing Center for Waldenstrom's Macroglobulinemia, Dana Farber Cancer Institute, Harvard Medical School, Boston, MA, USA"], 'affiliations': [{'raw_affiliation_string': "Bing Center for Waldenstrom's Macroglobulinemia, Dana Farber Cancer Institute, Harvard Medical School, Boston, MA, USA", 'institution_ids': ['https://openalex.org/I4210117453', 'https://openalex.org/I136199984']}]}, {'author_position': 'last', 'author': {'id': 'https://openalex.org/A5082571324', 'display_name': 'Steven L. Allen', 'orcid': 'https://orcid.org/0000-0002-3482-3182'}, 'institutions': [{'id': 'https://openalex.org/I1302444339', 'display_name': 'Northwell Health', 'ror': 'https://ror.org/02bxt4m23', 'country_code': 'US', 'type': 'healthcare', 'lineage': ['https://openalex.org/I1302444339']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'Steven L. Allen', 'raw_affiliation_strings': ['Division of Hematology, Northwell Health Cancer Institute, Hofstra Northwell School of Medicine, Lake Success, NY, USA'], 'affiliations': [{'raw_affiliation_string': 'Division of Hematology, Northwell Health Cancer Institute, Hofstra Northwell School of Medicine, Lake Success, NY, USA', 'institution_ids': ['https://openalex.org/I1302444339']}]}], 'institution_assertions': [], 'countries_distinct_count': 1, 'institutions_distinct_count': 4, 'corresponding_author_ids': ['https://openalex.org/A5081299017'], 'corresponding_institution_ids': ['https://openalex.org/I4210117453', 'https://openalex.org/I136199984'], 'apc_list': {'value': 4940, 'currency': 'USD', 'value_usd': 4940, 'provenance': 'doaj'}, 'apc_paid': None, 'fwci': None, 'has_fulltext': True, 'fulltext_origin': 'ngrams', 'cited_by_count': 64, 'citation_normalized_percentile': {'value': 0.997033, 'is_in_top_1_percent': True, 'is_in_top_10_percent': True}, 'cited_by_percentile_year': {'min': 97, 'max': 98}, 'biblio': {'volume': '179', 'issue': '2', 'first_page': '339', 'last_page': '341'}, 'is_retracted': False, 'is_paratext': False, 'primary_topic': {'id': 'https://openalex.org/T11157', 'display_name': 'Chronic Lymphocytic Leukemia Research', 'score': 1.0, 'subfield': {'id': 'https://openalex.org/subfields/2716', 'display_name': 'Genetics'}, 'field': {'id': 'https://openalex.org/fields/27', 'display_name': 'Medicine'}, 'domain': {'id': 'https://openalex.org/domains/4', 'display_name': 'Health Sciences'}}, 'topics': [{'id': 'https://openalex.org/T11157', 'display_name': 'Chronic Lymphocytic Leukemia Research', 'score': 1.0, 'subfield': {'id': 'https://openalex.org/subfields/2716', 'display_name': 'Genetics'}, 'field': {'id': 'https://openalex.org/fields/27', 'display_name': 'Medicine'}, 'domain': {'id': 'https://openalex.org/domains/4', 'display_name': 'Health Sciences'}}, {'id': 'https://openalex.org/T10185', 'display_name': 'Lymphoma Diagnosis and Treatment', 'score': 0.9961, 'subfield': {'id': 'https://openalex.org/subfields/2734', 'display_name': 'Pathology and Forensic Medicine'}, 'field': {'id': 'https://openalex.org/fields/27', 'display_name': 'Medicine'}, 'domain': {'id': 'https://openalex.org/domains/4', 'display_name': 'Health Sciences'}}, {'id': 'https://openalex.org/T10754', 'display_name': 'Neuroendocrine Tumor Research Advances', 'score': 0.9919, 'subfield': {'id': 'https://openalex.org/subfields/2713', 'display_name': 'Epidemiology'}, 'field': {'id': 'https://openalex.org/fields/27', 'display_name': 'Medicine'}, 'domain': {'id': 'https://openalex.org/domains/4', 'display_name': 'Health Sciences'}}], 'keywords': [], 'concepts': [{'id': 'https://openalex.org/C2779878957', 'wikidata': 'https://www.wikidata.org/wiki/Q5984881', 'display_name': 'Ibrutinib', 'level': 4, 'score': 0.86193717}, {'id': 'https://openalex.org/C71924100', 'wikidata': 'https://www.wikidata.org/wiki/Q11190', 'display_name': 'Medicine', 'level': 0, 'score': 0.82937336}, {'id': 'https://openalex.org/C2781038049', 'wikidata': 'https://www.wikidata.org/wiki/Q1778287', 'display_name': 'Waldenstrom macroglobulinemia', 'level': 3, 'score': 0.6007203}, {'id': 'https://openalex.org/C126322002', 'wikidata': 'https://www.wikidata.org/wiki/Q11180', 'display_name': 'Internal medicine', 'level': 1, 'score': 0.47100177}, {'id': 'https://openalex.org/C2780653079', 'wikidata': 'https://www.wikidata.org/wiki/Q412323', 'display_name': 'Rituximab', 'level': 3, 'score': 0.4157416}, {'id': 'https://openalex.org/C143998085', 'wikidata': 'https://www.wikidata.org/wiki/Q162555', 'display_name': 'Oncology', 'level': 1, 'score': 0.36494154}, {'id': 'https://openalex.org/C142724271', 'wikidata': 'https://www.wikidata.org/wiki/Q7208', 'display_name': 'Pathology', 'level': 1, 'score': 0.3239469}, {'id': 'https://openalex.org/C2779338263', 'wikidata': 'https://www.wikidata.org/wiki/Q208414', 'display_name': 'Lymphoma', 'level': 2, 'score': 0.24327007}, {'id': 'https://openalex.org/C2778461978', 'wikidata': 'https://www.wikidata.org/wiki/Q29496', 'display_name': 'Leukemia', 'level': 2, 'score': 0.16939175}, {'id': 'https://openalex.org/C2777938653', 'wikidata': 'https://www.wikidata.org/wiki/Q1088156', 'display_name': 'Chronic lymphocytic leukemia', 'level': 3, 'score': 0.0}], 'mesh': [{'descriptor_ui': 'D000970', 'descriptor_name': 'Antineoplastic Agents', 'qualifier_ui': 'Q000493', 'qualifier_name': 'pharmacokinetics', 'is_major_topic': True}, {'descriptor_ui': 'D001812', 'descriptor_name': 'Blood-Brain Barrier', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': True}, {'descriptor_ui': 'D016543', 'descriptor_name': 'Central Nervous System Neoplasms', 'qualifier_ui': 'Q000188', 'qualifier_name': 'drug therapy', 'is_major_topic': True}, {'descriptor_ui': 'D016543', 'descriptor_name': 'Central Nervous System Neoplasms', 'qualifier_ui': 'Q000556', 'qualifier_name': 'secondary', 'is_major_topic': True}, {'descriptor_ui': 'D047428', 'descriptor_name': 'Protein Kinase Inhibitors', 'qualifier_ui': 'Q000493', 'qualifier_name': 'pharmacokinetics', 'is_major_topic': True}, {'descriptor_ui': 'D011720', 'descriptor_name': 'Pyrazoles', 'qualifier_ui': 'Q000493', 'qualifier_name': 'pharmacokinetics', 'is_major_topic': True}, {'descriptor_ui': 'D011743', 'descriptor_name': 'Pyrimidines', 'qualifier_ui': 'Q000493', 'qualifier_name': 'pharmacokinetics', 'is_major_topic': True}, {'descriptor_ui': 'D008258', 'descriptor_name': 'Waldenstrom Macroglobulinemia', 'qualifier_ui': 'Q000188', 'qualifier_name': 'drug therapy', 'is_major_topic': True}, {'descriptor_ui': 'D008258', 'descriptor_name': 'Waldenstrom Macroglobulinemia', 'qualifier_ui': 'Q000150', 'qualifier_name': 'complications', 'is_major_topic': True}, {'descriptor_ui': 'D000970', 'descriptor_name': 'Antineoplastic Agents', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D000970', 'descriptor_name': 'Antineoplastic Agents', 'qualifier_ui': 'Q000008', 'qualifier_name': 'administration & dosage', 'is_major_topic': False}, {'descriptor_ui': 'D015415', 'descriptor_name': 'Biomarkers', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D001812', 'descriptor_name': 'Blood-Brain Barrier', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D016543', 'descriptor_name': 'Central Nervous System Neoplasms', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D016543', 'descriptor_name': 'Central Nervous System Neoplasms', 'qualifier_ui': 'Q000175', 'qualifier_name': 'diagnosis', 'is_major_topic': False}, {'descriptor_ui': 'D006801', 'descriptor_name': 'Humans', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D016130', 'descriptor_name': 'Immunophenotyping', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D008279', 'descriptor_name': 'Magnetic Resonance Imaging', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D008297', 'descriptor_name': 'Male', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D008875', 'descriptor_name': 'Middle Aged', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D000072078', 'descriptor_name': 'Positron Emission Tomography Computed Tomography', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D047428', 'descriptor_name': 'Protein Kinase Inhibitors', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D047428', 'descriptor_name': 'Protein Kinase Inhibitors', 'qualifier_ui': 'Q000008', 'qualifier_name': 'administration & dosage', 'is_major_topic': False}, {'descriptor_ui': 'D011720', 'descriptor_name': 'Pyrazoles', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D011720', 'descriptor_name': 'Pyrazoles', 'qualifier_ui': 'Q000008', 'qualifier_name': 'administration & dosage', 'is_major_topic': False}, {'descriptor_ui': 'D011743', 'descriptor_name': 'Pyrimidines', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D011743', 'descriptor_name': 'Pyrimidines', 'qualifier_ui': 'Q000008', 'qualifier_name': 'administration & dosage', 'is_major_topic': False}, {'descriptor_ui': 'D014057', 'descriptor_name': 'Tomography, X-Ray Computed', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D016896', 'descriptor_name': 'Treatment Outcome', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D008258', 'descriptor_name': 'Waldenstrom Macroglobulinemia', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D008258', 'descriptor_name': 'Waldenstrom Macroglobulinemia', 'qualifier_ui': 'Q000175', 'qualifier_name': 'diagnosis', 'is_major_topic': False}], 'locations_count': 2, 'locations': [{'is_oa': True, 'landing_page_url': 'https://doi.org/10.1111/bjh.14218', 'pdf_url': 'https://onlinelibrary.wiley.com/doi/pdfdirect/10.1111/bjh.14218', 'source': {'id': 'https://openalex.org/S153015021', 'display_name': 'British Journal of Haematology', 'issn_l': '0007-1048', 'issn': ['0007-1048', '1365-2141'], 'is_oa': False, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310320595', 'host_organization_name': 'Wiley', 'host_organization_lineage': ['https://openalex.org/P4310320595'], 'host_organization_lineage_names': ['Wiley'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, {'is_oa': False, 'landing_page_url': 'https://pubmed.ncbi.nlm.nih.gov/27409073', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S4306525036', 'display_name': 'PubMed', 'issn_l': None, 'issn': None, 'is_oa': False, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1299303238', 'host_organization_name': 'National Institutes of Health', 'host_organization_lineage': ['https://openalex.org/I1299303238'], 'host_organization_lineage_names': ['National Institutes of Health'], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}], 'best_oa_location': {'is_oa': True, 'landing_page_url': 'https://doi.org/10.1111/bjh.14218', 'pdf_url': 'https://onlinelibrary.wiley.com/doi/pdfdirect/10.1111/bjh.14218', 'source': {'id': 'https://openalex.org/S153015021', 'display_name': 'British Journal of Haematology', 'issn_l': '0007-1048', 'issn': ['0007-1048', '1365-2141'], 'is_oa': False, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310320595', 'host_organization_name': 'Wiley', 'host_organization_lineage': ['https://openalex.org/P4310320595'], 'host_organization_lineage_names': ['Wiley'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, 'sustainable_development_goals': [{'score': 0.71, 'id': 'https://metadata.un.org/sdg/3', 'display_name': 'Good health and well-being'}], 'grants': [], 'datasets': [], 'versions': [], 'referenced_works_count': 10, 'referenced_works': ['https://openalex.org/W1621503030', 'https://openalex.org/W1992008308', 'https://openalex.org/W2052794714', 'https://openalex.org/W2052855201', 'https://openalex.org/W2059430155', 'https://openalex.org/W2133192145', 'https://openalex.org/W2207094072', 'https://openalex.org/W2297198084', 'https://openalex.org/W2470506318', 'https://openalex.org/W2955948239'], 'related_works': ['https://openalex.org/W4287225533', 'https://openalex.org/W4230853347', 'https://openalex.org/W3032515387', 'https://openalex.org/W2980464729', 'https://openalex.org/W2912256758', 'https://openalex.org/W2805689516', 'https://openalex.org/W2551403197', 'https://openalex.org/W2430850754', 'https://openalex.org/W2274360660', 'https://openalex.org/W2111633421'], 'abstract_inverted_index': {'Bing': [0, 1026], 'Neel': [1], 'syndrome': [2], '(BNS)': [3], 'is': [4, 17, 59, 143, 707], 'a': [5, 60, 85, 162, 194, 202, 218, 269, 309, 378, 468, 579, 708, 731, 903], 'rare': [6], 'complication': [7], 'of': [8, 95, 102, 272, 357, 505, 582, 590, 632, 642, 661, 699, 723, 730, 775, 824, 830, 842, 849, 873, 887, 905, 923, 925, 976, 1014, 1108], 'Waldenström': [9], 'macroglobulinemia': [10], '(WM)': [11], '(Bing': [12], '&': [13], 'Neel,': [14], '1936).': [15], 'BNS': [16, 50, 114, 166, 352, 804], 'characterized': [18], 'by': [19, 25, 69, 145, 576, 1021], 'central': [20], 'nervous': [21], 'system': [22], '(CNS)': [23], 'infiltration': [24], 'clonal': [26, 574], 'lymphoplasmacytic': [27], 'cells': [28, 285, 333], 'with': [29, 51, 113, 165, 199, 211, 351, 382, 421, 541, 956], 'or': [30], 'without': [31], 'cerebrospinal': [32], 'fluid': [33], '(CSF)': [34], 'hyperglobulinaemia.': [35], 'Intrathecal': [36], 'chemotherapy': [37, 935], 'alone,': [38, 921], 'high': [39, 871], 'dose': [40, 774, 973], 'methotrexate': [41, 359], 'and': [42, 73, 76, 97, 120, 123, 151, 177, 181, 201, 214, 216, 236, 262, 278, 308, 322, 339, 353, 360, 370, 377, 399, 410, 431, 443, 454, 467, 489, 520, 560, 592, 620, 629, 634, 648, 697, 713, 728, 791, 799, 803, 899, 907, 914, 962, 974, 994, 1003, 1010, 1032, 1040, 1048, 1055, 1069, 1083, 1094, 1099], 'other': [43, 715], 'systemic': [44, 128, 369], 'chemotherapies': [45], 'are': [46, 855, 988], 'used': [47, 781], 'to': [48, 139, 175, 186, 230, 511, 517, 524, 608, 614, 788, 795, 861, 983, 990, 1110], 'treat': [49, 862], 'variable': [52], 'success': [53], '(Castillo': [54], 'et': [55, 109, 132, 344, 689, 742, 765, 769, 807, 852, 878, 939], 'al,': [56, 110, 133, 345, 690, 743, 766, 770, 879, 940], '2016).': [57, 771], 'Ibrutinib': [58, 497, 826, 881], 'Bruton': [61], 'Tyrosine': [62], 'Kinase': [63], '(BTK)': [64], 'inhibitor': [65], 'that': [66, 89, 148, 650, 705, 892, 947], 'was': [67, 197, 208, 316, 326, 349, 375, 386, 405, 415, 440, 446, 481, 486, 493, 500, 600, 663, 676, 786, 882, 936], 'approved': [68], 'the': [70, 77, 246, 323, 535, 588, 604, 640, 653, 667, 674, 678, 724, 831, 840, 846, 885, 894, 911, 926, 950, 1007, 1015, 1034, 1042, 1046, 1050, 1057, 1064, 1067, 1071, 1078, 1081, 1085], 'US': [71], 'Food': [72], 'Drug': [74], 'Administration': [75], 'European': [78], 'Medicines': [79], 'Agency': [80], 'for': [81, 137, 188, 336, 341, 395, 418, 683, 710, 833, 896, 902, 1000], 'treating': [82, 711], 'WM': [83, 163, 200, 783], 'following': [84], 'prospective,': [86], 'multicentre': [87], 'study': [88], 'showed': [90, 303, 462, 530, 551, 572], 'an': [91, 293, 490, 658], 'overall': [92], 'response': [93, 696, 740], 'rate': [94, 101], '91%': [96], '2-year': [98], 'progression-free': [99], 'survival': [100], '69%': [103], 'in': [104, 205, 245, 362, 407, 617, 666, 673, 752, 758, 782, 814, 828, 839, 884, 954, 967, 979, 1005], 'previously': [105], 'treated': [106, 209], 'patients': [107, 760, 819, 889, 929, 955], '(Treon': [108, 131, 741], '2015).': [111, 134, 744, 880, 941], 'Patients': [112], 'were': [115, 334, 644, 761, 836, 900, 1019], 'excluded': [116], 'from': [117, 1023, 1092, 1097], 'this': [118, 738], 'study,': [119], 'both': [121], 'MYD88': [122, 337, 725, 875], 'CXCR4': [124, 342, 732], 'mutation': [125, 727, 733], 'status': [126], 'impacted': [127, 737], 'ibrutinib': [129, 138, 176, 570, 623, 633, 651, 670, 706, 716, 750, 776, 798, 857, 920, 948, 968, 977], 'responses': [130, 813, 932], 'The': [135, 192, 347, 596, 611, 669, 692, 721, 971, 986, 1102], 'potential': [136], 'impact': [140, 964], 'CNS': [141, 168, 189, 371, 384, 695, 718, 812, 864, 965, 980], 'disease': [142, 169, 372, 385, 966, 981], 'supported': [144, 1020], 'rodent': [146], 'studies': [147, 566, 945, 1009, 1018], 'show': [149], 'brain': [150, 237, 655, 952], 'spinal': [152], 'cord': [153], 'drug': [154, 183, 190, 702, 756, 801], 'uptake': [155], '(McGinn,': [156], '2013).': [157], 'Herein,': [158], 'we': [159], 'report': [160], 'on': [161, 495, 622], 'patient': [164, 348, 612, 790, 1030, 1038, 1061, 1075], 'whose': [167], 'progressed': [170], 'despite': [171], 'multiple': [172], 'regimens,': [173], 'responded': [174], 'had': [178, 217, 368], 'synchronous': [179], 'plasma': [180, 628], 'CSF': [182, 266, 290, 478, 565, 630, 675, 701, 755, 797, 841, 886], 'levels': [184, 703, 757, 827], 'determined': [185, 645], 'evaluate': [187], 'penetration.': [191], 'patient,': [193], '59-year-old': [195], 'male': [196], 'diagnosed': [198, 350], 'pleural': [203, 311], 'amyloidoma': [204], '2009.': [206], 'He': [207, 391], 'initially': [210], 'rituximab,': [212], 'cyclophosphamide': [213], 'dexamethasone': [215], 'partial': [219, 380, 618, 931], 'response.': [220, 805], 'In': [221, 424], 'March,': [222], '2011,': [223], 'he': [224, 367, 427], 'developed': [225, 428], 'right': [226, 249, 252, 258, 310, 470, 536, 543, 553], 'ear': [227], 'congestion': [228], 'unresponsive': [229], 'antibiotics.': [231], 'Computerized': [232], 'tomography': [233, 459], '(CT)': [234], 'scans': [235, 302, 461], 'magnectic': [238], 'resonance': [239], 'imaging': [240], '(MRI)': [241], 'revealed': [242, 268, 292, 331, 451], 'extensive': [243], 'tumour': [244, 332], 'parapharyngeal': [247], 'space,': [248], 'cavernous': [250], 'sinus,': [251], 'ear,': [253], 'bilateral': [254, 263], 'frontal': [255], 'parietal': [256], 'areas,': [257], 'fifth': [259], 'cranial': [260, 472, 538, 555], 'nerve,': [261], 'parotid': [264], 'nodules.': [265], 'examination': [267], 'total': [270, 479, 580], 'protein': [271, 480, 581], '2·09': [273], 'g/l': [274, 318], '(normal': [275, 319], '0·15–0·45': [276], 'g/l),': [277], 'lambda': [279], 'light': [280], 'chain': [281], 'restricted': [282], 'monoclonal': [283], 'B': [284], '(CD19+,': [286], 'CD20+,': [287], 'CD23+,': [288], 'FMC7+).': [289], 'immunoelectrophoresis': [291], 'IgM': [294, 314, 324, 438, 444, 484, 515, 521, 585, 594, 598, 605], 'M-spike': [295, 325, 445, 522, 606], '(0·0385': [296], 'g/l;': [297], 'normal': [298], '<0·001': [299], 'g/l).': [300, 436], 'CT': [301], 'diffuse': [304, 465], 'adenopathy,': [305], 'pulmonary': [306], 'nodules': [307], 'mass.': [312], 'Serum': [313, 437], 'level': [315, 439, 485, 509, 586, 599, 671], '13·6': [317], '0·4–2·3': [320], 'g/l)': [321], '6·0': [327], 'g/l.': [328, 448, 526, 610], 'Molecular': [329, 1017], 'testing': [330], 'positive': [335], 'L265P': [338, 726], 'wild-type': [340], '(Hunter': [343], '2014).': [346], 'received': [354, 821, 1089], '2': [355, 389], 'cycles': [356], 'high-dose': [358], 'rituximab': [361], 'August': [363], '2011.': [364], 'Despite': [365], 'treatment,': [366], 'progression.': [373], 'Bendamustine': [374], 'added': [376], 'peripheral': [379, 562], 'remission': [381, 619], 'stable': [383, 422], 'achieved': [387, 930], 'after': [388, 569], 'cycles.': [390], 'remained': [392], 'asymptomatic': [393], 'except': [394], 'right-sided': [396], 'hearing': [397], 'loss': [398], 'aural': [400], 'congestion.': [401], 'An': [402], 'Ommaya': [403], 'reservoir': [404], 'placed': [406], 'February': [408], '2013,': [409], 'liposomal': [411], 'encapsulated': [412], 'cytosine': [413], 'arabinoside': [414], 'given': [416], 'intrathecally': [417], '4': [419, 567, 906], 'months': [420, 504, 568], 'disease.': [423], 'early': [425], '2014,': [426], 'increasing': [429], 'lymphadenopathy': [430, 466], 'progressive': [432, 464], 'anaemia': [433], '(Hb': [434], '77': [435], '12·50': [441], 'g/l,': [442, 483, 488, 513, 519, 584, 602], '8·0': [447], 'Brain': [449], 'MRI': [450, 529], 'increased': [452], 'oedema': [453], 'mass': [455], 'effect.': [456], 'CT/positron': [457], 'emission': [458], '(PET)': [460], 'markedly': [463], 'new': [469], 'middle': [471, 537, 554], 'fossa': [473, 539, 556], 'extra-axial': [474], 'lesion': [475], '(Fig': [476, 558], '1).': [477], '0·49': [482], '0·0089': [487], 'IgMλ': [491], 'paraprotein': [492], 'identified': [494], 'immunoelectrophoresis.': [496], '(560': [498, 777], 'mg/d)': [499, 778, 785], 'initiated.': [501], 'After': [502], '3': [503, 815], 'therapy,': [506], 'his': [507], 'hemoglobin': [508], 'improved': [510], '139': [512], 'serum': [514, 597], 'decreased': [516, 523, 531, 542, 561, 607], '2·75': [518], '5·0': [525], 'A': [527, 772], 'repeat': [528], 'nodular': [532], 'enhancement': [533], 'along': [534], 'floor': [540], 'temporal': [544], 'vasogenic': [545], 'edema.': [546], 'Repeat': [547, 564], 'CT/PET': [548], 'scan': [549], 'also': [550, 664, 837], 'resolved': [552], 'hypermetabolism': [557], '1),': [559], 'adenopathy.': [563], 'start': [571], 'no': [573, 593, 1106], 'B-cells': [575], 'flow': [577], 'cytometry,': [578], '0·29': [583], 'below': [587], 'limit': [589], 'detection,': [591], 'M-spike.': [595], '2·31': [601], 'while': [603], '2·0': [609], 'continues': [613], 'do': [615], 'well': [616], 'remains': [621, 982], 'at': [624, 858, 890, 910, 997], '23': [625], 'months.': [626], 'Synchronous': [627], 'concentrations': [631], 'its': [635], 'active': [636, 659], 'metabolite': [637, 660], 'PCI-45227': [638, 800], 'during': [639], 'course': [641], 'therapy': [643], '(Table': [646], '1)': [647], 'demonstrated': [649], 'penetrated': [652], 'blood': [654, 951], 'barrier.': [656], 'PCI-45227,': [657], 'ibrutinib,': [662], 'detected': [665, 672], 'CSF.': [668], 'above': [677], '50%': [679], 'inhibitory': [680], 'concentration': [681], '(IC50)': [682], 'BTK': [684, 834, 897], 'inhibition': [685, 835], '(0·5': [686], 'nmol/l)': [687], '(MacGlashan': [688], '2011).': [691], 'documented': [693], 'objective': [694], 'demonstration': [698], 'therapeutic': [700], 'suggests': [704], 'candidate': [709], 'BNS,': [712, 753], 'possibly': [714], 'responsive': [717], 'lymphoproliferative': [719], 'disorders.': [720], 'presence': [722], 'absence': [729], 'may': [734, 792], 'have': [735, 748, 793, 1105], 'favourably': [736], "patient's": [739], 'Two': [745], 'recent': [746], 'publications': [747], 'reported': [749, 811], 'activity': [751], 'but': [754], 'these': [759, 843, 888, 944], 'not': [762], 'measured': [763], '(Cabannes-Hamy': [764], '2016;': [767], 'Castillo': [768], 'higher': [773], 'than': [779], 'typically': [780], '(420': [784], 'administered': [787], 'our': [789], 'contributed': [794], 'measurable': [796], 'levels,': [802], 'Bernard': [806], 'al': [808, 853], '(2015)': [809, 854], 'recently': [810], 'mantle': [816], 'cell': [817], 'lymphoma': [818, 865], 'who': [820], '560': [822, 912], 'mg/d': [823, 860], 'ibrutinib.': [825], 'excess': [829], 'IC50': [832, 895], 'recognized': [838], 'patients.': [844], 'At': [845], 'National': [847], 'Institutes': [848], 'Health,': [850], 'Dunleavy': [851], 'exploring': [856], '560–840': [859], 'primary': [863], '(PCNSL),': [866], 'which,': [867], 'like': [868], 'WM,': [869, 961], 'shows': [870], 'rates': [872], 'activating': [874], 'mutations': [876], '(Yamada': [877], 'observed': [883], 'concentratons': [891], 'exceeded': [893], 'inhibition,': [898], 'maintained': [901], 'median': [904], '8·5': [908], 'h': [909], 'mg': [913, 916], '700': [915], 'doses,': [917], 'respectively.': [918], 'With': [919], '7': [922], '8': [924], 'evaluable': [927], 'PCNSL': [928], 'before': [933], 'combination': [934], 'introduced': [937], '(Dunleavy': [938], 'Taken': [942], 'together,': [943], 'demonstrate': [946], 'crosses': [949], 'barrier': [953], 'various': [957], 'B-cell': [958], 'malignancies,': [959], 'including': [960], 'can': [963], 'sensitive': [969], 'lymphomas.': [970], 'optimal': [972], 'schedule': [975], 'treatment': [978], 'be': [984], 'clarified.': [985], 'authors': [987, 1104], 'grateful': [989], 'Drs.': [991], 'Thorsten': [992], 'Graef': [993], 'Juthamas': [995], 'Sukbuntherng': [996], 'Pharmacyclics': [998, 1098], 'Inc.': [999], 'their': [1001, 1011], 'guidance': [1002], 'assistance': [1004], 'performing': [1006], 'pharmacokinetic': [1008], 'helpful': [1012], 'review': [1013], 'manuscript.': [1016, 1051, 1086], 'funding': [1022, 1091], 'Peter': [1024], 'S.': [1025], 'M.D.': [1027], 'CM': [1028], 'provided': [1029, 1037, 1060, 1074], 'care': [1031, 1039], 'wrote': [1033, 1084], 'manuscript;': [1035, 1043, 1072], 'SS': [1036], 'reviewed': [1041, 1049, 1070], 'JJC': [1044], 'analysed': [1045, 1056, 1066, 1080], 'data': [1047, 1068, 1082], 'LX': [1052], 'performed': [1053], 'experiments': [1054], 'data;': [1058], 'SPT': [1059, 1087], 'care,': [1062, 1076], 'designed': [1063, 1077], 'research,': [1065, 1079], 'SLA': [1073], 'has': [1088], 'grant': [1090], 'Pharmacyclics,': [1093], 'consulting': [1095], 'fees': [1096], 'Janssen': [1100], 'Oncology.': [1101], 'remaining': [1103], 'conflicts': [1107], 'interest': [1109], 'declare.': [1111]}, 'cited_by_api_url': 'https://api.openalex.org/works?filter=cites:W2474881968', 'counts_by_year': [{'year': 2024, 'cited_by_count': 7}, {'year': 2023, 'cited_by_count': 6}, {'year': 2022, 'cited_by_count': 6}, {'year': 2021, 'cited_by_count': 10}, {'year': 2020, 'cited_by_count': 8}, {'year': 2019, 'cited_by_count': 7}, {'year': 2018, 'cited_by_count': 13}, {'year': 2017, 'cited_by_count': 6}, {'year': 2016, 'cited_by_count': 1}], 'updated_date': '2025-01-08T11:35:43.102128', 'created_date': '2016-07-22'}