Title: Synthesis and Biological Evaluation of Macamides Derivatives as Potent Inhibitors of Breast Cancer Cell MCF-7
Abstract: A series of macamides (1-4) and their synthetic analogs (5-14) were synthesized and evaluated for in vitro inhibitory activities against breast cancer cell MCF-7. The results of bioactive assay showed that two of the macamides (compound 1 and 4) and one synthetic analog (compound 5) displayed comparable inhibitory activities against MCF-7 cell line, with IC50 values of 29.6, 36.2 and 27.2 µM, respectively. Keywords: Macamides derivatives, inhibitory activity, MCF-7.
Publication Year: 2016
Publication Date: 2016-06-18
Language: en
Type: article
Indexed In: ['crossref']
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Cited By Count: 3
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