Title: Assessment of the pyrogenic potency of the thromboxane A2-mimetics, SQ26655 and U46619, and thromboxane B2 by intrapreoptic injection in the cat.
Abstract:Using bilateral injection into the anterior hypothalamic/preoptic region of the conscious, indomethacin pretreated cat as an assay system, the pyrogenic activity of two thromboxane A2-mimetics (SQ2665...Using bilateral injection into the anterior hypothalamic/preoptic region of the conscious, indomethacin pretreated cat as an assay system, the pyrogenic activity of two thromboxane A2-mimetics (SQ26655 and U46619) and thromboxane B2 was assessed. PGE2 was used as a reference pyrogenic agent. Thromboxane B2 and both of the thromboxane A2-mimetics were at least 5263 times less potent than PGE2. The results do not support the putative role of thromboxanes as mediators of fever.Read More
Publication Year: 1985
Publication Date: 1985-08-01
Language: en
Type: article
Indexed In: ['pubmed']
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Cited By Count: 1
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