Get quick answers to your questions about the article from our AI researcher chatbot
{'id': 'https://openalex.org/W2469472190', 'doi': 'https://doi.org/10.1152/ajplegacy.1971.220.1.227', 'title': 'Effect of acetylcholine on proximal tubular sodium reabsorption in the dog', 'display_name': 'Effect of acetylcholine on proximal tubular sodium reabsorption in the dog', 'publication_year': 1971, 'publication_date': '1971-01-01', 'ids': {'openalex': 'https://openalex.org/W2469472190', 'doi': 'https://doi.org/10.1152/ajplegacy.1971.220.1.227', 'mag': '2469472190', 'pmid': 'https://pubmed.ncbi.nlm.nih.gov/5538656'}, 'language': 'en', 'primary_location': {'is_oa': False, 'landing_page_url': 'https://doi.org/10.1152/ajplegacy.1971.220.1.227', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S204210209', 'display_name': 'American Journal of Physiology-Legacy Content', 'issn_l': '0002-9513', 'issn': ['0002-9513', '2163-5773'], 'is_oa': False, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/P4310320155', 'host_organization_name': 'American Physiological Society', 'host_organization_lineage': ['https://openalex.org/P4310320155'], 'host_organization_lineage_names': ['American Physiological Society'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}, 'type': 'article', 'type_crossref': 'journal-article', 'indexed_in': ['crossref', 'pubmed'], 'open_access': {'is_oa': False, 'oa_status': 'closed', 'oa_url': None, 'any_repository_has_fulltext': False}, 'authorships': [{'author_position': 'first', 'author': {'id': 'https://openalex.org/A5055013057', 'display_name': 'James H. Stein', 'orcid': 'https://orcid.org/0000-0002-2770-8223'}, 'institutions': [], 'countries': [], 'is_corresponding': False, 'raw_author_name': 'JH Stein', 'raw_affiliation_strings': [], 'affiliations': []}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5076967488', 'display_name': 'JH Reineck', 'orcid': None}, 'institutions': [], 'countries': [], 'is_corresponding': False, 'raw_author_name': 'JH Reineck', 'raw_affiliation_strings': [], 'affiliations': []}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5018968111', 'display_name': 'RW Osgood', 'orcid': None}, 'institutions': [], 'countries': [], 'is_corresponding': False, 'raw_author_name': 'RW Osgood', 'raw_affiliation_strings': [], 'affiliations': []}, {'author_position': 'last', 'author': {'id': 'https://openalex.org/A5005846731', 'display_name': 'Ferris Tf', 'orcid': None}, 'institutions': [], 'countries': [], 'is_corresponding': False, 'raw_author_name': 'TF Ferris', 'raw_affiliation_strings': [], 'affiliations': []}], 'countries_distinct_count': 0, 'institutions_distinct_count': 0, 'corresponding_author_ids': [], 'corresponding_institution_ids': [], 'apc_list': None, 'apc_paid': None, 'fwci': 2.568, 'has_fulltext': True, 'fulltext_origin': 'ngrams', 'cited_by_count': 41, 'citation_normalized_percentile': {'value': 0.901491, 'is_in_top_1_percent': False, 'is_in_top_10_percent': True}, 'cited_by_percentile_year': {'min': 94, 'max': 95}, 'biblio': {'volume': '220', 'issue': '1', 'first_page': '227', 'last_page': '232'}, 'is_retracted': False, 'is_paratext': False, 'primary_topic': {'id': 'https://openalex.org/T10724', 'display_name': 'Molecular Mechanisms of Aquaporins in Physiology and Disease', 'score': 0.9334, 'subfield': {'id': 'https://openalex.org/subfields/1312', 'display_name': 'Molecular Biology'}, 'field': {'id': 'https://openalex.org/fields/13', 'display_name': 'Biochemistry, Genetics and Molecular Biology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}, 'topics': [{'id': 'https://openalex.org/T10724', 'display_name': 'Molecular Mechanisms of Aquaporins in Physiology and Disease', 'score': 0.9334, 'subfield': {'id': 'https://openalex.org/subfields/1312', 'display_name': 'Molecular Biology'}, 'field': {'id': 'https://openalex.org/fields/13', 'display_name': 'Biochemistry, Genetics and Molecular Biology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}, {'id': 'https://openalex.org/T11584', 'display_name': "Sweeteners' Taste and Impact on Health", 'score': 0.9219, 'subfield': {'id': 'https://openalex.org/subfields/2916', 'display_name': 'Nutrition and Dietetics'}, 'field': {'id': 'https://openalex.org/fields/29', 'display_name': 'Nursing'}, 'domain': {'id': 'https://openalex.org/domains/4', 'display_name': 'Health Sciences'}}], 'keywords': [{'id': 'https://openalex.org/keywords/renal-physiology', 'display_name': 'Renal physiology', 'score': 0.640138}, {'id': 'https://openalex.org/keywords/renal-sodium-reabsorption', 'display_name': 'Renal sodium reabsorption', 'score': 0.5461186}, {'id': 'https://openalex.org/keywords/metabolic-effects', 'display_name': 'Metabolic Effects', 'score': 0.502166}], 'concepts': [{'id': 'https://openalex.org/C159641895', 'wikidata': 'https://www.wikidata.org/wiki/Q108377937', 'display_name': 'Renal function', 'level': 2, 'score': 0.7180687}, {'id': 'https://openalex.org/C56906281', 'wikidata': 'https://www.wikidata.org/wiki/Q4391435', 'display_name': 'Reabsorption', 'level': 3, 'score': 0.68734396}, {'id': 'https://openalex.org/C161457703', 'wikidata': 'https://www.wikidata.org/wiki/Q3317402', 'display_name': 'Renal physiology', 'level': 3, 'score': 0.640138}, {'id': 'https://openalex.org/C57476199', 'wikidata': 'https://www.wikidata.org/wiki/Q7312501', 'display_name': 'Renal sodium reabsorption', 'level': 4, 'score': 0.5461186}, {'id': 'https://openalex.org/C134018914', 'wikidata': 'https://www.wikidata.org/wiki/Q162606', 'display_name': 'Endocrinology', 'level': 1, 'score': 0.5401865}, {'id': 'https://openalex.org/C126322002', 'wikidata': 'https://www.wikidata.org/wiki/Q11180', 'display_name': 'Internal medicine', 'level': 1, 'score': 0.51416135}, {'id': 'https://openalex.org/C2775910092', 'wikidata': 'https://www.wikidata.org/wiki/Q180623', 'display_name': 'Acetylcholine', 'level': 2, 'score': 0.5061907}, {'id': 'https://openalex.org/C185592680', 'wikidata': 'https://www.wikidata.org/wiki/Q2329', 'display_name': 'Chemistry', 'level': 0, 'score': 0.47391614}, {'id': 'https://openalex.org/C537181965', 'wikidata': 'https://www.wikidata.org/wiki/Q658', 'display_name': 'Sodium', 'level': 2, 'score': 0.44857654}, {'id': 'https://openalex.org/C71924100', 'wikidata': 'https://www.wikidata.org/wiki/Q11190', 'display_name': 'Medicine', 'level': 0, 'score': 0.36346573}, {'id': 'https://openalex.org/C2780091579', 'wikidata': 'https://www.wikidata.org/wiki/Q9377', 'display_name': 'Kidney', 'level': 2, 'score': 0.3497353}, {'id': 'https://openalex.org/C178790620', 'wikidata': 'https://www.wikidata.org/wiki/Q11351', 'display_name': 'Organic chemistry', 'level': 1, 'score': 0.0}], 'mesh': [{'descriptor_ui': 'D000109', 'descriptor_name': 'Acetylcholine', 'qualifier_ui': 'Q000494', 'qualifier_name': 'pharmacology', 'is_major_topic': True}, {'descriptor_ui': 'D007684', 'descriptor_name': 'Kidney Tubules', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': True}, {'descriptor_ui': 'D012964', 'descriptor_name': 'Sodium', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': True}, {'descriptor_ui': 'D000109', 'descriptor_name': 'Acetylcholine', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D000818', 'descriptor_name': 'Animals', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D004285', 'descriptor_name': 'Dogs', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D005919', 'descriptor_name': 'Glomerular Filtration Rate', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D007444', 'descriptor_name': 'Inulin', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D007677', 'descriptor_name': 'Kidney Function Tests', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D007684', 'descriptor_name': 'Kidney Tubules', 'qualifier_ui': 'Q000187', 'qualifier_name': 'drug effects', 'is_major_topic': False}, {'descriptor_ui': 'D007684', 'descriptor_name': 'Kidney Tubules', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D009997', 'descriptor_name': 'Osmotic Pressure', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D011677', 'descriptor_name': 'Punctures', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D012964', 'descriptor_name': 'Sodium', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D013997', 'descriptor_name': 'Time Factors', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}], 'locations_count': 2, 'locations': [{'is_oa': False, 'landing_page_url': 'https://doi.org/10.1152/ajplegacy.1971.220.1.227', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S204210209', 'display_name': 'American Journal of Physiology-Legacy Content', 'issn_l': '0002-9513', 'issn': ['0002-9513', '2163-5773'], 'is_oa': False, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/P4310320155', 'host_organization_name': 'American Physiological Society', 'host_organization_lineage': ['https://openalex.org/P4310320155'], 'host_organization_lineage_names': ['American Physiological Society'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}, {'is_oa': False, 'landing_page_url': 'https://pubmed.ncbi.nlm.nih.gov/5538656', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S4306525036', 'display_name': 'PubMed', 'issn_l': None, 'issn': None, 'is_oa': False, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1299303238', 'host_organization_name': 'National Institutes of Health', 'host_organization_lineage': ['https://openalex.org/I1299303238'], 'host_organization_lineage_names': ['National Institutes of Health'], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}], 'best_oa_location': None, 'sustainable_development_goals': [{'score': 0.43, 'display_name': 'Partnerships for the goals', 'id': 'https://metadata.un.org/sdg/17'}], 'grants': [], 'datasets': [], 'versions': [], 'referenced_works_count': 0, 'referenced_works': [], 'related_works': ['https://openalex.org/W4256073292', 'https://openalex.org/W2464081431', 'https://openalex.org/W2409087464', 'https://openalex.org/W2072920708', 'https://openalex.org/W2069273103', 'https://openalex.org/W2065463496', 'https://openalex.org/W2034378598', 'https://openalex.org/W2021161949', 'https://openalex.org/W1985778939', 'https://openalex.org/W1972735979'], 'abstract_inverted_index': {'ARTICLESEffect': [0], 'of': [1, 66, 119, 127, 134, 141, 150, 165, 168, 170, 184, 186, 192, 213, 231, 236, 283, 296, 312, 319, 337, 339, 349, 363, 369, 382, 394, 411, 414, 417, 432, 440, 446, 455, 462, 472, 479, 483, 503, 518, 538, 551], 'acetylcholine': [2, 232], 'on': [3, 152, 176, 205, 233, 304, 321, 343, 397, 443], 'proximal': [4, 207, 524, 533], 'tubular': [5, 58, 182], 'sodium': [6, 280, 534], 'reabsorption': [7, 535], 'in': [8, 53, 60, 90, 159, 222, 225, 258, 327, 366, 373, 403, 420, 424, 458, 496, 506, 523, 564, 599], 'the': [9, 64, 77, 116, 135, 142, 328, 367, 374, 386, 421, 444, 497, 507], 'dogJH': [10], 'Stein,': [11, 19], 'JH': [12, 20], 'Reineck,': [13, 21], 'RW': [14, 22], 'Osgood,': [15, 23], 'and': [16, 24, 56, 69, 76, 114, 155, 180, 219, 260, 278, 285, 299, 324, 331, 341, 346, 360, 400, 465, 467, 509, 512, 520, 536, 541, 549, 554], 'TF': [17, 25], 'FerrisJH': [18], 'FerrisPublished': [26], 'Online:01': [27], 'Jan': [28], '1971https://doi.org/10.1152/ajplegacy.1971.220.1.227MoreSectionsPDF': [29], '(1': [30], 'MB)Download': [31], 'PDF': [32, 47], 'ToolsExport': [33], 'citationAdd': [34], 'to': [35, 43, 85, 254], 'favoritesGet': [36], 'permissionsTrack': [37], 'citations': [38], 'ShareShare': [39], 'onFacebookTwitterLinkedInEmailWeChat': [40], 'Previous': [41], 'Back': [42], 'Top': [44], 'Next': [45], 'Download': [46], 'FiguresReferencesRelatedInformationCited': [48], 'ByProximal': [49], 'Nephron1': [50], 'July': [51, 307], '2013Changes': [52], 'renal': [54, 57, 91, 136, 153, 181, 279, 305, 322, 371, 401, 425, 448, 459, 485, 498], 'clearance': [55], 'function': [59, 154, 183, 402, 426], 'albino': [61], 'mice': [62], 'under': [63], 'influence': [65], 'DichlorvosPesticide': [67], 'Biochemistry': [68, 330], 'Physiology,': [70, 129, 214, 332, 513], 'Vol.': [71, 130, 146, 161, 188, 215, 227, 249, 264, 273, 288, 315, 333, 352, 377, 390, 407, 435, 450, 475, 488, 514, 527, 544, 559, 568], '91,': [72], 'No.': [73, 132, 148, 163, 190, 217, 229, 251, 266, 275, 290, 317, 335, 354, 379, 392, 409, 437, 452, 477, 490, 516, 529, 546, 561, 570], '3SFKs,': [74], 'Ras,': [75], 'classic': [78], 'MAPK': [79], 'pathway': [80], 'couple': [81], 'muscarinic': [82], 'receptor': [83], 'activation': [84], 'increased': [86], 'Na-HCO3': [87, 137], 'cotransport': [88], 'activity': [89], 'epithelial': [92], 'cellsR.': [93], 'Brooks': [94], 'Robey*,': [95], 'Ofelia': [96], 'S.': [97], 'Ruiz*,': [98], 'Jessica': [99], 'Baniqued,': [100], 'Dolores': [101], 'Mahmud,': [102], 'Doris': [103], 'Joy': [104], 'D.': [105], 'Espiritu,': [106], 'Angelito': [107], 'A.': [108, 111], 'Bernardo,': [109], 'Jose': [110], 'L.': [112], 'Arruda,': [113], 'With': [115], 'Technical': [117], 'Assistance': [118], 'Yi-Yong': [120], 'Qiu1': [121], 'May': [122], '2001': [123], '|': [124, 309], 'American': [125, 590], 'Journal': [126, 212, 311, 431], 'Physiology-Renal': [128], '280,': [131], '5Regulation': [133], 'cotransporter:': [138], 'VII.': [139], 'Mechanism': [140], 'cholinergic': [143, 494], 'stimulationKidney': [144], 'International,': [145, 389, 487, 543, 558, 567], '51,': [147], '4Effects': [149], 'Steviol': [151], 'mean': [156], 'arterial': [157], 'pressure': [158], 'ratsPhytomedicine,': [160], '3,': [162], '4Effect': [164], 'crude': [166], 'extract': [167], 'roots': [169], 'Bredemeyera': [171], 'floribunda': [172], 'Willd.': [173], 'II.': [174], 'Effect': [175], 'glomerular': [177], 'filtration': [178, 555, 563], 'rate': [179, 556], 'ratsJournal': [185], 'Ethnopharmacology,': [187], '43,': [189, 265], '3Control': [191], 'Sodium': [193, 347], 'Excretion:': [194], 'An': [195], 'Integrative': [196], 'Approach1': [197], 'January': [198, 202, 293, 596, 602], '2011Renal': [199], 'Blood': [200, 358], 'Flow1': [201], '2011Cholinergic': [203], 'effect': [204, 439], 'rat': [206], 'convoluted': [208], 'tubulePflügers': [209], 'Archiv': [210], 'European': [211], '415,': [216], '5Hypocalcemic': [218], 'hypercalcemic': [220], 'disorders': [221], 'childrenCurrent': [223], 'Problems': [224], 'Pediatrics,': [226], '19,': [228], '10Effect': [230], 'electrical': [234], 'properties': [235], 'subconfluent': [237], 'Madin': [238], 'Darby': [239], 'canine': [240], 'kidney': [241], 'cellsBiochimica': [242], 'et': [243], 'Biophysica': [244], 'Acta': [245], '(BBA)': [246], '-': [247], 'Biomembranes,': [248], '941,': [250], '2Renal': [252], 'responses': [253], 'atrial': [255], 'natriuretic': [256], 'factor': [257], 'hydrated': [259], 'hydropenic': [261], 'dogsLife': [262, 405], 'Sciences,': [263, 287, 351, 406], '11Sarin': [267], 'intoxication': [268], 'elevates': [269], 'plasma': [270], 'pralidoximeToxicology': [271], 'Letters,': [272], '28,': [274], '1Systemic': [276], 'vasodilatation': [277], 'excretion:': [281], 'Effects': [282, 338, 461], 'hydralazine': [284], 'diazoxideLife': [286], '34,': [289], '22Renal': [291], 'Circulation1': [292], '2011Acute': [294], 'effects': [295], 'combined': [297], 'vasodilation': [298, 372, 548], 'beta-adrenoceptor': [300], 'blockade': [301], 'with': [302], 'prizidilol': [303], 'function.26': [306], '2012': [308], 'British': [310], 'Clinical': [313, 433], 'Pharmacology,': [314, 434], '15,': [316], '2Effect': [318], 'parathion': [320], 'water': [323], 'electrolyte': [325, 525], 'excretion': [326, 537], 'dogPesticide': [329], '18,': [334], '3Comparison': [336], 'Cyanide': [340], 'Acetylcholine': [342], 'Renal': [344, 357], 'Hemodynamics': [345], 'ExcretionJournal': [348], 'Pharmaceutical': [350], '71,': [353], '1Chapter': [355], '11.': [356], 'Flow': [359], 'Dopaminergic': [361], 'AgonistsRole': [362], 'medullary': [364], 'hemodynamics': [365], 'natriuresis': [368, 445], 'drug-induced': [370, 447], 'rat.Circulation': [375], 'Research,': [376], '47,': [378], '6Cholinergic': [380], 'inhibition': [381, 442], 'urinary': [383], 'acidification': [384], 'by': [385, 428, 501, 589], 'turtle': [387], 'bladderKidney': [388], '17,': [391], '5Effects': [393], 'substance': [395], 'P': [396], 'renin': [398], 'release': [399], 'anesthetized': [404], '24,': [408], '3Disorders': [410], 'Glomerular': [412, 415], 'FiltrationMeasurements': [413], 'DynamicsRole': [416], 'physical': [418, 519], 'factors': [419, 522], 'acute': [422, 484], 'changes': [423], 'elicited': [427, 500], 'antihypertensive': [429], 'drugsEuropean': [430], '13,': [436, 451], '3The': [438], 'prostaglandin': [441], 'vasodilatationProstaglandins,': [449], '6Calcium-dependent': [453], 'regulation': [454], 'guanosine': [456], '3′,5′-monophosphate': [457], 'cortex:': [460], 'ionophore': [463], 'A23187': [464], 'tetracaine': [466], 'evidence': [468], 'for': [469], 'independent': [470], 'control': [471], 'adenosine': [473], '3′,5′-monophosphateMetabolism,': [474], '25,': [476], '10Pathophysiology': [478], 'a': [480], 'nephrotoxic': [481], 'model': [482], 'failureKidney': [486], '8,': [489], '1A': [491], 'possible': [492], 'sympathetic': [493], 'mechanism': [495], 'reflex': [499], 'stimulation': [502], 'abdominal': [504], 'viscera': [505], 'dogClinical': [508], 'Experimental': [510], 'Pharmacology': [511], '2,': [515], '2Role': [517], 'neuroendocrine': [521], 'reabsorptionMetabolism,': [526], '23,': [528], '8Natriuretic': [530], 'HormonesRelationship': [531], 'between': [532], 'calcium,': [539], 'magnesium': [540], 'phosphateKidney': [542], '4,': [545, 560], '6Renal': [547], 'uncoupling': [550], 'blood': [552], 'flow': [553], 'autoregulationKidney': [557], '1Glomerular': [562], 'single': [565], 'nephronsKidney': [566], '1,': [569], '4Chapter': [571], '10.': [572], 'Diuretics': [573], 'More': [574], 'from': [575], 'this': [576], 'issue': [577], '>': [578], 'Volume': [579], '220Issue': [580], '1January': [581], '1971Pages': [582], '227-232': [583], 'Copyright': [584], '&': [585], 'PermissionsCopyright': [586], '©': [587], '1971': [588, 597, 603], 'Physiological': [591], 'Societyhttps://doi.org/10.1152/ajplegacy.1971.220.1.227PubMed5538656History': [592], 'Published': [593, 598], 'online': [594], '1': [595, 601], 'print': [600], 'Metrics': [604]}, 'cited_by_api_url': 'https://api.openalex.org/works?filter=cites:W2469472190', 'counts_by_year': [{'year': 2013, 'cited_by_count': 1}], 'updated_date': '2024-08-16T01:57:22.334956', 'created_date': '2016-07-22'}