Publication Information

{'id': 'https://openalex.org/W2469253779', 'doi': 'https://doi.org/10.18632/oncotarget.10584', 'title': 'Cucurbitacin B exerts anti-cancer activities in human multiple myeloma cells<i>in vitro</i>and<i>in vivo</i>by modulating multiple cellular pathways', 'display_name': 'Cucurbitacin B exerts anti-cancer activities in human multiple myeloma cells<i>in vitro</i>and<i>in vivo</i>by modulating multiple cellular pathways', 'publication_year': 2016, 'publication_date': '2016-07-13', 'ids': {'openalex': 'https://openalex.org/W2469253779', 'doi': 'https://doi.org/10.18632/oncotarget.10584', 'mag': '2469253779', 'pmid': 'https://pubmed.ncbi.nlm.nih.gov/27418139', 'pmcid': 'https://www.ncbi.nlm.nih.gov/pmc/articles/5351590'}, 'language': 'en', 'primary_location': {'is_oa': True, 'landing_page_url': 'https://doi.org/10.18632/oncotarget.10584', 'pdf_url': 'https://www.oncotarget.com/article/10584/pdf/', 'source': {'id': 'https://openalex.org/S126644158', 'display_name': 'Oncotarget', 'issn_l': '1949-2553', 'issn': ['1949-2553'], 'is_oa': True, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310316297', 'host_organization_name': 'Impact Journals LLC', 'host_organization_lineage': ['https://openalex.org/P4310316297'], 'host_organization_lineage_names': ['Impact Journals LLC'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, 'type': 'article', 'type_crossref': 'journal-article', 'indexed_in': ['crossref', 'pubmed'], 'open_access': {'is_oa': True, 'oa_status': 'gold', 'oa_url': 'https://www.oncotarget.com/article/10584/pdf/', 'any_repository_has_fulltext': True}, 'authorships': [{'author_position': 'first', 'author': {'id': 'https://openalex.org/A5101993348', 'display_name': 'Tai Yang', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I207528943', 'display_name': 'Chengdu Medical College', 'ror': 'https://ror.org/01c4jmp52', 'country_code': 'CN', 'type': 'healthcare', 'lineage': ['https://openalex.org/I207528943']}], 'countries': ['CN'], 'is_corresponding': False, 'raw_author_name': 'Tai Yang', 'raw_affiliation_strings': ['Department of Immunology, Chengdu Medical College, Chengdu, China', 'School of Pharmacy, Chengdu Medical College, Chengdu, China'], 'affiliations': [{'raw_affiliation_string': 'School of Pharmacy, Chengdu Medical College, Chengdu, China', 'institution_ids': ['https://openalex.org/I207528943']}, {'raw_affiliation_string': 'Department of Immunology, Chengdu Medical College, Chengdu, China', 'institution_ids': ['https://openalex.org/I207528943']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5108047622', 'display_name': 'Jin Liu', 'orcid': 'https://orcid.org/0000-0002-2026-2513'}, 'institutions': [{'id': 'https://openalex.org/I207528943', 'display_name': 'Chengdu Medical College', 'ror': 'https://ror.org/01c4jmp52', 'country_code': 'CN', 'type': 'healthcare', 'lineage': ['https://openalex.org/I207528943']}], 'countries': ['CN'], 'is_corresponding': False, 'raw_author_name': 'Jin Liu', 'raw_affiliation_strings': ['Department of Immunology, Chengdu Medical College, Chengdu, China'], 'affiliations': [{'raw_affiliation_string': 'Department of Immunology, Chengdu Medical College, Chengdu, China', 'institution_ids': ['https://openalex.org/I207528943']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5060532255', 'display_name': 'Mali Yang', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I207528943', 'display_name': 'Chengdu Medical College', 'ror': 'https://ror.org/01c4jmp52', 'country_code': 'CN', 'type': 'healthcare', 'lineage': ['https://openalex.org/I207528943']}], 'countries': ['CN'], 'is_corresponding': False, 'raw_author_name': 'Mali Yang', 'raw_affiliation_strings': ['Department of Immunology, Chengdu Medical College, Chengdu, China'], 'affiliations': [{'raw_affiliation_string': 'Department of Immunology, Chengdu Medical College, Chengdu, China', 'institution_ids': ['https://openalex.org/I207528943']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5079141493', 'display_name': 'Ning Huang', 'orcid': 'https://orcid.org/0000-0001-5413-6825'}, 'institutions': [{'id': 'https://openalex.org/I207528943', 'display_name': 'Chengdu Medical College', 'ror': 'https://ror.org/01c4jmp52', 'country_code': 'CN', 'type': 'healthcare', 'lineage': ['https://openalex.org/I207528943']}, {'id': 'https://openalex.org/I24185976', 'display_name': 'Sichuan University', 'ror': 'https://ror.org/011ashp19', 'country_code': 'CN', 'type': 'education', 'lineage': ['https://openalex.org/I24185976']}, {'id': 'https://openalex.org/I4391768003', 'display_name': 'State Key Laboratory of Biotherapy', 'ror': 'https://ror.org/00x43yy22', 'country_code': None, 'type': 'facility', 'lineage': ['https://openalex.org/I24185976', 'https://openalex.org/I4391768003']}], 'countries': ['CN'], 'is_corresponding': False, 'raw_author_name': 'Ning Huang', 'raw_affiliation_strings': ['Department of Immunology, Chengdu Medical College, Chengdu, China', 'Laboratory for Aging Research, State Key Laboratory of Biotherapy and Cancer Center, West China Hospital, Sichuan University and Collaborative Innovation Center for Biotherapy, Chengdu, China'], 'affiliations': [{'raw_affiliation_string': 'Department of Immunology, Chengdu Medical College, Chengdu, China', 'institution_ids': ['https://openalex.org/I207528943']}, {'raw_affiliation_string': 'Laboratory for Aging Research, State Key Laboratory of Biotherapy and Cancer Center, West China Hospital, Sichuan University and Collaborative Innovation Center for Biotherapy, Chengdu, China', 'institution_ids': ['https://openalex.org/I24185976', 'https://openalex.org/I4391768003']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5085999689', 'display_name': 'Yueling Zhong', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I207528943', 'display_name': 'Chengdu Medical College', 'ror': 'https://ror.org/01c4jmp52', 'country_code': 'CN', 'type': 'healthcare', 'lineage': ['https://openalex.org/I207528943']}], 'countries': ['CN'], 'is_corresponding': False, 'raw_author_name': 'Yueling Zhong', 'raw_affiliation_strings': ['School of Pharmacy, Chengdu Medical College, Chengdu, China'], 'affiliations': [{'raw_affiliation_string': 'School of Pharmacy, Chengdu Medical College, Chengdu, China', 'institution_ids': ['https://openalex.org/I207528943']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5101880911', 'display_name': 'Ting Zeng', 'orcid': 'https://orcid.org/0000-0002-4586-7869'}, 'institutions': [{'id': 'https://openalex.org/I207528943', 'display_name': 'Chengdu Medical College', 'ror': 'https://ror.org/01c4jmp52', 'country_code': 'CN', 'type': 'healthcare', 'lineage': ['https://openalex.org/I207528943']}], 'countries': ['CN'], 'is_corresponding': False, 'raw_author_name': 'Ting Zeng', 'raw_affiliation_strings': ['Department of Immunology, Chengdu Medical College, Chengdu, China'], 'affiliations': [{'raw_affiliation_string': 'Department of Immunology, Chengdu Medical College, Chengdu, China', 'institution_ids': ['https://openalex.org/I207528943']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5110816798', 'display_name': 'Rong Wei', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I207528943', 'display_name': 'Chengdu Medical College', 'ror': 'https://ror.org/01c4jmp52', 'country_code': 'CN', 'type': 'healthcare', 'lineage': ['https://openalex.org/I207528943']}], 'countries': ['CN'], 'is_corresponding': False, 'raw_author_name': 'Rong Wei', 'raw_affiliation_strings': ['Department of Immunology, Chengdu Medical College, Chengdu, China'], 'affiliations': [{'raw_affiliation_string': 'Department of Immunology, Chengdu Medical College, Chengdu, China', 'institution_ids': ['https://openalex.org/I207528943']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5007050514', 'display_name': 'Zhongjun Wu', 'orcid': 'https://orcid.org/0000-0002-1627-0633'}, 'institutions': [{'id': 'https://openalex.org/I207528943', 'display_name': 'Chengdu Medical College', 'ror': 'https://ror.org/01c4jmp52', 'country_code': 'CN', 'type': 'healthcare', 'lineage': ['https://openalex.org/I207528943']}], 'countries': ['CN'], 'is_corresponding': False, 'raw_author_name': 'Zhongjun Wu', 'raw_affiliation_strings': ['Department of Immunology, Chengdu Medical College, Chengdu, China'], 'affiliations': [{'raw_affiliation_string': 'Department of Immunology, Chengdu Medical College, Chengdu, China', 'institution_ids': ['https://openalex.org/I207528943']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5028877244', 'display_name': 'Cui Xiao', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I207528943', 'display_name': 'Chengdu Medical College', 'ror': 'https://ror.org/01c4jmp52', 'country_code': 'CN', 'type': 'healthcare', 'lineage': ['https://openalex.org/I207528943']}], 'countries': ['CN'], 'is_corresponding': False, 'raw_author_name': 'Cui Xiao', 'raw_affiliation_strings': ['Department of Immunology, Chengdu Medical College, Chengdu, China'], 'affiliations': [{'raw_affiliation_string': 'Department of Immunology, Chengdu Medical College, Chengdu, China', 'institution_ids': ['https://openalex.org/I207528943']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5101692294', 'display_name': 'Xiaohua Cao', 'orcid': 'https://orcid.org/0000-0001-5207-6400'}, 'institutions': [{'id': 'https://openalex.org/I207528943', 'display_name': 'Chengdu Medical College', 'ror': 'https://ror.org/01c4jmp52', 'country_code': 'CN', 'type': 'healthcare', 'lineage': ['https://openalex.org/I207528943']}], 'countries': ['CN'], 'is_corresponding': False, 'raw_author_name': 'Xiaohua Cao', 'raw_affiliation_strings': ['Department of Immunology, Chengdu Medical College, Chengdu, China'], 'affiliations': [{'raw_affiliation_string': 'Department of Immunology, Chengdu Medical College, Chengdu, China', 'institution_ids': ['https://openalex.org/I207528943']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5100675642', 'display_name': 'Minhui Li', 'orcid': 'https://orcid.org/0000-0002-5366-8464'}, 'institutions': [{'id': 'https://openalex.org/I207528943', 'display_name': 'Chengdu Medical College', 'ror': 'https://ror.org/01c4jmp52', 'country_code': 'CN', 'type': 'healthcare', 'lineage': ['https://openalex.org/I207528943']}], 'countries': ['CN'], 'is_corresponding': False, 'raw_author_name': 'Minhui Li', 'raw_affiliation_strings': ['Department of Immunology, Chengdu Medical College, Chengdu, China'], 'affiliations': [{'raw_affiliation_string': 'Department of Immunology, Chengdu Medical College, Chengdu, China', 'institution_ids': ['https://openalex.org/I207528943']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5100691210', 'display_name': 'Li‐Mei Li', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I207528943', 'display_name': 'Chengdu Medical College', 'ror': 'https://ror.org/01c4jmp52', 'country_code': 'CN', 'type': 'healthcare', 'lineage': ['https://openalex.org/I207528943']}], 'countries': ['CN'], 'is_corresponding': False, 'raw_author_name': 'Limei Li', 'raw_affiliation_strings': ['Department of Immunology, Chengdu Medical College, Chengdu, China'], 'affiliations': [{'raw_affiliation_string': 'Department of Immunology, Chengdu Medical College, Chengdu, China', 'institution_ids': ['https://openalex.org/I207528943']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5101984862', 'display_name': 'Bin Han', 'orcid': 'https://orcid.org/0000-0002-7581-6202'}, 'institutions': [{'id': 'https://openalex.org/I207528943', 'display_name': 'Chengdu Medical College', 'ror': 'https://ror.org/01c4jmp52', 'country_code': 'CN', 'type': 'healthcare', 'lineage': ['https://openalex.org/I207528943']}], 'countries': ['CN'], 'is_corresponding': False, 'raw_author_name': 'Bin Han', 'raw_affiliation_strings': ['Department of Immunology, Chengdu Medical College, Chengdu, China', 'Department of Public Health, Chengdu Medical College, Chengdu, China'], 'affiliations': [{'raw_affiliation_string': 'Department of Public Health, Chengdu Medical College, Chengdu, China', 'institution_ids': ['https://openalex.org/I207528943']}, {'raw_affiliation_string': 'Department of Immunology, Chengdu Medical College, Chengdu, China', 'institution_ids': ['https://openalex.org/I207528943']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5101816388', 'display_name': 'Xiaoping Yu', 'orcid': 'https://orcid.org/0000-0002-2470-5510'}, 'institutions': [{'id': 'https://openalex.org/I207528943', 'display_name': 'Chengdu Medical College', 'ror': 'https://ror.org/01c4jmp52', 'country_code': 'CN', 'type': 'healthcare', 'lineage': ['https://openalex.org/I207528943']}], 'countries': ['CN'], 'is_corresponding': False, 'raw_author_name': 'Xiaoping Yu', 'raw_affiliation_strings': ['Department of Public Health, Chengdu Medical College, Chengdu, China'], 'affiliations': [{'raw_affiliation_string': 'Department of Public Health, Chengdu Medical College, Chengdu, China', 'institution_ids': ['https://openalex.org/I207528943']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5100601834', 'display_name': 'Hua Li', 'orcid': 'https://orcid.org/0000-0002-1449-801X'}, 'institutions': [{'id': 'https://openalex.org/I4210104667', 'display_name': 'Chengdu Military General Hospital', 'ror': 'https://ror.org/01bk73674', 'country_code': 'CN', 'type': 'healthcare', 'lineage': ['https://openalex.org/I4210104667']}], 'countries': ['CN'], 'is_corresponding': False, 'raw_author_name': 'Hua Li', 'raw_affiliation_strings': ['Cancer Center, Chengdu Military General Hospital, Chengdu, China'], 'affiliations': [{'raw_affiliation_string': 'Cancer Center, Chengdu Military General Hospital, Chengdu, China', 'institution_ids': ['https://openalex.org/I4210104667']}]}, {'author_position': 'last', 'author': {'id': 'https://openalex.org/A5021509099', 'display_name': 'Qiang Zou', 'orcid': 'https://orcid.org/0000-0001-9109-9365'}, 'institutions': [{'id': 'https://openalex.org/I207528943', 'display_name': 'Chengdu Medical College', 'ror': 'https://ror.org/01c4jmp52', 'country_code': 'CN', 'type': 'healthcare', 'lineage': ['https://openalex.org/I207528943']}], 'countries': ['CN'], 'is_corresponding': True, 'raw_author_name': 'Qiang Zou', 'raw_affiliation_strings': ['Department of Immunology, Chengdu Medical College, Chengdu, China'], 'affiliations': [{'raw_affiliation_string': 'Department of Immunology, Chengdu Medical College, Chengdu, China', 'institution_ids': ['https://openalex.org/I207528943']}]}], 'institution_assertions': [], 'countries_distinct_count': 1, 'institutions_distinct_count': 4, 'corresponding_author_ids': ['https://openalex.org/A5021509099'], 'corresponding_institution_ids': ['https://openalex.org/I207528943'], 'apc_list': None, 'apc_paid': None, 'fwci': 2.514, 'has_fulltext': True, 'fulltext_origin': 'ngrams', 'cited_by_count': 16, 'citation_normalized_percentile': {'value': 0.710378, 'is_in_top_1_percent': False, 'is_in_top_10_percent': False}, 'cited_by_percentile_year': {'min': 89, 'max': 90}, 'biblio': {'volume': '8', 'issue': '4', 'first_page': '5800', 'last_page': '5813'}, 'is_retracted': False, 'is_paratext': False, 'primary_topic': {'id': 'https://openalex.org/T13779', 'display_name': 'Cancer Mechanisms and Therapy', 'score': 0.9992, 'subfield': {'id': 'https://openalex.org/subfields/2734', 'display_name': 'Pathology and Forensic Medicine'}, 'field': {'id': 'https://openalex.org/fields/27', 'display_name': 'Medicine'}, 'domain': {'id': 'https://openalex.org/domains/4', 'display_name': 'Health Sciences'}}, 'topics': [{'id': 'https://openalex.org/T13779', 'display_name': 'Cancer Mechanisms and Therapy', 'score': 0.9992, 'subfield': {'id': 'https://openalex.org/subfields/2734', 'display_name': 'Pathology and Forensic Medicine'}, 'field': {'id': 'https://openalex.org/fields/27', 'display_name': 'Medicine'}, 'domain': {'id': 'https://openalex.org/domains/4', 'display_name': 'Health Sciences'}}, {'id': 'https://openalex.org/T10649', 'display_name': 'Multiple Myeloma Research and Treatments', 'score': 0.9982, 'subfield': {'id': 'https://openalex.org/subfields/2720', 'display_name': 'Hematology'}, 'field': {'id': 'https://openalex.org/fields/27', 'display_name': 'Medicine'}, 'domain': {'id': 'https://openalex.org/domains/4', 'display_name': 'Health Sciences'}}, {'id': 'https://openalex.org/T11041', 'display_name': 'Ubiquitin and proteasome pathways', 'score': 0.9977, 'subfield': {'id': 'https://openalex.org/subfields/1312', 'display_name': 'Molecular Biology'}, 'field': {'id': 'https://openalex.org/fields/13', 'display_name': 'Biochemistry, Genetics and Molecular Biology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}], 'keywords': [], 'concepts': [{'id': 'https://openalex.org/C71924100', 'wikidata': 'https://www.wikidata.org/wiki/Q11190', 'display_name': 'Medicine', 'level': 0, 'score': 0.60264957}, {'id': 'https://openalex.org/C121608353', 'wikidata': 'https://www.wikidata.org/wiki/Q12078', 'display_name': 'Cancer', 'level': 2, 'score': 0.48727548}, {'id': 'https://openalex.org/C556039675', 'wikidata': 'https://www.wikidata.org/wiki/Q771035', 'display_name': 'Traditional medicine', 'level': 1, 'score': 0.4778285}, {'id': 'https://openalex.org/C502942594', 'wikidata': 'https://www.wikidata.org/wiki/Q3421914', 'display_name': 'Cancer research', 'level': 1, 'score': 0.40511706}, {'id': 'https://openalex.org/C98274493', 'wikidata': 'https://www.wikidata.org/wiki/Q128406', 'display_name': 'Pharmacology', 'level': 1, 'score': 0.32821542}, {'id': 'https://openalex.org/C126322002', 'wikidata': 'https://www.wikidata.org/wiki/Q11180', 'display_name': 'Internal medicine', 'level': 1, 'score': 0.27204096}], 'mesh': [{'descriptor_ui': 'D000972', 'descriptor_name': 'Antineoplastic Agents, Phytogenic', 'qualifier_ui': 'Q000008', 'qualifier_name': 'administration & dosage', 'is_major_topic': True}, {'descriptor_ui': 'D064096', 'descriptor_name': 'Aurora Kinase A', 'qualifier_ui': 'Q000037', 'qualifier_name': 'antagonists & inhibitors', 'is_major_topic': True}, {'descriptor_ui': 'D009101', 'descriptor_name': 'Multiple Myeloma', 'qualifier_ui': 'Q000188', 'qualifier_name': 'drug therapy', 'is_major_topic': True}, {'descriptor_ui': 'D014315', 'descriptor_name': 'Triterpenes', 'qualifier_ui': 'Q000008', 'qualifier_name': 'administration & dosage', 'is_major_topic': True}, {'descriptor_ui': 'D000818', 'descriptor_name': 'Animals', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D000972', 'descriptor_name': 'Antineoplastic Agents, Phytogenic', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D000972', 'descriptor_name': 'Antineoplastic Agents, Phytogenic', 'qualifier_ui': 'Q000494', 'qualifier_name': 'pharmacology', 'is_major_topic': False}, {'descriptor_ui': 'D064096', 'descriptor_name': 'Aurora Kinase A', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D002453', 'descriptor_name': 'Cell Cycle', 'qualifier_ui': 'Q000187', 'qualifier_name': 'drug effects', 'is_major_topic': False}, {'descriptor_ui': 'D002453', 'descriptor_name': 'Cell Cycle', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D045744', 'descriptor_name': 'Cell Line, Tumor', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D049109', 'descriptor_name': 'Cell Proliferation', 'qualifier_ui': 'Q000187', 'qualifier_name': 'drug effects', 'is_major_topic': False}, {'descriptor_ui': 'D049109', 'descriptor_name': 'Cell Proliferation', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D015972', 'descriptor_name': 'Gene Expression Regulation, Neoplastic', 'qualifier_ui': 'Q000187', 'qualifier_name': 'drug effects', 'is_major_topic': False}, {'descriptor_ui': 'D015972', 'descriptor_name': 'Gene Expression Regulation, Neoplastic', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D006801', 'descriptor_name': 'Humans', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D016753', 'descriptor_name': 'Interleukin-10', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D016753', 'descriptor_name': 'Interleukin-10', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': False}, {'descriptor_ui': 'D053078', 'descriptor_name': 'Membrane Potential, Mitochondrial', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D051379', 'descriptor_name': 'Mice', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D009101', 'descriptor_name': 'Multiple Myeloma', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D009101', 'descriptor_name': 'Multiple Myeloma', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': False}, {'descriptor_ui': 'D010766', 'descriptor_name': 'Phosphorylation', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D050796', 'descriptor_name': 'STAT3 Transcription Factor', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': False}, {'descriptor_ui': 'D050796', 'descriptor_name': 'STAT3 Transcription Factor', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D015398', 'descriptor_name': 'Signal Transduction', 'qualifier_ui': 'Q000187', 'qualifier_name': 'drug effects', 'is_major_topic': False}, {'descriptor_ui': 'D015398', 'descriptor_name': 'Signal Transduction', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D014315', 'descriptor_name': 'Triterpenes', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D014315', 'descriptor_name': 'Triterpenes', 'qualifier_ui': 'Q000494', 'qualifier_name': 'pharmacology', 'is_major_topic': False}, {'descriptor_ui': 'D023041', 'descriptor_name': 'Xenograft Model Antitumor Assays', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}], 'locations_count': 4, 'locations': [{'is_oa': True, 'landing_page_url': 'https://doi.org/10.18632/oncotarget.10584', 'pdf_url': 'https://www.oncotarget.com/article/10584/pdf/', 'source': {'id': 'https://openalex.org/S126644158', 'display_name': 'Oncotarget', 'issn_l': '1949-2553', 'issn': ['1949-2553'], 'is_oa': True, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310316297', 'host_organization_name': 'Impact Journals LLC', 'host_organization_lineage': ['https://openalex.org/P4310316297'], 'host_organization_lineage_names': ['Impact Journals LLC'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, {'is_oa': True, 'landing_page_url': 'https://europepmc.org/articles/pmc5351590', 'pdf_url': 'https://europepmc.org/articles/pmc5351590?pdf=render', 'source': {'id': 'https://openalex.org/S4306400806', 'display_name': 'Europe PMC (PubMed Central)', 'issn_l': None, 'issn': None, 'is_oa': True, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1303153112', 'host_organization_name': 'European Bioinformatics Institute', 'host_organization_lineage': ['https://openalex.org/I1303153112'], 'host_organization_lineage_names': ['European Bioinformatics Institute'], 'type': 'repository'}, 'license': 'cc-by', 'license_id': 'https://openalex.org/licenses/cc-by', 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, {'is_oa': True, 'landing_page_url': 'https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5351590', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S2764455111', 'display_name': 'PubMed Central', 'issn_l': None, 'issn': None, 'is_oa': True, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1299303238', 'host_organization_name': 'National Institutes of Health', 'host_organization_lineage': ['https://openalex.org/I1299303238'], 'host_organization_lineage_names': ['National Institutes of Health'], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, {'is_oa': False, 'landing_page_url': 'https://pubmed.ncbi.nlm.nih.gov/27418139', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S4306525036', 'display_name': 'PubMed', 'issn_l': None, 'issn': None, 'is_oa': False, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1299303238', 'host_organization_name': 'National Institutes of Health', 'host_organization_lineage': ['https://openalex.org/I1299303238'], 'host_organization_lineage_names': ['National Institutes of Health'], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}], 'best_oa_location': {'is_oa': True, 'landing_page_url': 'https://doi.org/10.18632/oncotarget.10584', 'pdf_url': 'https://www.oncotarget.com/article/10584/pdf/', 'source': {'id': 'https://openalex.org/S126644158', 'display_name': 'Oncotarget', 'issn_l': '1949-2553', 'issn': ['1949-2553'], 'is_oa': True, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310316297', 'host_organization_name': 'Impact Journals LLC', 'host_organization_lineage': ['https://openalex.org/P4310316297'], 'host_organization_lineage_names': ['Impact Journals LLC'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, 'sustainable_development_goals': [{'score': 0.81, 'display_name': 'Good health and well-being', 'id': 'https://metadata.un.org/sdg/3'}], 'grants': [], 'datasets': [], 'versions': [], 'referenced_works_count': 59, 'referenced_works': ['https://openalex.org/W112133451', 'https://openalex.org/W1481973004', 'https://openalex.org/W1543577342', 'https://openalex.org/W1861416158', 'https://openalex.org/W1944381820', 'https://openalex.org/W1964819675', 'https://openalex.org/W1973654794', 'https://openalex.org/W1974851340', 'https://openalex.org/W1974929232', 'https://openalex.org/W1978425204', 'https://openalex.org/W1979795699', 'https://openalex.org/W1981073960', 'https://openalex.org/W1985040833', 'https://openalex.org/W1987466720', 'https://openalex.org/W1990317973', 'https://openalex.org/W1995985235', 'https://openalex.org/W2001236611', 'https://openalex.org/W2006901566', 'https://openalex.org/W2015376870', 'https://openalex.org/W2025924761', 'https://openalex.org/W2033591223', 'https://openalex.org/W2035633811', 'https://openalex.org/W2039047382', 'https://openalex.org/W2042945898', 'https://openalex.org/W2046816188', 'https://openalex.org/W2059069220', 'https://openalex.org/W2071797615', 'https://openalex.org/W2075850504', 'https://openalex.org/W2077301620', 'https://openalex.org/W2077945404', 'https://openalex.org/W2078563859', 'https://openalex.org/W2080142796', 'https://openalex.org/W2080680239', 'https://openalex.org/W2083800105', 'https://openalex.org/W2084304742', 'https://openalex.org/W2115015071', 'https://openalex.org/W2116050010', 'https://openalex.org/W2119005247', 'https://openalex.org/W2123639512', 'https://openalex.org/W2123723651', 'https://openalex.org/W2126572395', 'https://openalex.org/W2135064698', 'https://openalex.org/W2137218119', 'https://openalex.org/W2138778824', 'https://openalex.org/W2139737762', 'https://openalex.org/W2145123926', 'https://openalex.org/W2146557065', 'https://openalex.org/W2147079987', 'https://openalex.org/W2147319839', 'https://openalex.org/W2150422941', 'https://openalex.org/W2151154588', 'https://openalex.org/W2158366150', 'https://openalex.org/W2160226692', 'https://openalex.org/W2160239020', 'https://openalex.org/W2166030259', 'https://openalex.org/W2166049962', 'https://openalex.org/W2317698610', 'https://openalex.org/W3195431600', 'https://openalex.org/W4211135634'], 'related_works': ['https://openalex.org/W4389568370', 'https://openalex.org/W3108674512', 'https://openalex.org/W3032375762', 'https://openalex.org/W3031052312', 'https://openalex.org/W2748952813', 'https://openalex.org/W2586801360', 'https://openalex.org/W2080531066', 'https://openalex.org/W1995515455', 'https://openalex.org/W1506200166', 'https://openalex.org/W1489783725'], 'abstract_inverted_index': {'//': [0], 'Tai': [1, 142], 'Yang': [2, 13], '1,': [3], '2,': [4, 9, 14], '*': [5, 10, 15, 131], ',': [6, 11, 16, 20, 24, 28, 32, 36, 40, 44, 48, 52, 56, 60, 64, 188], 'Jin': [7], 'Liu': [8], 'Mali': [12], 'Ning': [17], 'Huang': [18], '3': [19, 86], 'Yueling': [21], 'Zhong': [22], '1': [23, 68], 'Ting': [25], 'Zeng': [26], '2': [27, 31, 35, 39, 43, 47, 51, 67, 77], 'Rong': [29], 'Wei': [30], 'Zhongjun': [33], 'Wu': [34], 'Cui': [37], 'Xiao': [38], 'Xiaohua': [41], 'Cao': [42], 'Minhui': [45], 'Li': [46, 50, 62], 'Limei': [49], 'Bin': [53], 'Han': [54], '4': [55, 59, 112], 'Xiaoping': [57], 'Yu': [58], 'Hua': [61], '5': [63, 122], 'Qiang': [65, 146], 'Zou': [66], 'School': [69], 'of': [70, 79, 94, 114, 185, 244, 269, 277, 283, 288, 293, 333], 'Pharmacy,': [71], 'Chengdu': [72, 81, 117, 125], 'Medical': [73, 82, 118], 'College,': [74, 83, 119], 'Chengdu,': [75, 84, 110, 120, 129], 'China': [76, 85, 100, 111, 121, 130], 'Department': [78, 113], 'Immunology,': [80], 'Laboratory': [87, 93], 'for': [88, 108, 330], 'Aging': [89], 'Research,': [90], 'State': [91], 'Key': [92], 'Biotherapy': [95], 'and': [96, 104, 196, 291], 'Cancer': [97, 123], 'Center,': [98, 124], 'West': [99], 'Hospital,': [101, 128], 'Sichuan': [102], 'University': [103], 'Collaborative': [105], 'Innovation': [106], 'Center': [107], 'Biotherapy,': [109], 'Public': [115], 'Health,': [116], 'Military': [126], 'General': [127], 'These': [132], 'authors': [133], 'have': [134, 205], 'contributed': [135], 'equally': [136], 'to': [137, 193, 223], 'this': [138, 214], 'work': [139], 'Correspondence': [140], 'to:': [141], 'Yang,': [143], 'email:': [144, 148], '[email protected]': [145], 'Zou,': [147], '[email protected]': [149], 'Keywords:': [150], 'cucurbitacin': [151], 'B,': [152], 'multiple': [153, 158, 248, 317], 'myeloma,': [154], 'Aurora': [155, 245], 'A': [156, 246], 'kinase,': [157], 'cellular': [159, 318], 'pathways,': [160], 'xenograft': [161], 'Received:': [162], 'March': [163], '07,': [164], '2016': [165, 169, 173], 'Accepted:': [166], 'June': [167], '30,': [168], 'Published:': [170], 'July': [171], '13,': [172], 'ABSTRACT': [174], 'Cucurbitacin': [175], 'B': [176], '(CuB),': [177], 'a': [178, 241, 301, 326], 'triterpenoid': [179], 'compound': [180], 'isolated': [181], 'from': [182], 'the': [183, 208, 225, 255, 266, 281, 331], 'stems': [184], 'Cucumis': [186], 'melo': [187], 'has': [189], 'long': [190], 'been': [191, 206], 'used': [192], 'treat': [194], 'hepatitis': [195], 'hepatoma': [197], 'in': [198, 247, 254, 271, 280, 300, 320], 'China.': [199], 'Although': [200], 'its': [201], 'remarkable': [202], 'anti-cancer': [203], 'activities': [204], 'reported,': [207], 'mechanism': [209], 'by': [210, 228], 'which': [211, 229], 'it': [212], 'achieves': [213], 'therapeutic': [215, 328], 'activity': [216, 268], 'remains': [217], 'unclear.': [218], 'This': [219], 'study': [220], 'was': [221], 'designed': [222], 'investigate': [224], 'molecular': [226], 'mechanisms': [227], 'CuB': [230, 239, 258, 274, 295, 314, 323], 'inhibits': [231], 'cancer': [232], 'cell': [233], 'proliferation.': [234], 'Our': [235], 'results': [236, 311], 'indicate': [237, 312], 'that': [238, 313], 'is': [240], 'novel': [242], 'inhibitor': [243], 'myeloma': [249], '(MM)': [250], 'cells,': [251], 'arresting': [252], 'cells': [253], 'G2/M': [256], 'phase.': [257], 'also': [259], 'inhibited': [260, 296], 'IL-10-induced': [261], 'STAT3': [262], 'phosphorylation,': [263], 'synergistically': [264], 'increasing': [265], 'anti-tumor': [267], 'Adriamycin': [270], 'vitro': [272], '.': [273], 'induced': [275], 'dephosphorylation': [276], 'cofilin,': [278], 'resulting': [279], 'loss': [282], 'mitochondrial': [284], 'membrane': [285], 'potential,': [286], 'release': [287], 'cytochrome': [289], 'c,': [290], 'activation': [292], 'caspase-8.': [294], 'MM': [297, 303, 321], 'tumor': [298], 'growth': [299], 'murine': [302], 'model,': [304], 'without': [305], 'host': [306], 'toxicity.': [307], 'In': [308], 'conclusion,': [309], 'these': [310], 'interferes': [315], 'with': [316], 'pathways': [319], 'cells.': [322], 'thus': [324], 'represents': [325], 'promising': [327], 'tool': [329], 'treatment': [332], 'MM.': [334]}, 'cited_by_api_url': 'https://api.openalex.org/works?filter=cites:W2469253779', 'counts_by_year': [{'year': 2021, 'cited_by_count': 1}, {'year': 2020, 'cited_by_count': 3}, {'year': 2019, 'cited_by_count': 4}, {'year': 2018, 'cited_by_count': 4}, {'year': 2017, 'cited_by_count': 3}], 'updated_date': '2024-12-15T07:44:32.892658', 'created_date': '2016-07-22'}