Adapted Treatment Guided by Interim PET-CT Scan in Advanced Hodgkin’s Lymphoma

Name: Work Video:
Duration: 3 min 30 s
Description: We tested interim positron-emission tomography–computed tomography (PET-CT) as a measure of early response to chemotherapy in order to guide treatment for patients with advanced Hodgkin’s lymphoma.
Peter Johnson; Massimo Federico; Amy A. Kirkwood; Alexander Fosså; Leanne Berkahn; Angelo Michele Carella; Francesco d’Amore; Gunilla Enblad; Antonella Franceschetto; Michael Fulham; Stefano Luminari; Michael O'Doherty; Pip Patrick; Thomas A. Roberts; Gamal Sidra; Lindsey Stevens; Paul Smith; Judith Trotman; Zaid Viney; John Radford; Sally F. Barrington
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Federico, A. Franceschetto, S.L.), the Department of Hematology, San Martino University Hospital, Genoa (A.C.), and Arcispedale Santa Maria Nuova-Istituti di Ricovero e Cura a Carattere Scientifico, Reggio Emilia (S.L.) - all in Italy; the Department of Medical Oncology, Oslo University Hospital, Oslo (A. Fosså); the Department of Haematology, Auckland City Hospital, Auckland, New Zealand (L.B.); the Department of Hematology, Aarhus University Hospital, Aarhus, Denmark (F.A.); the Department of Immunology, Genetics, and Pathology, Uppsala University, Uppsala, Sweden (G.E.); and the Department of Molecular Imaging, Royal Prince Alfred Hospital (M. Fulham), and Concord Repatriation General Hospital, University of Sydney (J.T.), Sydney."], 'affiliations': [{'raw_affiliation_string': "From the Cancer Research UK Centre, University of Southampton, Southampton (P.J.), Cancer Research UK and University College London Cancer Trials Centre (A.K., P.P., T.R., L.S., P.S.) and the PET Imaging Centre, King's College London, King's Health Partners, St. Thomas' Hospital (M.O., Z.V., S.B.), London, the Department of Haematology, Lincoln County Hospital, Lincoln (G.S.), and the Department of Medical Oncology, Christie Hospital, Manchester (J.R.) - all in the United Kingdom; the Department of Diagnostic, Clinical, and Public Health Medicine, University of Modena and Reggio Emilia, Modena (M. Federico, A. 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Federico, A. Franceschetto, S.L.), the Department of Hematology, San Martino University Hospital, Genoa (A.C.), and Arcispedale Santa Maria Nuova-Istituti di Ricovero e Cura a Carattere Scientifico, Reggio Emilia (S.L.) - all in Italy; the Department of Medical Oncology, Oslo University Hospital, Oslo (A. Fosså); the Department of Haematology, Auckland City Hospital, Auckland, New Zealand (L.B.); the Department of Hematology, Aarhus University Hospital, Aarhus, Denmark (F.A.); the Department of Immunology, Genetics, and Pathology, Uppsala University, Uppsala, Sweden (G.E.); and the Department of Molecular Imaging, Royal Prince Alfred Hospital (M. Fulham), and Concord Repatriation General Hospital, University of Sydney (J.T.), Sydney."], 'affiliations': [{'raw_affiliation_string': "From the Cancer Research UK Centre, University of Southampton, Southampton (P.J.), Cancer Research UK and University College London Cancer Trials Centre (A.K., P.P., T.R., L.S., P.S.) and the PET Imaging Centre, King's College London, King's Health Partners, St. Thomas' Hospital (M.O., Z.V., S.B.), London, the Department of Haematology, Lincoln County Hospital, Lincoln (G.S.), and the Department of Medical Oncology, Christie Hospital, Manchester (J.R.) - all in the United Kingdom; the Department of Diagnostic, Clinical, and Public Health Medicine, University of Modena and Reggio Emilia, Modena (M. Federico, A. Franceschetto, S.L.), the Department of Hematology, San Martino University Hospital, Genoa (A.C.), and Arcispedale Santa Maria Nuova-Istituti di Ricovero e Cura a Carattere Scientifico, Reggio Emilia (S.L.) - all in Italy; the Department of Medical Oncology, Oslo University Hospital, Oslo (A. Fosså); the Department of Haematology, Auckland City Hospital, Auckland, New Zealand (L.B.); the Department of Hematology, Aarhus University Hospital, Aarhus, Denmark (F.A.); the Department of Immunology, Genetics, and Pathology, Uppsala University, Uppsala, Sweden (G.E.); and the Department of Molecular Imaging, Royal Prince Alfred Hospital (M. 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Kirkwood', 'orcid': 'https://orcid.org/0000-0003-0133-7732'}, 'institutions': [{'id': 'https://openalex.org/I2800160768', 'display_name': 'Lincoln County Hospital', 'ror': 'https://ror.org/03p30f964', 'country_code': 'GB', 'type': 'healthcare', 'lineage': ['https://openalex.org/I2800160768', 'https://openalex.org/I2803040662']}, {'id': 'https://openalex.org/I183935753', 'display_name': "King's College London", 'ror': 'https://ror.org/0220mzb33', 'country_code': 'GB', 'type': 'education', 'lineage': ['https://openalex.org/I124357947', 'https://openalex.org/I183935753']}, {'id': 'https://openalex.org/I4210113441', 'display_name': 'Kings Health Partners', 'ror': 'https://ror.org/01xcsye48', 'country_code': 'GB', 'type': 'healthcare', 'lineage': ['https://openalex.org/I4210113441']}, {'id': 'https://openalex.org/I45129253', 'display_name': 'University College London', 'ror': 'https://ror.org/02jx3x895', 'country_code': 'GB', 'type': 'education', 'lineage': ['https://openalex.org/I124357947', 'https://openalex.org/I45129253']}, {'id': 'https://openalex.org/I4210088881', 'display_name': 'London Cancer', 'ror': 'https://ror.org/005kpb876', 'country_code': 'GB', 'type': 'other', 'lineage': ['https://openalex.org/I4210088881']}, {'id': 'https://openalex.org/I2801316944', 'display_name': 'Cancer Research UK', 'ror': 'https://ror.org/054225q67', 'country_code': 'GB', 'type': 'nonprofit', 'lineage': ['https://openalex.org/I2801316944']}, {'id': 'https://openalex.org/I1324925910', 'display_name': "St Thomas' Hospital", 'ror': 'https://ror.org/054gk2851', 'country_code': 'GB', 'type': 'healthcare', 'lineage': ['https://openalex.org/I1324925910', 'https://openalex.org/I200166805', 'https://openalex.org/I4210111135']}, {'id': 'https://openalex.org/I2801418622', 'display_name': 'Auckland City Hospital', 'ror': 'https://ror.org/05e8jge82', 'country_code': 'NZ', 'type': 'healthcare', 'lineage': ['https://openalex.org/I2801418622', 'https://openalex.org/I4210114327']}], 'countries': ['GB', 'NZ'], 'is_corresponding': False, 'raw_author_name': 'Amy Kirkwood', 'raw_affiliation_strings': ["From the Cancer Research UK Centre, University of Southampton, Southampton (P.J.), Cancer Research UK and University College London Cancer Trials Centre (A.K., P.P., T.R., L.S., P.S.) and the PET Imaging Centre, King's College London, King's Health Partners, St. Thomas' Hospital (M.O., Z.V., S.B.), London, the Department of Haematology, Lincoln County Hospital, Lincoln (G.S.), and the Department of Medical Oncology, Christie Hospital, Manchester (J.R.) - all in the United Kingdom; the Department of Diagnostic, Clinical, and Public Health Medicine, University of Modena and Reggio Emilia, Modena (M. Federico, A. Franceschetto, S.L.), the Department of Hematology, San Martino University Hospital, Genoa (A.C.), and Arcispedale Santa Maria Nuova-Istituti di Ricovero e Cura a Carattere Scientifico, Reggio Emilia (S.L.) - all in Italy; the Department of Medical Oncology, Oslo University Hospital, Oslo (A. Fosså); the Department of Haematology, Auckland City Hospital, Auckland, New Zealand (L.B.); the Department of Hematology, Aarhus University Hospital, Aarhus, Denmark (F.A.); the Department of Immunology, Genetics, and Pathology, Uppsala University, Uppsala, Sweden (G.E.); and the Department of Molecular Imaging, Royal Prince Alfred Hospital (M. Fulham), and Concord Repatriation General Hospital, University of Sydney (J.T.), Sydney."], 'affiliations': [{'raw_affiliation_string': "From the Cancer Research UK Centre, University of Southampton, Southampton (P.J.), Cancer Research UK and University College London Cancer Trials Centre (A.K., P.P., T.R., L.S., P.S.) and the PET Imaging Centre, King's College London, King's Health Partners, St. Thomas' Hospital (M.O., Z.V., S.B.), London, the Department of Haematology, Lincoln County Hospital, Lincoln (G.S.), and the Department of Medical Oncology, Christie Hospital, Manchester (J.R.) - all in the United Kingdom; the Department of Diagnostic, Clinical, and Public Health Medicine, University of Modena and Reggio Emilia, Modena (M. Federico, A. Franceschetto, S.L.), the Department of Hematology, San Martino University Hospital, Genoa (A.C.), and Arcispedale Santa Maria Nuova-Istituti di Ricovero e Cura a Carattere Scientifico, Reggio Emilia (S.L.) - all in Italy; the Department of Medical Oncology, Oslo University Hospital, Oslo (A. Fosså); the Department of Haematology, Auckland City Hospital, Auckland, New Zealand (L.B.); the Department of Hematology, Aarhus University Hospital, Aarhus, Denmark (F.A.); the Department of Immunology, Genetics, and Pathology, Uppsala University, Uppsala, Sweden (G.E.); and the Department of Molecular Imaging, Royal Prince Alfred Hospital (M. Fulham), and Concord Repatriation General Hospital, University of Sydney (J.T.), Sydney.", 'institution_ids': ['https://openalex.org/I2800160768', 'https://openalex.org/I183935753', 'https://openalex.org/I4210113441', 'https://openalex.org/I45129253', 'https://openalex.org/I4210088881', 'https://openalex.org/I2801316944', 'https://openalex.org/I1324925910', 'https://openalex.org/I2801418622']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5055817555', 'display_name': 'Alexander Fosså', 'orcid': 'https://orcid.org/0000-0002-4484-9319'}, 'institutions': [{'id': 'https://openalex.org/I183935753', 'display_name': "King's College London", 'ror': 'https://ror.org/0220mzb33', 'country_code': 'GB', 'type': 'education', 'lineage': ['https://openalex.org/I124357947', 'https://openalex.org/I183935753']}, {'id': 'https://openalex.org/I4210113441', 'display_name': 'Kings Health Partners', 'ror': 'https://ror.org/01xcsye48', 'country_code': 'GB', 'type': 'healthcare', 'lineage': ['https://openalex.org/I4210113441']}, {'id': 'https://openalex.org/I45129253', 'display_name': 'University College London', 'ror': 'https://ror.org/02jx3x895', 'country_code': 'GB', 'type': 'education', 'lineage': ['https://openalex.org/I124357947', 'https://openalex.org/I45129253']}, {'id': 'https://openalex.org/I1324925910', 'display_name': "St Thomas' Hospital", 'ror': 'https://ror.org/054gk2851', 'country_code': 'GB', 'type': 'healthcare', 'lineage': ['https://openalex.org/I1324925910', 'https://openalex.org/I200166805', 'https://openalex.org/I4210111135']}, {'id': 'https://openalex.org/I2801418622', 'display_name': 'Auckland City Hospital', 'ror': 'https://ror.org/05e8jge82', 'country_code': 'NZ', 'type': 'healthcare', 'lineage': ['https://openalex.org/I2801418622', 'https://openalex.org/I4210114327']}, {'id': 'https://openalex.org/I2800160768', 'display_name': 'Lincoln County Hospital', 'ror': 'https://ror.org/03p30f964', 'country_code': 'GB', 'type': 'healthcare', 'lineage': ['https://openalex.org/I2800160768', 'https://openalex.org/I2803040662']}, {'id': 'https://openalex.org/I4210088881', 'display_name': 'London Cancer', 'ror': 'https://ror.org/005kpb876', 'country_code': 'GB', 'type': 'other', 'lineage': ['https://openalex.org/I4210088881']}, {'id': 'https://openalex.org/I2801316944', 'display_name': 'Cancer Research UK', 'ror': 'https://ror.org/054225q67', 'country_code': 'GB', 'type': 'nonprofit', 'lineage': ['https://openalex.org/I2801316944']}], 'countries': ['GB', 'NZ'], 'is_corresponding': False, 'raw_author_name': 'Alexander Fosså', 'raw_affiliation_strings': ["From the Cancer Research UK Centre, University of Southampton, Southampton (P.J.), Cancer Research UK and University College London Cancer Trials Centre (A.K., P.P., T.R., L.S., P.S.) and the PET Imaging Centre, King's College London, King's Health Partners, St. Thomas' Hospital (M.O., Z.V., S.B.), London, the Department of Haematology, Lincoln County Hospital, Lincoln (G.S.), and the Department of Medical Oncology, Christie Hospital, Manchester (J.R.) - all in the United Kingdom; the Department of Diagnostic, Clinical, and Public Health Medicine, University of Modena and Reggio Emilia, Modena (M. Federico, A. Franceschetto, S.L.), the Department of Hematology, San Martino University Hospital, Genoa (A.C.), and Arcispedale Santa Maria Nuova-Istituti di Ricovero e Cura a Carattere Scientifico, Reggio Emilia (S.L.) - all in Italy; the Department of Medical Oncology, Oslo University Hospital, Oslo (A. Fosså); the Department of Haematology, Auckland City Hospital, Auckland, New Zealand (L.B.); the Department of Hematology, Aarhus University Hospital, Aarhus, Denmark (F.A.); the Department of Immunology, Genetics, and Pathology, Uppsala University, Uppsala, Sweden (G.E.); and the Department of Molecular Imaging, Royal Prince Alfred Hospital (M. 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