Publication Information

{'id': 'https://openalex.org/W2468601597', 'doi': 'https://doi.org/10.18632/oncotarget.10598', 'title': 'NETs: organ-related epigenetic derangements and potential clinical applications', 'display_name': 'NETs: organ-related epigenetic derangements and potential clinical applications', 'publication_year': 2016, 'publication_date': '2016-07-13', 'ids': {'openalex': 'https://openalex.org/W2468601597', 'doi': 'https://doi.org/10.18632/oncotarget.10598', 'mag': '2468601597', 'pmid': 'https://pubmed.ncbi.nlm.nih.gov/27418145', 'pmcid': 'https://www.ncbi.nlm.nih.gov/pmc/articles/5302998'}, 'language': 'en', 'primary_location': {'is_oa': True, 'landing_page_url': 'https://doi.org/10.18632/oncotarget.10598', 'pdf_url': 'http://www.oncotarget.com/index.php?journal=oncotarget&page=article&op=download&path%5B%5D=10598&path%5B%5D=33481', 'source': {'id': 'https://openalex.org/S126644158', 'display_name': 'Oncotarget', 'issn_l': '1949-2553', 'issn': ['1949-2553'], 'is_oa': True, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310316297', 'host_organization_name': 'Impact Journals LLC', 'host_organization_lineage': ['https://openalex.org/P4310316297'], 'host_organization_lineage_names': ['Impact Journals LLC'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, 'type': 'review', 'type_crossref': 'journal-article', 'indexed_in': ['crossref', 'pubmed'], 'open_access': {'is_oa': True, 'oa_status': 'gold', 'oa_url': 'http://www.oncotarget.com/index.php?journal=oncotarget&page=article&op=download&path%5B%5D=10598&path%5B%5D=33481', 'any_repository_has_fulltext': True}, 'authorships': [{'author_position': 'first', 'author': {'id': 'https://openalex.org/A5037900791', 'display_name': 'Mauro Cives', 'orcid': 'https://orcid.org/0000-0002-3013-1816'}, 'institutions': [{'id': 'https://openalex.org/I5561750', 'display_name': 'University of Bari Aldo Moro', 'ror': 'https://ror.org/027ynra39', 'country_code': 'IT', 'type': 'education', 'lineage': ['https://openalex.org/I5561750']}], 'countries': ['IT'], 'is_corresponding': False, 'raw_author_name': 'Mauro Cives', 'raw_affiliation_strings': ['Department of Biomedical Sciences and Human Oncology, Section of Internal Medicine and Clinical Oncology, University of Bari "Aldo Moro", Bari, Italy'], 'affiliations': [{'raw_affiliation_string': 'Department of Biomedical Sciences and Human Oncology, Section of Internal Medicine and Clinical Oncology, University of Bari "Aldo Moro", Bari, Italy', 'institution_ids': ['https://openalex.org/I5561750']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5061955427', 'display_name': 'Valeria De Simone', 'orcid': 'https://orcid.org/0009-0008-1619-3843'}, 'institutions': [{'id': 'https://openalex.org/I5561750', 'display_name': 'University of Bari Aldo Moro', 'ror': 'https://ror.org/027ynra39', 'country_code': 'IT', 'type': 'education', 'lineage': ['https://openalex.org/I5561750']}], 'countries': ['IT'], 'is_corresponding': False, 'raw_author_name': 'Valeria Simone', 'raw_affiliation_strings': ['Department of Biomedical Sciences and Human Oncology, Section of Internal Medicine and Clinical Oncology, University of Bari "Aldo Moro", Bari, Italy'], 'affiliations': [{'raw_affiliation_string': 'Department of Biomedical Sciences and Human Oncology, Section of Internal Medicine and Clinical Oncology, University of Bari "Aldo Moro", Bari, Italy', 'institution_ids': ['https://openalex.org/I5561750']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5076810301', 'display_name': 'Francesca Rizzo', 'orcid': 'https://orcid.org/0000-0003-1783-5015'}, 'institutions': [{'id': 'https://openalex.org/I5561750', 'display_name': 'University of Bari Aldo Moro', 'ror': 'https://ror.org/027ynra39', 'country_code': 'IT', 'type': 'education', 'lineage': ['https://openalex.org/I5561750']}], 'countries': ['IT'], 'is_corresponding': False, 'raw_author_name': 'Francesca Maria Rizzo', 'raw_affiliation_strings': ['Department of Biomedical Sciences and Human Oncology, Section of Internal Medicine and Clinical Oncology, University of Bari "Aldo Moro", Bari, Italy'], 'affiliations': [{'raw_affiliation_string': 'Department of Biomedical Sciences and Human Oncology, Section of Internal Medicine and Clinical Oncology, University of Bari "Aldo Moro", Bari, Italy', 'institution_ids': ['https://openalex.org/I5561750']}]}, {'author_position': 'last', 'author': {'id': 'https://openalex.org/A5039750643', 'display_name': 'Franco Silvestris', 'orcid': 'https://orcid.org/0000-0002-5555-2617'}, 'institutions': [{'id': 'https://openalex.org/I5561750', 'display_name': 'University of Bari Aldo Moro', 'ror': 'https://ror.org/027ynra39', 'country_code': 'IT', 'type': 'education', 'lineage': ['https://openalex.org/I5561750']}], 'countries': ['IT'], 'is_corresponding': True, 'raw_author_name': 'Franco Silvestris', 'raw_affiliation_strings': ['Department of Biomedical Sciences and Human Oncology, Section of Internal Medicine and Clinical Oncology, University of Bari "Aldo Moro", Bari, Italy'], 'affiliations': [{'raw_affiliation_string': 'Department of Biomedical Sciences and Human Oncology, Section of Internal Medicine and Clinical Oncology, University of Bari "Aldo Moro", Bari, Italy', 'institution_ids': ['https://openalex.org/I5561750', 'https://openalex.org/I5561750']}]}], 'institution_assertions': [], 'countries_distinct_count': 1, 'institutions_distinct_count': 1, 'corresponding_author_ids': ['https://openalex.org/A5039750643'], 'corresponding_institution_ids': ['https://openalex.org/I5561750'], 'apc_list': None, 'apc_paid': None, 'fwci': 0.743, 'has_fulltext': True, 'fulltext_origin': 'pdf', 'cited_by_count': 24, 'citation_normalized_percentile': {'value': 0.456434, 'is_in_top_1_percent': False, 'is_in_top_10_percent': False}, 'cited_by_percentile_year': {'min': 92, 'max': 93}, 'biblio': {'volume': '7', 'issue': '35', 'first_page': '57414', 'last_page': '57429'}, 'is_retracted': False, 'is_paratext': False, 'primary_topic': {'id': 'https://openalex.org/T10754', 'display_name': 'Neuroendocrine Tumor Research Advances', 'score': 1.0, 'subfield': {'id': 'https://openalex.org/subfields/2713', 'display_name': 'Epidemiology'}, 'field': {'id': 'https://openalex.org/fields/27', 'display_name': 'Medicine'}, 'domain': {'id': 'https://openalex.org/domains/4', 'display_name': 'Health Sciences'}}, 'topics': [{'id': 'https://openalex.org/T10754', 'display_name': 'Neuroendocrine Tumor Research Advances', 'score': 1.0, 'subfield': {'id': 'https://openalex.org/subfields/2713', 'display_name': 'Epidemiology'}, 'field': {'id': 'https://openalex.org/fields/27', 'display_name': 'Medicine'}, 'domain': {'id': 'https://openalex.org/domains/4', 'display_name': 'Health Sciences'}}, {'id': 'https://openalex.org/T12334', 'display_name': 'Lung Cancer Research Studies', 'score': 0.9997, 'subfield': {'id': 'https://openalex.org/subfields/2730', 'display_name': 'Oncology'}, 'field': {'id': 'https://openalex.org/fields/27', 'display_name': 'Medicine'}, 'domain': {'id': 'https://openalex.org/domains/4', 'display_name': 'Health Sciences'}}, {'id': 'https://openalex.org/T12226', 'display_name': 'Neuroblastoma Research and Treatments', 'score': 0.9799, 'subfield': {'id': 'https://openalex.org/subfields/2728', 'display_name': 'Neurology'}, 'field': {'id': 'https://openalex.org/fields/27', 'display_name': 'Medicine'}, 'domain': {'id': 'https://openalex.org/domains/4', 'display_name': 'Health Sciences'}}], 'keywords': [{'id': 'https://openalex.org/keywords/epigenome', 'display_name': 'Epigenome', 'score': 0.8615198}, {'id': 'https://openalex.org/keywords/epigenetic-therapy', 'display_name': 'Epigenetic Therapy', 'score': 0.48363125}, {'id': 'https://openalex.org/keywords/immune-checkpoint', 'display_name': 'Immune checkpoint', 'score': 0.43327743}], 'concepts': [{'id': 'https://openalex.org/C41091548', 'wikidata': 'https://www.wikidata.org/wiki/Q26939', 'display_name': 'Epigenetics', 'level': 3, 'score': 0.87834215}, {'id': 'https://openalex.org/C117717151', 'wikidata': 'https://www.wikidata.org/wiki/Q3589155', 'display_name': 'Epigenome', 'level': 5, 'score': 0.8615198}, {'id': 'https://openalex.org/C71924100', 'wikidata': 'https://www.wikidata.org/wiki/Q11190', 'display_name': 'Medicine', 'level': 0, 'score': 0.57547945}, {'id': 'https://openalex.org/C2779343474', 'wikidata': 'https://www.wikidata.org/wiki/Q3109175', 'display_name': 'Context (archaeology)', 'level': 2, 'score': 0.54125327}, {'id': 'https://openalex.org/C60644358', 'wikidata': 'https://www.wikidata.org/wiki/Q128570', 'display_name': 'Bioinformatics', 'level': 1, 'score': 0.52002954}, {'id': 'https://openalex.org/C167227067', 'wikidata': 'https://www.wikidata.org/wiki/Q5113739', 'display_name': 'Chromatin remodeling', 'level': 4, 'score': 0.51511306}, {'id': 'https://openalex.org/C535046627', 'wikidata': 'https://www.wikidata.org/wiki/Q30612', 'display_name': 'Clinical trial', 'level': 2, 'score': 0.48499367}, {'id': 'https://openalex.org/C2780737395', 'wikidata': 'https://www.wikidata.org/wiki/Q18353741', 'display_name': 'Epigenetic therapy', 'level': 5, 'score': 0.48363125}, {'id': 'https://openalex.org/C83640560', 'wikidata': 'https://www.wikidata.org/wiki/Q180951', 'display_name': 'Chromatin', 'level': 3, 'score': 0.45145428}, {'id': 'https://openalex.org/C2780851360', 'wikidata': 'https://www.wikidata.org/wiki/Q21686041', 'display_name': 'Immune checkpoint', 'level': 4, 'score': 0.43327743}, {'id': 'https://openalex.org/C70721500', 'wikidata': 'https://www.wikidata.org/wiki/Q177005', 'display_name': 'Computational biology', 'level': 1, 'score': 0.4022504}, {'id': 'https://openalex.org/C121608353', 'wikidata': 'https://www.wikidata.org/wiki/Q12078', 'display_name': 'Cancer', 'level': 2, 'score': 0.39841443}, {'id': 'https://openalex.org/C190727270', 'wikidata': 'https://www.wikidata.org/wiki/Q874745', 'display_name': 'DNA methylation', 'level': 4, 'score': 0.36634463}, {'id': 'https://openalex.org/C86803240', 'wikidata': 'https://www.wikidata.org/wiki/Q420', 'display_name': 'Biology', 'level': 0, 'score': 0.35976276}, {'id': 'https://openalex.org/C2777701055', 'wikidata': 'https://www.wikidata.org/wiki/Q1427096', 'display_name': 'Immunotherapy', 'level': 3, 'score': 0.2492994}, {'id': 'https://openalex.org/C104317684', 'wikidata': 'https://www.wikidata.org/wiki/Q7187', 'display_name': 'Gene', 'level': 2, 'score': 0.24284479}, {'id': 'https://openalex.org/C54355233', 'wikidata': 'https://www.wikidata.org/wiki/Q7162', 'display_name': 'Genetics', 'level': 1, 'score': 0.16255692}, {'id': 'https://openalex.org/C126322002', 'wikidata': 'https://www.wikidata.org/wiki/Q11180', 'display_name': 'Internal medicine', 'level': 1, 'score': 0.15778819}, {'id': 'https://openalex.org/C150194340', 'wikidata': 'https://www.wikidata.org/wiki/Q26972', 'display_name': 'Gene expression', 'level': 3, 'score': 0.09053573}, {'id': 'https://openalex.org/C151730666', 'wikidata': 'https://www.wikidata.org/wiki/Q7205', 'display_name': 'Paleontology', 'level': 1, 'score': 0.0}], 'mesh': [{'descriptor_ui': 'D018358', 'descriptor_name': 'Neuroendocrine Tumors', 'qualifier_ui': 'Q000235', 'qualifier_name': 'genetics', 'is_major_topic': True}, {'descriptor_ui': 'D010190', 'descriptor_name': 'Pancreatic Neoplasms', 'qualifier_ui': 'Q000235', 'qualifier_name': 'genetics', 'is_major_topic': True}, {'descriptor_ui': 'D048868', 'descriptor_name': 'Adaptor Proteins, Signal Transducing', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': False}, {'descriptor_ui': 'D014408', 'descriptor_name': 'Biomarkers, Tumor', 'qualifier_ui': 'Q000235', 'qualifier_name': 'genetics', 'is_major_topic': False}, {'descriptor_ui': 'D056970', 'descriptor_name': 'Co-Repressor Proteins', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D019175', 'descriptor_name': 'DNA Methylation', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D044127', 'descriptor_name': 'Epigenesis, Genetic', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D006801', 'descriptor_name': 'Humans', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D007107', 'descriptor_name': 'Immune System', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D008175', 'descriptor_name': 'Lung Neoplasms', 'qualifier_ui': 'Q000235', 'qualifier_name': 'genetics', 'is_major_topic': False}, {'descriptor_ui': 'D018832', 'descriptor_name': 'Molecular Chaperones', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D009154', 'descriptor_name': 'Mutation', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D009687', 'descriptor_name': 'Nuclear Proteins', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': False}, {'descriptor_ui': 'D009857', 'descriptor_name': 'Oncogenes', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D011379', 'descriptor_name': 'Prognosis', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D011518', 'descriptor_name': 'Proto-Oncogene Proteins', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': False}, {'descriptor_ui': 'D000075924', 'descriptor_name': 'X-linked Nuclear Protein', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': False}], 'locations_count': 5, 'locations': [{'is_oa': True, 'landing_page_url': 'https://doi.org/10.18632/oncotarget.10598', 'pdf_url': 'http://www.oncotarget.com/index.php?journal=oncotarget&page=article&op=download&path%5B%5D=10598&path%5B%5D=33481', 'source': {'id': 'https://openalex.org/S126644158', 'display_name': 'Oncotarget', 'issn_l': '1949-2553', 'issn': ['1949-2553'], 'is_oa': True, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310316297', 'host_organization_name': 'Impact Journals LLC', 'host_organization_lineage': ['https://openalex.org/P4310316297'], 'host_organization_lineage_names': ['Impact Journals LLC'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, {'is_oa': True, 'landing_page_url': 'https://europepmc.org/articles/pmc5302998', 'pdf_url': 'https://europepmc.org/articles/pmc5302998?pdf=render', 'source': {'id': 'https://openalex.org/S4306400806', 'display_name': 'Europe PMC (PubMed Central)', 'issn_l': None, 'issn': None, 'is_oa': True, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1303153112', 'host_organization_name': 'European Bioinformatics Institute', 'host_organization_lineage': ['https://openalex.org/I1303153112'], 'host_organization_lineage_names': ['European Bioinformatics Institute'], 'type': 'repository'}, 'license': 'cc-by', 'license_id': 'https://openalex.org/licenses/cc-by', 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, {'is_oa': True, 'landing_page_url': 'https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5302998', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S2764455111', 'display_name': 'PubMed Central', 'issn_l': None, 'issn': None, 'is_oa': True, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1299303238', 'host_organization_name': 'National Institutes of Health', 'host_organization_lineage': ['https://openalex.org/I1299303238'], 'host_organization_lineage_names': ['National Institutes of Health'], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, {'is_oa': True, 'landing_page_url': 'https://hdl.handle.net/11586/185404', 'pdf_url': 'https://ricerca.uniba.it/bitstream/11586/185404/2/20_Oncotarget.pdf', 'source': {'id': 'https://openalex.org/S4377196296', 'display_name': 'CINECA IRIS Institutional Research Information System (University of Bari Aldo Moro)', 'issn_l': None, 'issn': None, 'is_oa': False, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I5561750', 'host_organization_name': 'University of Bari Aldo Moro', 'host_organization_lineage': ['https://openalex.org/I5561750'], 'host_organization_lineage_names': ['University of Bari Aldo Moro'], 'type': 'repository'}, 'license': 'other-oa', 'license_id': 'https://openalex.org/licenses/other-oa', 'version': 'submittedVersion', 'is_accepted': False, 'is_published': False}, {'is_oa': False, 'landing_page_url': 'https://pubmed.ncbi.nlm.nih.gov/27418145', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S4306525036', 'display_name': 'PubMed', 'issn_l': None, 'issn': None, 'is_oa': False, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1299303238', 'host_organization_name': 'National Institutes of Health', 'host_organization_lineage': ['https://openalex.org/I1299303238'], 'host_organization_lineage_names': ['National Institutes of Health'], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}], 'best_oa_location': {'is_oa': True, 'landing_page_url': 'https://doi.org/10.18632/oncotarget.10598', 'pdf_url': 'http://www.oncotarget.com/index.php?journal=oncotarget&page=article&op=download&path%5B%5D=10598&path%5B%5D=33481', 'source': {'id': 'https://openalex.org/S126644158', 'display_name': 'Oncotarget', 'issn_l': '1949-2553', 'issn': ['1949-2553'], 'is_oa': True, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310316297', 'host_organization_name': 'Impact Journals LLC', 'host_organization_lineage': ['https://openalex.org/P4310316297'], 'host_organization_lineage_names': ['Impact Journals LLC'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, 'sustainable_development_goals': [{'display_name': 'Good health and well-being', 'score': 0.6, 'id': 'https://metadata.un.org/sdg/3'}], 'grants': [], 'datasets': [], 'versions': [], 'referenced_works_count': 108, 'referenced_works': ['https://openalex.org/W1473778466', 'https://openalex.org/W1571505119', 'https://openalex.org/W1577875429', 'https://openalex.org/W1681030413', 'https://openalex.org/W1772419959', 'https://openalex.org/W1880968219', 'https://openalex.org/W1892562842', 'https://openalex.org/W1900790478', 'https://openalex.org/W1905278501', 'https://openalex.org/W1931284432', 'https://openalex.org/W1953890763', 'https://openalex.org/W1964082229', 'https://openalex.org/W1967016314', 'https://openalex.org/W1973753716', 'https://openalex.org/W1975343614', 'https://openalex.org/W1985389100', 'https://openalex.org/W1985967354', 'https://openalex.org/W1986009297', 'https://openalex.org/W1991912136', 'https://openalex.org/W1995177932', 'https://openalex.org/W2002500034', 'https://openalex.org/W2005250386', 'https://openalex.org/W2010568588', 'https://openalex.org/W2015613797', 'https://openalex.org/W2017283276', 'https://openalex.org/W2018459913', 'https://openalex.org/W2019202377', 'https://openalex.org/W2023608054', 'https://openalex.org/W2025667689', 'https://openalex.org/W2026669761', 'https://openalex.org/W2029861048', 'https://openalex.org/W2033172867', 'https://openalex.org/W2036825872', 'https://openalex.org/W2042861906', 'https://openalex.org/W2044323880', 'https://openalex.org/W2046667178', 'https://openalex.org/W2050101620', 'https://openalex.org/W2053580956', 'https://openalex.org/W2057969865', 'https://openalex.org/W2059584939', 'https://openalex.org/W2060427373', 'https://openalex.org/W2062656198', 'https://openalex.org/W2063957403', 'https://openalex.org/W2066919884', 'https://openalex.org/W2072752570', 'https://openalex.org/W2085895339', 'https://openalex.org/W2087457210', 'https://openalex.org/W2088894923', 'https://openalex.org/W2088907162', 'https://openalex.org/W2092630032', 'https://openalex.org/W2093071455', 'https://openalex.org/W2105549148', 'https://openalex.org/W2106057638', 'https://openalex.org/W2107044147', 'https://openalex.org/W2110264425', 'https://openalex.org/W2112702770', 'https://openalex.org/W2113168685', 'https://openalex.org/W2113602644', 'https://openalex.org/W2115408721', 'https://openalex.org/W2116229314', 'https://openalex.org/W2118648577', 'https://openalex.org/W2118672029', 'https://openalex.org/W2119451851', 'https://openalex.org/W2119777818', 'https://openalex.org/W2121256763', 'https://openalex.org/W2121618708', 'https://openalex.org/W2124270614', 'https://openalex.org/W2126047347', 'https://openalex.org/W2127976626', 'https://openalex.org/W2128645075', 'https://openalex.org/W2128947421', 'https://openalex.org/W2128986947', 'https://openalex.org/W2130735070', 'https://openalex.org/W2134459196', 'https://openalex.org/W2135049144', 'https://openalex.org/W2135937937', 'https://openalex.org/W2143827882', 'https://openalex.org/W2143917018', 'https://openalex.org/W2150056778', 'https://openalex.org/W2150671102', 'https://openalex.org/W2153075036', 'https://openalex.org/W2154010291', 'https://openalex.org/W2156270057', 'https://openalex.org/W2157232603', 'https://openalex.org/W2159596111', 'https://openalex.org/W2160392555', 'https://openalex.org/W2160759504', 'https://openalex.org/W2162669199', 'https://openalex.org/W2164016448', 'https://openalex.org/W2168083077', 'https://openalex.org/W2171201030', 'https://openalex.org/W2171342611', 'https://openalex.org/W2173461168', 'https://openalex.org/W2177301634', 'https://openalex.org/W2196075541', 'https://openalex.org/W2209368665', 'https://openalex.org/W2222000795', 'https://openalex.org/W2226718724', 'https://openalex.org/W2289369916', 'https://openalex.org/W2312869190', 'https://openalex.org/W2323523295', 'https://openalex.org/W2333203880', 'https://openalex.org/W2346690872', 'https://openalex.org/W2409400193', 'https://openalex.org/W2970066253', 'https://openalex.org/W3084020307', 'https://openalex.org/W4210552688', 'https://openalex.org/W74962980'], 'related_works': ['https://openalex.org/W4389397408', 'https://openalex.org/W2519953954', 'https://openalex.org/W2137223914', 'https://openalex.org/W2118937292', 'https://openalex.org/W2090160141', 'https://openalex.org/W2081832748', 'https://openalex.org/W2040861513', 'https://openalex.org/W2023670712', 'https://openalex.org/W2014355739', 'https://openalex.org/W1605106831'], 'abstract_inverted_index': {'//': [0, 44], 'Mauro': [1], 'Cives': [2], '1': [3, 7, 12, 16, 17], ',': [4, 8], 'Valeria': [5], 'Simone': [6], 'Francesca': [9], 'Maria': [10], 'Rizzo': [11], 'and': [13, 22, 29, 94, 117, 195, 220, 290, 296, 304], 'Franco': [14, 41], 'Silvestris': [15], 'Department': [18], 'of': [19, 26, 33, 80, 84, 91, 115, 153, 162, 170, 182, 184, 205, 218, 236, 255, 265, 283, 293], 'Biomedical': [20], 'Sciences': [21], 'Human': [23], 'Oncology,': [24, 31], 'Section': [25], 'Internal': [27], 'Medicine': [28], 'Clinical': [30], 'University': [32], 'Bari': [34], '"Aldo': [35], 'Moro",': [36], 'Bari,': [37], 'Italy': [38], 'Correspondence': [39], 'to:': [40], 'Silvestris,': [42], 'email:': [43], 'Keywords': [45], ':': [46, 55, 60, 65], 'carcinoid': [47], 'tumors,': [48], 'DAXX,': [49], 'ATRX,': [50], 'MEN1,': [51], 'DNA': [52], 'methylation': [53], 'Received': [54], 'April': [56], '06,': [57], '2016': [58, 63, 68], 'Accepted': [59], 'June': [61], '30,': [62], 'Published': [64], 'July': [66], '13,': [67], 'Abstract': [69], 'High-throughput': [70], 'next-generation': [71], 'sequencing': [72], 'methods': [73], 'have': [74, 108, 229, 241], 'recently': [75], 'provided': [76], 'a': [77, 225], 'detailed': [78], 'picture': [79], 'the': [81, 112, 144, 151, 168, 177, 206, 253, 262, 284, 294], 'genetic': [82], 'landscape': [83], 'neuroendocrine': [85], 'tumors': [86], '(NETs),': [87], 'revealing': [88], 'recurrent': [89], 'mutations': [90], 'chromatin-remodeling': [92], 'genes': [93], 'little-to-no': [95], 'pathogenetic': [96], 'role': [97], 'for': [98, 215], 'oncogenes': [99], 'commonly': [100], 'mutated': [101], 'in': [102, 159, 173, 221, 239, 287], 'cancer.': [103], 'Concurrently,': [104], 'multiple': [105], 'epigenetic': [106, 199, 227, 237, 285], 'modifications': [107], 'been': [109, 125, 230, 242], 'described': [110], 'across': [111], 'whole': [113], 'spectrum': [114], 'NETs,': [116], 'their': [118, 301], 'putative': [119], 'function': [120], 'as': [121], 'tumorigenic': [122], 'drivers': [123], 'has': [124, 148], 'envisaged.': [126], 'As': [127], 'result,': [128], 'it': [129], 'is': [130, 193, 211], 'still': [131], 'unclear': [132], 'whether': [133], 'or': [134], 'not': [135], 'NETs': [136, 240, 292], 'are': [137, 164, 201, 249], 'epigenetically-driven,': [138], 'rather': [139], 'than': [140], 'genetically-induced': [141], 'malignancies.': [142], 'Although': [143, 233], 'NET': [145, 171], 'epigenome': [146], 'profiling': [147], 'led': [149], 'to': [150, 166, 188, 190, 251], 'identification': [152], 'molecularly-distinct': [154], 'tumor': [155], 'subsets,': [156], 'validation': [157], 'studies': [158, 197], 'larger': [160], 'cohorts': [161], 'patients': [163, 185], 'needed': [165], 'translate': [167], 'use': [169], 'epitypes': [172], 'clinical': [174, 234, 247], 'practice.': [175], 'In': [176, 258, 276], 'precision': [178], 'medicine': [179], 'era,': [180], 'recognition': [181], 'subpopulations': [183], 'more': [186], 'likely': [187], 'respond': [189], 'therapeutic': [191, 305], 'agents': [192, 228], 'critical,': [194], 'future': [196, 216], 'testing': [198], 'biomarkers': [200], 'therefore': [202], 'awaited.': [203], 'Restoration': [204], 'aberrant': [207], 'chromatin': [208], 'remodeling': [209], 'machinery': [210], 'an': [212, 281], 'attractive': [213], 'approach': [214], 'treatment': [217], 'cancer': [219], 'several': [222], 'hematological': [223], 'malignancies': [224], 'few': [226], 'already': [231], 'approved.': [232], 'outcomes': [235], 'therapies': [238, 268], 'disappointing': [243], 'so': [244], 'far,': [245], 'further': [246], 'trials': [248], 'required': [250], 'investigate': [252], 'efficacy': [254], 'these': [256], 'drugs.': [257], 'this': [259, 277], 'context,': [260], 'given': [261], 'immune-stimulating': [263], 'effects': [264], 'epidrugs,': [266], 'combination': [267], 'with': [269], 'immune': [270], 'checkpoint': [271], 'inhibitors': [272], 'should': [273], 'be': [274], 'tested.': [275], 'review,': [278], 'we': [279], 'provide': [280], 'overview': [282], 'changes': [286], 'both': [288], 'hereditary': [289], 'sporadic': [291], 'gastroenteropancreatic': [295], 'bronchial': [297], 'tract,': [298], 'focusing': [299], 'on': [300], 'diagnostic,': [302], 'prognostic': [303], 'implications.': [306]}, 'cited_by_api_url': 'https://api.openalex.org/works?filter=cites:W2468601597', 'counts_by_year': [{'year': 2022, 'cited_by_count': 5}, {'year': 2021, 'cited_by_count': 2}, {'year': 2020, 'cited_by_count': 2}, {'year': 2019, 'cited_by_count': 4}, {'year': 2018, 'cited_by_count': 5}, {'year': 2017, 'cited_by_count': 5}, {'year': 2016, 'cited_by_count': 1}], 'updated_date': '2024-12-14T16:02:47.486590', 'created_date': '2016-07-22'}