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'host_organization_lineage_names': ['Japanese Dermatological Association'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, 'sustainable_development_goals': [], 'grants': [], 'datasets': [], 'versions': [], 'referenced_works_count': 0, 'referenced_works': [], 'related_works': ['https://openalex.org/W2725118148', 'https://openalex.org/W2467019772', 'https://openalex.org/W242146478', 'https://openalex.org/W2132898409', 'https://openalex.org/W2093272887', 'https://openalex.org/W2066746614', 'https://openalex.org/W2037631372', 'https://openalex.org/W2030889776', 'https://openalex.org/W1979139803', 'https://openalex.org/W1966504330'], 'abstract_inverted_index': {'Cyproterone': [0, 22], 'acetate': [1, 5, 20, 23, 33, 51, 61], 'の投与による睾丸の造精機能および内分泌機能の変化を雄ラットで検討する目的で,': [2], '成熟雄ラットに': [3], 'cyproterone': [4, 19, 32, 50, 60], 'を10mg/kg/day連日2週間又は4週間投与し,': [6], '投与終了時に血漿中LH,': [7], 'FSH,': [8], 'testosterone': [9, 16, 39, 43], '値を測定し,': [10], '電気刺激射精法によつて得られた精液中精子数を算定した.': [11], 'さらに摘出睾丸潅流法により睾丸の': [12], 'progesterone,': [13], '17α-hydroxyprogesterone': [14, 56], 'および': [15], '分泌能を測定し,': [17], '睾丸間質の組織学的所見と併せて対照群と': [18], '投与群と比較検討した.': [21], '投与後の睾丸重量は,': [24], '対照群と比べ有意差はなく,': [25], '組織学的には,': [26], '精細管精子細胞の変性が認められたが,': [27], '睾丸間質細胞数には対照群と差はなかつた.': [28], '射精液中の精子数は対照群で742±200×104': [29], '(mean±SEM)': [30], 'に対し,': [31], '投与群で399±89×104と減少したが両者間に有意差はなかつた.': [34], '血中LH,': [35], 'FSH値は本剤投与により有意に上昇し': [36], '(p<0.001),': [37], '逆に': [38], '値は有意に減少した': [40], '(p<0.05).': [41, 58], '睾丸潅流法による': [42], '分泌能は,': [44], '対照群の3.39±0.67ng/minに対し,': [45], '投与2週後で1.55±0.67ng/minと減少し,': [46], '投与4週後には0.91±0.21ng/minと有意に抑制された': [47], '(p<0.001).': [48], 'また': [49], '投与により,': [52], '睾丸の': [53], 'progesterone': [54], '分泌能は対照群と比べ有意差はなかつたが,': [55], '分泌能は有意に増加した': [57], 'この事実から': [59], 'が睾丸の17,': [62], '20': [63], 'desmolase': [64], 'もしくは': [65], '17ketosteroid': [66], 'reductase': [67], '活性を抑制する可能性が示唆された.': 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