<scp>FADD</scp> is a key regulator of lipid metabolism

Name: Work Video:
Duration: 3 min 30 s
Hongqin Zhuang; Xueshi Wang; Daolong Zha; Ziyi Gan; Fangfang Cai; Pan Du; Yunwen Yang; Bingya Yang; Xiangyu Zhang; Chun Yao; Yuqiang Zhou; Chizhou Jiang; Shengwen Guan; Xuerui Zhang; Jing Zhang; Wenhui Jiang; Qingang Hu; Zi‐Chun Hua
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'PDF': [1315], 'article': [1317], 'text': [1318], 'main': [1320, 3869], 'figures.': [1321], 'Peer': [1322], 'ReviewDownload': [1323], 'summary': [1325], 'the': [1327, 1369, 1415, 1445, 1476, 1537, 1622, 1625, 1653, 1663, 1718, 1721, 1725, 1730, 1787, 1811, 1826, 1848, 1854, 1874, 1883, 1998, 2011, 2020, 2086, 2127, 2131, 2136, 2151, 2155, 2166, 2183, 2243, 2287, 2297, 2306, 2317, 2323, 2372, 2387, 2450, 2538, 2567, 2611, 2651, 2656, 2666, 2700, 2726, 2750, 2760, 2765, 2832, 2864, 2966, 2976, 2981, 2988, 2994, 3004, 3016, 3027, 3043, 3062, 3080, 3094, 3113, 3125, 3337, 3376, 3408, 3459, 3494, 3512, 3536, 3614, 3622, 3668, 3724, 3734, 3738, 3745, 3749, 3802, 3835, 3842, 3865, 3873, 3967, 4007, 4292], 'editorial': [1328, 1332], 'decision': [1329, 1333], 'process': [1330, 1840], 'including': [1331, 1742, 2342, 2507, 2579], 'letters,': [1334], 'reviewer': [1335], 'comments': [1336], 'responses': [1339], 'to': [1340, 1343, 1362, 1414, 1444, 1461, 1543, 1680, 1729, 1770, 1786, 1864, 1975, 2032, 2129, 2159, 2182, 2267, 2296, 2320, 2354, 2381, 2490, 2503, 2610, 2624, 2655, 2694, 2697, 2731, 2825, 2842, 2852, 2904, 2910, 2950, 3098, 3420, 3471, 3591, 3613, 3722, 3748, 3790, 3841, 3895, 3922, 3966, 3999, 4049], 'feedback.': [1341], 'ToolsAdd': [1342], 'favoritesDownload': [1344], 'CitationsTrack': [1345], 'CitationsPermissions': [1346], 'ShareFacebookTwitterLinked': [1347], 'InMendeleyWechatReddit': [1348], 'Figures': [1349], '&': [1350, 1685], 'Info': [1351], 'Abstract': [1352], 'FADD,': [1353, 2139], 'classical': [1355, 1529], 'apoptotic': [1356, 1888, 2004], 'signaling': [1357, 1836, 1866, 1906], 'adaptor,': [1358], 'was': [1359, 2148, 2252, 2608, 2668, 2691, 2709, 2734, 2850, 2870, 2899, 3072, 3086, 3270, 3303, 3333, 3478, 3627, 3672, 3687, 3758, 3798, 3808, 3818, 3861, 3903, 3945], 'recently': [1360], 'reported': [1361], 'have': [1363, 1544, 1832, 1964, 3585], 'non-apoptotic': [1364, 1968], 'functions.': [1365], 'Here,': [1366, 2119, 2454], 'we': [1367, 2120, 2455, 2630, 2758, 2974, 3603], 'report': [1368, 2121], 'discovery': [1370], 'that': [1371, 1390, 1504, 1828, 1966, 2054, 2070, 2095, 2122, 2374, 2414, 2457, 2719, 2762, 2819, 2875, 2896, 3002, 3093, 3605, 3770, 3938, 3960], 'regulates': [1373, 2395, 2764, 3124], 'metabolism.': [1375, 1876, 2409], 'PPAR-α': [1376, 1556, 2096, 2128, 2140, 2161, 2177, 2398, 2465, 2550, 2571, 2607, 2654, 2730, 2755, 2775, 2785, 2798, 2824, 2835, 2869, 2892, 2926, 2940, 2946, 2959, 2992, 3058, 3100, 3128, 3133, 3167, 3197, 3199, 3319, 3332, 3357, 3451, 3477, 3501, 3518, 3543, 3595, 3610], 'dietary': [1379], 'sensor,': [1381], 'whose': [1382], 'activation': [1383, 1416, 1446, 1565, 1927, 2167, 2179, 2397, 2527], 'results': [1384, 2360, 2677, 2805, 3091, 3184], 'in': [1385, 1441, 1466, 1492, 1532, 1548, 1569, 1572, 1580, 1600, 1628, 1692, 1708, 1713, 1775, 1810, 1853, 1903, 1912, 1980, 1985, 2056, 2060, 2074, 2105, 2192, 2215, 2229, 2278, 2282, 2292, 2328, 2386, 2403, 2468, 2482, 2494, 2532, 2553, 2575, 2628, 2644, 2650, 2662, 2670, 2680, 2699, 2703, 2712, 2776, 2786, 2808, 2900, 2953, 2993, 3003, 3023, 3055, 3061, 3083, 3111, 3138, 3169, 3257, 3284, 3291, 3317, 3323, 3361, 3375, 3401, 3452, 3508, 3523, 3552, 3600, 3630, 3663, 3674, 3689, 3762, 3793, 3801, 3821, 3834, 3914, 3918, 3935, 3939, 3950, 3969, 3991, 4006, 4023, 4032, 4034, 4041, 4153, 4253], 'hypolipidemic': [1386], 'effects.': [1387], 'We': [1388, 1502, 3000], 'show': [1389], 'interacts': [1392], 'with': [1393, 1436, 1484, 1515, 2144, 2254, 2339, 2537, 2769, 2774, 2784, 2792, 2844, 2855, 2874, 3145, 3272, 3305, 3411, 3422, 3462, 3473, 3983], 'RIP140,': [1394, 3007, 3065], 'which': [1395, 1782, 1995, 2614, 3526, 3555, 3686, 3737, 3958], 'corepressor': [1398, 2133, 2739], 'PPAR-α,': [1400], 'phosphorylation-mimic': [1403], 'mutation': [1404, 1473, 1559, 1575, 1595, 2021, 2153, 2175, 2196, 2251, 2289, 2442, 2565, 2721, 2830, 2907, 3731], '(FADD-D)': [1405, 2206, 2421], 'or': [1406, 1560, 1576, 1590, 1596, 2207, 2422, 2443, 2722, 2789, 2793, 2848, 2878, 2996, 3276, 3309, 3329, 3342, 3416, 3467, 3619, 4086, 4168], 'deficiency': [1408, 1562, 2172, 2424, 2445, 3053], 'abolishes': [1409], 'RIP140-mediated': [1410], 'transcriptional': [1411, 2132, 2178, 2526, 2738, 2756], 'repression,': [1412], 'leading': [1413, 1728], 'PPAR-α.': [1418, 1448, 2169, 2453, 2770, 2905, 3279], 'FADD-D-mutant': [1419], 'mice': [1420, 1581, 1601, 2034, 2193, 2211, 2225, 2236, 2294, 2313, 2334, 2560, 3144, 3175, 3213, 3584, 3638, 3676, 3681, 3706, 3739, 3769, 3804, 3823, 3837, 3889, 3920, 3941, 3980, 3993, 4027, 4066, 4075, 4234], 'exhibit': [1421, 1432], 'significantly': [1422, 3732], 'decreased': [1423, 1499, 1607, 2227, 2346, 3779, 3863, 3961, 4014], 'adipose': [1424, 1493, 1550, 1608, 1693, 1709, 2230, 2283, 2347, 2555, 3854, 4328], 'tissue': [1425, 1551, 1609, 2348, 2556, 3855, 4053, 4329], 'mass': [1426], 'triglyceride': [1428, 1500], 'accumulation.': [1429], 'Also,': [1430], 'they': [1431], 'increased': [1433, 2467, 2493, 2552, 2566, 2669, 2912, 3740, 3799, 3820], 'energy': [1434, 1647, 1673, 1682, 1700, 1703, 1722, 2075, 2216, 2269], 'expenditure': [1435, 1674, 2270], 'enhanced': [1437, 2176, 2268, 2428, 2711, 2871], 'fatty': [1438, 1486, 2078, 2098, 2106, 2109, 2187, 2279, 2404, 2429, 2484, 2533, 2576, 2625, 2638], 'acid': [1439, 1487, 2079, 2099, 2107, 2110, 2188, 2280, 2405, 2430, 2485, 2534, 2577, 2626, 2639, 2985, 3020, 3031], 'oxidation': [1440, 1488, 2080, 2100, 2281, 2406, 2486, 2627, 2640, 2986, 3021, 3032], 'adipocytes': [1442, 2684, 2714, 2812, 3011, 3041, 3085, 3258, 3269, 3292, 3302, 3934, 3954], 'due': [1443, 1974, 2266, 3789], 'Similar': [1449, 2676, 2804], 'metabolic': [1450, 1654, 1869, 2337, 3664, 4062], 'phenotypes,': [1451], 'such': [1452, 1716, 2259, 3871], 'as': [1453, 1630, 1632, 1717, 2260, 2501, 2586, 2636, 2736, 2872, 3152, 3220, 3654, 3872, 4145, 4259, 4306, 4343], 'reduced': [1454, 2343, 2954, 3586, 3629, 3733, 3891, 4022], 'fat': [1455, 1513, 2228, 2344, 2385, 3206, 3615, 3860, 3909, 3916, 3970, 4001, 4130, 4142, 4226, 4355, 4361, 4365], 'formation,': [1456, 2345], 'insulin': [1457, 1496, 1521, 1604, 1807, 2300, 2329, 2350], 'resistance,': [1458, 1497, 2351], 'resistance': [1460, 1522, 1605, 2330, 2353], 'HFD-induced': [1462, 1603], 'obesity,': [1463, 2258], 'are': [1464, 1695, 1783, 1972, 2028, 2088, 3150, 3182, 3218, 3348, 3386, 3437, 3484, 3521, 3550, 3567, 3589, 4118, 4183, 4257, 4304, 4341], 'shown': [1465, 1542, 2643, 3087, 3347, 3385, 3436, 3483, 3522, 3551, 3645], 'adipose-specific': [1467, 1577, 1597, 2208, 2307, 2310], 'knockout': [1469, 2210, 2724, 2788, 2810, 3328, 3344, 3366], 'mice.': [1470, 3265, 3298, 3620, 3751, 4140, 4162], 'Additionally,': [1471], 'FADD-D': [1472, 1558, 1574, 1594, 2224, 2250, 2340, 2441, 2472, 2496, 2559, 2564, 2671, 2713, 2720, 2790, 2829, 2840, 2867, 2957, 3143, 3174, 3212, 3297, 3330, 3428, 3541, 3583, 3675, 3680, 3705, 3730, 3768, 3803, 3822, 3836, 3888, 3919, 3940, 3956, 3979, 4026, 4065, 4074, 4137, 4159, 4231, 4287], 'can': [1474, 3652], 'reverse': [1475], 'severe': [1477], 'genetic': [1478, 2257], 'obesity': [1479, 1583, 1657, 1733, 1753, 2261, 3593], 'phenotype': [1480, 4063], 'ob/ob': [1482, 2293, 3636], 'mice,': [1483, 2341, 3957], 'elevated': [1485, 1771], 'oxygen': [1490], 'consumption': [1491, 1723, 3795, 3807, 3817], 'tissue,': [1494, 2231], 'improved': [1495], 'storage.': [1501, 1701], 'conclude': [1503], 'master': [1508], 'glucose': [1511, 2303], 'potential': [1516], 'applications': [1517], 'treatment': [1519], 'obesity.': [1524, 1780, 2332, 2358], 'Synopsis': [1525], 'adaptor': [1530, 1885], 'protein': [1531, 1880, 1886, 2369, 2462, 2547, 2913], 'death': [1533, 1878, 1892, 1904, 2368], 'receptor': [1534, 1905], 'signaling.': [1535], 'For': [1536], 'first': [1538], 'time,': [1539], 'major': [1546, 1697], 'role': [1547, 1902, 2325, 2402, 2968, 3108, 3599], 'modulating': [1549], 'regulating': [1555, 1868, 2102, 3112], 'activation.': [1557], 'promotes': [1563], "PPAR-α's": [1564, 2396, 2972], 'via': [1566, 1800, 2316], 'RIP140': [1567, 2145, 2163, 2733, 2768, 2772, 2782, 2827, 2845, 2856, 3046, 3071, 3081, 3102, 3130, 3321, 3359, 3400], 'derepression': [1568], 'vitro': [1570], 'vivo.': [1573], 'disruption': [1579, 1599], 'prevented': [1582, 1602], 'induced': [1584], 'feeding': [1586, 3825], 'on': [1587, 2010, 2042, 2449, 2754, 2971, 2980, 3728, 3744, 4076, 4235], 'HFD': [1589, 3827, 4088, 4102, 4170, 4237], 'leptin': [1592, 2264], 'deficiency.': [1593], 'inflammation.': [1610], 'Introduction': [1611], 'Metabolic': [1612, 1740], 'syndrome': [1613, 1655], 'an': [1615, 1641, 2362, 2447, 2616, 3423, 3432, 3474, 3946], 'epidemic': [1616], 'affecting': [1617], 'large': [1619], 'percentage': [1620, 4147], 'population': [1623, 1856], 'world.': [1626], 'Obesity': [1627], 'adults': [1629], 'well': [1631, 1844, 2093], 'children': [1633], 'global': [1636, 2213], 'health': [1637], 'problem,': [1638], 'resulting': [1639, 1774, 2262], 'from': [1640, 1752, 1899, 2263, 2541, 3140, 3156, 3171, 3185, 3204, 3207, 3224, 3260, 3268, 3294, 3301, 3336, 3407, 3458, 3717, 3955, 3973, 4157], 'imbalance': [1642], 'between': [1643, 2834, 2866, 2922, 2936, 2956, 3035], 'caloric': [1644, 2391], 'intake': [1645, 1677, 4097], 'expenditure.': [1648], 'increasing': [1650, 1801], 'prevalence': [1651, 1850], 'calls': [1658], 'new': [1660], 'approaches': [1661], 'prevention': [1664, 2255], 'management': [1666], 'these': [1668, 1967], 'diseases.': [1669], 'Precise': [1670], 'control': [1671, 3273, 3306], 'food': [1676, 2240, 3794, 3806, 4096], 'required': [1679, 2125, 2822], 'maintain': [1681], 'homeostasis': [1683], '(Spiegelman': [1684], 'Flier,': [1686], '2001).': [1687, 2118], 'In': [1688, 2135, 2285, 2688, 2838, 3997], 'mammals,': [1689], 'triglycerides': [1690], '(TGs)': [1691], 'tissues': [1694, 1710], 'form': [1698, 2197], 'Unburned': [1702], 'stored': [1705], 'at': [1706, 1997, 2203, 3736, 4052, 4238, 4291], 'TGs': [1707], 'subsequently': [1712, 1779, 2184], 'other': [1714, 3868, 3915], 'organs': [1715, 4133], 'liver,': [1719, 2232, 3874], 'when': [1720, 3070, 3805], 'exceeds': [1724, 1765], 'calories': [1726], 'combustion,': [1727], 'development': [1731, 1937], 'over': [1734, 3714, 4104], 'time': [1735], '(Duncan': [1736, 1814], 'et': [1737, 1755, 1759, 1815, 1819, 1858, 1895, 1917, 1921, 1929, 1933, 1939, 1943, 1949, 1953, 1959, 1988, 1992, 2015, 2036, 2063, 2082, 2116, 2433, 2744, 3648, 3696], 'al,': [1738, 1756, 1760, 1816, 1820, 1859, 1896, 1918, 1922, 1930, 1934, 1940, 1944, 1950, 1954, 1960, 1989, 1993, 2016, 2037, 2064, 2083, 2117, 2434, 2745, 3649, 3697], '2007).': [1739, 1821], 'syndrome,': [1741], 'type': [1743], '2': [1744], 'diabetes': [1745, 2046, 2061], 'mellitus,': [1746], 'atherosclerosis,': [1747], 'cancer,': [1749], 'may': [1750, 2072, 2379, 4046], 'result': [1751, 2059], '(Evans': [1754], '2004;': [1757, 1990], 'Gurevich-Panigrahi': [1758], '2009).': [1761], 'When': [1762], 'TG': [1763, 1772, 1830, 1875, 4043], 'synthesis': [1764], 'lipolysis,': [1766], 'it': [1767, 1861, 2050, 3797], 'will': [1768], 'lead': [1769, 2380], 'storage,': [1773], 'adipocyte': [1776], 'hypertrophy': [1777], 'Hormones,': [1781], 'secreted': [1784], 'according': [1785, 3894, 3921], 'nutritional': [1788], 'status,': [1789], 'tightly': [1790], 'regulate': [1791, 1829, 3099], 'lipolysis': [1792, 1797, 1809], 'within': [1793], 'adipocytes.': [1794, 2675], 'Catecholamines': [1795], 'stimulate': [1796], 'during': [1798], 'fasting': [1799], 'cyclic': [1802], 'AMP': [1803], '(cAMP)': [1804], 'levels.': [1805], 'However,': [1806], 'inhibits': [1808], 'fed': [1812, 3214, 3772, 4100, 4165], 'state': [1813], '2007;': [1817], 'Jaworski': [1818], 'To': [1822, 2604, 2747, 2963], 'date,': [1823], 'most': [1824], 'enzymes': [1827], 'been': [1833, 2052], 'identified;': [1834], 'however,': [1835, 2439], 'pathway': [1837], 'controlling': [1838], 'still': [1842], 'not': [1843, 3326, 3364, 3787, 3876, 4311], 'understood.': [1845, 2090], 'Because': [1846, 3594], 'high': [1849], 'dyslipidemia': [1852], 'general': [1855], '(Ginsberg': [1857], '2006),': [1860], 'important': [1863], 'identify': [1865], 'factors': [1867], 'regulatory': [1871], 'aspects': [1872], 'Fas-associated': [1877], 'domain-containing': [1879], '(FADD)': [1881], 'transmitting': [1887], 'signals': [1889], 'mediated': [1890], 'receptors': [1893, 2742], '(Chinnaiyan': [1894], '1995).': [1897], 'Apart': [1898], 'its': [1900, 1976], 'critical': [1901, 3107, 3598], 'apoptosis,': [1908], 'also': [1910, 2584, 2692, 3777, 3819, 3852, 4012], 'participates': [1911], 'cell': [1913, 2012, 3338, 3951, 3962], 'cycle': [1914, 2013], 'progression': [1915], '(Matsuyoshi': [1916], '2006;': [1919, 1951], 'Osborn': [1920], '2007),': [1923, 1955], 'lymphocyte': [1924], 'proliferation': [1925], '(Zhang': [1928, 1987], '1998;': [1931, 1941], '2003),': [1935, 3650], 'embryonic': [1936], '(Yeh': [1938], '2011),': [1945], 'innate': [1946], 'immunity': [1947], '(Imtiyaz': [1948], 'Zhande': [1952], 'chemosensitization': [1957], '(Shimada': [1958], '2005).': [1961], 'Previous': [1962], 'studies': [1963, 2068, 2191, 2412], 'revealed': [1965, 2212, 3929], 'activities': [1969], 'partly': [1973, 3964], 'phosphorylation': [1977, 2024, 2202, 3110], '(serine': [1978], '194': [1979], 'human': [1981, 3618, 3634], 'serine': [1983, 2204], '191': [1984, 2205], 'mouse)': [1986], 'Alappat': [1991], '2005),': [1994], 'C-terminal': [1999], 'tail': [2000], 'outside': [2003], 'domains': [2005], 'regulated': [2008], 'dependent': [2009, 3103], '(Scaffidi': [2014], '2000).': [2017], 'Mice': [2018, 4163], 'bearing': [2019, 2194, 2416], 'mimicking': [2022, 2200], 'constitutive': [2023, 2201, 2417], '(S191D)': [2025], 'immunologically': [2029], 'compromised,': [2030], 'similar': [2031, 2336, 3355, 3393, 3444, 3491, 4031], 'FADD-deficient': [2033], '(Hua': [2035, 3647], '2003).': [2038], 'located': [2041], 'chromosome': [2043], '11q13.3,': [2044], 'susceptibility': [2047], 'locus;': [2048], 'therefore,': [2049], 'has': [2051, 2399, 2446], 'suspected': [2053], 'alterations': [2055, 2214], 'might': [2058, 3611, 3838], '(Kim': [2062], '1996).': [2065], 'Our': [2066, 2410], 'previous': [2067, 2411], 'found': [2069, 2413, 2456, 2489, 2693, 2851, 3001, 3022], 'participate': [2073], 'metabolism,': [2076, 2219, 3602], 'especially': [2077], '(Zhuang': [2081, 2432], '2013a,b),': [2084], 'but': [2085, 2779, 3066, 3325, 3363], 'mechanisms': [2087], 'poorly': [2089], 'It': [2091, 2436, 2717], 'established': [2094], 'controls': [2097], 'genes': [2103, 2276, 2530, 2573], 'involved': [2104, 2481, 2531, 2574], 'transport,': [2108], 'oxidation,': [2111], 'mitochondrial': [2113, 2483], 'respiration': [2114], '(Minnich': [2115], 'recruit': [2130, 2826], 'RIP140.': [2134, 2837, 2999], 'absence': [2137, 2997, 3906], 'no': [2141, 3068], 'longer': [2142], 'interacted': [2143], 'therefore': [2147], 'activated.': [2149], 'Interestingly,': [2150, 2771], 'S191D': [2152, 2174, 2288], 'abolished': [2154], 'ability': [2156, 3095], 'promote': [2160], 'recruiting': [2162], 'promoted': [2165], 'Both': [2170], 'led': [2181, 2295], 'enhancement': [2185], 'oxidation.': [2189, 2535], 'Complementary': [2190], 'fuel': [2218], 'adiposity,': [2220], 'glucose–insulin': [2222], 'homeostasis.': [2223], 'showed': [2226], 'muscle.': [2234], 'These': [2235, 2359, 2816, 3090, 3784], 'consumed': [2237], 'even': [2238], 'than': [2241, 3014, 3937], 'did': [2242], 'wild-type,': [2244], 'yet': [2245], 'lost': [2246], 'body': [2247, 2384, 3690, 3693, 3742, 3764, 3811, 3832, 3882, 3896, 4068, 4109, 4149, 4283, 4332, 4354], 'weight.': [2248], 'Moreover,': [2249, 2479, 2563, 2906, 3859], 'associated': [2253, 2854], 'deficiency,': [2265], 'caused': [2271], 'PPAR-α-mediated': [2273], 'upregulation': [2274, 3056], 'participating': [2277], 'tissues.': [2284], 'addition,': [2286, 2689, 2839], 'improvement': [2298], 'sensitivity': [2301], 'tolerance.': [2304], 'Using': [2305], 'aP2-Cre': [2308], 'transgene,': [2309], 'deletion': [2311], '(ad-FADD)': [2312], 'were': [2314, 2466, 2488, 2551, 2678, 2806, 3033, 3282, 3315, 3373, 3418, 3429, 3469, 3707, 3771, 3875, 3981, 4011, 4020, 4164], 'created': [2315], 'Cre/LoxP': [2318], 'system': [2319], 'further': [2321, 2710, 2748, 2894, 2964], 'study': [2322, 2749], 'specific': [2324, 2967], 'Ad-FADD': [2333], 'exhibited': [2335, 2427, 3012, 3682, 3890], 'phenotypes': [2338], 'inflammation,': [2349], 'high-fat': [2355, 3774], 'diet': [2356, 3712, 3775], '(HFD)-caused': [2357], 'raise': [2361], 'unrevealed': [2363], 'function': [2364, 3115], 'canonical': [2367], 'possibility': [2373, 2761], 'pharmacological': [2375], 'manipulation': [2376], 'loss': [2382], 'context': [2388], 'normal': [2390], 'intake.': [2392], 'Results': [2393, 4117, 4182], 'central': [2401], 'MEFs': [2415, 2473, 2500, 2791, 3367], 'phosphorylated': [2418, 3625, 3658], 'mimic': [2420], '(FADD': [2425], 'KO)': [2426], 'β-oxidation': [2431], '2013a,b).': [2435], 'remains': [2437], 'unclear,': [2438], 'if': [2440], 'effect': [2448, 2751, 3069, 3725], 'regulation': [2451, 3608], 'both': [2458, 2495, 2543, 3655, 4035], 'gene': [2459, 2544, 2622], 'expression': [2460, 2545, 2569, 3168], 'level': [2463, 2548, 2990, 3060, 3623], 'KO': [2470, 2499, 2674, 2682, 3009, 3037], '(Appendix': [2474, 2522, 2685, 2813, 2960, 3047, 3074, 3118, 3639, 3677, 3828, 3899], 'Fig': [2475, 2523, 2645, 2686, 2814, 2861, 2884, 2961, 3048, 3075, 3119, 3640, 3678, 3829, 3857], 'S1A': [2476], 'B).': [2478, 3643], 'proteins': [2480], 'systems': [2487], 'be': [2491, 2695, 2853, 3788, 3839, 4047], 'strongly': [2492], 'compared': [2502, 2873], 'wild-type': [2504], '(WT)': [2505], 'MEFs,': [2506, 2542, 2778], 'very': [2508, 2597], 'long-chain': [2509, 2513, 2598], 'acyl-CoA': [2510, 2514, 2519, 2588, 2593, 2599], 'dehydrogenases': [2511, 2515, 2520], '(VLCAD),': [2512], '(LCAD),': [2516], 'medium-chain': [2518, 2592], '(MCAD)': [2521], 'S1C),': [2524], 'indicating': [2525], 'PPAR-α-regulated': [2529], 'Consistent': [2536], 'data': [2539, 2817, 3566], 'obtained': [2540, 2679, 2807], 'white': [2554], '(WAT)': [2557], '(Fig': [2561, 2602, 2715, 2800, 2857, 2880, 2942, 3766, 3782, 3813, 3847, 3884, 3925, 3942, 3994, 4015, 4028, 4037, 4055], '1A–C).': [2562], 'WAT': [2568, 3139, 3170, 3631, 3845], 'target': [2572, 3200], 'β-oxidation,': [2578], 'enoyl-CoA': [2580], 'hydratase/3-hydroxyacyl-CoA': [2581], 'dehydrogenase': [2582, 2594, 2600], '(Ehhadh,': [2583], 'known': [2585], 'HD),': [2587], 'oxidase': [2589], '1': [2590, 3577], '(Acox1),': [2591], '(Acadm),': [2595], '(Acadvl)': [2601], '1C).': [2603], 'confirm': [2605], 'whether': [2606], 'recruited': [2609, 2696], 'promoter': [2612, 2657, 2702, 3256, 3290], 'region,': [2613], 'contains': [2615], 'identified': [2617, 2661, 2735], 'PPAR-response': [2618], 'element': [2619], '(PPRE),': [2620], 'related': [2623], 'adipocytes,': [2629, 2664, 2705], 'performed': [2631, 3283, 3316], 'ChIP': [2632, 2647, 3252, 3286], 'assay': [2633, 2648, 3253, 3287], 'using': [2634, 3202, 3431], 'CPT1b': [2635, 2660, 2701, 3255, 3289], 'gene.': [2641], 'As': [2642, 3404, 3455, 3644], '1D,': [2646], 'resulted': [2649, 2952, 3054], 'binding': [2652, 2667, 2708, 2728], 'regions': [2658], 'WT': [2663, 2704, 2777, 3024, 3039, 3141, 3172, 3210, 3295, 3324, 3341, 3362, 3703, 3750, 3936, 3977, 3992, 4072, 4139, 4161, 4233, 4289], '3T3L1': [2683, 2811, 3010, 3040, 3084], 'S1D).': [2687], 'PPRE': [2698], '1E).': [2716], 'suggests': [2718], 'enhances': [2725], 'direct': [2727], 'PPRE.': [2732], 'nuclear': [2741], '(Treuter': [2743], '1998).': [2746], 'activation,': [2757, 2973], 'examined': [2759, 2975, 3374], 'association': [2766, 2893], 'coprecipitated': [2773, 2783], 'much': [2780], 'less': [2781], 'without': [2794], 'WY-14,643,': [2795], 'selective': [2797], 'agonist': [2799], '1F': [2801], 'G).': [2803], 'S1E).': [2815], 'indicate': [2818, 3092], 'impairs': [2831], 'interaction': [2833, 2865, 2955, 3126], 'failed': [2841], 'interact': [2843], 'while': [2846, 3666], 'FADD-A': [2849, 2879, 3426], '1H': [2858], 'Appendix': [2860, 2883], 'S1F).': [2862], 'Paradoxically,': [2863], '1I': [2881], 'S1G).': [2885], 'Molecular': [2886], 'modeling': [2887, 3505], 'analysis': [2888, 3396, 3447, 3898, 3924, 3928], 'predicted': [2895], 'S194': [2898, 2909, 2938, 3514], 'close': [2901], 'enough': [2902], 'proximity': [2903], 'D194': [2911, 2924, 3539], 'complex': [2914, 3496], 'thermostability': [2915], 'formation': [2917], 'stable': [2919], 'salt': [2920, 3562], 'bridges': [2921], 'Q445,': [2927, 3545], 'K448,': [2928, 3546], 'K449': [2929, 2947], 'R465': [2931, 2949, 3549], 'instead': [2932], 'hydrogen': [2934], 'bonding': [2935], 'K448': [2941, 3520], '1J).': [2943], 'Mutation': [2944], 'alanine': [2951], 'S1H).': [2962], 'clarify': [2965], 'influence': [2977], 'rates': [2982, 3028], 'oleic': [2984, 3019, 3030], 'mRNA': [2989, 3059], 'presence': [2995, 3005, 3063, 3377], 'twofold': [3015], 'rate': [3017, 3735], 'cells,': [3025], 'whereas': [3026], 'identical': [3034], 'following': [3042], 'downregulation': [3044], 'S1I,': [3049, 3076], 'left).': [3050], 'Similarly,': [3051], 'had': [3067, 3778], 'downregulated': [3073], 'right).': [3077, 3815, 3886, 3996], 'Efficiency': [3078], 'knockdown': [3082], 'immunoblot.': [3089], 'suggest': [3105], 'novel': [3114], 'S1J).': [3120], 'Figure': [3121, 3576, 4057], '1.': [3122], 'Immunoblot': [3131], 'tubulin': [3135], '(control)': [3136], '(top)': [3137], 'relative': [3146, 3747], 'quantification': [3147], '(bottom).': [3148], 'expressed': [3151, 3219, 4258, 4305, 4342], 'mean': [3153, 3221], '±': [3154, 3222, 4120, 4185, 4261, 4308, 4345], 'SEM': [3155, 3223], 'three': [3157, 3190, 3351, 3389, 3440, 3487, 4371], 'independent': [3158, 3226, 3352, 3390, 3441, 3488, 4372], 'experiments.': [3159, 3192], '*P': [3160, 3235, 4122, 4187, 4263, 4347], '=': [3161, 3178, 3229, 3236, 3239, 3242, 3245, 3248, 4081, 4090, 4112, 4123, 4177, 4188, 4191, 4194, 4197, 4200, 4203, 4206, 4209, 4212, 4215, 4218, 4221, 4244, 4264, 4267, 4270, 4273, 4298, 4335, 4348, 4375], '0.0035': [3162], "(Student's": [3163, 3250, 4125, 4275, 4314, 4350], 't-test).': [3164, 3251, 4126, 4276, 4315, 4351], 'Immunostaining': [3165], '(Scale': [3176], 'bars': [3177], '50': [3179], 'μm).': [3180], 'Shown': [3181], 'typical': [3183], 'four': [3186], 'different': [3187, 3191], 'fields': [3188], 'Quantitative': [3193], 'real-time': [3194], 'PCR': [3195], 'genes,': [3201], 'RNA': [3203], 'epididymal': [3205, 4000, 4254, 4317], '10-week-old': [3208, 4135], 'male': [3209, 4071, 4136, 4158, 4230, 4286], 'SD.': [3216], 'two': [3225], 'experiments': [3227, 3281, 3314, 3353, 3391, 3442, 3489, 4373], '(n': [3228, 4080, 4089, 4111, 4176, 4243, 4297, 4334, 4374], '6': [3230, 4091, 4178, 4245, 4299], 'total': [3231, 3881, 4003], 'each': [3233, 4084, 4093, 4115, 4180, 4247, 4301, 4338], 'genotype).': [3234, 4094, 4116, 4181, 4248, 4302, 4339], '0.0022,': [3237], '**P': [3238, 4190, 4266], '0.0083,': [3240], '***P': [3241, 4193, 4269], '0.0107,': [3243], '#P': [3244, 4205], '0.0011,': [3246], '##P': [3247, 4208], '0.0037': [3249], 'isolated': [3259, 3293], 'WT,': [3261], 'FADD-D,': [3262], 'ad-FADD': [3264], 'Soluble': [3266, 3299], 'chromatin': [3267, 3300], 'immunoprecipitated': [3271, 3304, 3334], 'mouse': [3274, 3307, 4099], 'IgG': [3275, 3308], 'antibodies': [3277, 3310], 'against': [3278, 3311], 'triplicate.': [3285, 3318], 'FADD.': [3312], 'coimmunoprecipitate': [3322, 3360], 'MEFs.': [3331, 3345], '(IP)': [3335], 'lysates': [3339, 3406, 3457], 'representative': [3349, 3387, 3438, 3485], 'having': [3354, 3392, 3443, 3490], 'results.': [3356, 3394, 3445, 3492], 'upon': [3368], 'WY-14,643': [3369, 3381], 'stimulation.': [3370], 'Ligand-dependent': [3371], 'interactions': [3372], '100': [3379], 'μM': [3380], 'where': [3382], 'indicated.': [3383], 'Coimmunoprecipitation': [3395, 3446], '293T': [3402, 3453], 'cells.': [3403, 3454], 'indicated,': [3405, 3456], 'cells': [3409, 3460], 'transfected': [3410, 3461], 'plasmids': [3412, 3463], 'encoding': [3413, 3464], 'Flag-RIP140,': [3414], 'HA-FADD-A,': [3415], 'HA-FADD-D': [3417], 'subjected': [3419, 3470], 'immunoprecipitation': [3421, 3472], 'anti-Flag': [3424, 3475], 'antibody.': [3425, 3434, 3476], 'detected': [3430, 3673], 'anti-HA': [3433], 'Flag-FADD-A,': [3465], 'Flag-FADD-D,': [3466], 'HA-PPAR-α': [3468], 'visualized': [3479], 'anti-HA.': [3481], 'Left,': [3493, 4067, 4141], 'putative': [3495], '(yellow)': [3499], '(colorful)': [3502], 'molecular': [3504], 'portrayed': [3507], 'ribbon': [3509], 'representation.': [3510], 'Middle,': [3511, 4225], 'residue': [3513, 3519, 3538, 3544], 'sphere': [3524, 3553], 'representation,': [3525, 3554], 'immediately': [3528, 3557], 'proximal': [3529, 3558], 'capable': [3531, 3560], 'hydrogen-bonding': [3533], 'interactions.': [3534, 3564], 'Right,': [3535, 4095, 4277], 'K449,': [3547], 'bridging': [3563], 'available': [3568], 'online': [3569], 'figure.': [3572], '[emmm201505924-sup-0003-SDataFig1.pdf]': [3578], 'Download': [3579, 3581], 'figure': [3580], 'PowerPoint': [3582], 'adiposity': [3587], 'resistant': [3590], 'diet-induced': [3592], 'plays': [3596], 'hypothesized': [3604], 'phosphorylation-mediated': [3607], 'contribute': [3612], 'distribution': [3616], 'Indeed,': [3621], 'obviously': [3628], 'obese': [3633, 3637], 'S2A': [3641], 'previously': [3646], 'appear': [3653], 'slower': [3656, 3669], 'migrating': [3657], 'faster': [3660], 'nonphosphorylated': [3661], 'bands': [3662], 'tissues,': [3665], 'only': [3667, 4366], 'species': [3671], 'S2C).': [3679], 'apparent': [3683], 'growth': [3684], 'retardation,': [3685], 'evident': [3688], 'length': [3691], 'weight': [3694, 3743, 3765, 3780, 3812, 3833, 3846, 3883, 4110, 4150, 4278, 4284, 4333], '(Cheng': [3695], '2014).': [3698], 'A': [3699], 'matched': [3700], 'set': [3701], 'given': [3708], 'standard': [3710, 4357], 'chow': [3711], '(SD)': [3713], '15': [3715, 4172, 4295], 'weeks': [3716, 3719, 3754, 4173, 4240, 4296], '5': [3718, 4336], 'age': [3721, 3727, 4175, 4242, 4293], 'evaluate': [3723], 'growth.': [3729], 'their': [3741, 4050], 'SD': [3746, 4079, 4167], 'At': [3752], '20': [3753, 4105], 'age,': [3756], 'there': [3757], '64%': [3760], 'difference': [3761], 'average': [3763], '2A).': [3767, 3783], '(HFD)': [3776], 'gain': [3781], 'differences': [3785, 4040, 4051], 'could': [3786], 'reduction': [3792, 3843, 3913, 3949], 'because': [3796], '1.6-fold': [3800], 'adjusted': [3809], '2A,': [3814], 'Food': [3816], 'before': [3824], 'S3).': [3830], 'Lower': [3831], 'attributable': [3840], '2B': [3848], 'C)': [3850], 'brown': [3853, 4327], '(BAT;': [3856], '2D).': [3858], 'specifically': [3862], 'weights': [3866, 4060, 4069, 4144, 4228], 'organs,': [3870], 'affected': [3877], 'after': [3878], 'correction': [3879], '2C,': [3885], 'triacylglycerol': [3892, 4004, 4250], 'accumulation': [3893], 'composition': [3897], 'Table': [3900], 'S1).': [3901], 'There': [3902, 3944], 'almost': [3904], 'complete': [3905], 's.c.': [3908], 'significant': [3912, 4313], 'depots': [3917], 'MRI': [3923, 4352], '2E).': [3926], 'Histological': [3927], 'greater': [3930], 'numbers': [3931], 'larger': [3933, 3990], '2F).': [3943], 'approximate': [3947], 'threefold': [3948], 'volume': [3952], 'suggested': [3959], 'size': [3963], 'contributed': [3965], 'decrease': [3968], 'mass.': [3971], 'Adipocytes': [3972], 'BAT': [3974], 'pads': [3975, 4131], 'filled': [3982], 'multilocular': [3984], 'droplets': [3986], 'that,': [3987], 'overall,': [3988], 'appeared': [3989], '2F,': [3995], 'addition': [3998], 'pads,': [4002], 'contents': [4005, 4019], 'liver': [4008, 4024, 4280], 'muscle': [4010], 'dramatically': [4013], '2G).': [4016], 'cholesterol': [4018], 'slightly': [4021], '2G)': [4029], 'plasma': [4033, 4042], 'groups': [4036], '2H).': [4038, 4056], '(38%': [4044], 'reduction)': [4045], 'secondary': [4048], 'levels': [4054], '2.': [4058], 'Body': [4059], 'either': [4077], '8': [4082], 'genotype)': [4085], 'per': [4098], 'measured': [4103], 'days': [4106], 'normalized': [4107, 4281, 4330], '10': [4113], 'means': [4119, 4184, 4260, 4307, 4344], 'SEM.': [4121, 4186, 4262, 4309, 4346], '0.0007': [4124], 'Representative': [4127, 4368], 'photographs': [4128], 'pad': [4143, 4227], '(BW)': [4151], 'absolute': [4154], 'amounts': [4155], '(inset)': [4156], 'until': [4171], '0.0012,': [4189], '0.0002,': [4192], '0.0027,': [4195], '****P': [4196, 4272], '0.0014,': [4198], '^P': [4199], '0.0038,': [4201], '^^P': [4202], '0.0019,': [4204, 4271], '0.0045,': [4207], '0.0007,': [4210], '*^P': [4211], '0.0252,': [4213], '*^^P': [4214], '0.0082,': [4216], '###P': [4217], '0.0275,': [4219], '####P': [4220], '0.0071': [4222], '(one-way': [4223], 'ANOVA).': [4224], '30': [4239], 'Inset,': [4249], '(TAG)': [4251], 'content': [4252], 'WAT.': [4255], '0.0003,': [4265], '0.0005,': [4268], '0.0011': [4274], 'littermates': [4290], 'NS,': [4310], 'statistically': [4312], 'Epi,': [4316], 'fat;': [4318, 4321], 'Ren,': [4319], 'renal': [4320], 'Ing,': [4322], 'inguinal': [4323], 'fat.': [4324], 'Weight': [4325], '0.0008': [4349], 'content:': [4356], 'non-fat': [4358], 'suppressed': [4359, 4362], '(left),': [4360], '(middle,)': [4363], '(right).': [4367], 'images': [4369]}, 'cited_by_api_url': 'https://api.openalex.org/works?filter=cites:W2466895948', 'counts_by_year': [{'year': 2024, 'cited_by_count': 7}, {'year': 2023, 'cited_by_count': 2}, {'year': 2022, 'cited_by_count': 5}, {'year': 2021, 'cited_by_count': 2}, {'year': 2020, 'cited_by_count': 3}, {'year': 2019, 'cited_by_count': 1}, {'year': 2018, 'cited_by_count': 1}, {'year': 2017, 'cited_by_count': 1}], 'updated_date': '2025-01-12T17:41:34.507755', 'created_date': '2016-07-22'}
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