Publication Information

{'id': 'https://openalex.org/W2466837466', 'doi': None, 'title': '[A case of lung adenocarcinoma of the lung with disappearance of brain metastasis by re-treatment with gefitinib].', 'display_name': '[A case of lung adenocarcinoma of the lung with disappearance of brain metastasis by re-treatment with gefitinib].', 'publication_year': 2005, 'publication_date': '2005-11-01', 'ids': {'openalex': 'https://openalex.org/W2466837466', 'mag': '2466837466', 'pmid': 'https://pubmed.ncbi.nlm.nih.gov/16366371'}, 'language': 'en', 'primary_location': {'is_oa': False, 'landing_page_url': 'https://pubmed.ncbi.nlm.nih.gov/16366371', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S4306525036', 'display_name': 'PubMed', 'issn_l': None, 'issn': None, 'is_oa': False, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1299303238', 'host_organization_name': 'National Institutes of Health', 'host_organization_lineage': ['https://openalex.org/I1299303238'], 'host_organization_lineage_names': ['National Institutes of Health'], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}, 'type': 'article', 'type_crossref': 'journal-article', 'indexed_in': ['pubmed'], 'open_access': {'is_oa': False, 'oa_status': 'closed', 'oa_url': None, 'any_repository_has_fulltext': False}, 'authorships': [{'author_position': 'first', 'author': {'id': 'https://openalex.org/A5103427544', 'display_name': 'Tatsuo Kato', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I2802631107', 'display_name': 'Nagara Medical Center', 'ror': 'https://ror.org/03vmdsx94', 'country_code': 'JP', 'type': 'healthcare', 'lineage': ['https://openalex.org/I2802631107', 'https://openalex.org/I4210137409']}], 'countries': ['JP'], 'is_corresponding': False, 'raw_author_name': 'Tatsuo Kato', 'raw_affiliation_strings': ['Respirtory Medicine, National Hospital Nagara Medical Center.'], 'affiliations': [{'raw_affiliation_string': 'Respirtory Medicine, National Hospital Nagara Medical Center.', 'institution_ids': ['https://openalex.org/I2802631107']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5015260569', 'display_name': 'Masanori Nakashima', 'orcid': None}, 'institutions': [], 'countries': [], 'is_corresponding': False, 'raw_author_name': 'Masanori Nakashima', 'raw_affiliation_strings': [], 'affiliations': []}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5000054295', 'display_name': 'Kotaro Yoshimura', 'orcid': 'https://orcid.org/0000-0002-7152-5475'}, 'institutions': [], 'countries': [], 'is_corresponding': False, 'raw_author_name': 'Kotaro Yoshimura', 'raw_affiliation_strings': [], 'affiliations': []}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5112063684', 'display_name': 'Motohiro Imao', 'orcid': None}, 'institutions': [], 'countries': [], 'is_corresponding': False, 'raw_author_name': 'Motohiro Imao', 'raw_affiliation_strings': [], 'affiliations': []}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5011238139', 'display_name': 'Hideko Goto', 'orcid': None}, 'institutions': [], 'countries': [], 'is_corresponding': False, 'raw_author_name': 'Hideko Goto', 'raw_affiliation_strings': [], 'affiliations': []}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5102724200', 'display_name': 'Shigeo Yasuda', 'orcid': 'https://orcid.org/0000-0002-6434-1723'}, 'institutions': [], 'countries': [], 'is_corresponding': False, 'raw_author_name': 'Shigeo Yasuda', 'raw_affiliation_strings': [], 'affiliations': []}, {'author_position': 'last', 'author': {'id': 'https://openalex.org/A5112067893', 'display_name': 'Kimiyasu Sano', 'orcid': None}, 'institutions': [], 'countries': [], 'is_corresponding': False, 'raw_author_name': 'Kimiyasu Sano', 'raw_affiliation_strings': [], 'affiliations': []}], 'institution_assertions': [], 'countries_distinct_count': 1, 'institutions_distinct_count': 1, 'corresponding_author_ids': [], 'corresponding_institution_ids': [], 'apc_list': None, 'apc_paid': None, 'fwci': 0.25, 'has_fulltext': False, 'cited_by_count': 3, 'citation_normalized_percentile': {'value': 0.591182, 'is_in_top_1_percent': False, 'is_in_top_10_percent': False}, 'cited_by_percentile_year': {'min': 71, 'max': 74}, 'biblio': {'volume': '43', 'issue': '11', 'first_page': '700', 'last_page': '3'}, 'is_retracted': False, 'is_paratext': False, 'primary_topic': {'id': 'https://openalex.org/T10417', 'display_name': 'Lung Cancer Treatments and Mutations', 'score': 0.9969, 'subfield': {'id': 'https://openalex.org/subfields/2740', 'display_name': 'Pulmonary and Respiratory Medicine'}, 'field': {'id': 'https://openalex.org/fields/27', 'display_name': 'Medicine'}, 'domain': {'id': 'https://openalex.org/domains/4', 'display_name': 'Health Sciences'}}, 'topics': [{'id': 'https://openalex.org/T10417', 'display_name': 'Lung Cancer Treatments and Mutations', 'score': 0.9969, 'subfield': {'id': 'https://openalex.org/subfields/2740', 'display_name': 'Pulmonary and Respiratory Medicine'}, 'field': {'id': 'https://openalex.org/fields/27', 'display_name': 'Medicine'}, 'domain': {'id': 'https://openalex.org/domains/4', 'display_name': 'Health Sciences'}}, {'id': 'https://openalex.org/T10202', 'display_name': 'Lung Cancer Diagnosis and Treatment', 'score': 0.9644, 'subfield': {'id': 'https://openalex.org/subfields/2740', 'display_name': 'Pulmonary and Respiratory Medicine'}, 'field': {'id': 'https://openalex.org/fields/27', 'display_name': 'Medicine'}, 'domain': {'id': 'https://openalex.org/domains/4', 'display_name': 'Health Sciences'}}, {'id': 'https://openalex.org/T11395', 'display_name': 'Radiopharmaceutical Chemistry and Applications', 'score': 0.9619, 'subfield': {'id': 'https://openalex.org/subfields/2741', 'display_name': 'Radiology, Nuclear Medicine and Imaging'}, 'field': {'id': 'https://openalex.org/fields/27', 'display_name': 'Medicine'}, 'domain': {'id': 'https://openalex.org/domains/4', 'display_name': 'Health Sciences'}}], 'keywords': [{'id': 'https://openalex.org/keywords/vinorelbine', 'display_name': 'Vinorelbine', 'score': 0.52870595}, {'id': 'https://openalex.org/keywords/carboplatin', 'display_name': 'Carboplatin', 'score': 0.4153446}], 'concepts': [{'id': 'https://openalex.org/C2780580887', 'wikidata': 'https://www.wikidata.org/wiki/Q417824', 'display_name': 'Gefitinib', 'level': 4, 'score': 0.97632}, {'id': 'https://openalex.org/C71924100', 'wikidata': 'https://www.wikidata.org/wiki/Q11190', 'display_name': 'Medicine', 'level': 0, 'score': 0.855419}, {'id': 'https://openalex.org/C2778164965', 'wikidata': 'https://www.wikidata.org/wiki/Q1620196', 'display_name': 'Brain metastasis', 'level': 4, 'score': 0.8124901}, {'id': 'https://openalex.org/C2779013556', 'wikidata': 'https://www.wikidata.org/wiki/Q181876', 'display_name': 'Metastasis', 'level': 3, 'score': 0.66276515}, {'id': 'https://openalex.org/C2776256026', 'wikidata': 'https://www.wikidata.org/wiki/Q47912', 'display_name': 'Lung cancer', 'level': 2, 'score': 0.63744324}, {'id': 'https://openalex.org/C143998085', 'wikidata': 'https://www.wikidata.org/wiki/Q162555', 'display_name': 'Oncology', 'level': 1, 'score': 0.5970464}, {'id': 'https://openalex.org/C2781182431', 'wikidata': 'https://www.wikidata.org/wiki/Q356033', 'display_name': 'Adenocarcinoma', 'level': 3, 'score': 0.56350935}, {'id': 'https://openalex.org/C2776694085', 'wikidata': 'https://www.wikidata.org/wiki/Q974135', 'display_name': 'Chemotherapy', 'level': 2, 'score': 0.5555655}, {'id': 'https://openalex.org/C126322002', 'wikidata': 'https://www.wikidata.org/wiki/Q11180', 'display_name': 'Internal medicine', 'level': 1, 'score': 0.53905547}, {'id': 'https://openalex.org/C2780350996', 'wikidata': 'https://www.wikidata.org/wiki/Q420532', 'display_name': 'Vinorelbine', 'level': 4, 'score': 0.52870595}, {'id': 'https://openalex.org/C2779563347', 'wikidata': 'https://www.wikidata.org/wiki/Q843799', 'display_name': 'Adenocarcinoma of the lung', 'level': 4, 'score': 0.4856964}, {'id': 'https://openalex.org/C2777714996', 'wikidata': 'https://www.wikidata.org/wiki/Q7886', 'display_name': 'Lung', 'level': 2, 'score': 0.45836836}, {'id': 'https://openalex.org/C2781190966', 'wikidata': 'https://www.wikidata.org/wiki/Q420436', 'display_name': 'Docetaxel', 'level': 3, 'score': 0.4405217}, {'id': 'https://openalex.org/C509974204', 'wikidata': 'https://www.wikidata.org/wiki/Q180507', 'display_name': 'Radiation therapy', 'level': 2, 'score': 0.4181808}, {'id': 'https://openalex.org/C2781451048', 'wikidata': 'https://www.wikidata.org/wiki/Q415588', 'display_name': 'Carboplatin', 'level': 4, 'score': 0.4153446}, {'id': 'https://openalex.org/C121608353', 'wikidata': 'https://www.wikidata.org/wiki/Q12078', 'display_name': 'Cancer', 'level': 2, 'score': 0.3009115}, {'id': 'https://openalex.org/C2779438470', 'wikidata': 'https://www.wikidata.org/wiki/Q424401', 'display_name': 'Epidermal growth factor receptor', 'level': 3, 'score': 0.26548123}, {'id': 'https://openalex.org/C2778239845', 'wikidata': 'https://www.wikidata.org/wiki/Q412415', 'display_name': 'Cisplatin', 'level': 3, 'score': 0.05121103}], 'mesh': [{'descriptor_ui': 'D000230', 'descriptor_name': 'Adenocarcinoma', 'qualifier_ui': 'Q000188', 'qualifier_name': 'drug therapy', 'is_major_topic': True}, {'descriptor_ui': 'D000970', 'descriptor_name': 'Antineoplastic Agents', 'qualifier_ui': 'Q000627', 'qualifier_name': 'therapeutic use', 'is_major_topic': True}, {'descriptor_ui': 'D001932', 'descriptor_name': 'Brain Neoplasms', 'qualifier_ui': 'Q000188', 'qualifier_name': 'drug therapy', 'is_major_topic': True}, {'descriptor_ui': 'D008175', 'descriptor_name': 'Lung Neoplasms', 'qualifier_ui': 'Q000473', 'qualifier_name': 'pathology', 'is_major_topic': True}, {'descriptor_ui': 'D011799', 'descriptor_name': 'Quinazolines', 'qualifier_ui': 'Q000627', 'qualifier_name': 'therapeutic use', 'is_major_topic': True}, {'descriptor_ui': 'D000230', 'descriptor_name': 'Adenocarcinoma', 'qualifier_ui': 'Q000556', 'qualifier_name': 'secondary', 'is_major_topic': False}, {'descriptor_ui': 'D000230', 'descriptor_name': 'Adenocarcinoma', 'qualifier_ui': 'Q000532', 'qualifier_name': 'radiotherapy', 'is_major_topic': False}, {'descriptor_ui': 'D000230', 'descriptor_name': 'Adenocarcinoma', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D000328', 'descriptor_name': 'Adult', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D000970', 'descriptor_name': 'Antineoplastic Agents', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D001921', 'descriptor_name': 'Brain', 'qualifier_ui': 'Q000000981', 'qualifier_name': 'diagnostic imaging', 'is_major_topic': False}, {'descriptor_ui': 'D001921', 'descriptor_name': 'Brain', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D001932', 'descriptor_name': 'Brain Neoplasms', 'qualifier_ui': 'Q000556', 'qualifier_name': 'secondary', 'is_major_topic': False}, {'descriptor_ui': 'D001932', 'descriptor_name': 'Brain Neoplasms', 'qualifier_ui': 'Q000532', 'qualifier_name': 'radiotherapy', 'is_major_topic': False}, {'descriptor_ui': 'D001932', 'descriptor_name': 'Brain Neoplasms', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D003131', 'descriptor_name': 'Combined Modality Therapy', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D016371', 'descriptor_name': 'Cranial Irradiation', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D000077156', 'descriptor_name': 'Gefitinib', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D006801', 'descriptor_name': 'Humans', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D008113', 'descriptor_name': 'Liver Neoplasms', 'qualifier_ui': 'Q000556', 'qualifier_name': 'secondary', 'is_major_topic': False}, {'descriptor_ui': 'D008113', 'descriptor_name': 'Liver Neoplasms', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D008175', 'descriptor_name': 'Lung Neoplasms', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D008297', 'descriptor_name': 'Male', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D011799', 'descriptor_name': 'Quinazolines', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D012074', 'descriptor_name': 'Remission Induction', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D019233', 'descriptor_name': 'Retreatment', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D014057', 'descriptor_name': 'Tomography, X-Ray Computed', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}], 'locations_count': 1, 'locations': [{'is_oa': False, 'landing_page_url': 'https://pubmed.ncbi.nlm.nih.gov/16366371', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S4306525036', 'display_name': 'PubMed', 'issn_l': None, 'issn': None, 'is_oa': False, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1299303238', 'host_organization_name': 'National Institutes of Health', 'host_organization_lineage': ['https://openalex.org/I1299303238'], 'host_organization_lineage_names': ['National Institutes of Health'], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}], 'best_oa_location': None, 'sustainable_development_goals': [{'id': 'https://metadata.un.org/sdg/3', 'score': 0.87, 'display_name': 'Good health and well-being'}], 'grants': [], 'datasets': [], 'versions': [], 'referenced_works_count': 0, 'referenced_works': [], 'related_works': ['https://openalex.org/W2753894119', 'https://openalex.org/W2466837466', 'https://openalex.org/W2439707001', 'https://openalex.org/W2402259451', 'https://openalex.org/W2280645856', 'https://openalex.org/W2181781335', 'https://openalex.org/W2141969051', 'https://openalex.org/W2119659897', 'https://openalex.org/W2115487703', 'https://openalex.org/W2053432470'], 'abstract_inverted_index': {'Tumor': [0], 'response': [1], 'rate': [2], 'to': [3, 151, 168], 'gefitinib': [4, 98, 118], 'by': [5, 97], 'previously': [6], 'treated': [7], 'patients': [8], 'with': [9, 26, 43, 93, 105, 117, 143, 145, 174], 'advanced': [10], 'non-small-cell': [11], 'lung': [12, 37], 'cancer': [13], 'was': [14, 30, 40, 62, 78, 87, 99, 102, 119, 125], 'approximately': [15], '20%.': [16], 'However,': [17, 127], 'there': [18], 'are': [19, 166], 'few': [20], 'reports': [21], 'about': [22, 158], 'effect': [23], 'of': [24, 34, 36, 67, 81, 113, 122, 156, 162, 172], 're-treatment': [25, 144, 173], 'gefitinib.A': [27], '40-year-old': [28], 'man': [29], 'given': [31, 64], 'a': [32, 137], 'diagnosis': [33], 'adenocarcinoma': [35], '(c-T2N3M1).': [38], 'Response': [39, 101], 'not': [41, 103], 'obtained': [42], 'chemotherapy': [44, 106], '(paclitaxel': [45], '+': [46, 49], 'carboplatin,': [47], 'vinorelbine': [48], 'gencitabin).': [50], 'He': [51, 61], 'developed': [52], 'brain': [53, 58, 71, 123, 140], 'metastasis': [54, 74, 77, 83, 86, 124, 131, 134], 'and': [55, 75, 84, 108, 132], 'received': [56], 'whole': [57], 'radiation': [59], 'therapy.': [60], 'then': [63], 'gefitinib.': [65, 94, 146, 163, 175], 'Reduction': [66], 'the': [68, 111, 114, 159, 170], 'primary': [69, 128], 'tumor,': [70, 129], 'metastasis,': [72], 'pulmonary': [73, 82, 130], 'liver': [76, 85, 133], 'seen.': [79], 'Recurrence': [80], 'discovered': [88], '8': [89], 'months': [90], 'after': [91], 'treatment': [92, 96], 'Therefore,': [95], 'stopped.': [100], 'achieved': [104], '(docetaxel': [107], 'amrubicin).': [109], 'At': [110], 'request': [112], 'patient,': [115], 'retreatment': [116], 'resumed.': [120], 'Disappearance': [121], 'achieved.': [126], 'progressed.We': [135], 'reported': [136], 'case': [138], 'whose': [139], 'metastases': [141], 'disappeared': [142], 'This': [147], 'report': [148], 'is': [149], 'thought': [150], 'be': [152], 'useful': [153], 'in': [154], 'terms': [155], 'information': [157], 'acquired': [160], 'resistance': [161], 'Further': [164], 'investigations': [165], 'needed': [167], 'determine': [169], 'indication': [171]}, 'cited_by_api_url': 'https://api.openalex.org/works?filter=cites:W2466837466', 'counts_by_year': [{'year': 2013, 'cited_by_count': 2}], 'updated_date': '2024-12-08T06:59:17.787444', 'created_date': '2016-07-22'}