Title: Activation of Nuclear Factor-κB (NF-κB) in Mononuclear Cells (MNC)
Abstract: AbstractThe transcription factor NF-κB was first identified as a regulator of the expression of the kappa light-chain gene in murine B lymphocytes (1). It has a central role in the immunological processes and regulates a wide range of genes in a rapid fashion (2). NF-κB interacts with its inhibitor protein IκB and activation of NF-κB causes it to move into the nucleus and this is controlled by the phosphorylation and subsequent degredation of IκB (3,4). The activated form of NF-κB is a heterodimer, which usually consists of two proteins, a p65 (relA) subunit and a p50 subunit. Other subunits (rel, relB, v-rel, and p52) can also bind to the activated NF-κB and thus can activate different sets of genes.KeywordsLabel OligonucleotideP47phox SubunitHela Nuclear ExtractRapid FashionFollow Glucose IntakeThese keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.
Publication Year: 2003
Publication Date: 2003-11-15
Language: en
Type: article
Indexed In: ['crossref', 'pubmed']
Access and Citation
Cited By Count: 3
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