Title: QSAR STUDY ON THE INHIBITION OF THE HUMAN CARBONIC ANHYDRASE CYTOSOLIC ISOZYME VII
Abstract: The inhibition of a newly cloned human carbonic anhydrase (CA, EC 4-2-1-1) isozyme VII (hCAII) by a series of 32 aromatic and heterocyclic sulfonamides, including some of the clinically used derivatives (acetazolamide, methazolamide, ethoxzolamide, dichlorophenamide, dorzolamide, brinzolamide, and benzolamide, as well as the sulfamate antiepileptic drug topiramate), has been modeled using a set of distance-based topological indices and structural descriptors. The results have shown that the Balaban-type indices play a dominant role Excellent results were obtained in multiparametric regressions. The results are discussed with a variety of statistical indicators.
Publication Year: 2006
Publication Date: 2006-01-01
Language: en
Type: article
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Cited By Count: 4
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