Get quick answers to your questions about the article from our AI researcher chatbot
{'id': 'https://openalex.org/W2465258693', 'doi': 'https://doi.org/10.18632/oncotarget.10361', 'title': 'Compounds from the marine sponge <i>Cribrochalina vasculum</i> offer a way to target IGF-1R mediated signaling in tumor cells', 'display_name': 'Compounds from the marine sponge <i>Cribrochalina vasculum</i> offer a way to target IGF-1R mediated signaling in tumor cells', 'publication_year': 2016, 'publication_date': '2016-07-01', 'ids': {'openalex': 'https://openalex.org/W2465258693', 'doi': 'https://doi.org/10.18632/oncotarget.10361', 'mag': '2465258693', 'pmid': 'https://pubmed.ncbi.nlm.nih.gov/27384680', 'pmcid': 'https://www.ncbi.nlm.nih.gov/pmc/articles/5226581'}, 'language': 'en', 'primary_location': {'is_oa': True, 'landing_page_url': 'https://doi.org/10.18632/oncotarget.10361', 'pdf_url': 'http://www.oncotarget.com/index.php?journal=oncotarget&page=article&op=download&path%5B%5D=10361&path%5B%5D=32686', 'source': {'id': 'https://openalex.org/S126644158', 'display_name': 'Oncotarget', 'issn_l': '1949-2553', 'issn': ['1949-2553'], 'is_oa': True, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310316297', 'host_organization_name': 'Impact Journals LLC', 'host_organization_lineage': ['https://openalex.org/P4310316297'], 'host_organization_lineage_names': ['Impact Journals LLC'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, 'type': 'article', 'type_crossref': 'journal-article', 'indexed_in': ['crossref', 'pubmed'], 'open_access': {'is_oa': True, 'oa_status': 'gold', 'oa_url': 'http://www.oncotarget.com/index.php?journal=oncotarget&page=article&op=download&path%5B%5D=10361&path%5B%5D=32686', 'any_repository_has_fulltext': True}, 'authorships': [{'author_position': 'first', 'author': {'id': 'https://openalex.org/A5032597296', 'display_name': 'Ana Zovko', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I28166907', 'display_name': 'Karolinska Institutet', 'ror': 'https://ror.org/056d84691', 'country_code': 'SE', 'type': 'education', 'lineage': ['https://openalex.org/I28166907']}], 'countries': ['SE'], 'is_corresponding': False, 'raw_author_name': 'Ana Zovko', 'raw_affiliation_strings': ['Department of Oncology and Pathology, Karolinska Biomics Center, Karolinska Institutet, Stockholm, Sweden'], 'affiliations': [{'raw_affiliation_string': 'Department of Oncology and Pathology, Karolinska Biomics Center, Karolinska Institutet, Stockholm, Sweden', 'institution_ids': ['https://openalex.org/I28166907']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5033691147', 'display_name': 'Metka Novak', 'orcid': 'https://orcid.org/0000-0002-3041-1156'}, 'institutions': [{'id': 'https://openalex.org/I28166907', 'display_name': 'Karolinska Institutet', 'ror': 'https://ror.org/056d84691', 'country_code': 'SE', 'type': 'education', 'lineage': ['https://openalex.org/I28166907']}], 'countries': ['SE'], 'is_corresponding': False, 'raw_author_name': 'Metka Novak', 'raw_affiliation_strings': ['Department of Oncology and Pathology, Karolinska Biomics Center, Karolinska Institutet, Stockholm, Sweden'], 'affiliations': [{'raw_affiliation_string': 'Department of Oncology and Pathology, Karolinska Biomics Center, Karolinska Institutet, Stockholm, Sweden', 'institution_ids': ['https://openalex.org/I28166907']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5071457269', 'display_name': 'Petra Hååg', 'orcid': 'https://orcid.org/0000-0002-7045-867X'}, 'institutions': [{'id': 'https://openalex.org/I28166907', 'display_name': 'Karolinska Institutet', 'ror': 'https://ror.org/056d84691', 'country_code': 'SE', 'type': 'education', 'lineage': ['https://openalex.org/I28166907']}], 'countries': ['SE'], 'is_corresponding': False, 'raw_author_name': 'Petra Hååg', 'raw_affiliation_strings': ['Department of Oncology and Pathology, Karolinska Biomics Center, Karolinska Institutet, Stockholm, Sweden'], 'affiliations': [{'raw_affiliation_string': 'Department of Oncology and Pathology, Karolinska Biomics Center, Karolinska Institutet, Stockholm, Sweden', 'institution_ids': ['https://openalex.org/I28166907']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5025512537', 'display_name': 'Dimitry Kovalerchick', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I16391192', 'display_name': 'Tel Aviv University', 'ror': 'https://ror.org/04mhzgx49', 'country_code': 'IL', 'type': 'education', 'lineage': ['https://openalex.org/I16391192']}], 'countries': ['IL'], 'is_corresponding': False, 'raw_author_name': 'Dimitry Kovalerchick', 'raw_affiliation_strings': ['School of Chemistry, Raymond and Beverly Sackler Faculty of Exact Sciences, Tel Aviv University, Tel Aviv, Israel'], 'affiliations': [{'raw_affiliation_string': 'School of Chemistry, Raymond and Beverly Sackler Faculty of Exact Sciences, Tel Aviv University, Tel Aviv, Israel', 'institution_ids': ['https://openalex.org/I16391192']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5090532079', 'display_name': 'Teresa Holmlund', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I28166907', 'display_name': 'Karolinska Institutet', 'ror': 'https://ror.org/056d84691', 'country_code': 'SE', 'type': 'education', 'lineage': ['https://openalex.org/I28166907']}], 'countries': ['SE'], 'is_corresponding': False, 'raw_author_name': 'Teresa Holmlund', 'raw_affiliation_strings': ['Department of Oncology and Pathology, Karolinska Biomics Center, Karolinska Institutet, Stockholm, Sweden'], 'affiliations': [{'raw_affiliation_string': 'Department of Oncology and Pathology, Karolinska Biomics Center, Karolinska Institutet, Stockholm, Sweden', 'institution_ids': ['https://openalex.org/I28166907']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5089684801', 'display_name': 'Katarina Färnegårdh', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I2800139495', 'display_name': 'Science for Life Laboratory', 'ror': 'https://ror.org/04ev03g22', 'country_code': 'SE', 'type': 'facility', 'lineage': ['https://openalex.org/I2800139495']}, {'id': 'https://openalex.org/I161593684', 'display_name': 'Stockholm University', 'ror': 'https://ror.org/05f0yaq80', 'country_code': 'SE', 'type': 'education', 'lineage': ['https://openalex.org/I161593684']}], 'countries': ['SE'], 'is_corresponding': False, 'raw_author_name': 'Katarina Färnegårdh', 'raw_affiliation_strings': ['Science for Life Laboratory, Drug Discovery and Development Platform, Department of Organic Chemistry, Stockholm University, Stockholm, Sweden'], 'affiliations': [{'raw_affiliation_string': 'Science for Life Laboratory, Drug Discovery and Development Platform, Department of Organic Chemistry, Stockholm University, Stockholm, Sweden', 'institution_ids': ['https://openalex.org/I2800139495', 'https://openalex.org/I161593684']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5031339525', 'display_name': 'Micha Ilan', 'orcid': 'https://orcid.org/0000-0002-4188-4573'}, 'institutions': [{'id': 'https://openalex.org/I16391192', 'display_name': 'Tel Aviv University', 'ror': 'https://ror.org/04mhzgx49', 'country_code': 'IL', 'type': 'education', 'lineage': ['https://openalex.org/I16391192']}], 'countries': ['IL'], 'is_corresponding': False, 'raw_author_name': 'Micha Ilan', 'raw_affiliation_strings': ['Department of Zoology, George S Wise Faculty of Life Sciences, Tel Aviv University, Tel Aviv, Israel'], 'affiliations': [{'raw_affiliation_string': 'Department of Zoology, George S Wise Faculty of Life Sciences, Tel Aviv University, Tel Aviv, Israel', 'institution_ids': ['https://openalex.org/I16391192']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5022153326', 'display_name': 'Shmuel Carmeli', 'orcid': 'https://orcid.org/0000-0002-9641-9943'}, 'institutions': [{'id': 'https://openalex.org/I16391192', 'display_name': 'Tel Aviv University', 'ror': 'https://ror.org/04mhzgx49', 'country_code': 'IL', 'type': 'education', 'lineage': ['https://openalex.org/I16391192']}], 'countries': ['IL'], 'is_corresponding': False, 'raw_author_name': 'Shmuel Carmeli', 'raw_affiliation_strings': ['School of Chemistry, Raymond and Beverly Sackler Faculty of Exact Sciences, Tel Aviv University, Tel Aviv, Israel'], 'affiliations': [{'raw_affiliation_string': 'School of Chemistry, Raymond and Beverly Sackler Faculty of Exact Sciences, Tel Aviv University, Tel Aviv, Israel', 'institution_ids': ['https://openalex.org/I16391192']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5087206674', 'display_name': 'Rolf Lewensohn', 'orcid': 'https://orcid.org/0000-0002-9941-9172'}, 'institutions': [{'id': 'https://openalex.org/I28166907', 'display_name': 'Karolinska Institutet', 'ror': 'https://ror.org/056d84691', 'country_code': 'SE', 'type': 'education', 'lineage': ['https://openalex.org/I28166907']}], 'countries': ['SE'], 'is_corresponding': False, 'raw_author_name': 'Rolf Lewensohn', 'raw_affiliation_strings': ['Department of Oncology and Pathology, Karolinska Biomics Center, Karolinska Institutet, Stockholm, Sweden'], 'affiliations': [{'raw_affiliation_string': 'Department of Oncology and Pathology, Karolinska Biomics Center, Karolinska Institutet, Stockholm, Sweden', 'institution_ids': ['https://openalex.org/I28166907']}]}, {'author_position': 'last', 'author': {'id': 'https://openalex.org/A5025252728', 'display_name': 'Kristina Viktorsson', 'orcid': 'https://orcid.org/0000-0003-4552-3561'}, 'institutions': [{'id': 'https://openalex.org/I28166907', 'display_name': 'Karolinska Institutet', 'ror': 'https://ror.org/056d84691', 'country_code': 'SE', 'type': 'education', 'lineage': ['https://openalex.org/I28166907']}], 'countries': ['SE'], 'is_corresponding': False, 'raw_author_name': 'Kristina Viktorsson', 'raw_affiliation_strings': ['Department of Oncology and Pathology, Karolinska Biomics Center, Karolinska Institutet, Stockholm, Sweden'], 'affiliations': [{'raw_affiliation_string': 'Department of Oncology and Pathology, Karolinska Biomics Center, Karolinska Institutet, Stockholm, Sweden', 'institution_ids': ['https://openalex.org/I28166907']}]}], 'institution_assertions': [], 'countries_distinct_count': 2, 'institutions_distinct_count': 4, 'corresponding_author_ids': [], 'corresponding_institution_ids': [], 'apc_list': None, 'apc_paid': None, 'fwci': 2.689, 'has_fulltext': True, 'fulltext_origin': 'pdf', 'cited_by_count': 21, 'citation_normalized_percentile': {'value': 0.904393, 'is_in_top_1_percent': False, 'is_in_top_10_percent': True}, 'cited_by_percentile_year': {'min': 91, 'max': 92}, 'biblio': {'volume': '7', 'issue': '31', 'first_page': '50258', 'last_page': '50276'}, 'is_retracted': False, 'is_paratext': False, 'primary_topic': {'id': 'https://openalex.org/T11340', 'display_name': 'Sponge-Associated Microorganisms and Biotechnological Potential', 'score': 0.997, 'subfield': {'id': 'https://openalex.org/subfields/1305', 'display_name': 'Biotechnology'}, 'field': {'id': 'https://openalex.org/fields/13', 'display_name': 'Biochemistry, Genetics and Molecular Biology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}, 'topics': [{'id': 'https://openalex.org/T11340', 'display_name': 'Sponge-Associated Microorganisms and Biotechnological Potential', 'score': 0.997, 'subfield': {'id': 'https://openalex.org/subfields/1305', 'display_name': 'Biotechnology'}, 'field': {'id': 'https://openalex.org/fields/13', 'display_name': 'Biochemistry, Genetics and Molecular Biology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}, {'id': 'https://openalex.org/T10952', 'display_name': 'mTOR Signaling in Growth and Disease', 'score': 0.9865, 'subfield': {'id': 'https://openalex.org/subfields/1312', 'display_name': 'Molecular Biology'}, 'field': {'id': 'https://openalex.org/fields/13', 'display_name': 'Biochemistry, Genetics and Molecular Biology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}, {'id': 'https://openalex.org/T10252', 'display_name': 'Natural Products as Sources of New Drugs', 'score': 0.9824, 'subfield': {'id': 'https://openalex.org/subfields/2736', 'display_name': 'Pharmacology'}, 'field': {'id': 'https://openalex.org/fields/27', 'display_name': 'Medicine'}, 'domain': {'id': 'https://openalex.org/domains/4', 'display_name': 'Health Sciences'}}], 'keywords': [{'id': 'https://openalex.org/keywords/docking', 'display_name': 'Docking (animal)', 'score': 0.48349765}, {'id': 'https://openalex.org/keywords/sponge-associated-microorganisms', 'display_name': 'Sponge-Associated Microorganisms', 'score': 0.481232}], 'concepts': [{'id': 'https://openalex.org/C41685203', 'wikidata': 'https://www.wikidata.org/wiki/Q1974042', 'display_name': 'Docking (animal)', 'level': 2, 'score': 0.48349765}, {'id': 'https://openalex.org/C502942594', 'wikidata': 'https://www.wikidata.org/wiki/Q3421914', 'display_name': 'Cancer research', 'level': 1, 'score': 0.46488425}, {'id': 'https://openalex.org/C170493617', 'wikidata': 'https://www.wikidata.org/wiki/Q208467', 'display_name': 'Receptor', 'level': 2, 'score': 0.43898952}, {'id': 'https://openalex.org/C185592680', 'wikidata': 'https://www.wikidata.org/wiki/Q2329', 'display_name': 'Chemistry', 'level': 0, 'score': 0.37038395}, {'id': 'https://openalex.org/C71924100', 'wikidata': 'https://www.wikidata.org/wiki/Q11190', 'display_name': 'Medicine', 'level': 0, 'score': 0.35500982}, {'id': 'https://openalex.org/C126322002', 'wikidata': 'https://www.wikidata.org/wiki/Q11180', 'display_name': 'Internal medicine', 'level': 1, 'score': 0.3202711}, {'id': 'https://openalex.org/C159110408', 'wikidata': 'https://www.wikidata.org/wiki/Q121176', 'display_name': 'Nursing', 'level': 1, 'score': 0.0}], 'mesh': [{'descriptor_ui': 'D002289', 'descriptor_name': 'Carcinoma, Non-Small-Cell Lung', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': True}, {'descriptor_ui': 'D008175', 'descriptor_name': 'Lung Neoplasms', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': True}, {'descriptor_ui': 'D011161', 'descriptor_name': 'Porifera', 'qualifier_ui': 'Q000737', 'qualifier_name': 'chemistry', 'is_major_topic': True}, {'descriptor_ui': 'D017526', 'descriptor_name': 'Receptor, IGF Type 1', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': True}, {'descriptor_ui': 'D011972', 'descriptor_name': 'Receptor, Insulin', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': True}, {'descriptor_ui': 'D000818', 'descriptor_name': 'Animals', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D000970', 'descriptor_name': 'Antineoplastic Agents', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D000970', 'descriptor_name': 'Antineoplastic Agents', 'qualifier_ui': 'Q000494', 'qualifier_name': 'pharmacology', 'is_major_topic': False}, {'descriptor_ui': 'D002289', 'descriptor_name': 'Carcinoma, Non-Small-Cell Lung', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D002289', 'descriptor_name': 'Carcinoma, Non-Small-Cell Lung', 'qualifier_ui': 'Q000188', 'qualifier_name': 'drug therapy', 'is_major_topic': False}, {'descriptor_ui': 'D045744', 'descriptor_name': 'Cell Line, Tumor', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D002470', 'descriptor_name': 'Cell Survival', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D066246', 'descriptor_name': 'ErbB Receptors', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D066246', 'descriptor_name': 'ErbB Receptors', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': False}, {'descriptor_ui': 'D005347', 'descriptor_name': 'Fibroblasts', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D005347', 'descriptor_name': 'Fibroblasts', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': False}, {'descriptor_ui': 'D020869', 'descriptor_name': 'Gene Expression Profiling', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D015972', 'descriptor_name': 'Gene Expression Regulation, Neoplastic', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D006801', 'descriptor_name': 'Humans', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D055504', 'descriptor_name': 'Insulin Receptor Substrate Proteins', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': False}, {'descriptor_ui': 'D055504', 'descriptor_name': 'Insulin Receptor Substrate Proteins', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D008175', 'descriptor_name': 'Lung Neoplasms', 'qualifier_ui': 'Q000188', 'qualifier_name': 'drug therapy', 'is_major_topic': False}, {'descriptor_ui': 'D008175', 'descriptor_name': 'Lung Neoplasms', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D010766', 'descriptor_name': 'Phosphorylation', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D011161', 'descriptor_name': 'Porifera', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D011485', 'descriptor_name': 'Protein Binding', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D047428', 'descriptor_name': 'Protein Kinase Inhibitors', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D047428', 'descriptor_name': 'Protein Kinase Inhibitors', 'qualifier_ui': 'Q000494', 'qualifier_name': 'pharmacology', 'is_major_topic': False}, {'descriptor_ui': 'D020794', 'descriptor_name': 'Receptor Protein-Tyrosine Kinases', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': False}, {'descriptor_ui': 'D020794', 'descriptor_name': 'Receptor Protein-Tyrosine Kinases', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D017526', 'descriptor_name': 'Receptor, IGF Type 1', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D017526', 'descriptor_name': 'Receptor, IGF Type 1', 'qualifier_ui': 'Q000187', 'qualifier_name': 'drug effects', 'is_major_topic': False}, {'descriptor_ui': 'D011972', 'descriptor_name': 'Receptor, Insulin', 'qualifier_ui': 'Q000187', 'qualifier_name': 'drug effects', 'is_major_topic': False}, {'descriptor_ui': 'D011972', 'descriptor_name': 'Receptor, Insulin', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D015398', 'descriptor_name': 'Signal Transduction', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D020032', 'descriptor_name': 'Tyrphostins', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D020032', 'descriptor_name': 'Tyrphostins', 'qualifier_ui': 'Q000494', 'qualifier_name': 'pharmacology', 'is_major_topic': False}], 'locations_count': 4, 'locations': [{'is_oa': True, 'landing_page_url': 'https://doi.org/10.18632/oncotarget.10361', 'pdf_url': 'http://www.oncotarget.com/index.php?journal=oncotarget&page=article&op=download&path%5B%5D=10361&path%5B%5D=32686', 'source': {'id': 'https://openalex.org/S126644158', 'display_name': 'Oncotarget', 'issn_l': '1949-2553', 'issn': ['1949-2553'], 'is_oa': True, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310316297', 'host_organization_name': 'Impact Journals LLC', 'host_organization_lineage': ['https://openalex.org/P4310316297'], 'host_organization_lineage_names': ['Impact Journals LLC'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, {'is_oa': True, 'landing_page_url': 'https://europepmc.org/articles/pmc5226581', 'pdf_url': 'https://europepmc.org/articles/pmc5226581?pdf=render', 'source': {'id': 'https://openalex.org/S4306400806', 'display_name': 'Europe PMC (PubMed Central)', 'issn_l': None, 'issn': None, 'is_oa': True, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1303153112', 'host_organization_name': 'European Bioinformatics Institute', 'host_organization_lineage': ['https://openalex.org/I1303153112'], 'host_organization_lineage_names': ['European Bioinformatics Institute'], 'type': 'repository'}, 'license': 'cc-by', 'license_id': 'https://openalex.org/licenses/cc-by', 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, {'is_oa': True, 'landing_page_url': 'https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5226581', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S2764455111', 'display_name': 'PubMed Central', 'issn_l': None, 'issn': None, 'is_oa': True, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1299303238', 'host_organization_name': 'National Institutes of Health', 'host_organization_lineage': ['https://openalex.org/I1299303238'], 'host_organization_lineage_names': ['National Institutes of Health'], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, {'is_oa': False, 'landing_page_url': 'https://pubmed.ncbi.nlm.nih.gov/27384680', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S4306525036', 'display_name': 'PubMed', 'issn_l': None, 'issn': None, 'is_oa': False, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1299303238', 'host_organization_name': 'National Institutes of Health', 'host_organization_lineage': ['https://openalex.org/I1299303238'], 'host_organization_lineage_names': ['National Institutes of Health'], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}], 'best_oa_location': {'is_oa': True, 'landing_page_url': 'https://doi.org/10.18632/oncotarget.10361', 'pdf_url': 'http://www.oncotarget.com/index.php?journal=oncotarget&page=article&op=download&path%5B%5D=10361&path%5B%5D=32686', 'source': {'id': 'https://openalex.org/S126644158', 'display_name': 'Oncotarget', 'issn_l': '1949-2553', 'issn': ['1949-2553'], 'is_oa': True, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310316297', 'host_organization_name': 'Impact Journals LLC', 'host_organization_lineage': ['https://openalex.org/P4310316297'], 'host_organization_lineage_names': ['Impact Journals LLC'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, 'sustainable_development_goals': [{'id': 'https://metadata.un.org/sdg/14', 'display_name': 'Life below water', 'score': 0.81}], 'grants': [], 'datasets': [], 'versions': [], 'referenced_works_count': 54, 'referenced_works': ['https://openalex.org/W1834944463', 'https://openalex.org/W1861705388', 'https://openalex.org/W1970156566', 'https://openalex.org/W1976447570', 'https://openalex.org/W1983695685', 'https://openalex.org/W1992059152', 'https://openalex.org/W1993251792', 'https://openalex.org/W1999608828', 'https://openalex.org/W2004314923', 'https://openalex.org/W2006159340', 'https://openalex.org/W2006508410', 'https://openalex.org/W2016098458', 'https://openalex.org/W2026122666', 'https://openalex.org/W2027326117', 'https://openalex.org/W2035447242', 'https://openalex.org/W2036080257', 'https://openalex.org/W2037332721', 'https://openalex.org/W2038036073', 'https://openalex.org/W2042278676', 'https://openalex.org/W2042406709', 'https://openalex.org/W2049853609', 'https://openalex.org/W2061477949', 'https://openalex.org/W2062752564', 'https://openalex.org/W2067613508', 'https://openalex.org/W2073895941', 'https://openalex.org/W2078663980', 'https://openalex.org/W2089055554', 'https://openalex.org/W2092273440', 'https://openalex.org/W2094825902', 'https://openalex.org/W2101078720', 'https://openalex.org/W2102437478', 'https://openalex.org/W2105183657', 'https://openalex.org/W2106949778', 'https://openalex.org/W2108949840', 'https://openalex.org/W2110290265', 'https://openalex.org/W2110901075', 'https://openalex.org/W2111139603', 'https://openalex.org/W2116610479', 'https://openalex.org/W2121520362', 'https://openalex.org/W2127152525', 'https://openalex.org/W2127628047', 'https://openalex.org/W2132629607', 'https://openalex.org/W2140867196', 'https://openalex.org/W2143541297', 'https://openalex.org/W2145355816', 'https://openalex.org/W2149278865', 'https://openalex.org/W2157206505', 'https://openalex.org/W2164124814', 'https://openalex.org/W2171255573', 'https://openalex.org/W2175803345', 'https://openalex.org/W2320896078', 'https://openalex.org/W2566863750', 'https://openalex.org/W4211040155', 'https://openalex.org/W4245608028'], 'related_works': ['https://openalex.org/W4387497383', 'https://openalex.org/W2948807893', 'https://openalex.org/W2778153218', 'https://openalex.org/W2748952813', 'https://openalex.org/W2527526854', 'https://openalex.org/W2078814861', 'https://openalex.org/W2062208111', 'https://openalex.org/W1986764834', 'https://openalex.org/W1976181487', 'https://openalex.org/W1531601525'], 'abstract_inverted_index': {'//': [0], 'Ana': [1, 112], 'Zovko': [2], '1': [3, 7, 11, 19, 35, 39, 40, 148, 206, 235, 267, 286], ',': [4, 8, 12, 16, 20, 24, 28, 32, 36], 'Metka': [5], 'Novak': [6], 'Petra': [9], 'Hååg': [10], 'Dimitry': [13], 'Kovalerchick': [14], '2': [15, 31, 53, 208], 'Teresa': [17], 'Holmlund': [18], 'Katarina': [21], 'Färnegårdh': [22], '3': [23, 71], 'Micha': [25], 'Ilan': [26], '4': [27, 89], 'Shmuel': [29], 'Carmeli': [30], 'Rolf': [33], 'Lewensohn': [34], 'Kristina': [37, 108], 'Viktorsson': [38], 'Department': [41, 81, 90], 'of': [42, 55, 62, 82, 91, 97, 195, 211, 226, 241], 'Oncology': [43], 'and': [44, 58, 78, 149, 155, 162, 174, 207, 222], 'Pathology,': [45], 'Karolinska': [46, 49], 'Biomics': [47], 'Center,': [48], 'Institutet,': [50], 'Stockholm,': [51, 87], 'Sweden': [52, 88], 'School': [54], 'Chemistry,': [56, 84], 'Raymond': [57], 'Beverly': [59], 'Sackler': [60], 'Faculty': [61, 96], 'Exact': [63], 'Sciences,': [64, 99], 'Tel': [65, 68, 100, 103], 'Aviv': [66, 101], 'University,': [67, 86, 102], 'Aviv,': [69, 104], 'Israel': [70, 105], 'Science': [72], 'for': [73, 318], 'Life': [74, 98], 'Laboratory,': [75], 'Drug': [76], 'Discovery': [77], 'Development': [79], 'Platform,': [80], 'Organic': [83], 'Stockholm': [85], 'Zoology,': [92], 'George': [93], 'S': [94], 'Wise': [95], 'Correspondence': [106], 'to:': [107], 'Viktorsson,': [109], 'email:': [110, 114], '[email protected]': [111], 'Zovko,': [113], '[email protected]': [115], 'Keywords:': [116], 'sponge,': [117], 'small': [118], 'molecule,': [119], 'natural': [120], 'products,': [121], 'lung': [122, 201], 'cancer,': [123], 'insulin': [124, 181], 'growth': [125, 183], 'factor': [126, 184], 'receptor': [127, 185, 279], 'Received:': [128], 'June': [129, 133], '11,': [130], '2015': [131], 'Accepted:': [132], '15,': [134], '2016': [135, 139], 'Published:': [136], 'July': [137], '1,': [138], 'ABSTRACT': [140], 'In': [141, 229], 'this': [142], 'work': [143], 'two': [144], 'acetylene': [145], 'alcohols,': [146], 'compound': [147, 150, 234, 266, 285], '2,': [151], 'which': [152, 163], 'were': [153, 167], 'isolated': [154], 'identified': [156], 'from': [157], 'the': [158, 238, 244, 249, 274], 'sponge': [159], 'Cribrochalina': [160], 'vasculum,': [161], 'showed': [164], 'anti-tumor': [165, 193, 319], 'effects': [166, 300], 'further': [168], 'studied': [169], 'with': [170, 298], 'respect': [171], 'to': [172, 188, 237, 269, 273], 'targets': [173], 'action': [175], 'mechanisms.': [176], 'Gene': [177], 'expression': [178], 'analyses': [179], 'suggested': [180], 'like': [182], '(IGF-1R)': [186], 'signaling': [187, 219, 317], 'be': [189], 'instrumental': [190], 'in': [191, 198, 295, 302], 'controlling': [192], 'efficacy': [194], 'these': [196, 307], 'compounds': [197, 205, 308], 'non-small': [199], 'cell': [200], 'cancer': [202], '(NSCLC).': [203], 'Indeed': [204], 'inhibited': [209], 'phosphorylation': [210], 'IGF-1Rβ': [212, 288], 'as': [213, 215, 248, 311], 'well': [214, 250], 'reduced': [216], 'its': [217], 'target': [218], 'molecules': [220], 'IRS-1': [221], 'PDK1': [223], 'allowing': [224], 'inhibition': [225], 'pro-survival': [227], 'signaling.': [228], 'silico': [230], 'docking': [231], 'indicated': [232], 'that': [233, 263, 284], 'binds': [236, 268], 'kinase': [239, 253, 278], 'domain': [240], 'IGF-1R': [242, 270, 316], 'at': [243], 'same': [245], 'binding': [246], 'site': [247], 'known': [251], 'tyrosine': [252, 277], 'inhibitor': [254], 'AG1024.': [255], 'Indeed,': [256], 'cellular': [257], 'thermal': [258], 'shift': [259], 'assay': [260], '(CETSA)': [261], 'confirmed': [262], 'C.': [264], 'vasculum': [265], 'but': [271, 289], 'not': [272, 290], 'membrane': [275], 'localized': [276], 'EGFR.': [280], 'Importantly,': [281], 'we': [282], 'demonstrate': [283], 'causes': [287], 'Insulin': [291], 'Receptor': [292], 'degradation': [293], 'specifically': [294], 'tumor': [296], 'cells': [297], 'no': [299], 'seen': [301], 'normal': [303], 'diploid': [304], 'fibroblasts.': [305], 'Thus,': [306], 'hold': [309], 'potential': [310], 'novel': [312], 'therapeutic': [313], 'agents': [314], 'targeting': [315], 'treatment.': [320]}, 'cited_by_api_url': 'https://api.openalex.org/works?filter=cites:W2465258693', 'counts_by_year': [{'year': 2024, 'cited_by_count': 1}, {'year': 2023, 'cited_by_count': 3}, {'year': 2022, 'cited_by_count': 3}, {'year': 2021, 'cited_by_count': 1}, {'year': 2020, 'cited_by_count': 2}, {'year': 2019, 'cited_by_count': 5}, {'year': 2018, 'cited_by_count': 4}, {'year': 2017, 'cited_by_count': 1}], 'updated_date': '2024-09-19T02:15:01.875374', 'created_date': '2016-07-22'}