Get quick answers to your questions about the article from our AI researcher chatbot
{'id': 'https://openalex.org/W2464839949', 'doi': 'https://doi.org/10.18632/oncotarget.10515', 'title': 'Systemic immune-inflammation index predicts the clinical outcome in patients with metastatic renal cell cancer treated with sunitinib', 'display_name': 'Systemic immune-inflammation index predicts the clinical outcome in patients with metastatic renal cell cancer treated with sunitinib', 'publication_year': 2016, 'publication_date': '2016-07-09', 'ids': {'openalex': 'https://openalex.org/W2464839949', 'doi': 'https://doi.org/10.18632/oncotarget.10515', 'mag': '2464839949', 'pmid': 'https://pubmed.ncbi.nlm.nih.gov/27409344', 'pmcid': 'https://www.ncbi.nlm.nih.gov/pmc/articles/5342364'}, 'language': 'en', 'primary_location': {'is_oa': True, 'landing_page_url': 'https://doi.org/10.18632/oncotarget.10515', 'pdf_url': 'http://www.oncotarget.com/index.php?journal=oncotarget&page=article&op=download&path%5B%5D=10515&path%5B%5D=33223', 'source': {'id': 'https://openalex.org/S126644158', 'display_name': 'Oncotarget', 'issn_l': '1949-2553', 'issn': ['1949-2553'], 'is_oa': True, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310316297', 'host_organization_name': 'Impact Journals LLC', 'host_organization_lineage': ['https://openalex.org/P4310316297'], 'host_organization_lineage_names': ['Impact Journals LLC'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, 'type': 'article', 'type_crossref': 'journal-article', 'indexed_in': ['crossref', 'pubmed'], 'open_access': {'is_oa': True, 'oa_status': 'gold', 'oa_url': 'http://www.oncotarget.com/index.php?journal=oncotarget&page=article&op=download&path%5B%5D=10515&path%5B%5D=33223', 'any_repository_has_fulltext': True}, 'authorships': [{'author_position': 'first', 'author': {'id': 'https://openalex.org/A5031994096', 'display_name': 'Cristian Lolli', 'orcid': 'https://orcid.org/0000-0003-0347-9179'}, 'institutions': [{'id': 'https://openalex.org/I4210097834', 'display_name': 'Istituto Scientifico Romagnolo per lo Studio e la Cura dei Tumori', 'ror': 'https://ror.org/013wkc921', 'country_code': 'IT', 'type': 'facility', 'lineage': ['https://openalex.org/I4210097834', 'https://openalex.org/I4210153126']}, {'id': 'https://openalex.org/I4210153126', 'display_name': 'Istituti di Ricovero e Cura a Carattere Scientifico', 'ror': 'https://ror.org/04tfzc498', 'country_code': 'IT', 'type': 'healthcare', 'lineage': ['https://openalex.org/I4210153126']}], 'countries': ['IT'], 'is_corresponding': False, 'raw_author_name': 'Cristian Lolli', 'raw_affiliation_strings': ['Department of Medical Oncology, Istituto Scientifico Romagnolo per lo Studio e la Cura dei Tumori (IRST) IRCCS, Meldola, Italy'], 'affiliations': [{'raw_affiliation_string': 'Department of Medical Oncology, Istituto Scientifico Romagnolo per lo Studio e la Cura dei Tumori (IRST) IRCCS, Meldola, Italy', 'institution_ids': ['https://openalex.org/I4210097834', 'https://openalex.org/I4210153126']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5082704939', 'display_name': 'Umberto Basso', 'orcid': 'https://orcid.org/0000-0002-5075-2177'}, 'institutions': [{'id': 'https://openalex.org/I4210109345', 'display_name': 'Istituto Oncologico Veneto', 'ror': 'https://ror.org/01xcjmy57', 'country_code': 'IT', 'type': 'healthcare', 'lineage': ['https://openalex.org/I4210109345', 'https://openalex.org/I4210153126']}, {'id': 'https://openalex.org/I4210153126', 'display_name': 'Istituti di Ricovero e Cura a Carattere Scientifico', 'ror': 'https://ror.org/04tfzc498', 'country_code': 'IT', 'type': 'healthcare', 'lineage': ['https://openalex.org/I4210153126']}], 'countries': ['IT'], 'is_corresponding': False, 'raw_author_name': 'Umberto Basso', 'raw_affiliation_strings': ['Medical Oncology Unit 1, Department of Clinical and Experimental Oncology, Istituto Oncologico Veneto IOV IRCCS, Padova, Italy'], 'affiliations': [{'raw_affiliation_string': 'Medical Oncology Unit 1, Department of Clinical and Experimental Oncology, Istituto Oncologico Veneto IOV IRCCS, Padova, Italy', 'institution_ids': ['https://openalex.org/I4210109345', 'https://openalex.org/I4210153126']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5054491406', 'display_name': 'Lisa Derosa', 'orcid': 'https://orcid.org/0000-0003-0527-2964'}, 'institutions': [{'id': 'https://openalex.org/I4210165410', 'display_name': 'Azienda Ospedaliera Universitaria Pisana', 'ror': 'https://ror.org/05xrcj819', 'country_code': 'IT', 'type': 'healthcare', 'lineage': ['https://openalex.org/I4210165410']}], 'countries': ['IT'], 'is_corresponding': False, 'raw_author_name': 'Lisa Derosa', 'raw_affiliation_strings': ['Oncology Unit 2, University Hospital of Pisa, Pisa, Italy'], 'affiliations': [{'raw_affiliation_string': 'Oncology Unit 2, University Hospital of Pisa, Pisa, Italy', 'institution_ids': ['https://openalex.org/I4210165410']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5006130493', 'display_name': 'Emanuela Scarpi', 'orcid': 'https://orcid.org/0000-0001-7230-9267'}, 'institutions': [{'id': 'https://openalex.org/I4210097834', 'display_name': 'Istituto Scientifico Romagnolo per lo Studio e la Cura dei Tumori', 'ror': 'https://ror.org/013wkc921', 'country_code': 'IT', 'type': 'facility', 'lineage': ['https://openalex.org/I4210097834', 'https://openalex.org/I4210153126']}, {'id': 'https://openalex.org/I4210153126', 'display_name': 'Istituti di Ricovero e Cura a Carattere Scientifico', 'ror': 'https://ror.org/04tfzc498', 'country_code': 'IT', 'type': 'healthcare', 'lineage': ['https://openalex.org/I4210153126']}], 'countries': ['IT'], 'is_corresponding': False, 'raw_author_name': 'Emanuela Scarpi', 'raw_affiliation_strings': ['Department of Medical Oncology, Istituto Scientifico Romagnolo per lo Studio e la Cura dei Tumori (IRST) IRCCS, Meldola, Italy'], 'affiliations': [{'raw_affiliation_string': 'Department of Medical Oncology, Istituto Scientifico Romagnolo per lo Studio e la Cura dei Tumori (IRST) IRCCS, Meldola, Italy', 'institution_ids': ['https://openalex.org/I4210097834', 'https://openalex.org/I4210153126']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5022699386', 'display_name': 'Teodoro Sava', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I4210094363', 'display_name': 'Azienda Ospedaliera Universitaria Integrata Verona', 'ror': 'https://ror.org/00sm8k518', 'country_code': 'IT', 'type': 'healthcare', 'lineage': ['https://openalex.org/I4210094363']}], 'countries': ['IT'], 'is_corresponding': False, 'raw_author_name': 'Teodoro Sava', 'raw_affiliation_strings': ['Department of Medical Oncology, Azienda Ospedaliera Universitaria Integrata Verona, Verona, Italy'], 'affiliations': [{'raw_affiliation_string': 'Department of Medical Oncology, Azienda Ospedaliera Universitaria Integrata Verona, Verona, Italy', 'institution_ids': ['https://openalex.org/I4210094363']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5021477463', 'display_name': 'Matteo Santoni', 'orcid': 'https://orcid.org/0000-0001-7340-6173'}, 'institutions': [{'id': 'https://openalex.org/I4210165056', 'display_name': 'Ospedali Riuniti Umberto I', 'ror': 'https://ror.org/05rsf2c37', 'country_code': 'IT', 'type': 'healthcare', 'lineage': ['https://openalex.org/I4210165056']}, {'id': 'https://openalex.org/I4210108813', 'display_name': 'Azienda Ospedaliero Universitaria Ospedali Riuniti', 'ror': 'https://ror.org/0213f0637', 'country_code': 'IT', 'type': 'healthcare', 'lineage': ['https://openalex.org/I4210108813']}], 'countries': ['IT'], 'is_corresponding': False, 'raw_author_name': 'Matteo Santoni', 'raw_affiliation_strings': ['Department of Medical Oncology, Polytechnic University of the Marche Region, Azienda Ospedaliero-Universitaria, Ospedali Riuniti Umberto I-GM Lancisi and G Salesi, Ancona, Italy'], 'affiliations': [{'raw_affiliation_string': 'Department of Medical Oncology, Polytechnic University of the Marche Region, Azienda Ospedaliero-Universitaria, Ospedali Riuniti Umberto I-GM Lancisi and G Salesi, Ancona, Italy', 'institution_ids': ['https://openalex.org/I4210165056', 'https://openalex.org/I4210108813']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5078099654', 'display_name': 'Simon J. Crabb', 'orcid': 'https://orcid.org/0000-0003-3521-9064'}, 'institutions': [{'id': 'https://openalex.org/I2802965805', 'display_name': 'University Hospital Southampton NHS Foundation Trust', 'ror': 'https://ror.org/0485axj58', 'country_code': 'GB', 'type': 'healthcare', 'lineage': ['https://openalex.org/I2802965805']}, {'id': 'https://openalex.org/I2801388914', 'display_name': 'Southampton General Hospital', 'ror': 'https://ror.org/011cztj49', 'country_code': 'GB', 'type': 'healthcare', 'lineage': ['https://openalex.org/I2801388914', 'https://openalex.org/I2802965805']}], 'countries': ['GB'], 'is_corresponding': False, 'raw_author_name': 'Simon J. Crabb', 'raw_affiliation_strings': ['Department of Medical Oncology, University Hospital Southampton NHS Foundation Trust, Southampton General Hospital, Southampton, UK'], 'affiliations': [{'raw_affiliation_string': 'Department of Medical Oncology, University Hospital Southampton NHS Foundation Trust, Southampton General Hospital, Southampton, UK', 'institution_ids': ['https://openalex.org/I2802965805', 'https://openalex.org/I2801388914']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5063795761', 'display_name': 'Francesco Massari', 'orcid': 'https://orcid.org/0000-0001-6476-6871'}, 'institutions': [{'id': 'https://openalex.org/I4210094363', 'display_name': 'Azienda Ospedaliera Universitaria Integrata Verona', 'ror': 'https://ror.org/00sm8k518', 'country_code': 'IT', 'type': 'healthcare', 'lineage': ['https://openalex.org/I4210094363']}, {'id': 'https://openalex.org/I4210097083', 'display_name': 'Policlinico S.Orsola-Malpighi', 'ror': 'https://ror.org/00t4vnv68', 'country_code': 'IT', 'type': 'healthcare', 'lineage': ['https://openalex.org/I4210097083']}], 'countries': ['IT'], 'is_corresponding': False, 'raw_author_name': 'Francesco Massari', 'raw_affiliation_strings': ['Department of Medical Oncology, Azienda Ospedaliera Universitaria Integrata Verona, Verona, Italy', 'Present address: Division of Oncology, S.Orsola-Malpighi Hospital, Bologna, Italy'], 'affiliations': [{'raw_affiliation_string': 'Department of Medical Oncology, Azienda Ospedaliera Universitaria Integrata Verona, Verona, Italy', 'institution_ids': ['https://openalex.org/I4210094363']}, {'raw_affiliation_string': 'Present address: Division of Oncology, S.Orsola-Malpighi Hospital, Bologna, Italy', 'institution_ids': ['https://openalex.org/I4210097083']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5004001131', 'display_name': 'Michele Aieta', 'orcid': 'https://orcid.org/0000-0001-9487-6238'}, 'institutions': [{'id': 'https://openalex.org/I4210094078', 'display_name': 'Centro di Riferimento Oncologico della Basilicata', 'ror': 'https://ror.org/00n6jcj93', 'country_code': 'IT', 'type': 'healthcare', 'lineage': ['https://openalex.org/I4210094078', 'https://openalex.org/I4210153126']}, {'id': 'https://openalex.org/I4210153126', 'display_name': 'Istituti di Ricovero e Cura a Carattere Scientifico', 'ror': 'https://ror.org/04tfzc498', 'country_code': 'IT', 'type': 'healthcare', 'lineage': ['https://openalex.org/I4210153126']}], 'countries': ['IT'], 'is_corresponding': False, 'raw_author_name': 'Michele Aieta', 'raw_affiliation_strings': ['Department of Medical Oncology, IRCCS CROB Centro di Riferimento Oncologico della Basilicata, Rionero in Vulture, Italy'], 'affiliations': [{'raw_affiliation_string': 'Department of Medical Oncology, IRCCS CROB Centro di Riferimento Oncologico della Basilicata, Rionero in Vulture, Italy', 'institution_ids': ['https://openalex.org/I4210094078', 'https://openalex.org/I4210153126']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5042277842', 'display_name': 'Vincenza Conteduca', 'orcid': 'https://orcid.org/0000-0002-6921-714X'}, 'institutions': [{'id': 'https://openalex.org/I4210097834', 'display_name': 'Istituto Scientifico Romagnolo per lo Studio e la Cura dei Tumori', 'ror': 'https://ror.org/013wkc921', 'country_code': 'IT', 'type': 'facility', 'lineage': ['https://openalex.org/I4210097834', 'https://openalex.org/I4210153126']}, {'id': 'https://openalex.org/I4210153126', 'display_name': 'Istituti di Ricovero e Cura a Carattere Scientifico', 'ror': 'https://ror.org/04tfzc498', 'country_code': 'IT', 'type': 'healthcare', 'lineage': ['https://openalex.org/I4210153126']}], 'countries': ['IT'], 'is_corresponding': False, 'raw_author_name': 'Vincenza Conteduca', 'raw_affiliation_strings': ['Department of Medical Oncology, Istituto Scientifico Romagnolo per lo Studio e la Cura dei Tumori (IRST) IRCCS, Meldola, Italy'], 'affiliations': [{'raw_affiliation_string': 'Department of Medical Oncology, Istituto Scientifico Romagnolo per lo Studio e la Cura dei Tumori (IRST) IRCCS, Meldola, Italy', 'institution_ids': ['https://openalex.org/I4210097834', 'https://openalex.org/I4210153126']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5034433849', 'display_name': 'Marco Maruzzo', 'orcid': 'https://orcid.org/0000-0002-6256-9249'}, 'institutions': [{'id': 'https://openalex.org/I4210109345', 'display_name': 'Istituto Oncologico Veneto', 'ror': 'https://ror.org/01xcjmy57', 'country_code': 'IT', 'type': 'healthcare', 'lineage': ['https://openalex.org/I4210109345', 'https://openalex.org/I4210153126']}, {'id': 'https://openalex.org/I4210153126', 'display_name': 'Istituti di Ricovero e Cura a Carattere Scientifico', 'ror': 'https://ror.org/04tfzc498', 'country_code': 'IT', 'type': 'healthcare', 'lineage': ['https://openalex.org/I4210153126']}], 'countries': ['IT'], 'is_corresponding': False, 'raw_author_name': 'Marco Maruzzo', 'raw_affiliation_strings': ['Medical Oncology Unit 1, Department of Clinical and Experimental Oncology, Istituto Oncologico Veneto IOV IRCCS, Padova, Italy'], 'affiliations': [{'raw_affiliation_string': 'Medical Oncology Unit 1, Department of Clinical and Experimental Oncology, Istituto Oncologico Veneto IOV IRCCS, Padova, Italy', 'institution_ids': ['https://openalex.org/I4210109345', 'https://openalex.org/I4210153126']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5104253853', 'display_name': 'Francesca La Russa', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I4210094363', 'display_name': 'Azienda Ospedaliera Universitaria Integrata Verona', 'ror': 'https://ror.org/00sm8k518', 'country_code': 'IT', 'type': 'healthcare', 'lineage': ['https://openalex.org/I4210094363']}], 'countries': ['IT'], 'is_corresponding': False, 'raw_author_name': 'Francesca La Russa', 'raw_affiliation_strings': ['Department of Medical Oncology, Azienda Ospedaliera Universitaria Integrata Verona, Verona, Italy'], 'affiliations': [{'raw_affiliation_string': 'Department of Medical Oncology, Azienda Ospedaliera Universitaria Integrata Verona, Verona, Italy', 'institution_ids': ['https://openalex.org/I4210094363']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5039402351', 'display_name': 'Matthew Wheater', 'orcid': 'https://orcid.org/0000-0001-6561-5290'}, 'institutions': [{'id': 'https://openalex.org/I2802965805', 'display_name': 'University Hospital Southampton NHS Foundation Trust', 'ror': 'https://ror.org/0485axj58', 'country_code': 'GB', 'type': 'healthcare', 'lineage': ['https://openalex.org/I2802965805']}, {'id': 'https://openalex.org/I2801388914', 'display_name': 'Southampton General Hospital', 'ror': 'https://ror.org/011cztj49', 'country_code': 'GB', 'type': 'healthcare', 'lineage': ['https://openalex.org/I2801388914', 'https://openalex.org/I2802965805']}], 'countries': ['GB'], 'is_corresponding': False, 'raw_author_name': 'Matthew Wheater', 'raw_affiliation_strings': ['Department of Medical Oncology, University Hospital Southampton NHS Foundation Trust, Southampton General Hospital, Southampton, UK'], 'affiliations': [{'raw_affiliation_string': 'Department of Medical Oncology, University Hospital Southampton NHS Foundation Trust, Southampton General Hospital, Southampton, UK', 'institution_ids': ['https://openalex.org/I2802965805', 'https://openalex.org/I2801388914']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5019053015', 'display_name': 'Rossana Berardi', 'orcid': 'https://orcid.org/0000-0002-9529-2960'}, 'institutions': [{'id': 'https://openalex.org/I4210165056', 'display_name': 'Ospedali Riuniti Umberto I', 'ror': 'https://ror.org/05rsf2c37', 'country_code': 'IT', 'type': 'healthcare', 'lineage': ['https://openalex.org/I4210165056']}, {'id': 'https://openalex.org/I4210108813', 'display_name': 'Azienda Ospedaliero Universitaria Ospedali Riuniti', 'ror': 'https://ror.org/0213f0637', 'country_code': 'IT', 'type': 'healthcare', 'lineage': ['https://openalex.org/I4210108813']}], 'countries': ['IT'], 'is_corresponding': False, 'raw_author_name': 'Rossana Berardi', 'raw_affiliation_strings': ['Department of Medical Oncology, Polytechnic University of the Marche Region, Azienda Ospedaliero-Universitaria, Ospedali Riuniti Umberto I-GM Lancisi and G Salesi, Ancona, Italy'], 'affiliations': [{'raw_affiliation_string': 'Department of Medical Oncology, Polytechnic University of the Marche Region, Azienda Ospedaliero-Universitaria, Ospedali Riuniti Umberto I-GM Lancisi and G Salesi, Ancona, Italy', 'institution_ids': ['https://openalex.org/I4210165056', 'https://openalex.org/I4210108813']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5029935476', 'display_name': 'Luca Galli', 'orcid': 'https://orcid.org/0000-0001-6008-0266'}, 'institutions': [{'id': 'https://openalex.org/I4210165410', 'display_name': 'Azienda Ospedaliera Universitaria Pisana', 'ror': 'https://ror.org/05xrcj819', 'country_code': 'IT', 'type': 'healthcare', 'lineage': ['https://openalex.org/I4210165410']}], 'countries': ['IT'], 'is_corresponding': False, 'raw_author_name': 'Luca Galli', 'raw_affiliation_strings': ['Oncology Unit 2, University Hospital of Pisa, Pisa, Italy'], 'affiliations': [{'raw_affiliation_string': 'Oncology Unit 2, University Hospital of Pisa, Pisa, Italy', 'institution_ids': ['https://openalex.org/I4210165410']}]}, {'author_position': 'last', 'author': {'id': 'https://openalex.org/A5071060598', 'display_name': 'Ugo De Giorgi', 'orcid': 'https://orcid.org/0000-0001-7520-2908'}, 'institutions': [{'id': 'https://openalex.org/I4210097834', 'display_name': 'Istituto Scientifico Romagnolo per lo Studio e la Cura dei Tumori', 'ror': 'https://ror.org/013wkc921', 'country_code': 'IT', 'type': 'facility', 'lineage': ['https://openalex.org/I4210097834', 'https://openalex.org/I4210153126']}, {'id': 'https://openalex.org/I4210153126', 'display_name': 'Istituti di Ricovero e Cura a Carattere Scientifico', 'ror': 'https://ror.org/04tfzc498', 'country_code': 'IT', 'type': 'healthcare', 'lineage': ['https://openalex.org/I4210153126']}], 'countries': ['IT'], 'is_corresponding': True, 'raw_author_name': 'Ugo De Giorgi', 'raw_affiliation_strings': ['Department of Medical Oncology, Istituto Scientifico Romagnolo per lo Studio e la Cura dei Tumori (IRST) IRCCS, Meldola, Italy'], 'affiliations': [{'raw_affiliation_string': 'Department of Medical Oncology, Istituto Scientifico Romagnolo per lo Studio e la Cura dei Tumori (IRST) IRCCS, Meldola, Italy', 'institution_ids': ['https://openalex.org/I4210097834', 'https://openalex.org/I4210153126']}]}], 'institution_assertions': [], 'countries_distinct_count': 2, 'institutions_distinct_count': 11, 'corresponding_author_ids': ['https://openalex.org/A5071060598'], 'corresponding_institution_ids': ['https://openalex.org/I4210097834', 'https://openalex.org/I4210153126'], 'apc_list': None, 'apc_paid': None, 'fwci': 7.795, 'has_fulltext': True, 'fulltext_origin': 'pdf', 'cited_by_count': 136, 'citation_normalized_percentile': {'value': 0.999955, 'is_in_top_1_percent': True, 'is_in_top_10_percent': True}, 'cited_by_percentile_year': {'min': 98, 'max': 99}, 'biblio': {'volume': '7', 'issue': '34', 'first_page': '54564', 'last_page': '54571'}, 'is_retracted': False, 'is_paratext': False, 'primary_topic': {'id': 'https://openalex.org/T11355', 'display_name': 'Inflammatory Biomarkers in Disease Prognosis', 'score': 0.9999, 'subfield': {'id': 'https://openalex.org/subfields/2730', 'display_name': 'Oncology'}, 'field': {'id': 'https://openalex.org/fields/27', 'display_name': 'Medicine'}, 'domain': {'id': 'https://openalex.org/domains/4', 'display_name': 'Health Sciences'}}, 'topics': [{'id': 'https://openalex.org/T11355', 'display_name': 'Inflammatory Biomarkers in Disease Prognosis', 'score': 0.9999, 'subfield': {'id': 'https://openalex.org/subfields/2730', 'display_name': 'Oncology'}, 'field': {'id': 'https://openalex.org/fields/27', 'display_name': 'Medicine'}, 'domain': {'id': 'https://openalex.org/domains/4', 'display_name': 'Health Sciences'}}, {'id': 'https://openalex.org/T10158', 'display_name': 'Cancer Immunotherapy and Biomarkers', 'score': 0.9997, 'subfield': {'id': 'https://openalex.org/subfields/2730', 'display_name': 'Oncology'}, 'field': {'id': 'https://openalex.org/fields/27', 'display_name': 'Medicine'}, 'domain': {'id': 'https://openalex.org/domains/4', 'display_name': 'Health Sciences'}}, {'id': 'https://openalex.org/T10449', 'display_name': 'Renal cell carcinoma treatment', 'score': 0.9987, 'subfield': {'id': 'https://openalex.org/subfields/2740', 'display_name': 'Pulmonary and Respiratory Medicine'}, 'field': {'id': 'https://openalex.org/fields/27', 'display_name': 'Medicine'}, 'domain': {'id': 'https://openalex.org/domains/4', 'display_name': 'Health Sciences'}}], 'keywords': [], 'concepts': [{'id': 'https://openalex.org/C71924100', 'wikidata': 'https://www.wikidata.org/wiki/Q11190', 'display_name': 'Medicine', 'level': 0, 'score': 0.83092666}, {'id': 'https://openalex.org/C2779490328', 'wikidata': 'https://www.wikidata.org/wiki/Q417542', 'display_name': 'Sunitinib', 'level': 3, 'score': 0.64278686}, {'id': 'https://openalex.org/C126322002', 'wikidata': 'https://www.wikidata.org/wiki/Q11180', 'display_name': 'Internal medicine', 'level': 1, 'score': 0.56103605}, {'id': 'https://openalex.org/C2777472916', 'wikidata': 'https://www.wikidata.org/wiki/Q1164529', 'display_name': 'Renal cell carcinoma', 'level': 2, 'score': 0.5470865}, {'id': 'https://openalex.org/C143998085', 'wikidata': 'https://www.wikidata.org/wiki/Q162555', 'display_name': 'Oncology', 'level': 1, 'score': 0.47515318}, {'id': 'https://openalex.org/C121608353', 'wikidata': 'https://www.wikidata.org/wiki/Q12078', 'display_name': 'Cancer', 'level': 2, 'score': 0.44599086}], 'mesh': [{'descriptor_ui': 'D000970', 'descriptor_name': 'Antineoplastic Agents', 'qualifier_ui': 'Q000627', 'qualifier_name': 'therapeutic use', 'is_major_topic': True}, {'descriptor_ui': 'D002292', 'descriptor_name': 'Carcinoma, Renal Cell', 'qualifier_ui': 'Q000188', 'qualifier_name': 'drug therapy', 'is_major_topic': True}, {'descriptor_ui': 'D007211', 'descriptor_name': 'Indoles', 'qualifier_ui': 'Q000627', 'qualifier_name': 'therapeutic use', 'is_major_topic': True}, {'descriptor_ui': 'D007680', 'descriptor_name': 'Kidney Neoplasms', 'qualifier_ui': 'Q000188', 'qualifier_name': 'drug therapy', 'is_major_topic': True}, {'descriptor_ui': 'D011758', 'descriptor_name': 'Pyrroles', 'qualifier_ui': 'Q000627', 'qualifier_name': 'therapeutic use', 'is_major_topic': True}, {'descriptor_ui': 'D000328', 'descriptor_name': 'Adult', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D000368', 'descriptor_name': 'Aged', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D000369', 'descriptor_name': 'Aged, 80 and over', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D000970', 'descriptor_name': 'Antineoplastic Agents', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D002292', 'descriptor_name': 'Carcinoma, Renal Cell', 'qualifier_ui': 'Q000276', 'qualifier_name': 'immunology', 'is_major_topic': False}, {'descriptor_ui': 'D002292', 'descriptor_name': 'Carcinoma, Renal Cell', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D002292', 'descriptor_name': 'Carcinoma, Renal Cell', 'qualifier_ui': 'Q000473', 'qualifier_name': 'pathology', 'is_major_topic': False}, {'descriptor_ui': 'D002292', 'descriptor_name': 'Carcinoma, Renal Cell', 'qualifier_ui': 'Q000401', 'qualifier_name': 'mortality', 'is_major_topic': False}, {'descriptor_ui': 'D005260', 'descriptor_name': 'Female', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D006801', 'descriptor_name': 'Humans', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D007211', 'descriptor_name': 'Indoles', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D007680', 'descriptor_name': 'Kidney Neoplasms', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D007680', 'descriptor_name': 'Kidney Neoplasms', 'qualifier_ui': 'Q000276', 'qualifier_name': 'immunology', 'is_major_topic': False}, {'descriptor_ui': 'D007680', 'descriptor_name': 'Kidney Neoplasms', 'qualifier_ui': 'Q000473', 'qualifier_name': 'pathology', 'is_major_topic': False}, {'descriptor_ui': 'D007680', 'descriptor_name': 'Kidney Neoplasms', 'qualifier_ui': 'Q000401', 'qualifier_name': 'mortality', 'is_major_topic': False}, {'descriptor_ui': 'D008297', 'descriptor_name': 'Male', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D008875', 'descriptor_name': 'Middle Aged', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D009362', 'descriptor_name': 'Neoplasm Metastasis', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D016016', 'descriptor_name': 'Proportional Hazards Models', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D011758', 'descriptor_name': 'Pyrroles', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D012189', 'descriptor_name': 'Retrospective Studies', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D000077210', 'descriptor_name': 'Sunitinib', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}], 'locations_count': 5, 'locations': [{'is_oa': True, 'landing_page_url': 'https://doi.org/10.18632/oncotarget.10515', 'pdf_url': 'http://www.oncotarget.com/index.php?journal=oncotarget&page=article&op=download&path%5B%5D=10515&path%5B%5D=33223', 'source': {'id': 'https://openalex.org/S126644158', 'display_name': 'Oncotarget', 'issn_l': '1949-2553', 'issn': ['1949-2553'], 'is_oa': True, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310316297', 'host_organization_name': 'Impact Journals LLC', 'host_organization_lineage': ['https://openalex.org/P4310316297'], 'host_organization_lineage_names': ['Impact Journals LLC'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, {'is_oa': True, 'landing_page_url': 'https://europepmc.org/articles/pmc5342364', 'pdf_url': 'https://europepmc.org/articles/pmc5342364?pdf=render', 'source': {'id': 'https://openalex.org/S4306400806', 'display_name': 'Europe PMC (PubMed Central)', 'issn_l': None, 'issn': None, 'is_oa': True, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1303153112', 'host_organization_name': 'European Bioinformatics Institute', 'host_organization_lineage': ['https://openalex.org/I1303153112'], 'host_organization_lineage_names': ['European Bioinformatics Institute'], 'type': 'repository'}, 'license': 'cc-by', 'license_id': 'https://openalex.org/licenses/cc-by', 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, {'is_oa': True, 'landing_page_url': 'https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5342364', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S2764455111', 'display_name': 'PubMed Central', 'issn_l': None, 'issn': None, 'is_oa': True, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1299303238', 'host_organization_name': 'National Institutes of Health', 'host_organization_lineage': ['https://openalex.org/I1299303238'], 'host_organization_lineage_names': ['National Institutes of Health'], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, {'is_oa': True, 'landing_page_url': 'https://eprints.soton.ac.uk/398109/1/__soton.ac.uk_ude_personalfiles_users_sjc7_mydesktop_10515-160102-2-PB.pdf', 'pdf_url': 'https://eprints.soton.ac.uk/398109/1/__soton.ac.uk_ude_personalfiles_users_sjc7_mydesktop_10515-160102-2-PB.pdf', 'source': {'id': 'https://openalex.org/S4306401019', 'display_name': 'ePrints Soton (University of Southampton)', 'issn_l': None, 'issn': None, 'is_oa': True, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I43439940', 'host_organization_name': 'University of Southampton', 'host_organization_lineage': ['https://openalex.org/I43439940'], 'host_organization_lineage_names': ['University of Southampton'], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': 'acceptedVersion', 'is_accepted': True, 'is_published': False}, {'is_oa': False, 'landing_page_url': 'https://pubmed.ncbi.nlm.nih.gov/27409344', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S4306525036', 'display_name': 'PubMed', 'issn_l': None, 'issn': None, 'is_oa': False, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1299303238', 'host_organization_name': 'National Institutes of Health', 'host_organization_lineage': ['https://openalex.org/I1299303238'], 'host_organization_lineage_names': ['National Institutes of Health'], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}], 'best_oa_location': {'is_oa': True, 'landing_page_url': 'https://doi.org/10.18632/oncotarget.10515', 'pdf_url': 'http://www.oncotarget.com/index.php?journal=oncotarget&page=article&op=download&path%5B%5D=10515&path%5B%5D=33223', 'source': {'id': 'https://openalex.org/S126644158', 'display_name': 'Oncotarget', 'issn_l': '1949-2553', 'issn': ['1949-2553'], 'is_oa': True, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310316297', 'host_organization_name': 'Impact Journals LLC', 'host_organization_lineage': ['https://openalex.org/P4310316297'], 'host_organization_lineage_names': ['Impact Journals LLC'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, 'sustainable_development_goals': [{'id': 'https://metadata.un.org/sdg/3', 'score': 0.8, 'display_name': 'Good health and well-being'}], 'grants': [], 'datasets': [], 'versions': [], 'referenced_works_count': 29, 'referenced_works': ['https://openalex.org/W1928445625', 'https://openalex.org/W1969121713', 'https://openalex.org/W1982906652', 'https://openalex.org/W1986188440', 'https://openalex.org/W1986683494', 'https://openalex.org/W1996274279', 'https://openalex.org/W2003521616', 'https://openalex.org/W2013408555', 'https://openalex.org/W2018038784', 'https://openalex.org/W2053991659', 'https://openalex.org/W2079168970', 'https://openalex.org/W2085655420', 'https://openalex.org/W2099752220', 'https://openalex.org/W2106787323', 'https://openalex.org/W2107934474', 'https://openalex.org/W2113322173', 'https://openalex.org/W2123105952', 'https://openalex.org/W2124422993', 'https://openalex.org/W2127768463', 'https://openalex.org/W2130201137', 'https://openalex.org/W2139448267', 'https://openalex.org/W2140995313', 'https://openalex.org/W2198124326', 'https://openalex.org/W2222086386', 'https://openalex.org/W2281395530', 'https://openalex.org/W2340964024', 'https://openalex.org/W2402143190', 'https://openalex.org/W2495021631', 'https://openalex.org/W2917837889'], 'related_works': ['https://openalex.org/W4210761006', 'https://openalex.org/W3133628686', 'https://openalex.org/W2377837277', 'https://openalex.org/W2106908546', 'https://openalex.org/W2075668427', 'https://openalex.org/W2027281830', 'https://openalex.org/W2011407321', 'https://openalex.org/W1972124796', 'https://openalex.org/W1931475962', 'https://openalex.org/W1748917316'], 'abstract_inverted_index': {'//': [0], 'Cristian': [1], 'Lolli': [2], '1': [3, 15, 41, 67, 68], ',': [4, 8, 12, 16, 20, 24, 29, 34, 38, 42, 46, 51, 55, 59, 63], 'Umberto': [5, 143], 'Basso': [6], '2': [7, 45, 88], 'Lisa': [9], 'Derosa': [10], '3': [11, 62, 106], 'Emanuela': [13], 'Scarpi': [14], 'Teodoro': [17], 'Sava': [18], '4': [19, 50, 116], 'Matteo': [21], 'Santoni': [22], '5': [23, 58, 128], 'Simon': [25], 'J.': [26], 'Crabb': [27], '6': [28, 54, 151, 257, 445], 'Francesco': [30], 'Massari': [31], '4,': [32], '8': [33, 184], 'Michele': [35], 'Aieta': [36], '7': [37, 167], 'Vincenza': [39], 'Conteduca': [40], 'Marco': [43], 'Maruzzo': [44], 'Francesca': [47], 'La': [48], 'Russa': [49], 'Matthew': [52], 'Wheater': [53], 'Rossana': [56], 'Berardi': [57], 'Luca': [60], 'Galli': [61], 'Ugo': [64, 196], 'De': [65, 197], 'Giorgi': [66], 'Department': [69, 93, 117, 129, 152, 168], 'of': [70, 94, 112, 118, 130, 135, 153, 169, 188, 238, 405, 413, 440, 446, 471], 'Medical': [71, 89, 119, 131, 154, 170], 'Oncology,': [72, 98, 120, 132, 155, 171, 189], 'Istituto': [73, 99], 'Scientifico': [74], 'Romagnolo': [75], 'per': [76], 'lo': [77], 'Studio': [78], 'e': [79], 'la': [80], 'Cura': [81], 'dei': [82], 'Tumori': [83], '(IRST)': [84], 'IRCCS,': [85, 103], 'Meldola,': [86], 'Italy': [87, 105, 115, 127, 150, 183, 193], 'Oncology': [90, 107], 'Unit': [91, 108], '1,': [92], 'Clinical': [95], 'and': [96, 146, 235, 248, 253, 278, 308, 338, 360, 373, 379, 421, 433, 450, 461], 'Experimental': [97], 'Oncologico': [100, 177], 'Veneto': [101], 'IOV': [102], 'Padova,': [104], '2,': [109], 'University': [110, 134, 156], 'Hospital': [111, 157], 'Pisa,': [113, 114], 'Azienda': [121, 139], 'Ospedaliera': [122], 'Universitaria': [123], 'Integrata': [124], 'Verona,': [125, 126], 'Polytechnic': [133], 'the': [136, 233, 239, 406, 410], 'Marche': [137], 'Region,': [138], 'Ospedaliero-Universitaria,': [140], 'Ospedali': [141], 'Riuniti': [142], 'I-GM': [144], 'Lancisi': [145], 'G': [147], 'Salesi,': [148], 'Ancona,': [149], 'Southampton': [158, 162], 'NHS': [159], 'Foundation': [160], 'Trust,': [161], 'General': [163], 'Hospital,': [164, 191], 'Southampton,': [165], 'UK': [166], 'IRCCS': [172], 'CROB': [173], 'Centro': [174], 'di': [175], 'Riferimento': [176], 'della': [178], 'Basilicata,': [179], 'Rionero': [180], 'in': [181, 261, 302, 314, 332, 344, 474], 'Vulture,': [182], 'Present': [185], 'address:': [186], 'Division': [187], 'S.Orsola-Malpighi': [190], 'Bologna,': [192], 'Correspondence': [194], 'to:': [195], 'Giorgi,': [198], 'email:': [199], '[email protected]': [200], 'Keywords:': [201], 'systemic': [202, 240], 'immune': [203], 'inflammation': [204], 'index,': [205], 'renal': [206, 265], 'cell': [207, 266], 'carcinoma,': [208], 'RCC,': [209], 'prognostic': [210, 234, 469], 'factor,': [211], 'sunitinib': [212, 260], 'Received:': [213], 'April': [214], '20,': [215], '2016 ': [216, 220], 'Accepted:': [217], 'May': [218], '23,': [219], 'Published:': [221], 'July': [222], '09,': [223], '2016': [224], 'ABSTRACT': [225], 'Background:': [226], 'In': [227, 353], 'this': [228], 'retrospective': [229], 'analysis,': [230, 355], 'we': [231], 'explored': [232], 'predictive': [236], 'value': [237, 412], 'immune-inflammation': [241], 'index': [242], '(SII),': [243], 'based': [244], 'on': [245, 448], 'lymphocyte,': [246], 'neutrophil,': [247], 'platelet': [249], 'counts,': [250], 'at': [251, 255, 443], 'baseline': [252], 'changes': [254, 463], 'week': [256, 444], 'during': [258, 464], 'first-line': [259, 389], 'patients': [262, 303, 333, 386, 475], 'with': [263, 287, 304, 316, 334, 346, 388, 435, 476], 'metastatic': [264, 477], 'cancer': [267], '(RCC).': [268], 'Results:': [269], 'Patients': [270], 'were': [271, 362, 428], 'stratified': [272], 'into': [273], 'high': [274], 'SII': [275, 280, 284, 305, 317, 335, 347, 361, 441, 460], '(≥': [276], '730)': [277, 282], 'low': [279], '(<': [281], 'groups.': [283], 'was': [285, 296, 326, 400, 452], 'associated': [286], 'objective': [288], 'response,': [289], 'p': [290, 320, 350], '<': [291, 318, 321, 336, 351], '0.0001.': [292, 322, 352], 'The': [293, 323, 391, 438, 459], 'median': [294, 324], 'PFS': [295, 449], '6.3': [297], 'months': [298, 310, 328, 340], '(95%': [299, 311, 329, 341, 426], 'CI': [300, 312, 330, 342], '5.5–8.9)': [301], '≥': [306, 348], '730': [307], '18.7': [309], '14.7–22.8)': [313], 'those': [315, 345], '730,': [319, 337, 349], 'OS': [325, 366, 451], '43.6': [327], '35.3–52.1)': [331], '13.5': [339], '9.8–18.5)': [343], 'multivariate': [354], 'performance': [356], 'status,': [357], 'IMDC': [358], 'score': [359], 'able': [363], 'to': [364, 408], 'predict': [365], '(HR': [367], '=': [368, 371, 375], '3.29,': [369], 'HR': [370, 374], '1.71': [372], '1.79,': [376], 'respectively).': [377], 'Materials': [378], 'Methods:': [380], 'We': [381], 'included': [382], '335': [383], 'consecutive': [384], 'RCC': [385], 'treated': [387], 'sunitinib.': [390], 'X-tile': [392], '3.6.1': [393], 'software': [394], '(Yale': [395], 'University,': [396], 'New': [397], 'Haven,': [398], 'CT)': [399], 'used': [401], 'for': [402], 'bioinformatic': [403], 'analysis': [404], 'data': [407], 'determine': [409], 'cutoff': [411], 'SII.': [414], 'Progression-free': [415], 'survival': [416, 419], '(PFS),': [417], 'overall': [418], '(OS)': [420], 'their': [422], '95%': [423], 'confidence': [424], 'interval': [425], 'CI)': [427], 'estimated': [429], 'by': [430, 454], 'Kaplan-Meier': [431], 'method': [432], 'compared': [434], 'logrank': [436], 'test.': [437], 'impact': [439], 'conversion': [442], 'treatment': [447, 465], 'evaluated': [453], 'Cox': [455], 'regression': [456], 'analyses.': [457], 'Conclusions:': [458], 'its': [462], 'represent': [466], 'a': [467], 'powerful': [468], 'indicator': [470], 'clinical': [472], 'outcome': [473], 'RCC.': [478]}, 'cited_by_api_url': 'https://api.openalex.org/works?filter=cites:W2464839949', 'counts_by_year': [{'year': 2024, 'cited_by_count': 10}, {'year': 2023, 'cited_by_count': 16}, {'year': 2022, 'cited_by_count': 16}, {'year': 2021, 'cited_by_count': 21}, {'year': 2020, 'cited_by_count': 20}, {'year': 2019, 'cited_by_count': 22}, {'year': 2018, 'cited_by_count': 19}, {'year': 2017, 'cited_by_count': 9}, {'year': 2016, 'cited_by_count': 3}], 'updated_date': '2024-12-08T11:12:43.258547', 'created_date': '2016-07-22'}