Human Leukocyte Antigen (HLA) Peptides Derived from Tumor Antigens Induced by Inhibition of DNA Methylation for Development of Drug-facilitated Immunotherapy

Name: Work Video:
Duration: 3 min 30 s
Bracha Shraibman; Dganit Melamed Kadosh; Eilon Barnea; Arie Admon
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3808, 3902, 3933, 3936, 3967, 3986, 4000, 4096, 4112, 4132, 4158, 4181, 4194], "tumor's": [22, 255], 'gene': [23, 195, 256, 428, 1845, 2448], 'expression': [24, 74, 257, 307, 1518, 1771, 1937, 2053, 2063, 2207, 2281, 2330, 2361, 2449], 'patterns,': [25, 258], 'including': [26, 78, 259, 311, 864, 1127], 'those': [27, 260], 'Cancer/Testis': [29, 262, 1762], 'Antigens': [30, 263, 1347, 1763, 2900], '(CTA).': [31, 264], 'The': [32, 136, 209, 265, 369, 442, 1056, 1077, 1089, 1143, 1502, 1770, 1841, 1885, 1988, 2395, 2734, 2820, 2928, 3097, 3141, 3493, 3574, 3586, 3624, 3756, 3877, 3892, 3927, 3957, 3979, 4011, 4086, 4147, 4200, 4221], 'degradation': [33, 266], 'products': [34, 267, 4156], 'antigens': [37, 270, 933, 964, 1117, 1125, 1289, 1296, 1376, 1395, 1408, 1765, 1767, 2218, 2238, 2286, 2624, 3516], 'can': [38, 120, 271, 353, 935, 2064, 2809, 3527], 'be': [39, 52, 121, 272, 285, 354, 2065, 2810, 3528], 'presented': [40, 273, 1107, 2989, 3116, 3202], 'as': [41, 274, 582, 587, 596, 960, 967, 1399, 1419, 1942, 2074, 2622, 3461, 3913, 4139], 'HLA': [42, 97, 118, 138, 178, 212, 275, 330, 351, 371, 411, 445, 865, 872, 928, 955, 974, 1090, 1098, 1114, 1625, 2235, 2283, 2333, 2620, 2642, 2653, 2807, 3109, 3377, 3476, 3664, 3689, 3702, 3821, 3894, 3958, 3981, 4159, 4201, 4251], 'peptides': [43, 98, 119, 276, 331, 352, 929, 1104, 2621, 2670, 2808, 2988, 3033, 3117, 3201, 3246, 3963, 3988, 4001, 4097, 4134, 4204, 4254], 'on': [44, 173, 277, 406, 1303, 2290, 2639, 2979, 2987, 3192, 3200, 3345, 3418, 3470, 3509, 3932, 3991, 4027, 4116], 'surface': [46, 279, 1111], 'tumor': [49, 282, 874, 932, 963, 976, 1135, 1189, 1304, 1394, 1521, 1627, 1764, 1812, 1848, 1926, 2217, 2623, 2640, 2793, 3515], 'and': [51, 102, 177, 202, 211, 222, 284, 335, 410, 435, 444, 455, 490, 508, 521, 559, 640, 662, 943, 1002, 1032, 1106, 1190, 1322, 1361, 1424, 1483, 1544, 1573, 1739, 1789, 1894, 1940, 2181, 2203, 2239, 2287, 2364, 2453, 2550, 2625, 2655, 2663, 2680, 2710, 2796, 2982, 3086, 3195, 3299, 3338, 3416, 3474, 3526, 3533, 3544, 3567, 3571, 3610, 3631, 3660, 3678, 3681, 3694, 3699, 3704, 3716, 3746, 3767, 3774, 3807, 3864, 3985, 3999, 4037, 4046, 4067, 4107, 4111, 4149, 4184, 4186, 4197, 4202, 4210, 4252], 'developed': [53, 286], 'into': [54, 287, 2093], 'immunotherapeutics.': [56, 289], 'For': [57, 290], 'example,': [58, 291], 'DNA': [60, 293, 1782, 1992, 2084, 2102, 2182, 2322, 2396], 'methyl': [61, 294], 'transferase': [62, 295], 'inhibitor,': [63, 296], '5-aza-2′-deoxycytidine': [64, 297, 1768, 2075, 2249, 2295, 2399], '(Decitabine)': [65, 298], 'has': [66, 299, 530, 2983, 3196], 'limited': [67, 300, 2646], 'antitumor': [68, 301, 2013], 'efficacy,': [69, 302], 'yet': [70, 303, 1516], 'it': [71, 304], 'induces': [72, 305, 2544], 'many': [76, 95, 141, 309, 328, 374, 1774], 'genes,': [77, 310], 'CTAs': [79, 101, 142, 312, 334, 375, 1507, 1777, 1941, 2055, 2368, 3456], 'that': [80, 143, 313, 376, 1297, 3517], 'are': [81, 144, 215, 226, 314, 377, 448, 459, 585, 656, 1100, 1123, 1291, 1298, 1405, 1411, 1427, 1912, 2588, 3496, 3518], 'normally': [82, 146, 315, 379, 3520], 'silenced': [83, 316], 'healthy': [86, 149, 319, 382, 1916], 'adult': [87, 320, 1917], 'tissues.': [88, 321], 'In': [89, 160, 322, 393, 3721], 'this': [90, 323, 2788, 4084], 'study,': [91, 324], 'presentation': [93, 115, 326, 348, 1001, 2638, 2679, 2805, 3107], 'new': [96, 126, 329, 359, 1007, 1740, 2685, 3504, 3613], 'derived': [99, 332, 930, 1129], 'from': [100, 333, 931, 1130, 1188, 1430, 1962, 1993, 2802, 3036, 3249, 3547, 3596, 3604, 3770, 3827, 3966, 4123, 4135], 'induced': [103, 336, 3457], 'by': [104, 337, 519, 659, 1112, 1464, 1780, 1816, 2067, 2086, 2554, 2631, 2647, 2656, 2936, 2990, 3082, 3149, 3203, 3295, 3375, 3458, 3512, 3522, 3882, 4093, 4098, 4127, 4153, 4207], 'Decitabine': [105, 172, 338, 405, 2077, 2195, 2357, 2486, 2570, 3651], 'was': [106, 339, 1523, 2196, 3629, 3797, 3844, 4003, 4088, 4114], 'demonstrated': [107, 340], 'three': [109, 192, 342, 425, 500, 3727, 3828], 'human': [110, 182, 343, 415, 1277, 1318, 1461, 1756, 1844, 1960, 1994, 2057, 2338, 2353, 2405, 2488, 2882, 3404, 3480, 3538, 3937], 'Glioblastoma': [111, 183, 344, 416, 556, 1754, 3539, 3673, 3718, 3833], 'cell': [112, 345, 2341, 3347, 3540, 3674, 3719, 3834, 3878], 'lines.': [113, 346, 3720], 'Such': [114, 347], 'CTA-derived': [117, 350], 'exploited': [122, 355, 1524], 'for': [123, 356, 528, 591, 610, 637, 667, 877, 962, 979, 1004, 1060, 1120, 1216, 1377, 1402, 1592, 1618, 1630, 2162, 2327, 2559, 2627, 2682, 2738, 2824, 3104, 3447, 3452, 3499, 3506, 3530, 3652, 3662, 3669, 3687, 3695, 3738, 3751, 3831, 3874, 3884, 4044, 4073, 4078, 4180, 4193], 'development': [124, 357, 3442, 3502], 'treatment': [127, 131, 360, 364, 589, 1620, 2068, 2111, 2543], 'modalities,': [128, 361, 580], 'combining': [129, 362, 1603, 3083, 3296], 'anti-CTA': [133, 366], 'targeted': [134, 367], 'immunotherapy.': [135, 368], 'Decitabine-induced': [137, 370], 'peptidomes': [139, 179, 372, 412, 956, 1091, 3409, 3477], 'include': [140, 373], 'not': [145, 378, 531, 1513, 2418, 2572, 3519], 'detected': [147, 380, 1463], 'tissues': [150, 383], 'or': [151, 384, 1096, 3637, 3668], 'cells,': [154, 387, 1422, 1934, 3482], 'unless': [155, 388], 'treated': [156, 389, 1530, 2293, 3680, 3715], 'drug.': [159, 208, 392, 441], 'addition,': [161, 394, 3722], 'study': [163, 396], 'included': [164, 397], 'large-scale': [165, 398], 'analyses': [166, 399, 3706], 'simultaneous': [169, 402], 'effects': [170, 403, 1944, 3412], 'transcriptomes,': [175, 408, 3472], 'proteomes': [176, 409, 3100], 'cells.': [184, 417, 950, 1927, 2641], 'It': [185, 418, 3463], 'demonstrates': [186, 419], 'poor': [188, 421], 'correlations': [189, 422], 'between': [190, 423, 3334], 'these': [191, 424, 2088, 3726], 'levels': [193, 201, 426, 434, 3113, 3122], 'expression,': [196, 429], 'both': [197, 430], 'their': [199, 204, 432, 437, 1517, 1785, 1963, 2062, 2552, 2637, 3124, 3961], 'total': [200, 433, 4176], 'response': [205, 438, 2244, 3040, 3253], 'proteomics': [210, 443, 3666, 3692, 3705], 'peptidomics': [213, 446, 3690, 3703], 'data': [214, 225, 447, 458, 2801, 3495, 3809], 'available': [216, 227, 449, 460], 'via': [217, 228, 450, 461], 'ProteomeXchange': [218, 451], 'identifier': [220, 231, 453, 464], 'PXD003790': [221, 454], 'transcriptomics': [224, 457], 'GEO': [229, 462], 'GSE80137.': [232, 465], 'Grade': [466], 'IV': [467], 'astrocytoma,': [468], 'also': [469, 2198, 3736], 'called': [470, 1093], 'glioblastoma': [471], 'multiforme': [472, 1755], '(GBM)': [473], '1The': [474], 'abbreviations': [475], 'used': [476, 3529, 3686, 3737, 3750, 3775, 4179, 4192], 'are:GBMGlioblastoma': [477], 'multiformeHLAhuman': [478], 'leukocyte': [479, 1319, 1757, 3405, 3938], 'antigenMHCmajor': [480], 'histocompatibility': [481, 1760, 2765, 2992, 3205, 3341], 'complexCTACancer/Testis': [482], 'AntigensTAtumor': [483], 'antigensTSAtumor-specific': [484], 'antigensDecitabine5-aza-2′-deoxycytidineTMZTemozolamide.,': [485], 'is': [486, 572, 1512, 1778, 1814, 1850, 1921, 2060, 2078, 2324, 2571, 2629, 2645, 2934, 3101, 3147], 'most': [488, 1907], 'common': [489], 'aggressive': [491], 'primary': [492], 'brain': [493], 'tumor,': [494], 'a': [496, 512, 545, 573, 1006, 1214, 1538, 1614, 2079, 2325, 2684, 2984, 3197, 3444, 3777, 4230, 4258], 'prognosis': [497], 'about': [499, 549, 1534, 3839], 'months': [501, 551], 'if': [502], 'untreated.': [503], 'Despite': [504], 'advances': [505], 'treatment,': [507], 'even': [509, 1613], 'after': [510, 2090], 'applying': [511], 'combination': [513], 'maximal': [515], 'surgical': [516], 'resection,': [517], 'followed': [518, 3464, 4092, 4126], 'radiation': [520], 'Temozolamide': [522], '(TMZ)': [523], 'chemotherapy,': [524], 'survival': [526, 547], 'rate': [527], 'GBM': [529, 597, 3481], 'changed': [532], 'much': [533], 'over': [534], 'past': [536], '50': [537], 'years,': [538], 'remaining': [539], 'largely': [540], 'an': [541], 'incurable': [542, 593], 'disease': [543], 'median': [546], '15': [550], '(1.Alifieris': [552], 'C.': [553, 706, 806, 902, 1030, 1055, 1170, 1829, 1836, 2228, 2315, 2708, 2733, 2755, 2819, 2925, 2973, 3022, 3030, 3063, 3138, 3186, 3235, 3243, 3276, 3313, 3372], 'Trafalis': [554], 'D.T.': [555, 724], 'multiforme:': [557], 'Pathogenesis': [558], 'treatment.Pharmacol.': [560], 'Ther.': [561], '2015;': [562, 644, 918, 1195, 1222, 1238, 1280, 1332, 1353, 1594, 1652, 1746, 2021, 2042, 2610, 2774, 2843, 2885, 2906, 3423], '152:': [563], '63-82Crossref': [564], 'PubMed': [565, 625, 647, 859, 886, 921, 988, 1017, 1043, 1084, 1150, 1198, 1225, 1241, 1283, 1335, 1356, 1385, 1475, 1497, 1558, 1578, 1597, 1639, 1655, 1725, 1749, 1862, 1901, 1969, 2001, 2045, 2125, 2168, 2190, 2256, 2301, 2346, 2412, 2463, 2506, 2565, 2613, 2695, 2721, 2782, 2846, 2888, 2909, 2944, 3006, 3045, 3092, 3157, 3219, 3258, 3305, 3359, 3388, 3431, 3952, 4057, 4168], 'Scopus': [566, 626, 648, 860, 887, 922, 989, 1018, 1044, 1085, 1151, 1199, 1226, 1242, 1284, 1336, 1357, 1386, 1476, 1498, 1559, 1598, 1640, 1656, 1726, 1750, 1863, 1902, 1970, 2002, 2046, 2126, 2169, 2191, 2257, 2302, 2347, 2413, 2464, 2507, 2566, 2614, 2696, 2722, 2783, 2847, 2889, 2910, 2945, 3007, 3046, 3093, 3158, 3220, 3259, 3306, 3360, 3389, 3432, 3953, 4058, 4169], '(456)': [567], 'Google': [568, 628, 650, 862, 889, 924, 991, 1020, 1046, 1087, 1153, 1201, 1228, 1244, 1286, 1338, 1359, 1388, 1478, 1500, 1561, 1579, 1600, 1642, 1658, 1728, 1752, 1825, 1865, 1904, 1972, 2004, 2024, 2048, 2128, 2171, 2193, 2259, 2304, 2349, 2415, 2466, 2509, 2568, 2616, 2698, 2724, 2785, 2849, 2891, 2912, 2947, 3009, 3048, 3095, 3160, 3222, 3261, 3308, 3362, 3391, 3434, 3955, 4060, 4171], 'Scholar).': [569, 651, 925, 1088, 1287, 1389, 1501, 1601, 1753, 1905, 2049, 2194, 2350, 2569, 2617, 2786, 3096, 3435, 3956, 4172], 'Hence,': [570], 'there': [571], 'pressing': [574], 'need': [575], 'develop': [577], 'better': [578], 'therapeutic': [579, 1010, 1895, 2688], 'immunotherapies,': [583], 'which': [584, 1410, 2082, 2803], 'emerging': [586], 'promising': [588], 'options': [590], 'otherwise': [592], 'cancers,': [594], '(2.Mohme': [598], 'M.': [599, 605, 633, 696, 1160, 1178, 1249, 1452, 1683, 1795, 1801, 1884, 1987, 2107, 2109, 2274, 2276, 2382, 2444, 2854, 3051, 3264, 3317, 3394, 3400, 3920, 4034], 'Neidert': [600], 'M.C.': [601, 2141], 'Regli': [602], 'L.': [603, 671, 680, 702, 718, 784, 846, 908, 912, 1882, 2264, 2442, 3077, 3290, 3918], 'Weller': [604, 632], 'Martin': [606], 'R.': [607, 756, 766, 820, 836, 996, 1701, 1878, 1981, 2105, 2139, 2226, 2674, 2761], 'Immunological': [608], 'challenges': [609], 'peptide-based': [611, 1327], 'immunotherapy': [612, 654, 1122, 1404, 1717, 1738, 2159, 2628, 3534], 'glioblastoma.Cancer': [614], 'Treat.': [615], 'Rev.': [616, 881, 983, 1039, 1491, 1552, 1634, 1743, 2717], '2014;': [617, 856, 1014, 1067, 1494, 1555, 1722, 2692, 2745, 2831, 3089, 3302, 4165], '40:': [618], '248-258Abstract': [619], 'Full': [620, 622, 2187, 2777, 2779, 3001, 3003, 3214, 3216, 3354, 3356, 3426, 3428, 3947, 3949], 'Text': [621, 623, 2188, 2778, 2780, 3002, 3004, 3215, 3217, 3355, 3357, 3427, 3429, 3948, 3950], 'PDF': [624, 2189, 2781, 3005, 3218, 3358, 3430, 3951], '(41)': [627], 'Scholar,': [629, 890, 992, 1021, 1047, 1070, 1154, 1202, 1229, 1245, 1339, 1479, 1562, 1580, 1643, 1659, 1729, 1826, 1866, 1973, 2005, 2025, 2129, 2172, 2260, 2305, 2467, 2510, 2699, 2725, 2748, 2834, 2850, 2892, 2913, 2948, 3010, 3049, 3161, 3223, 3262, 3309, 3363, 3392], '3.Weiss': [630], 'T.': [631, 1671, 1840, 2376, 2757, 3018, 3069, 3231, 3282, 3319], 'Roth': [634], 'P.': [635, 690, 698, 750, 1028, 1053, 1074, 1140, 2520, 2706, 2731, 2817, 2927, 2971, 3028, 3057, 3140, 3184, 3241, 3270], 'Immunotherapy': [636], 'glioblastoma:': [638], 'concepts': [639], 'challenges.Curr.': [641], 'Opin.': [642, 1065, 2743, 2829], 'Neurol.': [643], '28:': [645], '639-646Crossref': [646], '(22)': [649], 'Different': [652], 'regimens': [655], 'now': [657], 'approved': [658], 'FDA': [661], 'European': [664], 'Medicines': [665], 'Agency': [666], 'various': [668], 'cancers': [669, 1462, 1961], '(4.Galluzzi': [670], 'Vacchelli': [672], 'E.': [673, 710, 740, 760, 770, 826, 906, 1247, 1450, 1667, 1868, 2007, 2438, 2440, 2750, 2852, 2917, 2963, 3130, 3176, 3916, 3922], 'Bravo-San': [674], 'Pedro': [675], 'J.M.': [676, 758, 2011], 'Buque': [677, 895], 'A.': [678, 704, 714, 734, 744, 746, 762, 786, 796, 896, 898, 1253, 1872, 2220, 2266, 2270, 2272, 2374, 2425, 2431, 2475, 2481, 2858, 2961, 3174, 3325, 3926, 4146], 'Senovilla': [679], 'Baracco': [681], 'E.E.': [682], 'Bloy': [683, 893], 'N.': [684, 804, 894, 1803, 2145], 'Castoldi': [685], 'F.': [686, 694, 708, 736, 774, 1838, 1876, 2230, 2232, 2433], 'Abastado': [687], 'J.P.': [688, 772, 1669, 1691, 2133, 3024, 3237], 'Agostinis': [689], 'Apte': [691], 'R.N.': [692], 'Aranda': [693], 'Ayyoub': [695], 'Beckhove': [697], 'Blay': [699], 'J.Y.': [700], 'Bracci': [701], 'Caignard': [703], 'Castelli': [705], 'Cavallo': [707], 'Celis': [709], 'Cerundolo': [711], 'V.': [712, 2027, 2595], 'Clayton': [713], 'Colombo': [715], 'M.P.': [716, 2919, 2959, 3132, 3172], 'Coussens': [717], 'Dhodapkar': [719], 'M.V.': [720], 'Eggermont': [721, 897], 'A.M.': [722], 'Fearon': [723], 'Fridman': [725], 'W.H.': [726, 2143, 3370], 'Fucikova': [727], 'J.': [728, 732, 892, 904, 1080, 1146, 1675, 1793, 1805, 2251, 2317, 2394, 2407, 2458, 3059, 3067, 3272, 3280, 3323, 4032], 'Gabrilovich': [729], 'D.I.': [730], 'Galon': [731, 903], 'Garg': [733], 'Ghiringhelli': [735], 'Giaccone': [737], 'G.': [738, 850, 910, 1874, 2147, 2309, 2429, 2921, 3134], 'Gilboa': [739], 'Gnjatic': [741], 'S.': [742, 1255, 1265, 1313, 1341, 1446, 1870, 2222, 2262, 2380, 2423, 2436, 2479, 2860, 2870, 2894, 2923, 2967, 2969, 3026, 3053, 3061, 3136, 3180, 3182, 3239, 3266, 3274, 3331, 3396], 'Hoos': [743], 'Hosmalin': [745], 'Jager': [747], 'D.': [748, 776, 1024, 1797, 2702, 2951, 3164, 3321, 3368, 4142], 'Kalinski': [749], 'Karre': [751], 'K.': [752, 1162, 1164, 2378, 2384, 2965, 3178, 3327], 'Kepp': [753], 'O.': [754, 1442, 1832, 3315], 'Kiessling': [755], 'Kirkwood': [757], 'Klein': [759], 'Knuth': [761], 'Lewis': [763], 'C.E.': [764, 4144], 'Liblau': [765], 'Lotze': [767], 'M.T.': [768], 'Lugli': [769], 'Mach': [771], 'Mattei': [773], 'Mavilio': [775], 'Melero': [777], 'I.': [778, 900, 1834, 2224, 2268, 3073, 3286, 3365, 3924], 'Melief': [779, 1704], 'C.J.': [780, 1156, 1705], 'Mittendorf': [781], 'E.A.': [782], 'Moretta': [783], 'Odunsi': [785], 'Okada': [787], 'H.': [788, 808, 812, 838, 871, 973, 1624, 1665, 2137, 2390, 2759], 'Palucka': [789], 'A.K.': [790], 'Peter': [791], 'M.E.': [792], 'Pienta': [793], 'K.J.': [794], 'Porgador': [795], 'Prendergast': [797], 'G.C.': [798], 'Rabinovich': [799], 'G.A.': [800, 2516, 2528], 'Restifo': [801, 1372], 'N.P.': [802, 1373], 'Rizvi': [803], 'Sautes-Fridman': [805, 901], 'Schreiber': [807, 1209, 1232, 1646, 1712, 2837], 'Seliger': [809], 'B.': [810, 814, 1072, 1138, 1448, 1799, 1954], 'Shiku': [811], 'Silva-Santos': [813], 'Smyth': [815], 'M.J.': [816, 1438], 'Speiser': [817], 'D.E.': [818], 'Spisek': [819], 'Srivastava': [821], 'P.K.': [822], 'Talmadge': [823], 'J.E.': [824], 'Tartour': [825, 905], 'Van': [827, 831], 'Der': [828], 'Burg': [829], 'S.H.': [830], 'Den': [832], 'Eynde': [833], 'B.J.': [834], 'Vile': [835], 'Wagner': [837], 'Weber': [839], 'J.S.': [840, 1174], 'Whiteside': [841], 'T.L.': [842, 2953, 3020, 3166, 3233], 'Wolchok': [843], 'J.D.': [844, 994, 2672], 'Zitvogel': [845, 907], 'Zou': [847], 'W.': [848, 2471, 3014, 3227], 'Kroemer': [849, 909], 'Classification': [851], 'current': [853], 'immunotherapies.Oncotarget.': [855], '5:': [857, 1899, 4055], '12472-12508Crossref': [858], '(328)': [861], 'Scholar),': [863, 4061], 'peptide': [866, 2932, 3145, 4012], 'vaccines': [867, 969, 1605], '(5.Rammensee': [868, 970, 1621], 'H.G.': [869, 971, 1622, 1703, 3329], 'Singh-Jasuja': [870, 972, 1623], 'ligandome': [873, 975, 1626], 'antigen': [875, 977, 1000, 1320, 1457, 1487, 1548, 1628, 1758, 1813, 2678, 3380, 3406, 3419, 3939], 'discovery': [876, 978, 1629, 3486], 'personalized': [878, 980, 1217, 1631], 'vaccine': [879, 981, 1632], 'approach.Expert': [880, 982, 1633], 'Vaccines.': [882, 984, 1013, 1635, 2691], '2013;': [883, 985, 1081, 1147, 1382, 1636, 3944], '12:': [884, 986, 1637, 3945], '1211-1217Crossref': [885, 987, 1638], '(72)': [888, 990, 1641], '6.Pol': [891], 'Cremer': [899], 'Galluzzi': [911], 'Trial': [913], 'Watch:': [914], 'Peptide-based': [915], 'vaccines.Oncoimmunology.': [917], '4:': [919], 'e974411Crossref': [920], '(93)': [923], 'Presentation': [926], '(TA)': [934], 'lead': [936], 'activation': [938, 1488, 1549, 1842], 'T': [941, 1061, 1186, 1349, 2493, 2556, 2739, 2825, 2902], 'cytotoxic': [945], 'killing': [946], 'diseased': [949], 'Therefore,': [951], "cells'": [954, 1110, 2794, 3099], 'were': [957, 3552, 3576, 3593, 3608, 3657, 3685, 3709, 3735, 3749, 3758, 3785, 3810, 3825, 3880, 3898, 3964, 3989, 4014, 4081, 4178, 4191, 4205, 4226, 4255], 'studied': [958], 'extensively': [959], 'sources': [961], 'potentially': [965, 1118, 3497], 'useful': [966, 1119, 1293, 2800, 3103, 3498], '7.Comber': [993], 'Philip': [995, 2673], 'MHC': [997, 1035, 2210, 2675, 2713, 2929, 3031, 3142, 3244], 'class': [998, 2211, 2236, 2284, 2334, 2676, 2930, 3143, 3378, 3407, 3591, 3822, 3895, 3982], 'I': [999, 2212, 2237, 2285, 2335, 2677, 2931, 2994, 3144, 3207, 3379, 3408, 3823, 3896, 3983], 'implications': [1003, 2681], 'developing': [1005, 2683], 'generation': [1008, 2686, 3934], 'vaccines.Therap.': [1011, 2689], 'Adv.': [1012, 2690], '2:': [1015, 2693], '77-89Crossref': [1016, 2694], '(81)': [1019, 2697], '8.de': [1022, 2700], 'Verteuil': [1023, 2701, 2950, 3163], 'Granados': [1025, 2703, 2954, 3167], 'D.P.': [1026, 1049, 2704, 2727, 2813, 2955, 3012, 3168, 3225], 'Thibault': [1027, 1052, 2705, 2730, 2816, 2926, 2970, 3027, 3139, 3183, 3240], 'Perreault': [1029, 1054, 2707, 2732, 2818, 2924, 2972, 3029, 3137, 3185, 3242], 'Origin': [1031, 2709], 'plasticity': [1033, 2711], 'I-associated': [1036, 2714, 3032, 3245], 'self': [1037, 1059, 2715, 2737, 2823], 'peptides.Autoimmunity': [1038, 2716], '2012;': [1040, 2460, 2718, 3042, 3255, 3385], '11:': [1041, 1999, 2719], '627-635Crossref': [1042, 2720], '(40)': [1045, 2723], '9.Granados': [1048, 2726], 'Laumont': [1050, 2728, 2814, 3015, 3228], 'C.M.': [1051, 2729, 2815, 3016, 3229], 'nature': [1057, 2735, 2821, 4148], 'cells-a': [1062, 2740, 2826], 'systems-level': [1063, 2741, 2827], 'perspective.Curr.': [1064, 2742, 2828], 'Immunol.': [1066, 1330, 1352, 2020, 2744, 2830, 2905], '34C:': [1068, 2746, 2832], '1-8Google': [1069, 2747, 2833], '10.Heemskerk': [1071], 'Kvistborg': [1073, 1139], 'Schumacher': [1075, 1141, 1698], 'T.N.': [1076, 1142, 1231, 1645, 1699, 2836], 'antigenome.EMBO': [1079, 1145], '32:': [1082, 1148, 2123], '194-203Crossref': [1083, 1149], '(185)': [1086, 1152], '(also': [1092], 'immunopeptidome': [1095], 'ligandome)': [1099], 'assortments': [1102], 'bound': [1105, 3905, 3962], 'at': [1108, 2590, 3583, 3776, 3871, 3887], 'molecules.': [1115], 'Tumor': [1116, 1211, 1346, 2899], 'tumor-specific': [1124, 1766], '(TSA),': [1126], 'neo-antigens': [1128], 'mutations': [1131, 1275, 2880, 3081, 3294], 'unique': [1132], '(10.Heemskerk': [1137], '11.Cohen': [1155], 'Gartner': [1157, 1258, 2863], 'J.J.': [1158, 1259, 2864], 'Horovitz-Fried': [1159], 'Shamalov': [1161], 'Trebska-McGowan': [1163], 'Bliskovsky': [1165], 'V.V.': [1166, 2469], 'Parkhurst': [1167, 2517], 'M.R.': [1168, 2524], 'Ankri': [1169], 'Prickett': [1171], 'T.D.': [1172], 'Crystal': [1173], 'Li': [1175, 1262, 2144, 2146, 2867], 'Y.F.': [1176, 1263, 2868], 'El-Gamil': [1177], 'Rosenberg': [1179, 1270, 1806, 2535, 2875], 'S.A.': [1180, 1271, 1807, 2536, 2876], 'Robbins': [1181, 1256, 2861], 'P.F.': [1182, 1257, 2862], 'Isolation': [1183], 'neoantigen-specific': [1185], 'peripheral': [1191], 'lymphocytes.J.': [1192], 'Clin.': [1193, 1220], 'Invest.': [1194, 1221], '125:': [1196, 1223], '3981-3991Crossref': [1197], '(265)': [1200], '12.Gubin': [1203], 'M.M.': [1204, 1661], 'Artyomov': [1205, 1710], 'M.N.': [1206, 1711], 'Mardis': [1207, 1706], 'E.R.': [1208, 1707], 'R.D.': [1210, 1233, 1647, 1713, 2838], 'neoantigens:': [1212], 'building': [1213], 'framework': [1215], 'immunotherapy.J.': [1219], '3413-3421Crossref': [1224], '(402)': [1227], '13.Schumacher': [1230, 1644, 2835], 'Neoantigens': [1234, 1648, 2839], 'immunotherapy.Science.': [1237, 1651, 2842], '348:': [1239, 1653, 2844], '69-74Crossref': [1240, 1654, 2845], '(2981)': [1243, 1657, 2848], '14.Tran': [1246, 2851], 'Ahmadzadeh': [1248, 2853], 'Lu': [1250, 2855], 'Y.C.': [1251, 2856], 'Gros': [1252, 2857], 'Turcotte': [1254, 2859], 'Zheng': [1260, 2865], 'Z.': [1261, 2866, 3071, 3284], 'Ray': [1264, 2869], 'Wunderlich': [1266, 2871], 'J.R.': [1267, 2872, 3075, 3288], 'Somerville': [1268, 2873], 'R.P.': [1269, 2874], 'Immunogenicity': [1272, 2877], 'somatic': [1274, 1433, 2879], 'gastrointestinal': [1278, 2883], 'cancers.Science.': [1279, 2884], '350:': [1281, 2886], '1387-1390Crossref': [1282, 2887], '(500)': [1285, 2890], 'Tumor-associated': [1288], '(TAA)': [1290], 'another': [1292], 'group': [1294, 1392], 'expressed': [1299, 1413, 1459, 3521], 'larger': [1301], 'amounts': [1302], 'relative': [1306], 'normal': [1308, 1432, 1788, 1964, 2454], '(15.Peper': [1310], 'J.K.': [1311], 'Stevanovic': [1312, 3330], 'A': [1314, 1390, 1455], 'combined': [1315, 3531], 'approach': [1316], 'ligandomics': [1321], 'immunogenicity': [1323], 'analysis': [1324, 2644, 2666, 2790, 3796, 4080], 'improve': [1326], 'immunotherapy.Cancer': [1329], 'Immunother.': [1331, 2297, 2561], '64:': [1333], '1295-1303Crossref': [1334], '(10)': [1337], '16.Ilyas': [1340, 2893], 'Yang': [1342, 2308, 2320, 2895], 'J.C.': [1343, 2896], 'Landscape': [1344, 2897], 'Cell': [1350, 2903], 'Immunotherapy.J.': [1351, 2904], '195:': [1354, 2907], '5117-5122Crossref': [1355, 2908], '(102)': [1358, 2911], 'Scholar)': [1360, 2416], 'therefore': [1362], 'pose': [1363], 'some': [1364, 1959], 'risk': [1365], 'eliciting': [1367], 'autoimmune': [1368], 'reactions': [1369], '(17.Hinrichs': [1370], 'C.S.': [1371, 2321], 'Reassessing': [1374], 'target': [1375], 'adoptive': [1378, 2157], 'T-cell': [1379], 'therapy.Nat.': [1380], 'Biotechnol.': [1381], '31:': [1383], '999-1008Crossref': [1384], '(156)': [1387], 'special': [1391], 'attracting': [1396], 'significant': [1397], 'attention': [1398], 'potential': [1400, 3450], 'targets': [1401, 1718, 2117], 'cancer/testis': [1407, 1486, 1547, 1588], '(CTA),': [1409], 'preferentially': [1412, 2546, 3034, 3247], 'immune': [1415, 1527, 1609, 2014], 'privileged': [1416], 'sites,': [1417], 'male': [1420], 'germ': [1421], 'placenta,': [1423], 'ovary,': [1425], 'but': [1426, 2417], 'absent': [1429], '(18.Chen': [1435], 'Y.T.': [1436], 'Scanlan': [1437], 'Sahin': [1439], 'U.': [1440], 'Tureci': [1441], 'Gure': [1443], 'A.O.': [1444, 3311], 'Tsang': [1445], 'Williamson': [1447], 'Stockert': [1449], 'Pfreundschuh': [1451], 'Old': [1453], 'L.J.': [1454, 3398], 'testicular': [1456], 'aberrantly': [1458], 'autologous': [1465], 'antibody': [1466, 3764], 'screening.Proc.': [1467], 'Natl.': [1468, 1855, 4161], 'Acad.': [1469, 1856, 4162], 'Sci.': [1470, 1857, 4163], 'U.S.A.': [1471, 1858, 4164], '1997;': [1472], '94:': [1473, 2254], '1914-1918Crossref': [1474], '(1093)': [1477], '19.Whitehurst': [1480], 'A.W.': [1481, 1542], 'Cause': [1482, 1543], 'consequence': [1484, 1545], 'cancer.Annu.': [1490, 1551], 'Pharmacol.': [1492, 1553], 'Toxicol.': [1493, 1554], '54:': [1495, 1556, 1823], '251-272Crossref': [1496, 1557], '(170)': [1499, 1560], 'biological': [1503, 3707, 3829], 'role': [1504], 'germline': [1510], 'always': [1514], 'known,': [1515], 'elicit': [1526], 'responses': [1528, 2015], 'patients,': [1532], 'bringing': [1533], 'regressions': [1536], 'few': [1539], 'cases': [1540], '(19.Whitehurst': [1541], '20.Cheng': [1563], 'Y.H.': [1564], 'Wong': [1565], 'E.W.': [1566], 'Cheng': [1567], 'C.Y.': [1568], 'Cancer/testis': [1569], '(CT)': [1570], 'antigens,': [1571], 'carcinogenesis': [1572], 'spermatogenesis.Spermatogenesis.': [1574], '2011;': [1575, 1898, 2503], '1:': [1576], '209-220Crossref': [1577], '21.Gjerstorff': [1581], 'M.F.': [1582], 'Andersen': [1583], 'M.H.': [1584, 2915, 2957, 3128, 3170], 'Ditzel': [1585], 'H.J.': [1586, 1880, 2427], 'Oncogenic': [1587], 'antigens:': [1589, 1890], 'prime': [1590], 'candidates': [1591, 2626, 3451], 'immunotherapy.Oncotarget.': [1593], '6:': [1595, 2022, 3352], '15772-15787Crossref': [1596], '(220)': [1599], 'Furthermore,': [1602], 'TA': [1604], 'inhibitors': [1607, 2070], 'modulators': [1610], 'become': [1612], 'more': [1615], 'powerful': [1616], 'modality': [1617], '22.Gubin': [1660], 'Zhang': [1662], 'X.': [1663, 2313, 2526], 'Schuster': [1664, 2758], 'Caron': [1666, 2916, 2962, 3129, 3175], 'Ward': [1668], 'Noguchi': [1670], 'Ivanova': [1672], 'Y.': [1673, 2307, 2311, 2386, 2388, 2392, 4030], 'Hundal': [1674], 'Arthur': [1676], 'C.D.': [1677], 'Krebber': [1678], 'W.J.': [1679], 'Mulder': [1680], 'G.E.': [1681], 'Toebes': [1682], 'Vesely': [1684], 'M.D.': [1685], 'Lam': [1686], 'S.S.': [1687], 'Korman': [1688], 'A.J.': [1689], 'Allison': [1690], 'Freeman': [1692, 1734], 'G.J.': [1693, 1735], 'Sharpe': [1694], 'A.H.': [1695], 'Pearce': [1696], 'E.L.': [1697], 'Aebersold': [1700, 2760], 'Rammensee': [1702, 3328], 'Gillanders': [1708], 'W.E.': [1709], 'Checkpoint': [1714], 'blockade': [1715], 'tumour-specific': [1719], 'mutant': [1720], 'antigens.Nature.': [1721], '515:': [1723, 3090, 3303], '577-581Crossref': [1724], '(1433)': [1727], '23.Mahoney': [1730], 'K.M.': [1731], 'Rennert': [1732], 'P.D.': [1733], 'Combination': [1736], 'immunomodulatory': [1741], 'targets.Nat.': [1742], 'Drug': [1744], 'Discov.': [1745], '14:': [1747, 2775, 3424], '561-584Crossref': [1748], '(892)': [1751], 'major': [1759, 2764, 2991, 3204, 3340], 'complex': [1761, 2766, 2993, 3206, 3342], 'Temozolamide.': [1769], 'level': [1772], 'regulated': [1779], 'constant': [1781], 'methylation': [1783, 2098, 2202], 'promoters': [1786, 1911], 'transformed': [1790], '(24.Weber': [1792], 'Salgaller': [1794], 'Samid': [1796], 'Johnson': [1798], 'Herlyn': [1800], 'Lassam': [1802], 'Treisman': [1804], 'Expression': [1808], 'MAGE-1': [1811, 1846], 'up-regulated': [1815, 2066, 2359], 'demethylating': [1818, 2119, 2397], 'agent': [1819, 2398], '5-aza-2′-deoxycytidine.Cancer': [1820], 'Res.': [1821, 1997, 2041, 2609, 4053], '1994;': [1822], '1766-1771PubMed': [1824], '25.De': [1827], 'Smet': [1828], 'De': [1830], 'Backer': [1831], 'Faraoni': [1833], 'Lurquin': [1835], 'Brasseur': [1837], 'Boon': [1839], 'correlated': [1851], 'genome-wide': [1853], 'demethylation.Proc.': [1854], '1996;': [1859], '93:': [1860], '7149-7153Crossref': [1861], '(465)': [1864], '26.Fratta': [1867], 'Coral': [1869], 'Covre': [1871, 2424], 'Parisi': [1873, 2428], 'Colizzi': [1875, 2432], 'Danielli': [1877], 'Nicolay': [1879, 2426], 'Sigalotti': [1881, 2263, 2441], 'Maio': [1883, 2275, 2443], 'biology': [1886], 'testis': [1889], 'putative': [1891], 'function,': [1892], 'regulation': [1893, 1920], 'potential.Mol.': [1896], 'Oncol.': [1897, 2121, 2164], '164-182Crossref': [1900], '(240)': [1903], 'Although': [1906], 'CTA': [1910], 'methylated': [1913], 'tissues,': [1918], 'lost': [1923], 'These': [1928], 'epigenetic': [1929, 2017, 2032, 2585, 2600], 'abnormalities,': [1930], 'prevalent': [1931], 'differential': [1936], 'oncogenes': [1939], 'side': [1943], 'loss': [1947, 2328], 'cellular': [1949], 'control': [1950], '(27.Feinberg': [1951], 'A.P.': [1952], 'Vogelstein': [1953], 'Hypomethylation': [1955], 'distinguishes': [1956], 'genes': [1957, 2213, 2336], 'counterparts.Nature.': [1965], '1983;': [1966, 1998], '301:': [1967], '89-92Crossref': [1968], '(1894)': [1971], '28.Gama-Sosa': [1974], 'M.A.': [1975, 2477], 'Slagel': [1976], 'V.A.': [1977], 'Trewyn': [1978], 'R.W.': [1979], 'Oxenhandler': [1980], 'Kuo': [1982], 'K.C.': [1983], 'Gehrke': [1984], 'C.W.': [1985], 'Ehrlich': [1986], '5-methylcytosine': [1989], 'content': [1990], 'tumors.Nucleic': [1995], 'Acids': [1996], '6883-6894Crossref': [2000], '(701)': [2003], '29.Heninger': [2006], 'Krueger': [2008], 'T.E.': [2009], 'Lang': [2010], 'Augmenting': [2012], 'modifying': [2018], 'agents.Front.': [2019], '1-9PubMed': [2023], '30.Valdespino': [2026], 'Valdespino': [2028, 2596], 'P.M.': [2029, 2597], '(Potential': [2030, 2598], 'therapies': [2033, 2601], 'management': [2036, 2604], 'solid': [2038, 2606], 'tumors.Cancer': [2039, 2607], 'Manag.': [2040, 2608], '7:': [2043, 2611], '241-251Crossref': [2044, 2612], '(44)': [2047, 2615], 'Moreover,': [2050], 'although': [2051], 'heterogeneous,': [2061], 'methylation,': [2072], '(Decitabine).': [2076], 'cytosine': [2080], 'analog,': [2081], 'inhibits': [2083], 'methyltransferases': [2085], 'trapping': [2087], 'enzymes': [2089], 'its': [2091], 'incorporation': [2092], 'DNA,': [2095], 'thus': [2096], 'reducing': [2097], 'newly': [2100], 'synthesized': [2101], 'strands': [2103], '(31.Claus': [2104], 'Almstedt': [2106], 'Lubbert': [2108], 'Epigenetic': [2110, 2445], 'hematopoietic': [2113], 'malignancies:': [2114], 'vivo': [2116], 'agents.Semin.': [2120], '2005;': [2122], '511-520Crossref': [2124], '(64)': [2127], '32.Everson': [2130], 'R.G.': [2131], 'Antonios': [2132], 'Lisiero': [2134], 'D.N.': [2135], 'Soto': [2136], 'Scharnweber': [2138], 'Garrett': [2140], 'Yong': [2142], 'Kruse': [2148], 'C.A.': [2149], 'Liau': [2150, 2482], 'L.M.': [2151, 2483], 'Prins': [2152, 2484], 'R.M.': [2153, 2485], 'Efficacy': [2154], 'systemic': [2156], 'transfer': [2158], 'targeting': [2160, 2495], 'NY-ESO-1': [2161, 2363, 2401, 2491], 'glioblastoma.Neuro.': [2163], '2016;': [2165], '18:': [2166], '368-378Crossref': [2167], '(29)': [2170], '33.Jones': [2173], 'P.A.': [2174], 'Taylor': [2175], 'S.M.': [2176], 'Cellular': [2177], 'differentiation,': [2178], 'cytidine': [2179], 'analogs': [2180], 'methylation.Cell.': [2183], '1980;': [2184], '20:': [2185], '85-93Abstract': [2186], '(1421)': [2192], 'shown': [2197], 'reduce': [2200], 'elevate': [2205], 'along': [2214], 'different': [2216], '(34.Serrano': [2219], 'Tanzarella': [2221], 'Lionello': [2223], 'Mendez': [2225], 'Traversari': [2227], 'Ruiz-Cabello': [2229], 'Garrido': [2231], 'Rexpression': [2233], 'restoration': [2240], 'antigen-specific': [2242], 'CTL': [2243], 'melanoma': [2246, 2291], 'following': [2248, 3625], 'treatment.Int.': [2250], 'Cancer.': [2252, 2408, 2459], '2001;': [2253, 2343, 2562], '243-251Crossref': [2255], '(209)': [2258], '35.Coral': [2261], 'Gasparollo': [2265], 'Cattarossi': [2267], 'Visintin': [2269], 'Cattelan': [2271], 'Altomonte': [2273], 'Prolonged': [2277], 'upregulation': [2278], 'costimulatory': [2288], 'molecules': [2289, 2654, 3824, 3897, 3959], '(5-AZA-CdR).J.': [2296], '1999;': [2298], '22:': [2299, 2344], '16-24Crossref': [2300], '(121)': [2303], '36.Nie': [2306], 'Song': [2310], 'Zhao': [2312], 'So': [2314], 'Liao': [2316], 'Wang': [2318], 'L.D.': [2319], 'hypermethylation': [2323], 'mechanism': [2326], 'esophageal': [2339], 'squamous': [2340], 'carcinomas.Carcinogenesis.': [2342], '1615-1623Crossref': [2345], '(164)': [2348], 'glioma': [2354], 'uniformly': [2358], 'other': [2365, 4113], 'well': [2366], 'characterized': [2367], '(37.Natsume': [2373], 'Wakabayashi': [2375], 'Tsujimura': [2377], 'Shimato': [2379], 'Ito': [2381], 'Kuzushima': [2383], 'Kondo': [2385], 'Sekido': [2387], 'Kawatsura': [2389], 'Narita': [2391], 'Yoshida': [2393], 'activates': [2400], 'antigenicity': [2402], 'orthotopic': [2404], 'glioma.Int.': [2406], '2008;': [2409, 2941, 3154], '122:': [2410], '2542-2553Crossref': [2411], '(89)': [2414], 'nonmalignant': [2420], '(38.Coral': [2422], 'Rizzo': [2430], 'Dalla': [2434], 'Santa': [2435], 'Fonsatti': [2437], 'Fratta': [2439], 'remodelling': [2446], 'profiles': [2450], 'neoplastic': [2452], 'tissues:': [2455], 'immunotherapeutic': [2456], 'implications.Br.': [2457], '107:': [2461], '1116-1124Crossref': [2462], '(17)': [2465], '39.Konkankit': [2468], 'Kim': [2470], 'Koya': [2472], 'R.C.': [2473], 'Eskin': [2474], 'Dam': [2476], 'Nelson': [2478], 'Ribas': [2480], 'immunosensitizes': [2487], 'gliomas': [2489], 'specific': [2492, 2558], 'lymphocyte': [2494], 'through': [2496], 'Fas/Fas': [2498], 'ligand': [2499, 3343], 'pathway.J.': [2500], 'Transl.': [2501], 'Med.': [2502, 2940, 3153], '9:': [2504, 2999, 3212], '192Crossref': [2505], '(34)': [2508], '40.Weiser': [2511], 'T.S.': [2512], 'Guo': [2513], 'Z.S.': [2514], 'Ohnmacht': [2515], 'M.L.': [2518], 'Tong-On': [2519], 'Marincola': [2521], 'F.M.': [2522], 'Fischette': [2523], 'Yu': [2525], 'Chen': [2527], 'Hong': [2529], 'J.A.': [2530], 'Stewart': [2531], 'J.H.': [2532], 'Nguyen': [2533], 'D.M.': [2534], 'Schrump': [2537], 'D.S.': [2538], 'Sequential': [2539], '5-Aza-2': [2540], 'deoxycytidine-depsipeptide': [2541], 'FR901228': [2542], 'apoptosis': [2545], 'facilitates': [2551], 'recognition': [2553], 'cytolytic': [2555], 'lymphocytes': [2557], 'NY-ESO-1.J.': [2560], '24:': [2563], '151-161Crossref': [2564], '(155)': [2567], 'only': [2574], 'affecting': [2577], 'epigenome.': [2579], 'Currently,': [2580], '87': [2581], 'clinical': [2582], 'trials': [2583], 'therapy': [2587], 'registered': [2589], 'Clinical': [2591], 'Trials': [2592], '(http://www.clinicaltrials.gov)': [2593], '(30.Valdespino': [2594], 'Identification': [2618], 'complicated': [2630], 'difficulty': [2633], 'detection': [2635], 'peptidome': [2643], 'yield': [2649], 'immunoaffinity': [2651, 3899], 'purified': [2652, 3595, 3826, 3900], 'technical': [2658], 'limitations': [2659], 'chromatography': [2662, 4106, 4209], 'mass': [2664, 2770, 3084, 3297, 4109, 4213, 4217], 'spectrometry': [2665, 3085, 3298, 3402, 4110, 4214], 'recovered': [2669, 3893, 4004], '(7.Comber': [2671], '41.Caron': [2749], 'Kowalewski': [2751], 'D.J.': [2752], 'Chiek': [2753], 'Koh': [2754], 'Sturm': [2756], 'Analysis': [2762], '(MHC)': [2767], 'immunopeptidomes': [2768], 'using': [2769, 3799, 3812, 3901, 4016], 'spectrometry.Mol.': [2771], 'Cell.': [2772, 2996, 3209, 3349, 3421, 3942], 'Proteomics.': [2773, 2997, 3210, 3350, 3422, 3943], '3105-3117Abstract': [2776], '(147)': [2784], 'To': [2787], 'end,': [2789], 'exomes': [2795], 'transcriptomes': [2797], 'provide': [2799], 'inferred': [2811], '(9.Granados': [2812], '42.Fortier': [2914], 'Hardy': [2918, 2958, 3131, 3171], 'Voisin': [2920, 3133], 'Lemieux': [2922, 2968, 3025, 3135, 3181, 3238], 'repertoire': [2933, 3146], 'molded': [2935, 3148], 'transcriptome.J.': [2938, 3151], 'Exp.': [2939, 3152], '205:': [2942, 3155], '595-610Crossref': [2943, 3156], '(125)': [2946, 3159], '43.de': [2949, 3162], 'Muratore-Schroeder': [2952, 3019, 3165, 3232], 'Fortier': [2956, 3169], 'Bramoulle': [2960, 3173], 'Vincent': [2964, 3177], 'Mader': [2966, 3179], 'Deletion': [2974, 3187], 'immunoproteasome': [2976, 3189], 'subunits': [2977, 3190], 'imprints': [2978, 3191], 'transcriptome': [2981, 3194], 'broad': [2985, 3198], 'impact': [2986, 3199], 'molecules.Mol.': [2995, 3208], '2010;': [2998, 3211], '2034-2047Abstract': [3000, 3213], '(66)': [3008, 3221], '44.Granados': [3011, 3224], 'Yahyaoui': [3013, 3226], 'Daouda': [3017, 3230], 'Cote': [3021, 3234], 'Laverdure': [3023, 3236], 'derive': [3035, 3248], 'transcripts': [3037, 3250], 'bearing': [3038, 3251], 'miRNA': [3039, 3252], 'elements.Blood.': [3041, 3254], '119:': [3043, 3256], 'e181-e191Crossref': [3044, 3257], '(55)': [3047, 3260], '45.Yadav': [3050, 3263], 'Jhunjhunwala': [3052, 3265], 'Phung': [3054, 3267], 'Q.T.': [3055, 3268], 'Lupardus': [3056, 3269], 'Tanguay': [3058, 3271], 'Bumbaca': [3060, 3273], 'Franci': [3062, 3275], 'Cheung': [3064, 3277], 'T.K.': [3065, 3278], 'Fritsche': [3066, 3279], 'Weinschenk': [3068, 3281], 'Modrusan': [3070, 3283], 'Mellman': [3072, 3285], 'Lill': [3074, 3287], 'Delamarre': [3076, 3289], 'Predicting': [3078, 3291], 'immunogenic': [3079, 3292], 'tumour': [3080, 3293], 'exome': [3087, 3300], 'sequencing.Nature.': [3088, 3301], '572-576Crossref': [3091, 3304], '(816)': [3094, 3307], 'less': [3102], 'elucidation': [3105], 'peptides,': [3110], 'because': [3111], 'correlates': [3118], 'poorly': [3119], 'source': [3125], 'proteins': [3126, 3984, 4190], '(42.Fortier': [3127], '46.Weinzierl': [3310], 'Lemmel': [3312], 'Schoor': [3314], 'Muller': [3316], 'Kruger': [3318], 'Wernet': [3320], 'Hennenlotter': [3322], 'Stenzl': [3324], 'Klingel': [3326], 'Distorted': [3332], 'relation': [3333], 'mRNA': [3335], 'copy': [3336], 'number': [3337], 'corresponding': [3339], 'density': [3344], 'surface.Mol.': [3348], '2007;': [3351], '102-113Abstract': [3353], '(95)': [3361], '47.Hoof': [3364], 'van': [3366], 'Baarle': [3367], 'Hildebrand': [3369], 'Kesmir': [3371], 'Proteome': [3373, 4052], 'sampling': [3374], 'processing': [3381], 'pathway.PLoS': [3382], 'Comput.': [3383], 'Biol.': [3384], '8:': [3386], 'e1002517Crossref': [3387], '(24)': [3390], '48.Bassani-Sternberg': [3393], 'Pletscher-Frankild': [3395], 'Jensen': [3397], 'Mann': [3399, 4033], 'Mass': [3401], 'reveals': [3410], 'strong': [3411], 'protein': [3414, 4177], 'abundance': [3415], 'turnover': [3417], 'presentation.Mol.': [3420], '658-673Abstract': [3425], '(280)': [3433], 'This': [3436], 'research': [3437], 'aimed': [3438], 'promote': [3440], 'reliable': [3445], 'method': [3446], 'selection': [3448], 'immunotherapy,': [3454, 3507], 'especially': [3455], 'drugs,': [3459], 'Decitabine.': [3462], 'effect': [3466, 3928], 'proteomes,': [3473], 'cultured': [3479], 'resulting': [3483], 'large': [3488], 'sets': [3489], 'drug-induced': [3491], 'CTAs.': [3492], 'obtained': [3494], 'advancing': [3500], 'approaches': [3505, 4077], 'based': [3508, 4115], 'induction': [3511], 'treatment.': [3536, 3623], 'Three': [3537, 3672, 3701], 'lines,': [3541], 'U-87,': [3542], 'T98G,': [3543, 3677], 'LNT-229': [3545], '(obtained': [3546, 3603], 'ATCC,': [3549], 'Manassas,': [3550], 'VA)': [3551], 'maintained': [3553], 'DMEM': [3555], 'supplemented': [3556], '10%': [3558], 'FBS,': [3559], '1%': [3560, 3562, 3865], 'l-glutamine,': [3561], 'Na-pyruvate,': [3563], '0.1': [3564, 3975], 'mg/ml': [3565], 'streptomycin,': [3566], '100': [3568, 4021], 'μ/ml': [3569], 'penicillin': [3570], '0.1%': [3572, 4009, 4024, 4070], 'HEPES.': [3573], 'kept': [3577], '5%': [3579], 'CO2': [3580], 'humidified': [3581], 'incubator': [3582], '37': [3584], '°C.': [3585, 3891], 'monoclonal': [3587, 3763], 'antibodies': [3588, 3784], 'W6/32': [3589, 3762, 3903], '(anti-HLA': [3590], 'I)': [3592], 'affinity': [3594, 3968], 'growth': [3597], 'medium': [3598, 3635], 'HB95': [3601, 3772], 'hybridoma': [3602, 3773], 'ATCC).': [3606], 'Cells': [3607], 'counted': [3609, 3659], 'plated': [3611], '150': [3614], 'mm': [3615, 3851, 3854, 3862], 'Petri': [3616], 'dishes': [3617], '1': [3618, 3639, 3853, 3861, 3875], 'day': [3619], 'prior': [3620], 'day,': [3626], 'media': [3628], 'removed': [3630], 'replaced': [3632], 'fresh': [3634], 'without': [3638], 'μm': [3640, 4235, 4241], '5′-Aza-2′-deoxycytidine': [3642], '(Decitabine,': [3643], 'AdooQ': [3644], 'Bioscience,': [3645], 'Irvine,': [3646], 'CA).': [3647, 3820], 'After': [3648], 'incubation': [3649], '72': [3653], 'h,': [3654], 'harvested,': [3658], 'prepared': [3661], 'FACS,': [3663], 'peptidomics,': [3665], 'analysis,': [3667, 3691, 3693], 'RNA': [3670, 3697], 'sequencing.': [3671], 'lines': [3675, 3734], '(U-87,': [3676], 'LNT-229),': [3679], 'untreated': [3682, 3717, 3747], 'Decitabine,': [3684], 'sequencing': [3698], 'quantification.': [3700], 'replicates': [3708, 3728, 3830], 'performed': [3710, 3798, 4227], 'each': [3712, 3730, 3752, 3832, 4124, 4136], 'two': [3723, 4128], 'out': [3724], 'RNA-seq': [3739], 'analyses.': [3740], 'About': [3741], '2': [3742], '×': [3743, 3841], '105': [3744], 'Decitabine-treated': [3745], 'flow': [3753], 'cytometric': [3754], 'analysis.': [3755, 4075, 4199], 'tagged': [3759], '(anti-HLA-A,': [3765], 'B': [3766], 'C)': [3768], 'produced': [3769], 'final': [3778], 'concentration': [3779], '0.5': [3781], 'μg/μl.': [3782], 'Secondary': [3783], 'anti-mouse': [3786], 'IgG': [3787], 'conjugated': [3788], 'FITC': [3790], '(Sigma,': [3791], 'St.': [3792], 'Louis,': [3793], 'MO).': [3794], 'FACS': [3795], 'LSRII': [3800], 'instrument': [3801], '(BD': [3802], 'Biosciences,': [3803], 'San': [3804], 'Jose,': [3805], 'CA)': [3806], 'analyzed': [3811], 'FCS': [3813], 'Express': [3814], '5': [3815, 3840, 4120], 'Plus': [3816], '(DeNovo': [3817], 'Software,': [3818], 'Glendale,': [3819], 'line.': [3835], 'Each': [3836], 'replica': [3837], '108': [3842], 'lysed': [3845], '0.25%': [3847], 'sodium': [3848], 'deoxycholate,': [3849], '0.2': [3850], 'iodoacetamide,': [3852], 'EDTA,': [3855], '1:200': [3856], 'Protease': [3857], 'Inhibitors': [3858], 'Mixture': [3859], '(Sigma),': [3860], 'PMSF,': [3863], 'octyl-β-D': [3866], 'glucopyranoside': [3867], '(Sigma)': [3868], 'PBS': [3870], '4': [3872, 3890], '°C': [3873], 'h.': [3876], 'extracts': [3879], 'cleared': [3881], 'centrifugation': [3883], '45': [3885], 'min': [3886], '18,000': [3888], 'rpm,': [3889], 'mAb': [3904], 'Amino-Link': [3907], 'beads': [3908], '(Thermo': [3909, 4219], 'Scientific,': [3910], 'Waltham,': [3911], 'MA)': [3912, 3998], '(49.Milner': [3915], 'Gutter-Kapon': [3917], 'Bassani-Strenberg': [3919], 'Barnea': [3921], 'Beer': [3923], 'Admon': [3925, 4145], 'proteasome': [3930], 'inhibition': [3931], '(HLA)': [3940], 'peptidome.Mol.': [3941], '1853-1864Abstract': [3946], '(58)': [3954], 'eluted': [3965, 3980, 4062, 4256], 'column': [3969, 3972, 4238], 'five': [3971], 'volumes': [3973], 'N': [3976], 'acetic': [3977], 'acid.': [3978], 'released': [3987], 'loaded': [3990], 'disposable': [3992], 'C18': [3993], 'columns': [3994], '(Harvard': [3995], 'Apparatus,': [3996], 'Holliston,': [3997], 'fraction': [4002], '30%': [4006], 'acetonitrile': [4007], 'TFA.': [4010], 'fractions': [4013], 'dried': [4015], 'vacuum': [4017], 'centrifugation,': [4018], 'reconstituted': [4019, 4068], 'μl': [4022], 'TFA,': [4025], 'reloaded': [4026], 'Stage-Tips': [4028], '(50.Ishihama': [4029], 'Rappsilber': [4031], 'Modular': [4035], 'stop': [4036], 'go': [4038], 'extraction': [4039], 'tips': [4040], 'stacked': [4042], 'disks': [4043], 'parallel': [4045], 'multidimensional': [4047], 'Peptide': [4048], 'fractionation': [4049], 'proteomics.J.': [4051], '2006;': [4054], '988-994Crossref': [4056], '(224)': [4059], '80%': [4064], 'ACN,': [4065], 'dried,': [4066], 'formic': [4071], 'acid': [4072], 'μLC-MS-MS': [4074, 4130, 4185, 4198], 'Two': [4076], 'proteome': [4079], 'employed': [4082], 'study.': [4085], 'first': [4087], 'in-solution': [4089, 4195], 'tryptic': [4090, 4133, 4203, 4253], 'digest': [4091, 4183, 4196], 'resolution': [4094], 'long': [4099], '(3': [4100], 'h)': [4101], 'one-dimensional': [4102], 'reversed': [4103, 4222], 'phase': [4104, 4223], 'capillary': [4105, 4208, 4224], 'tandem': [4108, 4212], 'in-gel': [4117, 4182], 'proteolysis': [4118], 'gel': [4121, 4137], 'slices': [4122], 'lane,': [4125], 'hours': [4129], 'slice,': [4138], '(51.Bourdetsky': [4141], 'Schmelzer': [4143], 'extent': [4150], 'contributions': [4152], 'defective': [4154], 'ribosome': [4155], 'peptidome.Proc.': [4160], '111:': [4166], 'E1591-E1599Crossref': [4167], '(74)': [4170], 'Thirty': [4173], 'μg': [4174, 4188], '2.5': [4187], 'resolved': [4206], 'electrospray': [4211], 'Q-Exactive-plus': [4216], 'spectrometers': [4218], 'Scientific).': [4220], 'chromatographies': [4225], 'home-packed': [4229], '30': [4231], 'cm': [4232], 'long,': [4233], '75': [4234], 'inner': [4236], 'diameter': [4237], '3.5': [4240], 'silica': [4242], 'ReproSil-Pur': [4243], 'C18-AQ': [4244], 'resin': [4245], '(Dr.': [4246], 'Maisch': [4247], 'GmbH,': [4248], 'Ammerbuch-Entringen,': [4249], 'Germany).': [4250], 'linear': [4259], 'gradient': [4260], '5–28%': [4262], 'buf': [4264]}, 'cited_by_api_url': 'https://api.openalex.org/works?filter=cites:W2464113003', 'counts_by_year': [{'year': 2024, 'cited_by_count': 4}, {'year': 2023, 'cited_by_count': 11}, {'year': 2022, 'cited_by_count': 4}, {'year': 2021, 'cited_by_count': 9}, {'year': 2020, 'cited_by_count': 12}, {'year': 2019, 'cited_by_count': 7}, {'year': 2018, 'cited_by_count': 11}, {'year': 2017, 'cited_by_count': 4}], 'updated_date': '2024-12-08T05:28:39.907228', 'created_date': '2016-07-22'}
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