Abstract:To understand biological membranes, and especially to predict their behavior, requires a detailed knowledge of their components. It is appropriate to start with the lipids that make up the bilayer, be...To understand biological membranes, and especially to predict their behavior, requires a detailed knowledge of their components. It is appropriate to start with the lipids that make up the bilayer, because they are not just a solvent providing the “sea” in which membrane proteins float. If this were the case, a few lipidic species would suffice to provide the amphiphilic base of the bilayer and some variation of shapes for packing it. Instead, the diversity of membrane lipids is amazing. A typical biomembrane contains more than a hundred species of lipids, which vary in general structure and in the length and degree of saturation of their fatty acyl chains. This chapter begins with the properties and modulation of the acyl chains and then reviews the structural features of the major complex lipids. It describes the properties of lipid aggregates, including their polymorphism and phase separations, which are the basis of their ability to form lateral microdomains. It addresses the characteristics of lipid rafts in membranes. The chapter ends with studies of lipid metabolism in Escherichia coli that address the biological need for diversity of lipids and support a role for non–bilayer-forming lipids in maintaining the elasticity of the membrane.Read More
Publication Year: 2008
Publication Date: 2008-03-17
Language: en
Type: book-chapter
Indexed In: ['crossref']
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Cited By Count: 2
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