Get quick answers to your questions about the article from our AI researcher chatbot
{'id': 'https://openalex.org/W2463639643', 'doi': 'https://doi.org/10.18632/oncotarget.10581', 'title': 'Gallic acid inhibition of Src-Stat3 signaling overcomes acquired resistance to EGF receptor tyrosine kinase inhibitors in advanced non-small cell lung cancer', 'display_name': 'Gallic acid inhibition of Src-Stat3 signaling overcomes acquired resistance to EGF receptor tyrosine kinase inhibitors in advanced non-small cell lung cancer', 'publication_year': 2016, 'publication_date': '2016-07-13', 'ids': {'openalex': 'https://openalex.org/W2463639643', 'doi': 'https://doi.org/10.18632/oncotarget.10581', 'mag': '2463639643', 'pmid': 'https://pubmed.ncbi.nlm.nih.gov/27419630', 'pmcid': 'https://www.ncbi.nlm.nih.gov/pmc/articles/5342374'}, 'language': 'en', 'primary_location': {'is_oa': True, 'landing_page_url': 'https://doi.org/10.18632/oncotarget.10581', 'pdf_url': 'http://www.oncotarget.com/index.php?journal=oncotarget&page=article&op=download&path%5B%5D=10581&path%5B%5D=33430', 'source': {'id': 'https://openalex.org/S126644158', 'display_name': 'Oncotarget', 'issn_l': '1949-2553', 'issn': ['1949-2553'], 'is_oa': True, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310316297', 'host_organization_name': 'Impact Journals LLC', 'host_organization_lineage': ['https://openalex.org/P4310316297'], 'host_organization_lineage_names': ['Impact Journals LLC'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, 'type': 'article', 'type_crossref': 'journal-article', 'indexed_in': ['crossref', 'pubmed'], 'open_access': {'is_oa': True, 'oa_status': 'gold', 'oa_url': 'http://www.oncotarget.com/index.php?journal=oncotarget&page=article&op=download&path%5B%5D=10581&path%5B%5D=33430', 'any_repository_has_fulltext': True}, 'authorships': [{'author_position': 'first', 'author': {'id': 'https://openalex.org/A5004446856', 'display_name': 'Ai N. H. Phan', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I193775966', 'display_name': 'Yonsei University', 'ror': 'https://ror.org/01wjejq96', 'country_code': 'KR', 'type': 'education', 'lineage': ['https://openalex.org/I193775966']}], 'countries': ['KR'], 'is_corresponding': False, 'raw_author_name': 'Ai N.H. Phan', 'raw_affiliation_strings': ['Department of Biochemistry, Wonju College of Medicine, Yonsei University, Wonju, Gangwon-do, Republic of Korea', 'Department of Global Medical Science, Institute of Lifestyle Medicine, Nuclear Receptor Research Consortium, Wonju College of Medicine, Yonsei University, Wonju, Gangwon-do, Republic of Korea'], 'affiliations': [{'raw_affiliation_string': 'Department of Biochemistry, Wonju College of Medicine, Yonsei University, Wonju, Gangwon-do, Republic of Korea', 'institution_ids': ['https://openalex.org/I193775966']}, {'raw_affiliation_string': 'Department of Global Medical Science, Institute of Lifestyle Medicine, Nuclear Receptor Research Consortium, Wonju College of Medicine, Yonsei University, Wonju, Gangwon-do, Republic of Korea', 'institution_ids': ['https://openalex.org/I193775966']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5103695673', 'display_name': 'Tuyen N. M. Hua', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I193775966', 'display_name': 'Yonsei University', 'ror': 'https://ror.org/01wjejq96', 'country_code': 'KR', 'type': 'education', 'lineage': ['https://openalex.org/I193775966']}], 'countries': ['KR'], 'is_corresponding': False, 'raw_author_name': 'Tuyen N.M. Hua', 'raw_affiliation_strings': ['Department of Biochemistry, Wonju College of Medicine, Yonsei University, Wonju, Gangwon-do, Republic of Korea', 'Department of Global Medical Science, Institute of Lifestyle Medicine, Nuclear Receptor Research Consortium, Wonju College of Medicine, Yonsei University, Wonju, Gangwon-do, Republic of Korea'], 'affiliations': [{'raw_affiliation_string': 'Department of Biochemistry, Wonju College of Medicine, Yonsei University, Wonju, Gangwon-do, Republic of Korea', 'institution_ids': ['https://openalex.org/I193775966']}, {'raw_affiliation_string': 'Department of Global Medical Science, Institute of Lifestyle Medicine, Nuclear Receptor Research Consortium, Wonju College of Medicine, Yonsei University, Wonju, Gangwon-do, Republic of Korea', 'institution_ids': ['https://openalex.org/I193775966']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5073453700', 'display_name': 'Min-Kyu Kim', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I193775966', 'display_name': 'Yonsei University', 'ror': 'https://ror.org/01wjejq96', 'country_code': 'KR', 'type': 'education', 'lineage': ['https://openalex.org/I193775966']}], 'countries': ['KR'], 'is_corresponding': False, 'raw_author_name': 'Min-Kyu Kim', 'raw_affiliation_strings': ['Department of Biochemistry, Wonju College of Medicine, Yonsei University, Wonju, Gangwon-do, Republic of Korea', 'Department of Global Medical Science, Institute of Lifestyle Medicine, Nuclear Receptor Research Consortium, Wonju College of Medicine, Yonsei University, Wonju, Gangwon-do, Republic of Korea'], 'affiliations': [{'raw_affiliation_string': 'Department of Biochemistry, Wonju College of Medicine, Yonsei University, Wonju, Gangwon-do, Republic of Korea', 'institution_ids': ['https://openalex.org/I193775966']}, {'raw_affiliation_string': 'Department of Global Medical Science, Institute of Lifestyle Medicine, Nuclear Receptor Research Consortium, Wonju College of Medicine, Yonsei University, Wonju, Gangwon-do, Republic of Korea', 'institution_ids': ['https://openalex.org/I193775966']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5048484380', 'display_name': 'Vu T. A. Vo', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I193775966', 'display_name': 'Yonsei University', 'ror': 'https://ror.org/01wjejq96', 'country_code': 'KR', 'type': 'education', 'lineage': ['https://openalex.org/I193775966']}], 'countries': ['KR'], 'is_corresponding': False, 'raw_author_name': 'Vu T.A. Vo', 'raw_affiliation_strings': ['Department of Biochemistry, Wonju College of Medicine, Yonsei University, Wonju, Gangwon-do, Republic of Korea', 'Department of Global Medical Science, Institute of Lifestyle Medicine, Nuclear Receptor Research Consortium, Wonju College of Medicine, Yonsei University, Wonju, Gangwon-do, Republic of Korea'], 'affiliations': [{'raw_affiliation_string': 'Department of Biochemistry, Wonju College of Medicine, Yonsei University, Wonju, Gangwon-do, Republic of Korea', 'institution_ids': ['https://openalex.org/I193775966']}, {'raw_affiliation_string': 'Department of Global Medical Science, Institute of Lifestyle Medicine, Nuclear Receptor Research Consortium, Wonju College of Medicine, Yonsei University, Wonju, Gangwon-do, Republic of Korea', 'institution_ids': ['https://openalex.org/I193775966']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5068551422', 'display_name': 'Jong-Whan Choi', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I193775966', 'display_name': 'Yonsei University', 'ror': 'https://ror.org/01wjejq96', 'country_code': 'KR', 'type': 'education', 'lineage': ['https://openalex.org/I193775966']}], 'countries': ['KR'], 'is_corresponding': False, 'raw_author_name': 'Jong-Whan Choi', 'raw_affiliation_strings': ['Department of Biochemistry, Wonju College of Medicine, Yonsei University, Wonju, Gangwon-do, Republic of Korea'], 'affiliations': [{'raw_affiliation_string': 'Department of Biochemistry, Wonju College of Medicine, Yonsei University, Wonju, Gangwon-do, Republic of Korea', 'institution_ids': ['https://openalex.org/I193775966']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5088512069', 'display_name': 'Hyun-Won Kim', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I193775966', 'display_name': 'Yonsei University', 'ror': 'https://ror.org/01wjejq96', 'country_code': 'KR', 'type': 'education', 'lineage': ['https://openalex.org/I193775966']}], 'countries': ['KR'], 'is_corresponding': False, 'raw_author_name': 'Hyun-Won Kim', 'raw_affiliation_strings': ['Department of Biochemistry, Wonju College of Medicine, Yonsei University, Wonju, Gangwon-do, Republic of Korea'], 'affiliations': [{'raw_affiliation_string': 'Department of Biochemistry, Wonju College of Medicine, Yonsei University, Wonju, Gangwon-do, Republic of Korea', 'institution_ids': ['https://openalex.org/I193775966']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5067969008', 'display_name': 'Jin Kyung Rho', 'orcid': 'https://orcid.org/0000-0003-3918-0099'}, 'institutions': [{'id': 'https://openalex.org/I40542001', 'display_name': 'University of Ulsan', 'ror': 'https://ror.org/02c2f8975', 'country_code': 'KR', 'type': 'education', 'lineage': ['https://openalex.org/I40542001']}, {'id': 'https://openalex.org/I2801680663', 'display_name': 'Asan Medical Center', 'ror': 'https://ror.org/03s5q0090', 'country_code': 'KR', 'type': 'healthcare', 'lineage': ['https://openalex.org/I2801680663']}, {'id': 'https://openalex.org/I116631150', 'display_name': 'Ulsan College', 'ror': 'https://ror.org/02tec3785', 'country_code': 'KR', 'type': 'education', 'lineage': ['https://openalex.org/I116631150']}, {'id': 'https://openalex.org/I193775966', 'display_name': 'Yonsei University', 'ror': 'https://ror.org/01wjejq96', 'country_code': 'KR', 'type': 'education', 'lineage': ['https://openalex.org/I193775966']}], 'countries': ['KR'], 'is_corresponding': False, 'raw_author_name': 'Jin Kyung Rho', 'raw_affiliation_strings': ['Department of Biochemistry, Wonju College of Medicine, Yonsei University, Wonju, Gangwon-do, Republic of Korea', 'Department of Convergence Medicine, Asan Medical Center, University of Ulsan, College of Medicine, Seoul, Republic of Korea'], 'affiliations': [{'raw_affiliation_string': 'Department of Convergence Medicine, Asan Medical Center, University of Ulsan, College of Medicine, Seoul, Republic of Korea', 'institution_ids': ['https://openalex.org/I40542001', 'https://openalex.org/I2801680663', 'https://openalex.org/I116631150']}, {'raw_affiliation_string': 'Department of Biochemistry, Wonju College of Medicine, Yonsei University, Wonju, Gangwon-do, Republic of Korea', 'institution_ids': ['https://openalex.org/I193775966']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5035968290', 'display_name': 'Ki Woo Kim', 'orcid': 'https://orcid.org/0000-0002-7790-1515'}, 'institutions': [{'id': 'https://openalex.org/I193775966', 'display_name': 'Yonsei University', 'ror': 'https://ror.org/01wjejq96', 'country_code': 'KR', 'type': 'education', 'lineage': ['https://openalex.org/I193775966']}], 'countries': ['KR'], 'is_corresponding': False, 'raw_author_name': 'Ki Woo Kim', 'raw_affiliation_strings': ['Department of Global Medical Science, Institute of Lifestyle Medicine, Nuclear Receptor Research Consortium, Wonju College of Medicine, Yonsei University, Wonju, Gangwon-do, Republic of Korea', 'Department of Pharmacology, Wonju College of Medicine, Yonsei University, Wonju, Gangwon-do, Republic of Korea'], 'affiliations': [{'raw_affiliation_string': 'Department of Pharmacology, Wonju College of Medicine, Yonsei University, Wonju, Gangwon-do, Republic of Korea', 'institution_ids': ['https://openalex.org/I193775966']}, {'raw_affiliation_string': 'Department of Global Medical Science, Institute of Lifestyle Medicine, Nuclear Receptor Research Consortium, Wonju College of Medicine, Yonsei University, Wonju, Gangwon-do, Republic of Korea', 'institution_ids': ['https://openalex.org/I193775966']}]}, {'author_position': 'last', 'author': {'id': 'https://openalex.org/A5055833995', 'display_name': 'Yangsik Jeong', 'orcid': 'https://orcid.org/0000-0002-3298-0766'}, 'institutions': [{'id': 'https://openalex.org/I193775966', 'display_name': 'Yonsei University', 'ror': 'https://ror.org/01wjejq96', 'country_code': 'KR', 'type': 'education', 'lineage': ['https://openalex.org/I193775966']}], 'countries': ['KR'], 'is_corresponding': True, 'raw_author_name': 'Yangsik Jeong', 'raw_affiliation_strings': ['Department of Biochemistry, Wonju College of Medicine, Yonsei University, Wonju, Gangwon-do, Republic of Korea', 'Department of Global Medical Science, Institute of Lifestyle Medicine, Nuclear Receptor Research Consortium, Wonju College of Medicine, Yonsei University, Wonju, Gangwon-do, Republic of Korea'], 'affiliations': [{'raw_affiliation_string': 'Department of Biochemistry, Wonju College of Medicine, Yonsei University, Wonju, Gangwon-do, Republic of Korea', 'institution_ids': ['https://openalex.org/I193775966']}, {'raw_affiliation_string': 'Department of Global Medical Science, Institute of Lifestyle Medicine, Nuclear Receptor Research Consortium, Wonju College of Medicine, Yonsei University, Wonju, Gangwon-do, Republic of Korea', 'institution_ids': ['https://openalex.org/I193775966']}]}], 'countries_distinct_count': 1, 'institutions_distinct_count': 4, 'corresponding_author_ids': ['https://openalex.org/A5055833995'], 'corresponding_institution_ids': ['https://openalex.org/I193775966'], 'apc_list': None, 'apc_paid': None, 'fwci': 2.773, 'has_fulltext': True, 'fulltext_origin': 'ngrams', 'cited_by_count': 35, 'citation_normalized_percentile': {'value': 0.915906, 'is_in_top_1_percent': False, 'is_in_top_10_percent': True}, 'cited_by_percentile_year': {'min': 94, 'max': 95}, 'biblio': {'volume': '7', 'issue': '34', 'first_page': '54702', 'last_page': '54713'}, 'is_retracted': False, 'is_paratext': False, 'primary_topic': {'id': 'https://openalex.org/T13817', 'display_name': 'Microbial Tannase Production and Applications', 'score': 0.9992, 'subfield': {'id': 'https://openalex.org/subfields/2402', 'display_name': 'Applied Microbiology and Biotechnology'}, 'field': {'id': 'https://openalex.org/fields/24', 'display_name': 'Immunology and Microbiology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}, 'topics': [{'id': 'https://openalex.org/T13817', 'display_name': 'Microbial Tannase Production and Applications', 'score': 0.9992, 'subfield': {'id': 'https://openalex.org/subfields/2402', 'display_name': 'Applied Microbiology and Biotechnology'}, 'field': {'id': 'https://openalex.org/fields/24', 'display_name': 'Immunology and Microbiology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}, {'id': 'https://openalex.org/T13779', 'display_name': 'Role of Pim Oncogenes in Tumorigenesis', 'score': 0.9972, 'subfield': {'id': 'https://openalex.org/subfields/2734', 'display_name': 'Pathology and Forensic Medicine'}, 'field': {'id': 'https://openalex.org/fields/27', 'display_name': 'Medicine'}, 'domain': {'id': 'https://openalex.org/domains/4', 'display_name': 'Health Sciences'}}, {'id': 'https://openalex.org/T10274', 'display_name': 'Heterocyclic Compounds for Drug Discovery', 'score': 0.9936, 'subfield': {'id': 'https://openalex.org/subfields/1605', 'display_name': 'Organic Chemistry'}, 'field': {'id': 'https://openalex.org/fields/16', 'display_name': 'Chemistry'}, 'domain': {'id': 'https://openalex.org/domains/3', 'display_name': 'Physical Sciences'}}], 'keywords': [{'id': 'https://openalex.org/keywords/anticancer-agents', 'display_name': 'Anticancer Agents', 'score': 0.524645}, {'id': 'https://openalex.org/keywords/gallic-acid', 'display_name': 'Gallic Acid', 'score': 0.522568}, {'id': 'https://openalex.org/keywords/acquired-resistance', 'display_name': 'Acquired resistance', 'score': 0.51521903}], 'concepts': [{'id': 'https://openalex.org/C108636557', 'wikidata': 'https://www.wikidata.org/wiki/Q21109354', 'display_name': 'Proto-oncogene tyrosine-protein kinase Src', 'level': 3, 'score': 0.6790018}, {'id': 'https://openalex.org/C2778362808', 'wikidata': 'https://www.wikidata.org/wiki/Q375837', 'display_name': 'Gallic acid', 'level': 3, 'score': 0.67851853}, {'id': 'https://openalex.org/C42362537', 'wikidata': 'https://www.wikidata.org/wiki/Q87099740', 'display_name': 'Tyrosine kinase', 'level': 3, 'score': 0.64632916}, {'id': 'https://openalex.org/C502942594', 'wikidata': 'https://www.wikidata.org/wiki/Q3421914', 'display_name': 'Cancer research', 'level': 1, 'score': 0.6275592}, {'id': 'https://openalex.org/C101544691', 'wikidata': 'https://www.wikidata.org/wiki/Q420511', 'display_name': 'Receptor tyrosine kinase', 'level': 3, 'score': 0.5481192}, {'id': 'https://openalex.org/C62478195', 'wikidata': 'https://www.wikidata.org/wiki/Q828130', 'display_name': 'Signal transduction', 'level': 2, 'score': 0.53686094}, {'id': 'https://openalex.org/C2994294914', 'wikidata': 'https://www.wikidata.org/wiki/Q1645075', 'display_name': 'Acquired resistance', 'level': 3, 'score': 0.51521903}, {'id': 'https://openalex.org/C71924100', 'wikidata': 'https://www.wikidata.org/wiki/Q11190', 'display_name': 'Medicine', 'level': 0, 'score': 0.4682575}, {'id': 'https://openalex.org/C170493617', 'wikidata': 'https://www.wikidata.org/wiki/Q208467', 'display_name': 'Receptor', 'level': 2, 'score': 0.4650769}, {'id': 'https://openalex.org/C2776256026', 'wikidata': 'https://www.wikidata.org/wiki/Q47912', 'display_name': 'Lung cancer', 'level': 2, 'score': 0.44255063}, {'id': 'https://openalex.org/C2778923194', 'wikidata': 'https://www.wikidata.org/wiki/Q14912019', 'display_name': 'STAT3', 'level': 3, 'score': 0.41511208}, {'id': 'https://openalex.org/C86803240', 'wikidata': 'https://www.wikidata.org/wiki/Q420', 'display_name': 'Biology', 'level': 0, 'score': 0.31884256}, {'id': 'https://openalex.org/C121608353', 'wikidata': 'https://www.wikidata.org/wiki/Q12078', 'display_name': 'Cancer', 'level': 2, 'score': 0.31691962}, {'id': 'https://openalex.org/C95444343', 'wikidata': 'https://www.wikidata.org/wiki/Q7141', 'display_name': 'Cell biology', 'level': 1, 'score': 0.27755883}, {'id': 'https://openalex.org/C143998085', 'wikidata': 'https://www.wikidata.org/wiki/Q162555', 'display_name': 'Oncology', 'level': 1, 'score': 0.20267099}, {'id': 'https://openalex.org/C126322002', 'wikidata': 'https://www.wikidata.org/wiki/Q11180', 'display_name': 'Internal medicine', 'level': 1, 'score': 0.19283989}, {'id': 'https://openalex.org/C55493867', 'wikidata': 'https://www.wikidata.org/wiki/Q7094', 'display_name': 'Biochemistry', 'level': 1, 'score': 0.17886189}, {'id': 'https://openalex.org/C2778004101', 'wikidata': 'https://www.wikidata.org/wiki/Q133948', 'display_name': 'Antioxidant', 'level': 2, 'score': 0.0}], 'mesh': [{'descriptor_ui': 'D002289', 'descriptor_name': 'Carcinoma, Non-Small-Cell Lung', 'qualifier_ui': 'Q000188', 'qualifier_name': 'drug therapy', 'is_major_topic': True}, {'descriptor_ui': 'D019008', 'descriptor_name': 'Drug Resistance, Neoplasm', 'qualifier_ui': 'Q000187', 'qualifier_name': 'drug effects', 'is_major_topic': True}, {'descriptor_ui': 'D005707', 'descriptor_name': 'Gallic Acid', 'qualifier_ui': 'Q000494', 'qualifier_name': 'pharmacology', 'is_major_topic': True}, {'descriptor_ui': 'D008175', 'descriptor_name': 'Lung Neoplasms', 'qualifier_ui': 'Q000188', 'qualifier_name': 'drug therapy', 'is_major_topic': True}, {'descriptor_ui': 'D050796', 'descriptor_name': 'STAT3 Transcription Factor', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': True}, {'descriptor_ui': 'D019061', 'descriptor_name': 'src-Family Kinases', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': True}, {'descriptor_ui': 'D000818', 'descriptor_name': 'Animals', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D002289', 'descriptor_name': 'Carcinoma, Non-Small-Cell Lung', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': False}, {'descriptor_ui': 'D002289', 'descriptor_name': 'Carcinoma, Non-Small-Cell Lung', 'qualifier_ui': 'Q000473', 'qualifier_name': 'pathology', 'is_major_topic': False}, {'descriptor_ui': 'D002289', 'descriptor_name': 'Carcinoma, Non-Small-Cell Lung', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D045744', 'descriptor_name': 'Cell Line, Tumor', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D019008', 'descriptor_name': 'Drug Resistance, Neoplasm', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D066246', 'descriptor_name': 'ErbB Receptors', 'qualifier_ui': 'Q000037', 'qualifier_name': 'antagonists & inhibitors', 'is_major_topic': False}, {'descriptor_ui': 'D066246', 'descriptor_name': 'ErbB Receptors', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D066246', 'descriptor_name': 'ErbB Receptors', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': False}, {'descriptor_ui': 'D005260', 'descriptor_name': 'Female', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D005707', 'descriptor_name': 'Gallic Acid', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D000077156', 'descriptor_name': 'Gefitinib', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D006801', 'descriptor_name': 'Humans', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D008175', 'descriptor_name': 'Lung Neoplasms', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': False}, {'descriptor_ui': 'D008175', 'descriptor_name': 'Lung Neoplasms', 'qualifier_ui': 'Q000473', 'qualifier_name': 'pathology', 'is_major_topic': False}, {'descriptor_ui': 'D008175', 'descriptor_name': 'Lung Neoplasms', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D008807', 'descriptor_name': 'Mice, Inbred BALB C', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D008819', 'descriptor_name': 'Mice, Nude', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D047428', 'descriptor_name': 'Protein Kinase Inhibitors', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D047428', 'descriptor_name': 'Protein Kinase Inhibitors', 'qualifier_ui': 'Q000494', 'qualifier_name': 'pharmacology', 'is_major_topic': False}, {'descriptor_ui': 'D011799', 'descriptor_name': 'Quinazolines', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D011799', 'descriptor_name': 'Quinazolines', 'qualifier_ui': 'Q000494', 'qualifier_name': 'pharmacology', 'is_major_topic': False}, {'descriptor_ui': 'D050796', 'descriptor_name': 'STAT3 Transcription Factor', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D015398', 'descriptor_name': 'Signal Transduction', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D015398', 'descriptor_name': 'Signal Transduction', 'qualifier_ui': 'Q000187', 'qualifier_name': 'drug effects', 'is_major_topic': False}, {'descriptor_ui': 'D023041', 'descriptor_name': 'Xenograft Model Antitumor Assays', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D019061', 'descriptor_name': 'src-Family Kinases', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}], 'locations_count': 4, 'locations': [{'is_oa': True, 'landing_page_url': 'https://doi.org/10.18632/oncotarget.10581', 'pdf_url': 'http://www.oncotarget.com/index.php?journal=oncotarget&page=article&op=download&path%5B%5D=10581&path%5B%5D=33430', 'source': {'id': 'https://openalex.org/S126644158', 'display_name': 'Oncotarget', 'issn_l': '1949-2553', 'issn': ['1949-2553'], 'is_oa': True, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310316297', 'host_organization_name': 'Impact Journals LLC', 'host_organization_lineage': ['https://openalex.org/P4310316297'], 'host_organization_lineage_names': ['Impact Journals LLC'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, {'is_oa': True, 'landing_page_url': 'https://europepmc.org/articles/pmc5342374', 'pdf_url': 'https://europepmc.org/articles/pmc5342374?pdf=render', 'source': {'id': 'https://openalex.org/S4306400806', 'display_name': 'Europe PMC (PubMed Central)', 'issn_l': None, 'issn': None, 'is_oa': True, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1303153112', 'host_organization_name': 'European Bioinformatics Institute', 'host_organization_lineage': ['https://openalex.org/I1303153112'], 'host_organization_lineage_names': ['European Bioinformatics Institute'], 'type': 'repository'}, 'license': 'cc-by', 'license_id': 'https://openalex.org/licenses/cc-by', 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, {'is_oa': True, 'landing_page_url': 'https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5342374', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S2764455111', 'display_name': 'PubMed Central', 'issn_l': None, 'issn': None, 'is_oa': True, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1299303238', 'host_organization_name': 'National Institutes of Health', 'host_organization_lineage': ['https://openalex.org/I1299303238'], 'host_organization_lineage_names': ['National Institutes of Health'], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, {'is_oa': False, 'landing_page_url': 'https://pubmed.ncbi.nlm.nih.gov/27419630', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S4306525036', 'display_name': 'PubMed', 'issn_l': None, 'issn': None, 'is_oa': False, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1299303238', 'host_organization_name': 'National Institutes of Health', 'host_organization_lineage': ['https://openalex.org/I1299303238'], 'host_organization_lineage_names': ['National Institutes of Health'], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}], 'best_oa_location': {'is_oa': True, 'landing_page_url': 'https://doi.org/10.18632/oncotarget.10581', 'pdf_url': 'http://www.oncotarget.com/index.php?journal=oncotarget&page=article&op=download&path%5B%5D=10581&path%5B%5D=33430', 'source': {'id': 'https://openalex.org/S126644158', 'display_name': 'Oncotarget', 'issn_l': '1949-2553', 'issn': ['1949-2553'], 'is_oa': True, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310316297', 'host_organization_name': 'Impact Journals LLC', 'host_organization_lineage': ['https://openalex.org/P4310316297'], 'host_organization_lineage_names': ['Impact Journals LLC'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, 'sustainable_development_goals': [{'id': 'https://metadata.un.org/sdg/3', 'score': 0.81, 'display_name': 'Good health and well-being'}], 'grants': [], 'datasets': [], 'versions': [], 'referenced_works_count': 42, 'referenced_works': ['https://openalex.org/W1106153875', 'https://openalex.org/W150693630', 'https://openalex.org/W1603705665', 'https://openalex.org/W1985264867', 'https://openalex.org/W1985931135', 'https://openalex.org/W1990013637', 'https://openalex.org/W1991601855', 'https://openalex.org/W1992831404', 'https://openalex.org/W1998971866', 'https://openalex.org/W2012780861', 'https://openalex.org/W2020995084', 'https://openalex.org/W2028544780', 'https://openalex.org/W2032397471', 'https://openalex.org/W2037720820', 'https://openalex.org/W2042278676', 'https://openalex.org/W2044246917', 'https://openalex.org/W2050849992', 'https://openalex.org/W2052705131', 'https://openalex.org/W2063391304', 'https://openalex.org/W2068244265', 'https://openalex.org/W2068691832', 'https://openalex.org/W2071323719', 'https://openalex.org/W2073725745', 'https://openalex.org/W2078776487', 'https://openalex.org/W2082079559', 'https://openalex.org/W2102365935', 'https://openalex.org/W2103245557', 'https://openalex.org/W2108688207', 'https://openalex.org/W2110841878', 'https://openalex.org/W2119005247', 'https://openalex.org/W2119146437', 'https://openalex.org/W2123735209', 'https://openalex.org/W2133963438', 'https://openalex.org/W2143819289', 'https://openalex.org/W2147588709', 'https://openalex.org/W2149268447', 'https://openalex.org/W2153086428', 'https://openalex.org/W2169816570', 'https://openalex.org/W2221195493', 'https://openalex.org/W2285354269', 'https://openalex.org/W2338377057', 'https://openalex.org/W2566863750'], 'related_works': ['https://openalex.org/W6610818', 'https://openalex.org/W4312084407', 'https://openalex.org/W2890254886', 'https://openalex.org/W2795031019', 'https://openalex.org/W2738627170', 'https://openalex.org/W2604934725', 'https://openalex.org/W2471078498', 'https://openalex.org/W2391636262', 'https://openalex.org/W2035476026', 'https://openalex.org/W2011110130'], 'abstract_inverted_index': {'//': [0], 'Ai': [1], 'N.H.': [2], 'Phan': [3], '1,': [4, 10, 15, 21, 45], '2': [5, 11, 16, 22, 46, 62], ',': [6, 12, 17, 23, 27, 31, 36, 42], 'Tuyen': [7], 'N.M.': [8], 'Hua': [9], 'Min-Kyu': [13], 'Kim': [14, 29, 39], 'Vu': [18], 'T.A.': [19], 'Vo': [20], 'Jong-Whan': [24], 'Choi': [25], '1': [26, 30, 47], 'Hyun-Won': [28], 'Jin': [32], 'Kyung': [33], 'Rho': [34], '3': [35, 87], 'Ki': [37], 'Woo': [38], '2,': [40], '4': [41, 105], 'Yangsik': [43, 122], 'Jeong': [44], 'Department': [48, 63, 88, 106], 'of': [49, 53, 60, 64, 69, 78, 85, 89, 96, 99, 103, 107, 111, 118, 168, 243, 267, 308, 325, 341], 'Biochemistry,': [50], 'Wonju': [51, 76, 109], 'College': [52, 77, 98, 110], 'Medicine,': [54, 71, 79, 91, 100, 112], 'Yonsei': [55, 80, 113], 'University,': [56, 81, 114], 'Wonju,': [57, 82, 115], 'Gangwon-do,': [58, 83, 116], 'Republic': [59, 84, 102, 117], 'Korea': [61, 86, 104, 119], 'Global': [65], 'Medical': [66, 93], 'Science,': [67], 'Institute': [68], 'Lifestyle': [70], 'Nuclear': [72], 'Receptor': [73], 'Research': [74], 'Consortium,': [75], 'Convergence': [90], 'Asan': [92], 'Center,': [94], 'University': [95], 'Ulsan,': [97], 'Seoul,': [101], 'Pharmacology,': [108], 'Correspondence': [120], 'to:': [121], 'Jeong,': [123], 'email:': [124], '[email protected]': [125], 'Keywords:': [126], 'gallic': [127, 209], 'acid,': [128], 'Src,': [129], 'Stat3,': [130], 'EGFR-TKI': [131], 'resistance,': [132], 'lung': [133, 162, 185, 223, 282, 346], 'cancer': [134, 163, 186, 224, 251, 283], 'Received:': [135], 'April': [136], '27,': [137], '2016': [138, 142, 146], 'Accepted:': [139], 'June': [140], '30,': [141], 'Published:': [143], 'July': [144], '13,': [145], 'ABSTRACT': [147], 'Tyrosine': [148], 'kinase': [149], 'inhibitors': [150], '(TKIs)': [151], 'targeting': [152], 'epidermal': [153], 'growth': [154, 230, 304], 'factor': [155], 'receptor': [156], '(EGFR)': [157], 'have': [158, 189], 'clinically': [159], 'benefited': [160], 'to': [161, 194, 197, 253], 'patients': [164, 187], 'harboring': [165], 'a': [166, 212, 337], 'subset': [167], 'activating': [169], 'EGFR': [170], 'mutations.': [171], 'However,': [172], 'even': [173], 'with': [174, 291], 'the': [175, 180, 198, 249, 254, 265, 280, 287, 292, 301, 312, 317], 'remarkable': [176], 'therapeutic': [177, 339], 'response': [178], 'at': [179], 'initial': [181], 'TKI': [182], 'treatment,': [183], 'most': [184], 'eventually': [188], 'relapsed': [190], 'aggressive': [191], 'tumors': [192, 314], 'due': [193], 'acquired': [195], 'resistance': [196], 'TKIs.': [199], 'Here,': [200], 'we': [201, 238], 'report': [202], 'that': [203], '3,': [204], '4,': [205], '5-trihydroxybenzoic': [206], 'acid': [207, 210], 'or': [208], '(GA),': [211], 'natural': [213], 'polyphenolic': [214], 'compound,': [215], 'shows': [216], 'anti-tumorigenic': [217], 'effects': [218], 'in': [219, 228, 233, 279, 286, 293, 296, 311, 329], 'TKI-resistant': [220, 250, 281, 302, 345], 'non-small': [221], 'cell': [222, 276], '(NSCLC).': [225], 'Using': [226], 'both': [227], 'vitro': [229, 294], 'assay': [231], 'and': [232, 263, 275, 306], 'vivo': [234, 297], 'xenograft': [235, 298, 318], 'animal': [236], 'model,': [237], 'demonstrated': [239], 'tumor': [240, 269], 'suppressive': [241], 'effect': [242], 'GA': [244, 258, 342], 'was': [245], 'more': [246, 334], 'selective': [247], 'for': [248, 343], 'compared': [252], 'TKI-sensitive': [255, 288], 'one.': [256, 289], 'Mechanistically,': [257], 'treatment': [259], 'inhibited': [260], 'Src-Stat3-mediated': [261], 'signaling': [262, 310, 327], 'decreased': [264], 'expression': [266], 'Stat3-regulated': [268], 'promoting': [270], 'genes,': [271], 'subsequently': [272], 'inducing': [273], 'apoptosis': [274], 'cycle': [277], 'arrest': [278], 'but': [284], 'not': [285], 'Consistent': [290], 'results,': [295], 'experiments': [299], 'showed': [300], 'tumor-selective': [303], 'inhibition': [305], 'suppression': [307], 'Src-Stat3-dependent': [309], 'GA-treated': [313], 'isolated': [315], 'from': [316], 'model.': [319], 'This': [320], 'finding': [321], 'identified': [322], 'an': [323], 'importance': [324], 'Src-Stat3': [326], 'cascade': [328], 'GA-mediated': [330], 'tumor-suppression': [331], 'activity': [332], 'and,': [333], 'importantly,': [335], 'provides': [336], 'novel': [338], 'insight': [340], 'advanced': [344], 'cancer.': [347]}, 'cited_by_api_url': 'https://api.openalex.org/works?filter=cites:W2463639643', 'counts_by_year': [{'year': 2024, 'cited_by_count': 4}, {'year': 2023, 'cited_by_count': 3}, {'year': 2022, 'cited_by_count': 4}, {'year': 2021, 'cited_by_count': 8}, {'year': 2020, 'cited_by_count': 3}, {'year': 2019, 'cited_by_count': 3}, {'year': 2018, 'cited_by_count': 6}, {'year': 2017, 'cited_by_count': 4}], 'updated_date': '2024-09-11T12:12:46.655189', 'created_date': '2016-07-22'}