Title: Temporal lobe proton magnetic resonance spectroscopy of patients with first-episode psychosis
Abstract: Back to table of contents Previous article Next article No AccessTemporal lobe proton magnetic resonance spectroscopy of patients with first-episode psychosisPublished Online:1 Apr 2006https://doi.org/10.1176/ajp.152.3.444AboutSectionsView articleAbstractPDF/EPUB ToolsAdd to favoritesDownload CitationsTrack Citations ShareShare onFacebookTwitterLinked InEmail View articleAbstractOBJECTIVE: The authors measured the ratio of N-acetyl aspartate (a putative neuronal marker) to creatine-phosphocreatine in patients with first-episode psychosis by using proton magnetic resonance spectroscopy (MRS). METHOD: Temporal lobe 1H MRS was performed bilaterally on 13 patients with first-episode psychosis and 15 comparison subjects. The N- acetyl aspartate/creatine-phosphocreatine and choline/creatine- phosphocreatine ratios were determined. RESULTS: The N-acetyl aspartate/creatine-phosphocreatine ratio of the psychotic patients was significantly lower than that of the comparison subjects. CONCLUSIONS: These preliminary data suggest that abnormalities in temporal lobe N- acetyl aspartate concentration are present early in psychotic illness. Access content To read the fulltext, please use one of the options below to sign in or purchase access. Personal login Institutional Login Sign in via OpenAthens Purchase Save for later Item saved, go to cart PPV Articles - American Journal of Psychiatry $35.00 Add to cart PPV Articles - American Journal of Psychiatry Checkout Please login/register if you wish to pair your device and check access availability. Not a subscriber? Subscribe Now / Learn More PsychiatryOnline subscription options offer access to the DSM-5 library, books, journals, CME, and patient resources. This all-in-one virtual library provides psychiatrists and mental health professionals with key resources for diagnosis, treatment, research, and professional development. Need more help? PsychiatryOnline Customer Service may be reached by emailing [email protected] or by calling 800-368-5777 (in the U.S.) or 703-907-7322 (outside the U.S.). FiguresReferencesCited byDetailsCited byProton Magnetic Resonance Spectroscopy of N-acetyl Aspartate in Chronic Schizophrenia, First Episode of Psychosis and High-Risk of Psychosis: A Systematic Review and Meta-AnalysisNeuroscience & Biobehavioral Reviews, Vol. 119Peripheral biomarkers allow differential diagnosis between schizophrenia and bipolar disorderJournal of Psychiatric Research, Vol. 119N-acetylaspartate (NAA) peak21 February 2014Psychiatry Research: Neuroimaging, Vol. 213, No. 2Molecular imaging of bipolar illnessProton MRS in twin pairs discordant for schizophrenia22 July 2008 | Molecular Psychiatry, Vol. 15, No. 3Ethyl-Eicosapentaenoic Acid in First-Episode Psychosis. A 1H-MRS Study16 January 2008 | Neuropsychopharmacology, Vol. 33, No. 10Brain Research Bulletin, Vol. 75, No. 5Bipolar Disorders, Vol. 10, No. 6Psychosis in Bipolar DisorderProgress in Neuro-Psychopharmacology and Biological Psychiatry, Vol. 30, No. 7Measurement of Brain Metabolites by 1H Magnetic Resonance Spectroscopy in Patients with Schizophrenia: A Systematic Review and Meta-Analysis10 August 2005 | Neuropsychopharmacology, Vol. 30, No. 11Der Radiologe, Vol. 45, No. 2Schizophrenia Research, Vol. 75, No. 2-3Schizophrenia Research, Vol. 66, No. 1Biological Psychiatry, Vol. 56, No. 4Brain Research Reviews, Vol. 44, No. 2-3Psychiatry Research: Neuroimaging, Vol. 131, No. 2Neuropsychopharmacology, Vol. 29, No. 10Lower Concentration of Hippocampal N-Acetylaspartate in Familial Bipolar I DisorderRaymond F. Deicken, M.S., M.D., Mary P. Pegues, M.S.W., Susan Anzalone, B.A., Robert Feiwell, M.D., and Brian Soher, Ph.D.1 May 2003 | American Journal of Psychiatry, Vol. 160, No. 5Biological Psychiatry, Vol. 53, No. 12Biological Psychiatry, Vol. 54, No. 6Glutamatergic Mechanisms in SchizophreniaAnnual Review of Pharmacology and Toxicology, Vol. 42, No. 1Magnetic Resonance Spectroscopy and its Applications in Psychiatry17 November 2016 | Australian & New Zealand Journal of Psychiatry, Vol. 36, No. 1Biological Psychiatry, Vol. 49, No. 1Biological Psychiatry, Vol. 50, No. 11Psychiatry Research: Neuroimaging, Vol. 106, No. 1Magnetic Resonance Spectroscopy and Schizophrenia: What have we Learnt?17 November 2016 | Australian & New Zealand Journal of Psychiatry, Vol. 34, No. 1Specific Relationship Between Prefrontal NeuronalN-Acetylaspartate and Activation of the Working Memory Cortical Network in SchizophreniaAlessandro Bertolino, M.D., Giuseppe Esposito, M.D., Joseph H. Callicott, M.D., Venkata S. Mattay, M.D., John D. Van Horn, Ph.D., Joseph A. Frank, M.D., Karen Faith Berman, M.D., and Daniel R. Weinberger, M.D.1 January 2000 | American Journal of Psychiatry, Vol. 157, No. 1Current Psychiatry Reports, Vol. 2, No. 4Biological Psychiatry, Vol. 47, No. 6Progress in Neuro-Psychopharmacology and Biological Psychiatry, Vol. 24, No. 4Psychiatry Research: Neuroimaging, Vol. 98, No. 3British Journal of Psychiatry, Vol. 176, No. 3Subtype-associated metabolite differences in the temporal lobe in schizophrenia detected by proton magnetic resonance spectroscopyPsychiatry Research: Neuroimaging, Vol. 92, No. 1Neurochemical brain imaging investigations of schizophreniaBiological Psychiatry, Vol. 46, No. 5Applications of Magnetic Resonance Spectroscopy to Psychiatry29 June 2016 | The Neuroscientist, Vol. 5, No. 3The neuropathology of schizophrenia1 April 1999 | Brain, Vol. 122, No. 4Biological Psychiatry, Vol. 45, No. 6Biological Psychiatry, Vol. 45, No. 11Journal of Psychiatric Research, Vol. 33, No. 1European Journal of Radiology, Vol. 30, No. 2Schizophrenia Research, Vol. 37, No. 3Psychiatry Research: Neuroimaging, Vol. 92, No. 2-3Epidemiology and Psychiatric Sciences, Vol. 8, No. 4Functional Magnetic Resonance Imaging and Magnetic Resonance Spectroscopy in SchizophreniaCommon Pattern of Cortical Pathology in Childhood-Onset and Adult-Onset Schizophrenia as Identified by Proton Magnetic Resonance Spectroscopic ImagingAlessandro Bertolino, M.D., Sanjiv Kumra, M.D., Joseph H. Callicott, M.D., Venkata S. Mattay, M.D., Rachel M. Lestz, B.S., Leslie Jacobsen, M.D., lan S. Barnett, Ph.D., Jeff H. Duyn, Ph.D., Joseph A. Frank, M.D., Judith L. Rapoport, M.D., and Daniel R. Weinberger, M.D.1 October 1998 | American Journal of Psychiatry, Vol. 155, No. 10In vivo neurochemistry of the brain in schizophrenia as revealed by magnetic resonance spectroscopyBiological Psychiatry, Vol. 44, No. 6Diagnosis, Neurobiology, and Treatment of First-episode Schizophrenia29 June 2016 | Journal of the American Psychiatric Nurses Association, Vol. 4, No. 1Biological Psychiatry, Vol. 43, No. 4Biological Psychiatry, Vol. 43, No. 7Biological Psychiatry, Vol. 43, No. 9Biological Psychiatry, Vol. 44, No. 8Biological Psychiatry, Vol. 44, No. 10Psychiatric Clinics of North America, Vol. 21, No. 1Psychiatry Research: Neuroimaging, Vol. 83, No. 2Biological Psychiatry, Vol. 42, No. 5Current Opinion in Psychiatry, Vol. 10, No. 1International Journal of Psychiatry in Clinical Practice, Vol. 1, No. 4Regionally specific pattern of neurochemical pathology in schizophrenia as assessed by multislice proton magnetic resonance spectroscopic imaging1 April 2006 | American Journal of Psychiatry, Vol. 153, No. 12Proton magnetic resonance spectroscopy of the basal ganglia in patients with schizophrenia: a preliminary reportSchizophrenia Research, Vol. 22, No. 1Current Opinion in Psychiatry, Vol. 9, No. 1 Volume 152Issue 3 March 1995Pages 444-446 Metrics PDF download History Published online 1 April 2006 Published in print 1 March 1995
Publication Year: 1995
Publication Date: 1995-03-01
Language: en
Type: article
Indexed In: ['crossref', 'pubmed']
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Cited By Count: 90
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