Title: Synthesis and bronchodilatory activity of four new derivatives of deoxyvasicine.
Abstract: As part of a continuing effort aimed at the development of efficacious antihistaminic and bronchodilator agents for the treatment of asthma and related respiratory diseases, a series of novel trisubstituted deoxyvasicine derivatives was designed and synthesized. Bronchodilatory activity of pure samples of ligands 17a-d, and DL-8-chlorovasicine hydrochloride is investigated and compared with isoprenaline and aminophylline. These studies confirm the activity of ligands 17a-d and the potentiating effect of 17c on aminophylline.
Publication Year: 1996
Publication Date: 1996-03-01
Language: en
Type: article
Indexed In: ['pubmed']
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Cited By Count: 6
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