Abstract: Cimetidine forms a complex with theophylline in vitro in both pH 7.4 buffer and human plasma. The increase in the amount of theophylline in solution is about 20% in the buffer system and about 36% in plasma. It is hypothesized that this complex formation may contribute to and be part of the mechanism of the clinically observed decreased theophylline clearance in man in presence of cimetidine.
Publication Year: 1983
Publication Date: 1983-01-01
Language: en
Type: article
Indexed In: ['pubmed']
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Cited By Count: 8
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