Title: Risk factors of novel severe influenza A(H1N1) with concurrent adult respiratory distress syndrome
Abstract: Objective To analyze the risk factors of novel severe influenza A (H1N1) with concurrent adult respiratory distress syndrome (ARDS).Methods A multivariable Logistic regression analysis was conducted for ARDS risk factors in controlled clinical trials for comparing the clinical features between the ARDS and non-ARDS groups and comparing ARDS patients' lymphocyte counts and T lymphocyte subsets between the smoking and non-smoking groups through a retrospective analysis of 92 novel influenza A (H1N1) patients who admitted to our hospital from October 2009 to January 2010.Results Through a single factor analysis between ARDS and non-ARDS groups,the comparisons in the factors including smoking(17 cases vs 11 cases),T lymphocyte subsets,lactate dehydrogenase (LDH),initial treatment point of oseltamivir and initial oxygen flow greater than 2 L/min (28 cases vs 18 cases) had statistically significant differences (all P < 0.05).The comparison in T lymphocyte subsets had statistically significant difference between the smoking and non-smoking groups in ARDS patients (all P < 0.05).The multivariable Logistic regression analysis showed that smoking (P=0.027,OR=8.05,95% CI:1.28-50.80) and initial oxygen flow greater than 2 L/min (P =0.010,OR=16.70,95%CI:3.29-84.84)were relevant to the incidence of ARDS in novel influenza A (H1N1) patients.Conclusion Smoking and initial oxygen flow greater than 2 L/min were the risk factors of novel severe influenza A (H1N1) with concurrent ARDS.
Key words:
Influenza A virus,human; Respiratory distress syndrome,adult; Risk factors; Smoking; Initial oxygen flow
Publication Year: 2010
Publication Date: 2010-09-14
Language: en
Type: article
Indexed In: ['pubmed']
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Cited By Count: 1
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