Publication Information

{'id': 'https://openalex.org/W2433681220', 'doi': 'https://doi.org/10.4269/ajtmh.1993.49.113', 'title': 'A Novel Pyrrolidonoalkaneamine (WR268954) That Modulates Chloroquine Resistance of Plasmodium falciparum In Vitro', 'display_name': 'A Novel Pyrrolidonoalkaneamine (WR268954) That Modulates Chloroquine Resistance of Plasmodium falciparum In Vitro', 'publication_year': 1993, 'publication_date': '1993-07-01', 'ids': {'openalex': 'https://openalex.org/W2433681220', 'doi': 'https://doi.org/10.4269/ajtmh.1993.49.113', 'mag': '2433681220', 'pmid': 'https://pubmed.ncbi.nlm.nih.gov/8352383'}, 'language': 'en', 'primary_location': {'is_oa': False, 'landing_page_url': 'https://doi.org/10.4269/ajtmh.1993.49.113', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S100045985', 'display_name': 'American Journal of Tropical Medicine and Hygiene', 'issn_l': '0002-9637', 'issn': ['0002-9637', '1476-1645'], 'is_oa': False, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310315658', 'host_organization_name': 'American Society of Tropical Medicine and Hygiene', 'host_organization_lineage': ['https://openalex.org/P4310315658'], 'host_organization_lineage_names': ['American Society of Tropical Medicine and Hygiene'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}, 'type': 'article', 'type_crossref': 'journal-article', 'indexed_in': ['crossref', 'pubmed'], 'open_access': {'is_oa': False, 'oa_status': 'closed', 'oa_url': None, 'any_repository_has_fulltext': False}, 'authorships': [{'author_position': 'first', 'author': {'id': 'https://openalex.org/A5113769532', 'display_name': 'D De', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I92664306', 'display_name': 'Walter Reed Army Institute of Research', 'ror': 'https://ror.org/0145znz58', 'country_code': 'US', 'type': 'government', 'lineage': ['https://openalex.org/I106965489', 'https://openalex.org/I1304082316', 'https://openalex.org/I1330347796', 'https://openalex.org/I2802581893', 'https://openalex.org/I4210088792', 'https://openalex.org/I92664306']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'D De', 'raw_affiliation_strings': ['Department of Parasitology, Walter Reed Army Institute of Research, Washington, District of Columbia.'], 'affiliations': [{'raw_affiliation_string': 'Department of Parasitology, Walter Reed Army Institute of Research, Washington, District of Columbia.', 'institution_ids': ['https://openalex.org/I92664306']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5108557492', 'display_name': 'A. P. BHADURI', 'orcid': None}, 'institutions': [], 'countries': [], 'is_corresponding': False, 'raw_author_name': 'A P Bhaduri', 'raw_affiliation_strings': [], 'affiliations': []}, {'author_position': 'last', 'author': {'id': 'https://openalex.org/A5112177472', 'display_name': 'Wilbur K. Milhous', 'orcid': None}, 'institutions': [], 'countries': [], 'is_corresponding': False, 'raw_author_name': 'W K Milhous', 'raw_affiliation_strings': [], 'affiliations': []}], 'institution_assertions': [], 'countries_distinct_count': 1, 'institutions_distinct_count': 1, 'corresponding_author_ids': [], 'corresponding_institution_ids': [], 'apc_list': None, 'apc_paid': None, 'fwci': 0.0, 'has_fulltext': False, 'cited_by_count': 9, 'citation_normalized_percentile': {'value': 0.686331, 'is_in_top_1_percent': False, 'is_in_top_10_percent': False}, 'cited_by_percentile_year': {'min': 76, 'max': 77}, 'biblio': {'volume': '49', 'issue': '1', 'first_page': '113', 'last_page': '120'}, 'is_retracted': False, 'is_paratext': False, 'primary_topic': {'id': 'https://openalex.org/T10091', 'display_name': 'Malaria Research and Control', 'score': 0.9998, 'subfield': {'id': 'https://openalex.org/subfields/2739', 'display_name': 'Public Health, Environmental and Occupational Health'}, 'field': {'id': 'https://openalex.org/fields/27', 'display_name': 'Medicine'}, 'domain': {'id': 'https://openalex.org/domains/4', 'display_name': 'Health Sciences'}}, 'topics': [{'id': 'https://openalex.org/T10091', 'display_name': 'Malaria Research and Control', 'score': 0.9998, 'subfield': {'id': 'https://openalex.org/subfields/2739', 'display_name': 'Public Health, Environmental and Occupational Health'}, 'field': {'id': 'https://openalex.org/fields/27', 'display_name': 'Medicine'}, 'domain': {'id': 'https://openalex.org/domains/4', 'display_name': 'Health Sciences'}}, {'id': 'https://openalex.org/T10094', 'display_name': 'Epilepsy research and treatment', 'score': 0.9961, 'subfield': {'id': 'https://openalex.org/subfields/2738', 'display_name': 'Psychiatry and Mental health'}, 'field': {'id': 'https://openalex.org/fields/27', 'display_name': 'Medicine'}, 'domain': {'id': 'https://openalex.org/domains/4', 'display_name': 'Health Sciences'}}, {'id': 'https://openalex.org/T13047', 'display_name': 'Pharmacological Receptor Mechanisms and Effects', 'score': 0.9915, 'subfield': {'id': 'https://openalex.org/subfields/1312', 'display_name': 'Molecular Biology'}, 'field': {'id': 'https://openalex.org/fields/13', 'display_name': 'Biochemistry, Genetics and Molecular Biology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}], 'keywords': [{'id': 'https://openalex.org/keywords/quinine', 'display_name': 'Quinine', 'score': 0.6038814}, {'id': 'https://openalex.org/keywords/efflux', 'display_name': 'Efflux', 'score': 0.5273641}, {'id': 'https://openalex.org/keywords/ic50', 'display_name': 'IC50', 'score': 0.44993284}], 'concepts': [{'id': 'https://openalex.org/C2777425658', 'wikidata': 'https://www.wikidata.org/wiki/Q422438', 'display_name': 'Chloroquine', 'level': 3, 'score': 0.97516406}, {'id': 'https://openalex.org/C2778371730', 'wikidata': 'https://www.wikidata.org/wiki/Q311383', 'display_name': 'Plasmodium falciparum', 'level': 3, 'score': 0.8818164}, {'id': 'https://openalex.org/C98274493', 'wikidata': 'https://www.wikidata.org/wiki/Q128406', 'display_name': 'Pharmacology', 'level': 1, 'score': 0.71592605}, {'id': 'https://openalex.org/C2777199930', 'wikidata': 'https://www.wikidata.org/wiki/Q736270', 'display_name': 'Mefloquine', 'level': 4, 'score': 0.66057616}, {'id': 'https://openalex.org/C2777022698', 'wikidata': 'https://www.wikidata.org/wiki/Q410291', 'display_name': 'Verapamil', 'level': 3, 'score': 0.6315814}, {'id': 'https://openalex.org/C2777617192', 'wikidata': 'https://www.wikidata.org/wiki/Q189522', 'display_name': 'Quinine', 'level': 3, 'score': 0.6038814}, {'id': 'https://openalex.org/C202751555', 'wikidata': 'https://www.wikidata.org/wiki/Q221681', 'display_name': 'In vitro', 'level': 2, 'score': 0.5453838}, {'id': 'https://openalex.org/C200082930', 'wikidata': 'https://www.wikidata.org/wiki/Q22327148', 'display_name': 'Efflux', 'level': 2, 'score': 0.5273641}, {'id': 'https://openalex.org/C114851261', 'wikidata': 'https://www.wikidata.org/wiki/Q12147416', 'display_name': 'Drug resistance', 'level': 2, 'score': 0.5233278}, {'id': 'https://openalex.org/C2780035454', 'wikidata': 'https://www.wikidata.org/wiki/Q8386', 'display_name': 'Drug', 'level': 2, 'score': 0.5164573}, {'id': 'https://openalex.org/C86803240', 'wikidata': 'https://www.wikidata.org/wiki/Q420', 'display_name': 'Biology', 'level': 0, 'score': 0.4813743}, {'id': 'https://openalex.org/C2777752497', 'wikidata': 'https://www.wikidata.org/wiki/Q286779', 'display_name': 'IC50', 'level': 3, 'score': 0.44993284}, {'id': 'https://openalex.org/C2778048844', 'wikidata': 'https://www.wikidata.org/wiki/Q12156', 'display_name': 'Malaria', 'level': 2, 'score': 0.37239042}, {'id': 'https://openalex.org/C89423630', 'wikidata': 'https://www.wikidata.org/wiki/Q7193', 'display_name': 'Microbiology', 'level': 1, 'score': 0.26344097}, {'id': 'https://openalex.org/C71924100', 'wikidata': 'https://www.wikidata.org/wiki/Q11190', 'display_name': 'Medicine', 'level': 0, 'score': 0.22492063}, {'id': 'https://openalex.org/C55493867', 'wikidata': 'https://www.wikidata.org/wiki/Q7094', 'display_name': 'Biochemistry', 'level': 1, 'score': 0.15334845}, {'id': 'https://openalex.org/C203014093', 'wikidata': 'https://www.wikidata.org/wiki/Q101929', 'display_name': 'Immunology', 'level': 1, 'score': 0.1479043}, {'id': 'https://openalex.org/C519063684', 'wikidata': 'https://www.wikidata.org/wiki/Q706', 'display_name': 'Calcium', 'level': 2, 'score': 0.09725022}, {'id': 'https://openalex.org/C126322002', 'wikidata': 'https://www.wikidata.org/wiki/Q11180', 'display_name': 'Internal medicine', 'level': 1, 'score': 0.07964563}], 'mesh': [{'descriptor_ui': 'D000840', 'descriptor_name': 'Anisoles', 'qualifier_ui': 'Q000494', 'qualifier_name': 'pharmacology', 'is_major_topic': True}, {'descriptor_ui': 'D000962', 'descriptor_name': 'Antimalarials', 'qualifier_ui': 'Q000494', 'qualifier_name': 'pharmacology', 'is_major_topic': True}, {'descriptor_ui': 'D002738', 'descriptor_name': 'Chloroquine', 'qualifier_ui': 'Q000494', 'qualifier_name': 'pharmacology', 'is_major_topic': True}, {'descriptor_ui': 'D010963', 'descriptor_name': 'Plasmodium falciparum', 'qualifier_ui': 'Q000187', 'qualifier_name': 'drug effects', 'is_major_topic': True}, {'descriptor_ui': 'D011759', 'descriptor_name': 'Pyrrolidines', 'qualifier_ui': 'Q000494', 'qualifier_name': 'pharmacology', 'is_major_topic': True}, {'descriptor_ui': 'D000818', 'descriptor_name': 'Animals', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D000840', 'descriptor_name': 'Anisoles', 'qualifier_ui': 'Q000737', 'qualifier_name': 'chemistry', 'is_major_topic': False}, {'descriptor_ui': 'D000840', 'descriptor_name': 'Anisoles', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D000962', 'descriptor_name': 'Antimalarials', 'qualifier_ui': 'Q000737', 'qualifier_name': 'chemistry', 'is_major_topic': False}, {'descriptor_ui': 'D000962', 'descriptor_name': 'Antimalarials', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D002738', 'descriptor_name': 'Chloroquine', 'qualifier_ui': 'Q000737', 'qualifier_name': 'chemistry', 'is_major_topic': False}, {'descriptor_ui': 'D002738', 'descriptor_name': 'Chloroquine', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D004351', 'descriptor_name': 'Drug Resistance', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D004357', 'descriptor_name': 'Drug Synergism', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D015394', 'descriptor_name': 'Molecular Structure', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D010963', 'descriptor_name': 'Plasmodium falciparum', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D011759', 'descriptor_name': 'Pyrrolidines', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D011759', 'descriptor_name': 'Pyrrolidines', 'qualifier_ui': 'Q000737', 'qualifier_name': 'chemistry', 'is_major_topic': False}, {'descriptor_ui': 'D011803', 'descriptor_name': 'Quinine', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D011803', 'descriptor_name': 'Quinine', 'qualifier_ui': 'Q000494', 'qualifier_name': 'pharmacology', 'is_major_topic': False}, {'descriptor_ui': 'D014700', 'descriptor_name': 'Verapamil', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D014700', 'descriptor_name': 'Verapamil', 'qualifier_ui': 'Q000494', 'qualifier_name': 'pharmacology', 'is_major_topic': False}], 'locations_count': 2, 'locations': [{'is_oa': False, 'landing_page_url': 'https://doi.org/10.4269/ajtmh.1993.49.113', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S100045985', 'display_name': 'American Journal of Tropical Medicine and Hygiene', 'issn_l': '0002-9637', 'issn': ['0002-9637', '1476-1645'], 'is_oa': False, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310315658', 'host_organization_name': 'American Society of Tropical Medicine and Hygiene', 'host_organization_lineage': ['https://openalex.org/P4310315658'], 'host_organization_lineage_names': ['American Society of Tropical Medicine and Hygiene'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}, {'is_oa': False, 'landing_page_url': 'https://pubmed.ncbi.nlm.nih.gov/8352383', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S4306525036', 'display_name': 'PubMed', 'issn_l': None, 'issn': None, 'is_oa': False, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1299303238', 'host_organization_name': 'National Institutes of Health', 'host_organization_lineage': ['https://openalex.org/I1299303238'], 'host_organization_lineage_names': ['National Institutes of Health'], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}], 'best_oa_location': None, 'sustainable_development_goals': [{'score': 0.74, 'display_name': 'Good health and well-being', 'id': 'https://metadata.un.org/sdg/3'}], 'grants': [], 'datasets': [], 'versions': [], 'referenced_works_count': 0, 'referenced_works': [], 'related_works': ['https://openalex.org/W2411826739', 'https://openalex.org/W2411013561', 'https://openalex.org/W2409312553', 'https://openalex.org/W2398251522', 'https://openalex.org/W2398106433', 'https://openalex.org/W2396358117', 'https://openalex.org/W2022025781', 'https://openalex.org/W1998937714', 'https://openalex.org/W1995455854', 'https://openalex.org/W1508279239'], 'abstract_inverted_index': {'With': [0], 'the': [1, 32, 40, 63, 78, 82, 89, 104, 114, 130, 137, 149, 154, 160, 163, 169, 207, 210], 'recent': [2], 'observations': [3], 'of': [4, 6, 13, 26, 34, 42, 65, 84, 87, 93, 111, 116, 139, 151, 166, 172, 177, 188, 212, 215], 'efflux': [5], 'chloroquine': [7, 14, 71, 94, 117, 173, 202], 'from': [8], 'Plasmodium': [9], 'falciparum': [10, 68, 98], 'and': [11, 72], 'modulation': [12], 'resistance': [15, 203], 'by': [16], 'calcium': [17], 'channel': [18], 'blockers,': [19], 'such': [20], 'as': [21], 'verapamil,': [22], 'a': [23, 46, 122, 194], 'great': [24], 'deal': [25], 'attention': [27], 'has': [28, 51], 'been': [29], 'focused': [30], 'on': [31, 168, 185], 'development': [33], 'new': [35, 47], 'modulators': [36], 'that': [37, 50, 127], 'can': [38], 'potentiate': [39], 'efficacy': [41, 138, 150], 'chloroquine.': [43, 58], 'We': [44], 'report': [45], 'compound,': [48], 'WR268954,': [49, 88], 'weak': [52], 'intrinsic': [53], 'antimalarial': [54, 170], 'activity': [55, 171, 205], 'compared': [56], 'to': [57, 70, 121, 126, 193], 'In': [59, 81, 157], 'vitro,': [60], 'it': [61], 'increased': [62, 113], 'susceptibilities': [64], 'chloroquine-resistant': [66], 'P.': [67, 97, 178], 'strains': [69, 120, 176, 187], 'quinine,': [73], 'but': [74, 180], 'did': [75, 146], 'not': [76, 147], 'affect': [77], 'chloroquine-susceptible': [79], 'strains.': [80], 'presence': [83], '2,000': [85], 'nM': [86], '50%': [90], 'inhibitory': [91], 'concentration': [92, 110], 'for': [95, 129, 209], 'drug-resistant': [96, 142, 175], 'decreased': [99], '90-fold': [100], 'in': [101, 118, 141, 153, 174, 200], 'comparison': [102], 'with': [103], 'control': [105], '(chloroquine': [106], 'only).': [107], 'The': [108], 'same': [109], 'WR268954': [112, 145, 167, 191], 'potentiation': [115], 'resistant': [119], 'level': [123], 'approximately': [124], 'equivalent': [125], 'observed': [128], 'sensitive': [131], 'strain.': [132], 'This': [133], 'compound': [134], 'also': [135], 'potentiates': [136], 'quinine': [140], 'parasites.': [143, 156, 189], 'However,': [144], 'enhance': [148], 'mefloquine': [152], 'mefloquine-resistant': [155], 'this': [158, 213], 'report,': [159], 'data': [161], 'show': [162], 'synergistic': [164], 'effect': [165, 184], 'falciparum,': [179], 'only': [181], 'an': [182], 'additive': [183], 'drug-sensitive': [186], 'Compound': [190], 'belongs': [192], 'pyrrolidino': [195], 'alkane': [196], 'amine': [197], 'class': [198, 214], 'whose': [199], 'vitro': [201], 'modulator': [204], 'supports': [206], 'basis': [208], 'synthesis': [211], 'compounds.': [216]}, 'cited_by_api_url': 'https://api.openalex.org/works?filter=cites:W2433681220', 'counts_by_year': [{'year': 2016, 'cited_by_count': 1}], 'updated_date': '2024-12-08T20:36:57.118395', 'created_date': '2016-06-24'}