The effect of reserpine on stress-induced stomach ulcer in rats

Name: Work Video:
Duration: 3 min 30 s
Sadao NAKANE; Takeshi Sakai
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['https://openalex.org/W4249176446', 'https://openalex.org/W2748952813', 'https://openalex.org/W2132898409', 'https://openalex.org/W2037631372', 'https://openalex.org/W2030889776', 'https://openalex.org/W1984079239', 'https://openalex.org/W1979139803', 'https://openalex.org/W1974041167', 'https://openalex.org/W1966775726', 'https://openalex.org/W1966504330'], 'abstract_inverted_index': {'reserpine投与ラットのストレス潰瘍発生につき検討した.': [0], '1)': [1], 'reserpine': [2, 15], '(1mg/kg/day,': [3], 'i.': [4, 26, 31], 'p.)': [5, 19, 27, 32], '5回反復投与は,ストレス潰瘍の形成を有意に抑制した.': [6], '2)': [7], 'reserpine反復投与によるストレス潰瘍抑制の要因を検討するため,ストレス負荷時の胃液分泌,胃運動および胃粘膜血管透過性を検討した.': [8], 'reserpine反復投与は,ストレス負荷時の胃液分泌抑制に有意の影響を示さず,胃緊張と運動の亢進をやや増強した.他方,': [9], 'PSB胃漏出量減少を軽減した.すなわち,': [10], 'reserpineの潰瘍抑制作用の少くとも一部は,ストレス時の胃粘膜血流減少の阻止によるものであろう.': [11], '3)': [12], 'ストレス潰瘍の形成は,': [13], 'reserpine投与30m後にストレスを負荷すると増強の傾向がみられ,': [14], '25,': [16], '5mg/kg': [17], '(i.': [18], '投与8または12h後にストレスを負荷すると抑制された.': [20], 'reserpine投与後初期のストレス潰瘍増大には,生体アミンの遊離促進が関与すると考えられる.': [21], '4)': [22], 'α-methyl': [23, 34], 'dopa': [24], '(400mg/kg,': [25], 'は,ストレス潰蕩を抑制し,': [28], 'p-CPA': [29], '(300mg/kg,': [30], 'は潰瘍形成増強の傾向を示した.また,': [33], 'dopaとp-CPAの併用は,潰瘍形成を抑制した.これより,': [35], 'reserpineのストレス潰瘍抑制には,': [36], '5-HTよりもCAの減少がより大きく関与するのであろう。': [37]}, 'cited_by_api_url': 'https://api.openalex.org/works?filter=cites:W2429750345', 'counts_by_year': [], 'updated_date': '2024-12-15T15:58:03.154128', 'created_date': '2016-06-24'}
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