Get quick answers to your questions about the article from our AI researcher chatbot
{'id': 'https://openalex.org/W2426644328', 'doi': None, 'title': 'A phase I trial of combination fludarabine monophosphate and chlorambucil in chronic lymphocytic leukemia: a Southwest Oncology Group study.', 'display_name': 'A phase I trial of combination fludarabine monophosphate and chlorambucil in chronic lymphocytic leukemia: a Southwest Oncology Group study.', 'publication_year': 1993, 'publication_date': '1993-03-01', 'ids': {'openalex': 'https://openalex.org/W2426644328', 'mag': '2426644328', 'pmid': 'https://pubmed.ncbi.nlm.nih.gov/7680398'}, 'language': 'en', 'primary_location': {'is_oa': False, 'landing_page_url': 'https://pubmed.ncbi.nlm.nih.gov/7680398', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S4306525036', 'display_name': 'PubMed', 'issn_l': None, 'issn': None, 'is_oa': False, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1299303238', 'host_organization_name': 'National Institutes of Health', 'host_organization_lineage': ['https://openalex.org/I1299303238'], 'host_organization_lineage_names': ['National Institutes of Health'], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}, 'type': 'article', 'type_crossref': 'journal-article', 'indexed_in': ['pubmed'], 'open_access': {'is_oa': False, 'oa_status': 'closed', 'oa_url': None, 'any_repository_has_fulltext': False}, 'authorships': [{'author_position': 'first', 'author': {'id': 'https://openalex.org/A5068040261', 'display_name': 'Laurence Elias', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I169521973', 'display_name': 'University of New Mexico', 'ror': 'https://ror.org/05fs6jp91', 'country_code': 'US', 'type': 'education', 'lineage': ['https://openalex.org/I169521973']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'Laurence Elias', 'raw_affiliation_strings': ['University of New Mexico, Albuquerque.'], 'affiliations': [{'raw_affiliation_string': 'University of New Mexico, Albuquerque.', 'institution_ids': ['https://openalex.org/I169521973']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5023121371', 'display_name': 'Donna Stock-Novack', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I4210165553', 'display_name': 'SWOG Cancer Research Network', 'ror': 'https://ror.org/05n6zrm60', 'country_code': 'US', 'type': 'facility', 'lineage': ['https://openalex.org/I1299022934', 'https://openalex.org/I1299303238', 'https://openalex.org/I4210140884', 'https://openalex.org/I4210165553']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'Donna Stock-Novack', 'raw_affiliation_strings': ['SW Oncology Group Statistical Center'], 'affiliations': [{'raw_affiliation_string': 'SW Oncology Group Statistical Center', 'institution_ids': ['https://openalex.org/I4210165553']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5103722102', 'display_name': 'David R. Head', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I1313298211', 'display_name': "St. Jude Children's Research Hospital", 'ror': 'https://ror.org/02r3e0967', 'country_code': 'US', 'type': 'healthcare', 'lineage': ['https://openalex.org/I1313298211', 'https://openalex.org/I2802152183']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'David R. Head', 'raw_affiliation_strings': ['St. Jude Children Research Hospital'], 'affiliations': [{'raw_affiliation_string': 'St. Jude Children Research Hospital', 'institution_ids': ['https://openalex.org/I1313298211']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5051619378', 'display_name': 'Michael R. Grever', 'orcid': 'https://orcid.org/0000-0002-1605-7875'}, 'institutions': [{'id': 'https://openalex.org/I52357470', 'display_name': 'The Ohio State University', 'ror': 'https://ror.org/00rs6vg23', 'country_code': 'US', 'type': 'education', 'lineage': ['https://openalex.org/I52357470']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'Michael R. Grever', 'raw_affiliation_strings': ['the Ohio State University'], 'affiliations': [{'raw_affiliation_string': 'the Ohio State University', 'institution_ids': ['https://openalex.org/I52357470']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5003121290', 'display_name': 'James K. Weick', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I1316902750', 'display_name': 'Cleveland Clinic', 'ror': 'https://ror.org/03xjacd83', 'country_code': 'US', 'type': 'healthcare', 'lineage': ['https://openalex.org/I1316902750']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'James K. Weick', 'raw_affiliation_strings': ['[Cleveland Clinic Foundation]'], 'affiliations': [{'raw_affiliation_string': '[Cleveland Clinic Foundation]', 'institution_ids': ['https://openalex.org/I1316902750']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5016443781', 'display_name': 'Robert Chapman', 'orcid': None}, 'institutions': [], 'countries': [], 'is_corresponding': False, 'raw_author_name': 'Robert A. Chapman', 'raw_affiliation_strings': ['Internal Medicine'], 'affiliations': [{'raw_affiliation_string': 'Internal Medicine', 'institution_ids': []}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5054425800', 'display_name': 'John Godwin', 'orcid': 'https://orcid.org/0000-0003-3876-2505'}, 'institutions': [{'id': 'https://openalex.org/I1925986', 'display_name': 'Loyola University Chicago', 'ror': 'https://ror.org/04b6x2g63', 'country_code': 'US', 'type': 'education', 'lineage': ['https://openalex.org/I1925986']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'John E. Godwin', 'raw_affiliation_strings': ['[Loyola University Chicago.]'], 'affiliations': [{'raw_affiliation_string': '[Loyola University Chicago.]', 'institution_ids': ['https://openalex.org/I1925986']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5028269504', 'display_name': 'Earl N. Metz', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I52357470', 'display_name': 'The Ohio State University', 'ror': 'https://ror.org/00rs6vg23', 'country_code': 'US', 'type': 'education', 'lineage': ['https://openalex.org/I52357470']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'Earl N. Metz', 'raw_affiliation_strings': ['the Ohio State University'], 'affiliations': [{'raw_affiliation_string': 'the Ohio State University', 'institution_ids': ['https://openalex.org/I52357470']}]}, {'author_position': 'last', 'author': {'id': 'https://openalex.org/A5056405520', 'display_name': 'Frederick R. Appelbaum', 'orcid': 'https://orcid.org/0000-0002-1839-5069'}, 'institutions': [{'id': 'https://openalex.org/I4210089486', 'display_name': 'Fred Hutch Cancer Center', 'ror': 'https://ror.org/007ps6h72', 'country_code': 'US', 'type': 'nonprofit', 'lineage': ['https://openalex.org/I4210089486']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'Frederick R. Appelbaum', 'raw_affiliation_strings': ['Fred Hutchinson Cancer Research Center'], 'affiliations': [{'raw_affiliation_string': 'Fred Hutchinson Cancer Research Center', 'institution_ids': ['https://openalex.org/I4210089486']}]}], 'institution_assertions': [], 'countries_distinct_count': 1, 'institutions_distinct_count': 7, 'corresponding_author_ids': [], 'corresponding_institution_ids': [], 'apc_list': {'value': 3890, 'currency': 'EUR', 'value_usd': 4790, 'provenance': 'doaj'}, 'apc_paid': None, 'fwci': 1.66, 'has_fulltext': False, 'cited_by_count': 64, 'citation_normalized_percentile': {'value': 0.828446, 'is_in_top_1_percent': False, 'is_in_top_10_percent': False}, 'cited_by_percentile_year': {'min': 94, 'max': 95}, 'biblio': {'volume': '7', 'issue': '3', 'first_page': '361', 'last_page': '5'}, 'is_retracted': False, 'is_paratext': False, 'primary_topic': {'id': 'https://openalex.org/T11157', 'display_name': 'Genomic Aberrations and Treatment of Chronic Lymphocytic Leukemia', 'score': 0.9999, 'subfield': {'id': 'https://openalex.org/subfields/2716', 'display_name': 'Genetics'}, 'field': {'id': 'https://openalex.org/fields/27', 'display_name': 'Medicine'}, 'domain': {'id': 'https://openalex.org/domains/4', 'display_name': 'Health Sciences'}}, 'topics': [{'id': 'https://openalex.org/T11157', 'display_name': 'Genomic Aberrations and Treatment of Chronic Lymphocytic Leukemia', 'score': 0.9999, 'subfield': {'id': 'https://openalex.org/subfields/2716', 'display_name': 'Genetics'}, 'field': {'id': 'https://openalex.org/fields/27', 'display_name': 'Medicine'}, 'domain': {'id': 'https://openalex.org/domains/4', 'display_name': 'Health Sciences'}}, {'id': 'https://openalex.org/T10185', 'display_name': 'Lymphoid Neoplasms', 'score': 0.9551, 'subfield': {'id': 'https://openalex.org/subfields/2734', 'display_name': 'Pathology and Forensic Medicine'}, 'field': {'id': 'https://openalex.org/fields/27', 'display_name': 'Medicine'}, 'domain': {'id': 'https://openalex.org/domains/4', 'display_name': 'Health Sciences'}}, {'id': 'https://openalex.org/T10950', 'display_name': 'Epidemiology and Treatment of Childhood Leukemia', 'score': 0.9489, 'subfield': {'id': 'https://openalex.org/subfields/2739', 'display_name': 'Public Health, Environmental and Occupational Health'}, 'field': {'id': 'https://openalex.org/fields/27', 'display_name': 'Medicine'}, 'domain': {'id': 'https://openalex.org/domains/4', 'display_name': 'Health Sciences'}}], 'keywords': [{'id': 'https://openalex.org/keywords/chlorambucil', 'display_name': 'Chlorambucil', 'score': 0.9363346}, {'id': 'https://openalex.org/keywords/bendamustine', 'display_name': 'Bendamustine', 'score': 0.6437769}, {'id': 'https://openalex.org/keywords/treatment-outcomes', 'display_name': 'Treatment Outcomes', 'score': 0.45213}], 'concepts': [{'id': 'https://openalex.org/C2779263901', 'wikidata': 'https://www.wikidata.org/wiki/Q185916', 'display_name': 'Fludarabine', 'level': 4, 'score': 0.9550551}, {'id': 'https://openalex.org/C2777866208', 'wikidata': 'https://www.wikidata.org/wiki/Q415939', 'display_name': 'Chlorambucil', 'level': 4, 'score': 0.9363346}, {'id': 'https://openalex.org/C2777938653', 'wikidata': 'https://www.wikidata.org/wiki/Q1088156', 'display_name': 'Chronic lymphocytic leukemia', 'level': 3, 'score': 0.7682455}, {'id': 'https://openalex.org/C2778397455', 'wikidata': 'https://www.wikidata.org/wiki/Q50429865', 'display_name': 'Antimetabolite', 'level': 3, 'score': 0.6991202}, {'id': 'https://openalex.org/C71924100', 'wikidata': 'https://www.wikidata.org/wiki/Q11190', 'display_name': 'Medicine', 'level': 0, 'score': 0.6944093}, {'id': 'https://openalex.org/C2781442060', 'wikidata': 'https://www.wikidata.org/wiki/Q425745', 'display_name': 'Bendamustine', 'level': 4, 'score': 0.6437769}, {'id': 'https://openalex.org/C126322002', 'wikidata': 'https://www.wikidata.org/wiki/Q11180', 'display_name': 'Internal medicine', 'level': 1, 'score': 0.6243429}, {'id': 'https://openalex.org/C2908647359', 'wikidata': 'https://www.wikidata.org/wiki/Q2625603', 'display_name': 'Population', 'level': 2, 'score': 0.47305882}, {'id': 'https://openalex.org/C90924648', 'wikidata': 'https://www.wikidata.org/wiki/Q120569', 'display_name': 'Gastroenterology', 'level': 1, 'score': 0.42076182}, {'id': 'https://openalex.org/C143998085', 'wikidata': 'https://www.wikidata.org/wiki/Q162555', 'display_name': 'Oncology', 'level': 1, 'score': 0.39404}, {'id': 'https://openalex.org/C2776694085', 'wikidata': 'https://www.wikidata.org/wiki/Q974135', 'display_name': 'Chemotherapy', 'level': 2, 'score': 0.37715238}, {'id': 'https://openalex.org/C2778461978', 'wikidata': 'https://www.wikidata.org/wiki/Q29496', 'display_name': 'Leukemia', 'level': 2, 'score': 0.34986824}, {'id': 'https://openalex.org/C203014093', 'wikidata': 'https://www.wikidata.org/wiki/Q101929', 'display_name': 'Immunology', 'level': 1, 'score': 0.33192563}, {'id': 'https://openalex.org/C2776755627', 'wikidata': 'https://www.wikidata.org/wiki/Q408524', 'display_name': 'Cyclophosphamide', 'level': 3, 'score': 0.10807547}, {'id': 'https://openalex.org/C99454951', 'wikidata': 'https://www.wikidata.org/wiki/Q932068', 'display_name': 'Environmental health', 'level': 1, 'score': 0.0}], 'mesh': [{'descriptor_ui': 'D000971', 'descriptor_name': 'Antineoplastic Combined Chemotherapy Protocols', 'qualifier_ui': 'Q000627', 'qualifier_name': 'therapeutic use', 'is_major_topic': True}, {'descriptor_ui': 'D015451', 'descriptor_name': 'Leukemia, Lymphocytic, Chronic, B-Cell', 'qualifier_ui': 'Q000188', 'qualifier_name': 'drug therapy', 'is_major_topic': True}, {'descriptor_ui': 'D000284', 'descriptor_name': 'Administration, Oral', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D000328', 'descriptor_name': 'Adult', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D000368', 'descriptor_name': 'Aged', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D000964', 'descriptor_name': 'Antimetabolites, Antineoplastic', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D000964', 'descriptor_name': 'Antimetabolites, Antineoplastic', 'qualifier_ui': 'Q000008', 'qualifier_name': 'administration & dosage', 'is_major_topic': False}, {'descriptor_ui': 'D000971', 'descriptor_name': 'Antineoplastic Combined Chemotherapy Protocols', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D000971', 'descriptor_name': 'Antineoplastic Combined Chemotherapy Protocols', 'qualifier_ui': 'Q000009', 'qualifier_name': 'adverse effects', 'is_major_topic': False}, {'descriptor_ui': 'D001792', 'descriptor_name': 'Blood Platelets', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D001792', 'descriptor_name': 'Blood Platelets', 'qualifier_ui': 'Q000187', 'qualifier_name': 'drug effects', 'is_major_topic': False}, {'descriptor_ui': 'D002699', 'descriptor_name': 'Chlorambucil', 'qualifier_ui': 'Q000008', 'qualifier_name': 'administration & dosage', 'is_major_topic': False}, {'descriptor_ui': 'D002699', 'descriptor_name': 'Chlorambucil', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D004305', 'descriptor_name': 'Dose-Response Relationship, Drug', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D004334', 'descriptor_name': 'Drug Administration Schedule', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D005260', 'descriptor_name': 'Female', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D006801', 'descriptor_name': 'Humans', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D015451', 'descriptor_name': 'Leukemia, Lymphocytic, Chronic, B-Cell', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D008297', 'descriptor_name': 'Male', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D008875', 'descriptor_name': 'Middle Aged', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D001084', 'descriptor_name': 'Vidarabine Phosphate', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D001084', 'descriptor_name': 'Vidarabine Phosphate', 'qualifier_ui': 'Q000008', 'qualifier_name': 'administration & dosage', 'is_major_topic': False}, {'descriptor_ui': 'D001084', 'descriptor_name': 'Vidarabine Phosphate', 'qualifier_ui': 'Q000031', 'qualifier_name': 'analogs & derivatives', 'is_major_topic': False}], 'locations_count': 1, 'locations': [{'is_oa': False, 'landing_page_url': 'https://pubmed.ncbi.nlm.nih.gov/7680398', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S4306525036', 'display_name': 'PubMed', 'issn_l': None, 'issn': None, 'is_oa': False, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1299303238', 'host_organization_name': 'National Institutes of Health', 'host_organization_lineage': ['https://openalex.org/I1299303238'], 'host_organization_lineage_names': ['National Institutes of Health'], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}], 'best_oa_location': None, 'sustainable_development_goals': [], 'grants': [], 'datasets': [], 'versions': [], 'referenced_works_count': 0, 'referenced_works': [], 'related_works': ['https://openalex.org/W2426644328', 'https://openalex.org/W2413682050', 'https://openalex.org/W2334528356', 'https://openalex.org/W2256304711', 'https://openalex.org/W2113187717', 'https://openalex.org/W2070910753', 'https://openalex.org/W2053375377', 'https://openalex.org/W1997101371', 'https://openalex.org/W1968821539', 'https://openalex.org/W1576916642'], 'abstract_inverted_index': None, 'cited_by_api_url': 'https://api.openalex.org/works?filter=cites:W2426644328', 'counts_by_year': [{'year': 2020, 'cited_by_count': 1}, {'year': 2016, 'cited_by_count': 1}, {'year': 2014, 'cited_by_count': 2}, {'year': 2013, 'cited_by_count': 1}, {'year': 2012, 'cited_by_count': 1}], 'updated_date': '2024-09-15T10:37:10.676934', 'created_date': '2016-06-24'}