Title: [Correlation between expression of vascular endothelial growth factor-C in tumor-associated macrophages and lymphatic metastasis in oral cancer].
Abstract: Previous study shows that both vascular endothelial growth-C (VEGF-C) and tumor-associated macrophages (TAMs) are related to lymphatic metastasis. This study aimed to explore the correlation between the expression of VEGF-C in TAMs and lymphatic metastasis in human oral squamous-cell carcinoma (OSCC).After immunohistochemical staining, light microscope was used for counting macrophages and automated image analysis quantification was used to determine VEGF-C expression,which was reflected by positive index (PI). In addition,the double staining was also used to determine VEGF-C expression in TAMs.VEGF-C expression was higher in lymphatic metastasis group (PI=12.169+/-2.778) than in no-metastasis group (PI=8.498+/-2.674, P< 0.05). TAMs counts was related to VEGF-C expression in OSCC (r=0.370, P< 0.05). The result of double staining indicated that macrophage with positive VEGF-C expression accounted for about 22.8% of the total.Not only tumor cells but also TAMs secrete the VEGF-C in OSCC, and TAMs may play a major role in peritumoral lymphatic neoangiogenesis and lymphatic metastasis.
Publication Year: 2004
Publication Date: 2004-03-01
Language: en
Type: article
Indexed In: ['pubmed']
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Cited By Count: 6
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