Title: Risperidone in Combination with Mood Stabilizers for Acute Mania : A Multicentre, Open Study
Abstract: Objective : The primary purpose of this study was a replication of the effectiveness and tolerability of risperidone in the treatment of patients with acute mania in very larger cohort in naturalistic treatment setting to extend the data on the effect and tolerability of risperidone in the treatment of patients with acute mania to Asian population. Methods : A total of 909 patients with DSM-IV criteria of bipolar disorder current manic and hypomanic episode, entered this large, open, multicentre study. The Young Mania Rating Scale (YMRS), Clinical Global Impression (CGl) and Simpson Angus Rating Scale (SARS) were measured at baseline and weeks 1,3 and 6, for the assessment of effectiveness and extrapyramidal symptom (EPS). Results: This study showed statistically significant reduction of scores on the YMRS and CGI-s (mean change = -23.511.8, p1.5, p
Publication Year: 2005
Publication Date: 2005-01-01
Language: en
Type: article
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